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中国化学会第28届学术年会

作者： teck-Peng Loh Department of Chemistry University of Science and Technology of China Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological University

＜正＞The biosynthetic cationic polyene cyclizations of acyclic precursors squalene and（3S）-2,3-oxidosqualene lead to a vast array of known tricyclic,tetracyclic and pentacyclic natural products.2 In particular,lanosterol is biosynthesized in a single,economical and effective step from （3S）-2,3-oxidosqualene by a single 83-kDa *** impressive part about this reaction is the ability

关键词： polyene acetal-initiated natural products aqueous media high enantioselectivies

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Asymmetric Allylation of Ketones Catalyzed by Chiral In（Ⅲ）-PYBOX Complex Immobilized in [Hmim]PF6

Asymmetric Allylation of Ketones Catalyzed by Chiral In（Ⅲ...

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中国化学会第四届有机化学学术会议

作者： LOH,teck-Peng Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering Suzhou University Suzhou 215006 China Division of Chemistry and Biological ChemistryNanyang Technological UniversitySingapore 637616Singapore

＜正＞Recently, ionic liquids have attracted extensive interest as excellent alternatives to organic solvents, due to their favourable properties, such as non-flammability, no measurable vapour pressure, low toxicity, reusability, low cost and high thermal stability. Over the past few years, ionic liquids have generated a significant amount of interest. It was reported that the allylation reaction of carbonyl functionality with allytributystannane in ionic liquids

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Rencent Progress In The Total Synthesis Of Natural Products

Rencent Progress In The Total Synthesis Of Natural Products

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中国化学会第九届全国有机化学学术会议

作者： teck-Peng Loh Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University Department of Chemistry University of Science and Technology of China

＜正＞One of the objectives in our group is to search for new synthetic methods and concepts through the total synthesis of natural *** this presentation,I will go through some of the methodologies and concepts develo...

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Copper Catalyzed Highly Regioselective Silylcupration of Terminal Alkynes to Form α-Vinylsilanes

Copper Catalyzed Highly Regioselective Silylcupration of Ter...

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氟化学与美好生活——中国化学会第十一届全国氟化学会议

作者： teck-Peng Loh Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological University

＜正＞A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper（Ⅰ）was developed using methanol as *** corresponding vinylsilanes were obtain...

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Enantioselective Addition of Methailyitributyitin to Aldehydes Catalyzed by Chiral In（Ⅲ）-PYBOX Complex

Enantioselective Addition of Methailyitributyitin to Aldehyd...

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中国化学会第四届有机化学学术会议

作者： LOH,teck-Peng Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical EngineeringSuzhou UniversitySuzhou 215006China Division of Chemistry and Biological ChemistryNanyang Technological UniversitySingapore 637616Singapore

＜正＞The synthesis of enantiomerically enriched homoallylic alcohols is an important goal in organic synthesis. This is because homoallylic alcohols are versatile intermediates which can be converted to a wide variety of synthetically useful compounds. Therefore, there has been intense research activity in this area in recent years, leading to the development of a large and diverse array of chiral catalysts, especially chiral Lewis acid-catalyzed addition of the allyl transfer reagents to carbonyl functionality.

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Indium（Ⅲ） Iodine Catalyzed Strecker Reaction in Water: An Efficient and Environmentally-friendly Method for the Synthesis of a-Aminonitrile via a Three-component Condensation

Indium（Ⅲ） Iodine Catalyzed Strecker Reaction in Water: An...

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中国化学会第四届有机化学学术会议

作者： LOH,teck-Peng Key Lab of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering Suzhou University Suzhou 215006 China Division of Chemistry and Biological ChemistryNanyang Technological UniversitySingapore 637616Singapore

＜正＞α-Aminonitriles are significantly important intermediates for the synthesis of a wide variety of amino acids, amides, diamines and nitrogen-containing heterocycles. Among the numerous methods described for the syntheses of α-aminonitriles, Strecker reaction which proceeded via the addition of HCN to imine proved to be an effective method for the preparation of α-aminonitrile. Recently, modified method using one-pot procedure via three-component condensation of aldehyde, amine and trimethylsilyl cyanide catalyzed by Lewis acids in organic

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The audit expectation gap： A review of the contributing factors

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Journal of Modern Accounting and Auditing 2008年第8期4卷 30-37页

作者： LEE teck-Heang Azham Md. Ali Faculty of Accountancy and Management Universiti Tunku Abdul Rahman Selangon 43000 Malaysia College of Business Accounting BuiMing Universiti Utara Malaysia UUM Sintok Kedah Darul Aman 06010 Malaysia

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The evolution of auditing： An analysis of the historical development

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Journal of Modern Accounting and Auditing 2008年第12期4卷 1-8页

作者： LEE teck-Heang Azham Md. Ali Faculty of Accountancy and Management Universiti Tunku Abdul Rahman Selangon 43000 Malaysia College of Business Accounting Building Universiti Utara Malaysia UUM Sintok Kedah Darul Aman 06010 Malaysia

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基于FOXM1蛋白的定量恶性肿瘤指数诊断系统在口腔鳞癌基因诊断的应用

基于FOXM1蛋白的定量恶性肿瘤指数诊断系统在口腔鳞癌基因诊断的...

