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Alkaline phosphatase predicts relapse in chronic hepatitis C patients with end-of-treatment response

World Journal of Gastroenterology 2010年第19期16卷 2407-2410页

作者： Gerd Bodlaj Rainer Hubmann Karim Saleh tatjana stojakovic Georg Biesenbach Jrg Berg Second Department of Medicine General Hospital Linz A-4020 Linz Austria Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz A-8010 Graz Austria Institute of Laboratory Medicine General Hospital Linz A-4020 Linz Austria

AIM: To investigate relapse predictors in chronic hepatitis C (CHC) patients with end-of-treatment response (ETR), after pegylated interferon-α (PegIFN-α) and ribavirin treatment. METHODS: In a retrospective study we evaluated a spectrum of predictors of relapse after PegIFN-α and ribavirin treatment in 86 CHC patients with ETR. Viral loads were determined with real-time reverse transcrip-tion polymerase chain reaction. Hepatitis C virus geno-typing was performed by sequencing analysis. Patients with genotype 1 were treated for 48 wk with 180 μg PegIFN-α2a or 1.5 μg/kg PegIFN-α2b once weekly plus ribavirin at a dosage of 1000 mg/d for those under 75 kg or 1200 mg/d for those over 75 kg. Patients with geno- types 2 and 3 were treated for 24 wk with 180 μgPegIFN-α2a or 1.5 μg/kg PegIFN-α2b once weekly plus ribavirin at a dosage of 800 mg/d. RESULTS: In all ETR patients, binary logistic regression analysis identif ied absence of complete early virological response (cEVR) (OR 27.07, 95% CI: 3.09-237.26, P 26 kg/m2 (OR: 8.27, 95% CI: 2.22-30.84, P < 0.005) as independent predictors of relapse. When cEVR patients were analyzed exclusively, ALP prior to therapy < 75 U/L remained the only predictor of relapse. CONCLUSION: Lower levels of ALP prior to, during and after therapy seem to be associated with a higher risk of relapse in CHC patients with ETR.

关键词： Alkaline phosphatase Chronic hepatitis C Pegylated interferon Predictor Relapse

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An Application of the Shark Skin Denticle Geometry for Windbreak Fence Design and Fabrication

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Journal of Bionic Engineering 2017年第3期14卷 579-587页

作者： Ivana Bajsanski Vesna stojakovic Bojan Tepavcevic Marko Jovanovic Dejan Mitov Department of Architecture Faculty of Technical Sciences University of Novi Sad Trg Dositeja Obradoviea 6 21000 Novi Sad Serbia

Windbreak fences in open and urban areas can be used to effectively reduce the wind velocity. In this paper we examine how the geometrical shape of the windbreak fence can optimally mitigate wind velocity. We propose an approach for windbreak fence design based on a bionic parametric model of the shark skin denticle geometry, which improves the reduction of the wind velocity around and behind the windbreak fences. The generative model was used to estimate improvements by variations in the parameters of the fence panel＇s geometrical shape, inspired by shark skin denticles. The results of the Computational Fluid Dynamics （CFD） analysis indicates that the fence surface inspired by shark skin performs much better than both flat and cor- rugated surfaces. Taking into account the complex geometry of the surface inspired by shark skin denticles, we propose a fab- rication process using an expanded polystyrene foam （EPS） material, created using an industrial robot arm with a hot-wire tool. Creating EPS moulds for the shark skin denticle panels allows for a richer variety material to be used in the final design, leading both to higher efficiency and a more attractive design.

关键词： bioinspiration shark skin denticle windbreak fence design generative models CFD

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