Indium（Ⅲ） Iodine Catalyzed Strecker Reaction in Water: An Efficient and Environmentally-friendly Method for the Synthesis of a-Aminonitrile via a Three-component Condensation

作     者：LOH,Teck-Peng 

作者单位：Key Lab of Organic Synthesis of Jiangsu ProvinceCollege of Chemistry and Chemical Engineering Suzhou University Suzhou 215006 China Division of Chemistry and Biological ChemistryNanyang Technological UniversitySingapore 637616Singapore 

会议名称：《中国化学会第四届有机化学学术会议》

会议日期：2005年

学科分类：081705[工学-工业催化] 08[工学] 0817[工学-化学工程与技术] 

基　　金：Project supported by the National Natural Science Foundation of China (Nos. 20172039 and 20472062) Nanyang Technological University of Singapore 

摘      要：正α-Aminonitriles are significantly important intermediates for the synthesis of a wide variety of amino acids, amides, diamines and nitrogen-containing heterocycles. Among the numerous methods described for the syntheses of α-aminonitriles, Strecker reaction which proceeded via the addition of HCN to imine proved to be an effective method for the preparation of α-aminonitrile. Recently, modified method using one-pot procedure via three-component condensation of aldehyde, amine and trimethylsilyl cyanide catalyzed by Lewis acids in organic