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2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展

作者：马洪周可 Muy teck Teh 贵州医科大学附属口腔医院英国伦敦大学玛丽皇后学院

研究目的:FOXM1转录因子基因已经涉及到人类几乎所有类型的癌症。本课题组联合伦敦大学玛丽皇后学院(QMUL)应用定量恶性肿瘤指数诊断系统(qMIDS)对中国与欧洲口腔癌患者进行检测。对比中国与欧洲口腔癌患者分析口腔癌基因与年龄、性别... 详细信息

研究目的:FOXM1转录因子基因已经涉及到人类几乎所有类型的癌症。本课题组联合伦敦大学玛丽皇后学院(QMUL)应用定量恶性肿瘤指数诊断系统(qMIDS)对中国与欧洲口腔癌患者进行检测。对比中国与欧洲口腔癌患者分析口腔癌基因与年龄、性别、种族、肿瘤分型分期及转移是否相关,并制定适合中国患者的诊疗手段及方案。研究方法:应用qMIDS技术对251例口腔鳞癌和107例健康对照人群进行FOXM1相关基因联合检测。该技术针对16个量化的FOXM1相关基因的mRNA水平(HOXA7, AURKA, NEK2, FOXM1B,CCNB1, CEP55, CENPA, DNMT3B, DNMT1, HELLS, MAPK8, BMI1,ITGB1,IVL)整合后用以计算癌症的恶性肿瘤指数(MI)。其中14个基因涉及细胞增殖、调控、分化、凋亡,基因组稳定,表观遗传和干细胞的重组。同时分析其基因水平与性别和年龄、肿瘤分化程度、临床分期和淋巴转移状态的关系。

关键词：口腔鳞癌 FOXM1 基因诊断早期肿瘤标志物

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Exploring the association between gastrointestinal heat retention syndrome and adult chronic eczema: A caseecontrol study

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 114-120页

作者： Chencheng Mei He Yu Wenlong Li Xueyan Ma Yunbi Zhang Qi Sun Yuhong Kong Tiegang Liu teck Chuan Kong Xiaohong Gu Beijing University of Chinese Medicine Beijing100029China Department of Dermatology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Department of Orthopaedics Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Department Dermatology Dongfang HospitalBeijing University of Chinese MedicineBeijing100078China School of Biological Sciences Nanyang Technological UniversityNanyang Avenue639815Singapore

Objective:To investigate the association between gastrointestinal heat retention syndrome(GHRS)and adult chronic ***:This caseecontrol study compared GHRS/GHRS accompanied by damp-heat syndrome(GHRSDHS)and other patient characteristics between subjects with(cases)and without chronic eczema(controls)to identify potential factors associated with this ***-structured questionnaires were used to collect data via face-to-face *** were recruited from Dongzhimen Hospital affiliated with Beijing University of Chinese Medicine.A logistic regression analysis was performed on the collected data,and odds ratios(ORs)were ***:A total of 168 cases and 172 controls were *** the cases of adult chronic eczema,there were 79 subjects with GHRS and 68 with ***(P=.02,OR=0.54,95%confidence interval[CI]:0.32-0.91),GHRS(P=.04,OR=1.90,95%CI:1.02-3.51),GHRS-DHS(P<.001,OR=4.89,95%CI:2.36-10.15),high sweet food consumption(P=.04,OR=2.03,95%CI:1.03-3.97),and mental stress(P=.01,OR=2.37,95%CI:1.26-4.47)were each found to be associated with chronic ***,GHRS had a weak positive correlation with eczema EASI severity as measured by the eczema area and severity index(EASI)(P=003).Conclusion:GHRS/GHRS-DHS may be associated with adult chronic *** the future,prospective cohort studies with larger samples should be conducted to investigate the cause and effect association between GHRS and adult chronic eczema.

关键词： Adult chronic eczema Gastrointestinal heat retention syndrome Case-control study Traditional Chinese medicine

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