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Facile in situ synthesis and characterization of Fe@Si/zeolite Na composites with magnetic core–shell structures from natural materials for enhanced curcumin loading capacity

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Nanotechnology and Precision Engineering 2024年第2期7卷 69-86页

作者： Munasir Nasir Nuhaa Faaizatunnisa Muhammad Naufal Ariesta lydia Rohmawati Rifqi Aul Department of Physics Faculty of Mathematics and Natural ScienceUniversitas Negeri Surabaya(Unesa)Surabaya60231Indonesia Department of Chemistry Faculty of Science and Data AnalyticsInstitut Teknologi Sepuluh Nopember(ITS)Surabaya 60111Indonesia Department of Chemistry Faculty of Mathematics and Natural SciencesUniversitas Sebelas Maret(UNS)Surakarta57126Indonesia Department of Medicine Faculty of Medical and Health ScienceUniversitas Islam Negeri(UIN)Maulana Malik IbrahimMalang65151Indonesia

Curcumin is a natural polyphenol that is used in various traditional medicines.However,its inherent properties,such as its rapid degradation and metabolism,low bioavailability,and short half-life,are serious problems that must be resolved.To this end,a drug carrier incorporating natural magnetic cores in a zeolite framework was developed and applied to the loading of curcumin in ethanol solutions.In this system,curcumin is encapsulated in a zeolite Na(ZNA)magnetic core–shell structure(Fe@Si/ZNA),which can be easily synthesized using an in situ method.Synthesis of Fe_(3)O_(4) nanoparticles was carried out from natural materials using a co-precipitation method.Analysis of the prepared magnetic core–shell structures and composites was carried out using vibrating-sample magnetometery,Fourier transform infrared spectroscopy,transmission electron microscopy,and x-ray diffraction.The cumulative loading of curcumin in the ZNA composite with 9%nanoparticles was found to reach 90.70%with a relatively long half-life of 32.49 min.Stability tests of curcumin loading in the composite showed that adding magnetic particles to the zeolite framework also increased the stability of the composite structure.Adsorption kinetics and isotherm studies also found that the system follows the pseudo-second-order and Langmuir isotherm models.

关键词： Zeolite Na Magnetic core–shell nanoparticles(MNPs) ZNA Adsorption Curcumin

Sex differences in Alzheimer's disease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel Jiménez-Herrera Ana Contreras Juan D.Navarro-López lydia Jiménez-Díaz Neurophysiology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

Due to increasing life expectancy,the amount of people with dementia worldwide is expected to experience a substantial rise,with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the year 2050.Among the various forms of dementia.Alzheimer's disease(AD)stands out as the predominant and most prevalent.

关键词： Alzheimer predominant estimates

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic lydia Jiménez-Díaz Juan D.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the pathology.However,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one another.Some researchers argue that these proteins are mere executors rather than primary causes of pathology.Therefore,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early AD.Moreover,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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基于符号数值计算的代数曲线区间插值

中国科学：数学 2024年第5期54卷 699-730页

作者： lydia Dehbi 杨争峰彭超徐姚晨曾振柄华东师范大学软件工程学院上海200062 上海大学数学系上海200444

本文研究的代数曲线区间插值问题,是针对预先给定平面上的若干矩形小邻域,构造经过它们的次数最低的代数曲线、项数最少的代数曲线以及系数是整数的代数曲线.本文将上述问题转化为优化问题,给出基于符号数值计算和Lagrange乘子法的求解... 详细信息

本文研究的代数曲线区间插值问题,是针对预先给定平面上的若干矩形小邻域,构造经过它们的次数最低的代数曲线、项数最少的代数曲线以及系数是整数的代数曲线.本文将上述问题转化为优化问题,给出基于符号数值计算和Lagrange乘子法的求解方法,应用这一方法解决了几个具体的有趣问题,包括基于太阳系行星、小行星和矮行星的轨道数据重新发现Kepler第三定律.

关键词：代数曲线数学机械化符号数值计算稀疏插值

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未完成:为什么我们会被不完美所吸引?

