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English and Black Walnut Phenolic Antioxidant Activity <i>in Vitro</i>and Following Human Nut Consumption

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Food and Nutrition Sciences 2011年第3期2卷 193-200页

作者： Jacki M Rorabaugh Ajay P Singh Isabel M Sherrell Michelle R Freeman Nicholi Vorsa Peter Fitschen Christopher Malone Margaret A Maher ted wilson 不详

Background: Walnut consumption may reduce the risk of cardiovascular disease by providing antioxidant protection to low density lipoproteins (LDL). Aim: This study compared the phenolic profile and antioxidant activity of English ver- sus black walnuts. Methods: Nuts were extracted in methanol or acetone prior to analysis with HPLC/LC-MS-MS for phenolic identification and quantitation. The ability to prevent oxidation of LDL was examined in vitro using walnut extracts and ex vivo after walnut consumption for 28 days. Results: Flavonoids identified/quantified with HPLC/LC- MS-MS included the phenolic acids 5-caffeoylquinic acid, 3-caffeoylquinic acid (black walnut only), 4-caffeoylquinic acid, and the flavonol glycosides quercetin-3-rutinoside, quercetin-3-galactoside, quercetin-3-pentoside, quercetin-3- arabinoside, quercetin-3-rhamnoside, and the aglycone quercetin (English walnut only). Total phenolic yield of acetone extracts were 166.1 and 24.2 μg/g for English and black walnut respectively, and yield for methanol extracts were 147.6 and 4.1 μg/g for English and black walnut respectively. In vitro LDL oxidation by Cu++ with English walnut ex- tracts significantly extended oxidation lag-time (A234) in a dose dependent manner at 1.0 and 0.1 μg/ml and reduced TBARS formation (1.0 μg/ml). Black walnut extracts reduced TBARS significantly but had no effect on A234. Human consumption of English or black walnuts (30 g nuts/day) for 28 days resulted in no differences in LDL antioxidant ca- pacity (A234) between groups or within groups. Conclusion: This study suggests that the English walnuts have a pheno- lic profile and in vitro antioxidant capacity that is better than black walnuts, but that walnut consumption for 28 days does not improve LDL resistance to oxidation.

关键词： Walnut Lipoprotein Oxidation Antioxidant Phenolic Flavonol

LC-MS-MS Analysis and the Antioxidant Activity of Flavonoids from Eggplant Skins Grown in Organic and Conventional Environments

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Food and Nutrition Sciences 2017年第9期8卷 873-888页

作者： Ajay P. Singh Yifei Wang Rachel M. Olson Devanand Luthria Gary S. Banuelos Sajeemas Pasakdee Nicholi Vorsa ted wilson Department of Plant Biology & Pathology Rutgers The State University of New Jersey New Brunswick NJ USA Department of Biology Winona State University Winona MN USA USDA Agricultural Research Service Food Composition and Methods Development Lab Beltsville MD USA USDA Agricultural Research Service San Joaquin Valley Agricultural Sciences Center Parlier CA USA

Eggplant fruits are known to contain different classes of phenolic phytochemicals (flavonols, phenolic acids, and anthocyanins) that can exert beneficial effects on human health. This study developed methods for the qualitative and quantitative composition analysis of phenolic compounds in the skin of eggplant fruits harvested following conventional and certified organic farming conditions. Eggplant skin was extracted using aqueous methanol prior to phenolic profiling with UHPLC-ESI-MS-MS. Eggplant skin extracts yielded a profile of 16 phenolic acids, 4 anthocyanins, and 11 flavonols, the first report of quercetin-3-diglucoside, myricetin-3-neohesperidoside, myricetin-3-galactoside, kaempferol-3,7-diglucoside, kaempferol-diglucoside and quercetin-3-rhamnoside. Polyphenolic extracts from all sources potently delayed the cupric ion-mediated lag-time for LDL lipid oxidation and protected Apo-B100 proteins against oxidative modification. Organic growing environment positively influences eggplant skin extract phenolic profile but not antioxidant capacity. In conclusion, eggplant skin has a robust profile of phenolic phytochemicals with excellent antioxidant properties.

