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体位性低血压与心血管预后及不良事件:来自收缩压干预试验的结果

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中华高血压杂志(中英文) 2020年第2期 199-199页

作者： Juraschek SP taylor aa Jr JTW Evans GW Miller ER Plante TB Cushman WC Gure TR Haley WE Moinuddin I Nord J Oparil S Pedley C Roumie CL Whittle J Wiggers A Finucane C Kenny RA Appel LJ Townsend RR 赵狄刘莉 SPRINT research group

体位性低血压(orthostatic hypotension, OH)在高血压治疗中经常发生,但它对不良预后的影响并不明确。收缩压干预试验(systolic blood pressure intervention trial,SPRINT)是一个成人随机试验,参加者年龄>50岁、伴心血管病高风险且坐... 详细信息

体位性低血压(orthostatic hypotension, OH)在高血压治疗中经常发生,但它对不良预后的影响并不明确。收缩压干预试验(systolic blood pressure intervention trial,SPRINT)是一个成人随机试验,参加者年龄>50岁、伴心血管病高风险且坐位收缩压130～180 mm Hg(1 mm Hg=0.133 kPa),立位收缩压≥110 mm Hg。参加者收缩压降压靶目标随机分为<1

关键词：收缩压干预试验体位性低血压不良事件

Synthesis of Silsesquioxane Cages from Phenyl-cis-tetrol, 1,3-Divinyltetraethoxydisiloxane and Cyclopentyl Resins

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Chemical Research in Chinese Universities 2004年第4期20卷 433-436页

作者： Alan R. Bassindale Peter G. taylor Department of Chemistry Open UniversityDepartment of Chemistry Open University Walton Hall Milton Keynes MK7 6AA UKWalton Hall Milton Keynes MK7 6AA UK

The synthesis of T_8, T_ 10 and T_ 12 silsesquioxane cages from a range of starting materials: phenyl-cis-tetrol, 1,3-divinyltetraethoxydisiloxane and cyclopentyl T resins by using tetra n-butylammonium fluoride(TBAF) as the catalyst is described in this paper. The reaction yields obtained viathe current route are better compared to those viathe literature routes. Some of the cage compounds have been characterized by X-ray crystallography.

关键词： Synthesis Silsesquioxane cage Phenyl-cis-tetrol 1,3-Divinyltetraethoxydisiloxane Cyclopentyl T resin

Alcohol-induced Wnt signaling inhibition during bone fracture healing is normalized by intermittent parathyroid hormone treatment

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Animal Models and Experimental Medicine 2020年第2期3卷 200-207页

作者： Esha M.Kapania taylor JReif aaron Tsumura Jonathan M。Eby John J.Callaci Internal Medicine-Pediatric Resident Rush University Medical CenterChicagoILUSA Limb Lengthening and Complex Reconstruction Fellowship Hospital for Special SurgeryNew YorkNYUSA Department of Orthopaedic Surgery and Rehabilitation Loyola University Medical CenterMaywoodILUSA Alcohol Research Program(ARP) Loyola University Chicago Stritch School of MedicineMaywoodILUSA

Nearly half of orthopaedic trauma patients are intoxicated at the time of injury, and excess alcohol consumption increases the risk for fracture nonunion. Previous studies show alcohol disrupts fracture associated Wnt signaling required for normal bone fracture repair. Intermittent parathyroid hormone(PTH) promotes bone growth through canonical Wnt signaling, however, no studies have investigated the effect of PTH on alcohol-inhibited bone fracture repair. Male C57 BL/6 mice received two-3 day alcohol binges separated by 4 days before receiving a mid-shaft tibia fracture. Postoperatively, mice received PTH daily until euthanasia. Wnt/β-catenin signaling was analyzed at 9 days post-fracture. As previously observed, acute alcohol exposure resulted in a >2-fold decrease in total and the active form of β-catenin and a 2-fold increase in inactive β-catenin within the fracture callus. Intermittent PTH abrogated the effect of alcohol on β-catenin within the fracture callus. Upstream of β-catenin, alcohol-treated animals had a 2-fold decrease in total LRP6, the Wnt co-receptor, which was restored with PTH treatment. Alcohol nor PTH had any significant effect on GSK-3β. These data show that intermittent PTH following a tibia fracture restores normal expression of Wnt signaling proteins within the fracture callus of alcohol-treated mice.

