Alkaline phosphatase predicts relapse in chronic hepatitis C patients with end-of-treatment response

作     者：Gerd Bodlaj Rainer Hubmann Karim Saleh Tatjana Stojakovic Georg Biesenbach Jrg Berg 

作者机构：Second Department of Medicine General Hospital Linz A-4020 Linz Austria Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz A-8010 Graz Austria Institute of Laboratory Medicine General Hospital Linz A-4020 Linz Austria 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第19期

页      面：2407-2410页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Alkaline phosphatase Chronic hepatitis C Pegylated interferon Predictor Relapse 

摘      要：AIM: To investigate relapse predictors in chronic hepatitis C (CHC) patients with end-of-treatment response (ETR), after pegylated interferon-α (PegIFN-α) and ribavirin treatment. METHODS: In a retrospective study we evaluated a spectrum of predictors of relapse after PegIFN-α and ribavirin treatment in 86 CHC patients with ETR. Viral loads were determined with real-time reverse transcrip-tion polymerase chain reaction. Hepatitis C virus geno-typing was performed by sequencing analysis. Patients with genotype 1 were treated for 48 wk with 180 μg PegIFN-α2a or 1.5 μg/kg PegIFN-α2b once weekly plus ribavirin at a dosage of 1000 mg/d for those under 75 kg or 1200 mg/d for those over 75 kg. Patients with geno- types 2 and 3 were treated for 24 wk with 180 μgPegIFN-α2a or 1.5 μg/kg PegIFN-α2b once weekly plus ribavirin at a dosage of 800 mg/d. RESULTS: In all ETR patients, binary logistic regression analysis identif ied absence of complete early virological response (cEVR) (OR 27.07, 95% CI: 3.09-237.26, P 26 kg/m2 (OR: 8.27, 95% CI: 2.22-30.84, P 0.005) as independent predictors of relapse. When cEVR patients were analyzed exclusively, ALP prior to therapy 75 U/L remained the only predictor of relapse. CONCLUSION: Lower levels of ALP prior to, during and after therapy seem to be associated with a higher risk of relapse in CHC patients with ETR.