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A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B

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World Journal of Gastroenterology 2009年第13期15卷 1650-1652页

作者： Kazuyuki Matsumoto Yasuhiro Miyake Hirokazu Miyatake Masahiro Takahara Takayuki Imada Satoru Yagi tatsuya toyokawa Morihito Nakatsu Masaharu Ando Mamoru Hirohata Department of Internal Medicine Mitoyo General Hospital Department of Molecular Hepatology Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences

Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy,20%-30%have a fatal *** this report,we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and *** both cases,rapid reductions in serum hepatitis B virus(HBV)-DNA levels were observed,and corticosteroid was stopped after serum HBV-DNA levels became *** treatment was ***,entecavir treatment reduced serum HBV-DNA levels rapidly,although the improvement in liver function was delayed by a few *** this time lag,liver cell injury continued and the disease *** suppressed the excessive host immune response and was useful for stopping progressive deterioration.A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B.

关键词： Acute exacerbation Chronic hepatitis B Corticosteroid Entecavir Hepatitis B virus Hepaticcoma

Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene

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World Journal of Gastroenterology 2017年第33期23卷 6155-6163页

作者： Masaya Iwamuro Ryuta Takenaka Masahiro Nakagawa Yuki Moritou Shunsuke Saito Shinichiro Hori Tomoki Inaba Yoshinari Kawai tatsuya toyokawa Takehiro Tanaka Tadashi Yoshino Hiroyuki Okada Department of Gastroen-terology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical Sciences Department of Internal Medicine Tsuyama Chuo Hospital Department of Internal Medicine Hiroshima City Hospital Department of Gastroenterology Mitoyo General Hospital Department of Internal Medicine Okayama Saiseikai General Hospital Department of Gastroenterology Shikoku Cancer Center Department of Gastroenterology Kagawa Prefectural Central Hospital Department of Gastroenterology Onomichi Municipal Hospital Department of Gastroenterology Fukuyama Medical Center Department of Pathology Okayama University Hospital Department of Pathology Okayama University Graduate School of MedicineDentistryand Pharmaceutical Sciences

AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue(MALT) lymphoma with extra copies of *** This is a multi-centered,retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1(Group A,n = 88),patients with t(11;18) translocation(Group B,n = 27),and patients with extra copies of MALT1(Group C,n = 31). The clinical background,treatment,and outcomes of each group were *** Groups A and C showed slight female predominance,whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A(69.3%),22 in Group B(81.5%),and 21 in Group C(67.7%). Helicobacter pylori(H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B,14 patients underwent radiotherapy alone,which resulted in lymphoma disappearance. Although the difference was not statistically significant,event-free survival in Group C tended to be inferior to that in Group A(P = 0.10).CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication,similar to patients without t(11;18) translocation or extra copies of MALT1.

关键词： Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue Gastric neoplasms Esophagogastroduodenoscopy t(11 18) translocation Trisomy 18

Synchronous Double Primary Combined Hepatocellularcholangiocarcinoma and Cholangiolocarcinoma in a Cirrhotic Liver

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 991-997页

作者： Masahiro Sakata Koji Kitada Rika Omote Hiroshi Sonobe Masashi Utsumi Naoyuki Tokunaga Takashi Fushimi Ryota Nagao Tatsuro Sakata Toshihiko Kaneyoshi tatsuya toyokawa Masaru Inagaki Department of Gastroenterology and Hepatology National Hospital OrganizationFukuyama Medical CenterFukuyamaHiroshimaJapan Department of Surgery National Hospital OrganizationFukuyama Medical CenterFukuyamaHiroshimaJapan Department of Laboratory and Pathology National Hospital OrganizationFukuyama Medical CenterFukuyamaHiroshimaJapan Department of Radiology National Hospital OrganizationFukuyama Medical CenterFukuyamaHiroshimaJapan