关键词： ethanol fracture callus parathyroid hormone Wnt signaling pathway

阅读困难的色彩治疗英国失读症慈善机构应该提出更平衡的观点

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英国医学杂志中文版 2015年第4期18卷 185-186页

作者： Lisa M Henderson Robert H taylor Brendan Barrett Philip G Griffiths 张春雨 Department ofPsychology Universityof York York UK Department of Ophthalmology YorkHospital York UK School of Optometryand Vision Science University of BradfordBradford UK St Bernard's Hospital Harbour Views RoadGibraltar GX11 1AA 北京大学第一医院儿科

英国有3％-6％的儿童存在严重的阅读困难，这种情况通常被称为失读症，该症增加了教育失败的风险。1996年Margaret Snowling在BMJ发表述评称失读症属于词语障碍，而不是视觉障碍。有一系列积累的证据支持这种观点，而且发现治疗失读症... 详细信息

英国有3％-6％的儿童存在严重的阅读困难，这种情况通常被称为失读症，该症增加了教育失败的风险。1996年Margaret Snowling在BMJ发表述评称失读症属于词语障碍，而不是视觉障碍。有一系列积累的证据支持这种观点，而且发现治疗失读症最佳的方法是针对语音技能和词语知识进行干预。2009年的Rose报告强调了早期语音干预手段的重要性,这份报告为学校里专业人员如何发现和教导那些有失读症和阅读困难的学生，提供专业性指南。

关键词：阅读障碍慈善机构平衡英国色彩治疗

降低日粮蛋白质含量并补充氨基酸对泌乳母猪生产性能、乳腺吸收效率和转运体基因表达的影响

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中国饲料 2016年第15期 32-43页

作者： Manjarin R Zamora V Wu G Steibel J P Kirkwood R N taylor N P Wils-Plotz E Trifilo K Trottier N L 密歇根州立大学动物科学学院东兰辛48824 墨西哥州Montecillo研究生院墨西哥56230 德克萨斯州农工大学动物科学和营养学部学院站77843 密歇根州立大学渔业和野生动物系东兰辛48824 美国密歇根州立大学大型动物临床科学系东兰辛48824

为验证降低日粮蛋白质水平并补充晶体氨基酸是否可以提高氨基酸用于泌乳母猪产奶的使用效率,试验选用3种日粮,蛋白质含量分别为9.5%(不足型)、13.5%(理想型)和17.5%(标准型)饲喂泌乳母猪,各日粮氨基酸水平相同。检测乳腺氨基酸动静脉浓... 详细信息

为验证降低日粮蛋白质水平并补充晶体氨基酸是否可以提高氨基酸用于泌乳母猪产奶的使用效率,试验选用3种日粮,蛋白质含量分别为9.5%(不足型)、13.5%(理想型)和17.5%(标准型)饲喂泌乳母猪,各日粮氨基酸水平相同。检测乳腺氨基酸动静脉浓度差(A-V)、氨基酸运输效率(A-V/A×100)、氨基酸转运载体和乳蛋白基因的转录丰度。在第7和18天,收集采食后动脉、乳腺静脉血液和乳腺组织样品。使用定量PCR测定氨基酸转运载体b0,+AT(SLC7A9)、Y+LAT2(SLC7A6)、ATB0,+(SLC6A14)、CAT-1(SLC7A1)、CAT-2b(SLC7A2)以及β酪蛋白(CSN2)和α乳清蛋白(LALBA)的转录丰度。结果表明,随着蛋白质含量从不足型到标准型逐渐增加,仔猪日增重呈曲线上升(线性和二次方,Paa(BCaa):赖氨酸(Lys)比值呈二次方降低(Paa∶Lys比值下降有关,表明氨基酸运输至乳腺细胞时,阳离子型aa和BCaa之间存在竞争机制。

关键词：氨基酸效率基因哺乳期母猪转运载体

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卒中介入治疗培训指南：国际多学会共识文件

国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine SD Cockroft K Hoh B Bambakidis N Khalessi aa Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩孙瑞郭芮兵 From the American Association of Neurological Surgeons/Congress of Neurological Surgeons (aaNS/CNS) Rolling Meadows IL USA American Society of Neuroradiology (ASNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic Neuroradiology (aaFITN) Bali Indonesia Australian and New Zealand Society of Neuroradiobgy-Conjomt Committee for Recognition of Training in Interventional Neuroradiology (CCINR) representing the RANZCR (ANZSNR) ANZAN and NSA Sydney Australia Canadian Interventional Neuro Group (CING) Edmonton AB Canada World Federation of Interventional and Therapeutic Neuroradiology (WFITN) Gold Coast Australia European Society of Neuroradiology (ESNR) Milan Italy European Society of Minimally Invasive Neurologic Therapy (ESMINT) Nice France Japanese Society for Neuroendovascular therapy (JSNET) Okayama Japan Sociedad Ibero Latino Americana de Neuroradiologica (SILAN) Cartagena Colombia Society of Neurolnterventional Surgery (SNIS) Washington DC USA Society of Vascular and Interventional Neurology (SVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

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