艺术品鉴 2024年第2期 50-55页

作者： lydia Figes 不详

一件艺术品什么时候才算是真正完成?尽管艺术家在画布上花了很多时间来完善一幅画,但我们有时会更喜欢不完整的版本,为什么呢?无论是被刻意遗弃,还是因病、意外事变、甚至死亡而被遗弃,我们仍然可以通过观看艺术家的未完成作品来了解他... 详细信息

一件艺术品什么时候才算是真正完成?尽管艺术家在画布上花了很多时间来完善一幅画,但我们有时会更喜欢不完整的版本,为什么呢?无论是被刻意遗弃,还是因病、意外事变、甚至死亡而被遗弃,我们仍然可以通过观看艺术家的未完成作品来了解他们的创作过程。例如达·芬奇,众所周知,他的许多画没有完成,因为他是一个出了名的拖延者,或者至少,他总是从一个项目跳到另一个项目,即使前一幅未画完成。

关键词：达·芬奇一幅画艺术品被遗弃艺术家意外

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沟通的力量

空中英语教室（高级版．彭蒙惠英语） 2024年第1期 20-22,44,45页

作者： lydia Dishman Jeff Steen 不详

15这些策略能帮你和难相处的人共事我们一旦面对自己觉得难以共事和理解的人,本能反应就是避开对方。但是,世界上充满了“难搞”的人。所以,如果你想要成长并掌握自己的命运,就必须掌握将与难搞人的相处困境成功化解的艺术。

关键词：本能反应共事掌握

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表达感激

空中英语教室（高级版．彭蒙惠英语） 2024年第6期 6-6,38页

作者： lydia Dishman 不详

我们知道,人们喜欢因工作出色而得到认可。大多数时候,一句简单的“谢谢你”就足够了。事实上,我们人类依赖于这个举动。研究表明,养成感恩的习惯对我们的神经系统有立竿见影的效果,它能降低应激激素皮质醇,促进有益激素——血清素和多... 详细信息

我们知道,人们喜欢因工作出色而得到认可。大多数时候,一句简单的“谢谢你”就足够了。事实上,我们人类依赖于这个举动。研究表明,养成感恩的习惯对我们的神经系统有立竿见影的效果,它能降低应激激素皮质醇,促进有益激素——血清素和多巴胺——的分泌。

关键词：应激激素血清素皮质醇多巴胺神经系统立竿见影

How to integrate hemodynamic variables during resuscitation of septic shock?

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Journal of Intensive Medicine 2023年第2期3卷 131-137页

作者： Jean-Louis teboul Service de Médecine Intensive-Réanimation Hopital de BicêtreGHU AP-HPUniversitéParis-SaclayParis 94270France

Resuscitation of septic shock is a complex issue because the cardiovascular disturbances that characterize septic shock vary from one patient to another and can also change over time in the same patient. Therefore, different therapies (fluids, vasopressors, and inotropes) should be individually and carefully adapted to provide personalized and adequate treatment. Implementation of this scenario requires the collection and collation of all feasible information, including multiple hemodynamic variables. In this review article, we propose a logical stepwise approach to integrate relevant hemodynamic variables and provide the most appropriate treatment for septic shock.

关键词： Lactate Capillary refill time Central venous oxygen saturation Veno-arterial carbon dioxide gap Transpulmonary thermodilution

Diet,lipids,and antitumor immunity

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Cellular & Molecular Immunology 2022年第3期19卷 432-444页

作者： Hannah Prendeville lydia Lynch Trinity Biomedical Sciences Institute Trinity College DublinDublinIreland Brigham and Women’s Hospital Harvard Medical SchoolBostonMAUSA

Tumour growth and dissemination is largely dependent on nutrient availability.It has recently emerged that the tumour microenvironment is rich in a diverse array of lipids that increase in abundance with tumour progression and play a role in promoting tumour growth and metastasis.Here,we describe the pro-tumorigenic roles of lipid uptake,metabolism and synthesis and detail the therapeutic potential of targeting lipid metabolism in cancer.Additionally,we highlight new insights into the distinct immunosuppressive effects of lipids in the tumour microenvironment.Lipids threaten an anti-tumour environment whereby metabolic adaptation to lipid metabolism is linked to immune dysfunction.Finally,we describe the differential effects of commondietary lipids on cancer growth which may uncover a role for specific dietary regimens in association with traditional cancer therapies.Understanding the relationship between dietary lipids,tumour,and immune cells is important in the context of obesity which may reveal a possibility to harness the diet in the treatment of cancers.

关键词： Lipids cancer obesity β-oxidation anti-tumour immunity