Both combined hepatocellular-cholangiocarcinoma(cHCCCCA)and cholangiolocarcinoma are rare primary liver ***-CCA is believed to originate from transformed hepatocellular carcinoma or liver stem/progenitor *** is characterized by ductular reaction-like anastomosing cords and glands resembling cholangioles or canals containing hepatocellular carcinoma components and adenocarcinoma *** to the 2019 revision of the World Health Organization criteria,a subtype with stem cell features as a subclassification of cHCC-CCA was abolished for lack of conclusive evidence of the stem cell origin *** led to the classification of cholangiolocarcinoma with hepatocytic differentiation as ***,cholangiolocarcinoma without hepatocytic differentiation is classified as a subtype of small-duct cholangiocarcinoma and is assumed to originate from the bile ***,we report the first case of double primary cHCC-CCA and cholangiolocarcinoma without hepatocytic differentiation in different hepatic segments of a cirrhotic *** believe this case supports the validity of the new World Health Organization criteria because the pathological finding of cHCC-CCA in this case shows the transformation of hepatocellular carcinoma to ***,this case may demonstrate that immature ductular cell stemness and mature hepatocyte cell stemness in hepatocarcinogenesis can coexist in the same *** results provide valuable insights into the mechanisms of growth,differentiation,and regulation of liver cancers.

关键词： Bile duct neoplasms Combined hepatocellular-cholangiocarcinoma Cholangiolocarcinoma Cirrhosis Liver neoplasms

Efficacy and safety of endoscopic submucosal dissection for gastric tube cancer:A multicenter retrospective study

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World Journal of Gastroenterology 2021年第11期27卷 1043-1054页

作者： Takuya Satomi Seiji Kawano Tomoki Inaba Masahiro Nakagawa Hirokazu Mouri Masao Yoshioka Shoichi Tanaka tatsuya toyokawa Sayo Kobayashi Takehiro Tanaka Hiromitsu Kanzaki Masaya Iwamuro Yoshiro Kawahara Hiroyuki OkadaDepartment of Gastroenterology and Hepatology Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558OkayamaJapan Department of Gastroenterology Kagawa Prefectural Central HospitalTakamatsu 760-8557KagawaJapan Department of Endoscopy Hiroshima City Hiroshima Citizens HospitalHiroshima 730-8518HiroshimaJapan Department of Gastroenterology and Hepatology Kurashiki Central HospitalKurashiki 710-8602OkayamaJapan Department of Gastroenterology and Hepatology Okayama Saiseikai General HospitalOkayama 700-8511OkayamaJapan Department of Gastroenterology National Hospital Organization Iwakuni Clinical CenterIwakuni 740-8510YamaguchiJapan Department of Gastroenterology National Hospital Organization Fukuyama Medical CenterFukuyama 720-8521HiroshimaJapan Department of Internal Medicine Fukuyama City HospitalFukuyama 721-8511HiroshimaJapan Department of Pathology Okayama University HospitalOkayama 700-8558OkayamaJapan Department of Practical Gastrointestinal Endoscopy Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558OkayamaJapan

BACKGROUND Recent improvements in the prognosis of patients with esophageal cancer have led to the increased occurrence of gastric tube cancer(GTC)in the reconstructed gastric ***,there are few reports on the treatment results of endoscopic submucosal dissection(ESD)for *** To evaluate the efficacy and safety of ESD for GTC after esophagectomy in a multicenter *** We retrospectively investigated 48 GTC lesions in 38 consecutive patients with GTC in the reconstructed gastric tube after esophagectomy who had undergone ESD between January 2005 and December 2019 at 8 institutions participating in the Okayama Gut Study *** clinical indications of ESD for early gastric cancer were similarly applied for GTC after *** specimens were evaluated in 2-mm slices according to the Japanese Classification of Gastric Carcinoma with curability assessments divided into curative and non-curative resection based on the Gastric Cancer Treatment *** characteristics,treatment results,clinical course,and treatment outcomes were *** The median age of patients was 71.5 years(range,57-84years),and there were 34 men and 4 *** median observation period after ESD was 884 d(range,8-4040 d).The median procedure time was 81 min(range,29-334 min),the en bloc resection rate was 91.7%(44/48),and the curative resection rate was 79%(38/48).Complications during ESD were seen in 4%(2/48)of case,and those after ESD were seen in 10%(5/48)of *** survival rate at 5 years was 59.5%.During the observation period after ESD,10 patients died of other *** there were differences in the procedure time between institutions,a multivariate analysis showed that tumor size was the only factor associated with prolonged procedure *** ESD for GTC after esophagectomy was shown to be safe and effective.