关键词： Eggplant Skin Polyphenols LDL Antioxidant Activity Conventional and Organic HPLC LC-MS

Glycemic Response of Type 2 Diabetics to Raisins

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Food and Nutrition Sciences 2012年第8期3卷 1162-1166页

作者： ted wilson Jared A. Anderson Kristine F. Andersen Rachael A. Heimerman Megan M. Larson Michelle R. Freeman Sarah E. Baker Department of Biology Winona State University Winona MN 55987

Background: Raisins are a nutritious fruit snack containing fiber, antioxidants, and potassium. Diabetics tend to have low fruit intakes, possibly due to concerns about glycemic response. Aim: This study sought to characterize the utility of raisins as a way to improve fruit consumption by type 2 diabetics. Methods: Fasting type 2 diabetics randomly received 100 Calorie servings of bananas (BA;103.1 g), white bread (WB;40.2 g), raisins (RA;30.3 g), or Thompson seedless grapes (TG;112.4 g) on each of four separate lab visits in single cross-over fashion. Blood glucose (n = 15) and plasma insulin (n = 7) were measured before and 30, 60, 120 minutes after snack consumption. Results: Relative to baseline, blood glucose peaked significantly at 30 minutes for TG, RA and WB at 204.6 ± 16.2, 180.5 ± 12.7, and 176.2 ± 12.2 mg/dL, respectively, the 30 minute value for BA (173.2 ± 11.6 mg/dL) approached significance (p = 0.12). At 30 minutes, the blood glucose values for BA and TG differed significantly, at all other times no significant differences were observed, and all values returned to near baseline 120 minutes after consumption. Postprandial plasma insulin increased for all treatments, though not significantly. Conclusion: The extended shelf life and portability of raisins may make them an attractive choice for improving fruit consumption in type 2 diabetics.

关键词： Diabetes Glycemic Response Raisin Grape Bread Banana Fruit

LXI instrument development platform based on an open embedded operating system

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仪器仪表学报 2007年第5期28卷 788-791页

作者： Yu wilson Deovo Technologics Inc. 45 Bristol Rd.E Suite 21Mississauga ONCCanada L4Z 3P5

This paper introduces the architecture and components of LXI instrument development platform based on an open embedded operating system,which is a modular and configurable *** platform is a total solution to develop LXI instrument modules and *** the other hand,it also supports other types of instrument *** is a generic and efficient *** the end,this paper addresses the technical tends, challenges,and recormnends solutions.

关键词：开放式嵌入操作系统仪器扩展 LXI 技术对策 LAN接口

Current status and future directions of high-throughput ADME screening in drug discovery

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Journal of Pharmaceutical Analysis 2020年第3期10卷 201-208页

作者： wilson Z.Shou Bristol-Myers Squibb PO Box 4000PrincetonNJ08540USA

During the last decade high-throughput in vitro absorption,distribution,metabolism and excretion(HTADME)screening has become an essential part of any drug discovery effort of synthetic *** conduct of HT-ADME screening has been"industrialized"due to the extensive development of software and automation tools in cell culture,assay incubation,sample analysis and data *** HT-ADME assay portfolio continues to expand in emerging areas such as drug-transporter interactions,early soft spot identification,and ADME screening of peptide drug ***,thanks to the very large and high-quality HT-ADME data sets available in many biopharma companies,in silico prediction of ADME properties using machine learning has also gained much momentum in recent *** this review,we discuss the current state-of-the-art practices in HT-ADME screening including assay portfolio,assay automation,sample analysis,data processing,and prediction model *** addition,we also offer perspectives in future development of this exciting field.