关键词： Endoscopic submucosal dissection Gastric tube Gastric cancer Esophagectomy Multicenter study Retrospective study

Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction

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World Journal of Gastroenterology 2012年第21期18卷 2735-2738页

作者： Toshihiro Nishizawa Hidekazu Suzuki Takama Maekawa Naohiko Harada tatsuya toyokawa Toshio Kuwai Masanori Ohara Takahiro Suzuki Masahiro Kawanishi Kenji Noguchi Toshiyuki Yoshio Shinji Katsushima Hideo Tsuruta Eiji Masuda Munehiro Tanaka Shunsuke Katayama Norio Kawamura Yuko Nishizawa Toshifumi Hibi Masahiko Takahashi Division of Gastroenterology National Hospital Organization Tokyo Medical CenterTokyo 1528902 Japan Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of MedicineTokyo 1608582 Japan Division of Gastroenterology National Hospital Organization Kyoto Medical CenterKyoto 6128555 Japan Division of Gastroenterology National Kyushu Medical CenterFukuoka 8108563 Japan Division of Gastroenterology National Hospital Organization Fukuyama Medical CenterFukuyama 7208520 Japan Division of Gastroenterology National Hospital Organization Kure Medical CenterKure 7370023 Japan Division of Gastroenterology National Hospital Organization Hakodate Medical CenterHakodate 0418512 Japan Division of Gastroenterology National Hospital Organization Maizuru Medical CenterMaizuru 6258502 Japan Division of Gastroenterology National Hospital Organization Higashihiroshima Medical CenterHigashihiroshima 7390041 Japan Division of Gastroenterology National Hospital Organization Sendai Medical CenterSendai 9838520 Japan Division of Gastroenterology National Hospital Organization Osaka Medical CenterOsaka 5400006 Japan Division of Gastroenterology National Hospital Organization Ureshino Medical CenterUreshino 8430393 Japan Division of Gastroenterology National Hospital Organization Osaka Minami Medical CenterKawachinagano 5868521 Japan Division of Gastroenterology National Hospital Organization Fukuoka Higashi Medical CenterKoga 8113195 Japan Division of Gastroenterology National Hospital Organization Yonago Medical CenterYonago 6838518 Japan Division of Gastroenterology National Hospital Organization Disaster Medical CenterTachikawa 1900014 Japan Pharmaceutical Department National Center for Global Health and MedicineTokyo 1658655 Japan

We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT.

关键词： Helicobacter pylori Amoxicillin Dual therapy Eradication Urea breath test

Factors Affecting Behaviors that Precede Evacuation at the Onset of a Heavy Rainstorm in Japan

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International Journal of Disaster Risk Science 2022年第6期13卷 903-912页

作者： tatsuya Nogami Japan Fire and Crisis Management Association Tokyo 105-0021Japan

There exist certain behaviors that people tend to do in disaster situations before evacuation. Such behaviors include warning confirmation behavior(for example, seeking information) and family-oriented behavior(for example,contacting one’s family). Identifying factors that affect these behaviors is of particular importance in building a better understanding of why people often fail to respond quickly to evacuation orders. For this purpose, the present study employed some of the established factors affecting evacuation behavior as predictor variables along with the timing of an evacuation order. A total of 518 participants took part in a 12-item online questionnaire survey that contained a hypothetical disaster scenario. The results of ordinal logistic regression analyses revealed that only risk area residence and disaster preparedness were associated with warning confirmation behavior, while gender, age, disaster preparedness,and risk perception had some associations with family-oriented behavior. Also, the participants were not more likely to engage in these behaviors in the morning and the afternoon than the evening in the hypothetical scenario. These findings imply the possibility that people engage in warning confirmation behavior and family-oriented behavior before evacuation regardless of individual characteristics and the circumstances surrounding them.

关键词： Disaster preparedness Disaster psychology Evacuation behavior Evacuation order Japan Rainstorm

A study of Corrosion Protection of Aluminum Metal by Tetraethoxysilane Plasma Polymerized Coatings -Influence of Aluminum Surface Pretreatments-

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材料热处理学报 2004年第05B期25卷 1325-1328页

作者： Yoshihiro Motnose tatsuya Yabuki Department of Materials Science Ibaraki University Hitachi Ibaraki 316-8511 JapanDepartment of Materials Science Ibaraki University Hitachi Ibaraki 316-8511 Japan

The corrosion-protective performance of plasma-polymerized (PP) coatings on pretreated aluminum substrates has been investigated by cathodic polarization curve measurement. The surface composition and electronic properties of the pretreated and PP film coated metal surfaces were also characterized by XPS and the temperature-programmed photoelectron emission (TPPE). A PP coating was prepared on the pretreated surfaces by plasma polymerization of a mixture of tetraethoxysilane (TEOS) monomer vapor and oxygen using a 13.56MHz radiofrequency generator. The polarization curve of PP film coated samples was measured in NaCl aqueous solution. The weight loss rate calculated from the value of the corrosion current of the curve was used to estimate the protective performance of the PP film coated samples. Argon plasma treatment of the metal surface gave much better corrosion-protective performance than pretreatments such as oxidation by heating in air and diamond scratching. The XPS analysis indicated that the silicon oxide assigned to SiO2 was formed on the PP film coated surface. The TPPE analysis revealed that the electron emission characteristics for the metal surfaces pretreated only were strongly influenced by the pretreatments, while all the PP film coated samples exhibited nearly the same electron emission trend with a much decreased intensity.

关键词：防腐蚀等离子聚合铝四乙氧基甲硅烷 TPPE 极化曲线

NUMERICAL SIMULATION ON COMPRESSIBLE TURBULENCE BY SPECTRAL METHOD

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Acta Mechanica Sinica 1998年第3期14卷 193-207页

作者：王健平 tatsuya Hasegawa State Key Laboratory for Turbulence Research Department of Mechanics and Engineering SciencePeking UniversityBeijing 100871China Department of Mechanical Engineering Nagoya Institute of TechnologyGokiso-choShowa-kuNagoya 466Japan

The numerical and physical issues of simulations on compressible turbulence are reviewed in the present paper. An outline of the global spectral methods and the progress of recent local spectral methods are illustrated. Several typical subjects in this field are studied, including homogeneous isotropic turbulence, autoignition in premixed turbulence, interaction between flames and turbulence, and shock wave in turbulence. The results of the numerical simulations are discussed, enabling us to discover and to understand the physical phenomena which have not been solved by experiments.

关键词： compressible turbulence turbulent flame spectral method

Bin-scanning:Segmentation of X-ray CT volume of binned parts using Morse skeleton graph of distance transform

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Computational Visual Media 2023年第2期9卷 319-333页

作者： Yuta Yamauchi tatsuya Yatagawa Yutaka Ohtake Hiromasa Suzuki School of Engineering The University of Tokyo7–3–1HongoBunkyo-kuTokyoJapan

X-ray CT scanners,due to the transmissive nature of X-rays,have enabled the non-destructive evaluation of industrial products,even inside their *** light of its effectiveness,this study introduces a new approach to accelerate the inspection of many mechanical parts with the same shape in a *** input to this problem is a volumetric image(i.e.,CT volume)of many parts obtained by a single CT *** need to segment the parts in the volume to inspect each of them;however,random postures and dense contacts of the parts prohibit part segmentation using traditional template *** address this problem,we convert both the scanned volumetric images of the template and the binned parts to simpler graph structures and solve a subgraph matching problem to segment the *** perform a distance transform to convert the CT volume into a distance ***,we construct a graph based on Morse theory,in which graph nodes are located at the extremum points of the distance *** experimental evaluation demonstrates that our fully automatic approach can detect target parts appropriately,even for a heap of 50 ***,the overall computation can be performed in approximately 30 min for a large CT volume of approximately 2000×2000×1000 voxels.

关键词： X-ray computed tomography(CT) volume segmentation graph matching non-destructive inspection