关键词： In vitro HT-ADME Automation Bioanalysis Mass spectrometry Acoustic ejection mass spectrometry

More evidence intratumoral DHT synthesis drives castration-resistant prostate cancer

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Asian Journal of Andrology 2014年第1期16卷 99-100页

作者： Elizabeth M wilson Laboratories for Reproductive Biology Department of Pediatrics Lineberger Comprehensive Cancer Center Department of Biochemistry and Biophysics University of North Carolina

Again-of-function stabilizing somatic mutation in 3β-hydroxysteroiddehydrogenase type 1 （3βHSDI, HSD3B1） was reported in castration-resistant prostate cancer. The A-C nucleotide polymorphism replaced asparagine-367 with threonine （3βHSD1-N367T） as a homozygous somatic mutation in a subset of castration-resistant prostate cancers by loss of heterozygosity of the wild-type allele. Increased stability of 3[HSD I-N367T was associated with decreased ubiquitin-mediated degradation and higher levels of dihydrotestosterone （DHT）. The studies suggest that genetic instability in castration-resistant prostate cancer favors the more stable 313HSD I-N367T mutant that contributes to drug resistance. A somatic mutation in a steroid metabolic enzyme required for DHT synthesis provides further support for intratumoral androgen synthesis contributing to prostate cancer progression.

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Can dietary flavonoids be useful in the personalized treatment of colorectal cancer?

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1115-1123页

作者： Cristina Pereira-wilson Department of Biology Centre of Biological EngineeringLABBELS Associate LaboratoryUniversity of MinhoBraga 4710-057Portugal

Activating mutations in the oncogenes KRAS,BRAF and PI3K define molecular colorectal cancer(CRC)subtypes because they play key roles in promoting CRC development and in determining the efficacy of chemotherapeutic agents such as 5-fluorouracil and anti-epidermal growth factor receptor monoclonal *** of patients with cancers displaying these molecular profiles is *** the limited efficacy of therapeutic strategies for CRC presenting mutational activations in mitogen-activated protein kinase and/or PI3K pathways,developing combination therapies with natural flavonoids or other phytochemicals with demonstrated effects on these pathways(and little or no toxic effects)may constitute a valuable path *** has been published on the anticancer effects of dietary ***,even an exhaustive characterization of potential beneficial effects produced by in vitro studies cannot be extrapolated to effects in *** far,the available data constitute a good starting *** results show quercetin and curcumin as possibly the best candidates to be further explored in the context of adjuvant CRC therapy either as part of dietary prescriptions or as purified compounds in combination regimens with the drugs currently used in CRC *** trial data is still largely missing and is urgently needed to verify relevant effects and for the development of more personalized treatment approaches.

关键词： Colorectal cancer Personalized treatment Quercetin Curcumin KRAS BRAF

Special Issue on Machine Fault Diagnostics and Prognostics

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Chinese Journal of Mechanical Engineering 2017年第6期30卷 1283-1284页

作者： Zhigang Tian wilson Wang University of Alberta Edmonton Canada Lakehead University Thunder Bay Canada

Machine components and systems, such as gears, bearings, pipes, cutting tools and turbines, may experience various types of faults, such as breakage, crack, pitting, wear, corrosion. If not being properly monitored and treated, such faults can propagate and lead to machinery perfor- mance degradation, malfunction, or even severe compo- nent/system failure. It is significant to reliably detect machinery defects, evaluate their severity, predict the fault propagation trends, and schedule optimized maintenance and inspection activities to prevent unexpected failures. Advances in these areas will support ensuring equipment and production reliability, safety, quality and productivity.

关键词： Special Issue Machine Fault Diagnostics Prognostics

The Birth of Bio-data Science:Trends,Expectations,and Applications

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Genomics, Proteomics & Bioinformatics 2020年第1期18卷 5-15页

作者： wilson Wen Bin Goh Limsoon Wong School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Department of Computer Science National University of SingaporeSingapore 117417Singapore

Components of bio-data science Biology is becoming increasingly digitized and has now taken on the sheen of a quantitative scientific discipline.A key driving factor is the increasing pervasiveness of high-throughput technological platforms in biological research,allowing millions of data points on genes,proteins,and other biological moieties across thousands of tissues and organisms to be compiled,cleaned,stored,and integrated for the purpose of systematic *** this data-rich landscape.

关键词： driving becoming landscape.