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Ecological significance of dorsal polymorphism in a Batesian mimic snake

Current Zoology 2018年第6期64卷 745-753页

作者： Xavier SANTOS Jairo S.AZOR Sergio CORTES elisa RODRIGUEZ Jose LARIOS Juan M.PLEGUEZUELOS CIBIO/InBIO Centro de Investigacao em Biodiversidade e Recursos Geneticos da Universidade do PortoRua Padre Armando QuintasVairao 4485-661Portugal Departamento de Zoologia Facultad de CienciasUniversidad de GranadaGranada E-18071Spain Ayuntamiento de Motril Plaza de Espana 1Motril E-18600Spain

Batesian mimicry is the process in which harmless species adopt the appearance of a dangerous, aposematic *** some prey species,both Batesian mimetic and non-Batesian morphs coexist,presupposing that both morphs have to be evolutionarily *** viperine snake, Natrix maura,exhibits a zigzag dorsal pattern and antipredatory behavior that mimics European *** snake also has a striped dorsal pattern that coexists with the zigzag *** have examined whether individuals belonging to different geographically structured clades were more likely to exhibit a certain dorsal pattern,and whether the zigzag pattern has a protective function by exposing artificial snakes to predation in natural environments,in addition to comparing antipredatory behavior between zigzag and striped snakes also in natural *** results indicate that the striped pattern was not geographically structured,but *** predators less frequently attacked zigzag plasticine models than striped or unpatterned *** detected a shift in antipredator behavior between the 2 morphs,as Batesian mimicking *** responded to an approaching potential predator by remaining immobile or fleeing at shorter distances than did striped *** conclude that Batesian mimics maintain the cryptic and aposematic value by resembling vipers,whereas in open habitats the non-Batesian mimic has altered its antipredator behavior to maintain its fitness.

关键词： antipredatory strategies aposematism Batesian mimicry crypsis dorsal pattern Natrix maura

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Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis

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Cellular & Molecular Immunology 2021年第2期18卷 452-460页

作者： Amir Boufenzer Kevin Carrasco Lucie Jolly Benjamin Brustolin elisa Di-Pillo Marc Derive Sébastien Gibot INOTREM Vandœuvre-lès-NancyNancyFrance UMR-S 1116 Défaillance Cardiovasculaire Aigue et ChroniqueVandœuvre-lès-NancyNancyFrance CHRU Nancy Hôpital CentralService de Réanimation MédicaleNancyFrance

During sepsis,neutrophil activation induces endothelial cell(EC)dysfunction partly through neutrophil extracellular trap(NET)*** triggering receptor expressed on myeloid cell-1(TREM-1)is an orphan immune receptor that amplifies the inflammatory response mediated by Toll-like receptor-4(TLR4)*** the key role of TLR4 signaling in NETosis is known,the role of TREM-1 in this process has not yet been ***,we report that TREM-1 potentiates NET release by human and murine neutrophils and is a component of the NET *** contrast,pharmacologic inhibition or genetic ablation of TREM-1 decreased NETosis in vitro and during experimental septic shock in ***,isolated NETs were able to activate ECs and impair vascular reactivity,and these deleterious effects were dampened by TREM-1 ***-1 may,therefore,constitute a new therapeutic target to prevent NETosis and associated endothelial dysfunction.

关键词： TREM-1 NETs sepsis endothelial cell activation vascular dysfunction LR12

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The Impact of Earnouts in M&A Agreement: An Overview of Empirical Findings

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Journal of Modern Accounting and Auditing 2020年第9期16卷 385-394页

作者： elisa Roncagliolo University of Genoa GenoaItaly

From a theoretical perspective,the use of earnouts should mitigate valuation risk of the acquirer involved in mergers and acquisitions(M&A)*** contracts should reduce information asymmetries and moral hazard *** contrast,the definition of the terms of such contracts can be difficult and they provide several implementation issues to be *** on these premises,this study aims to examine if the inclusion of earnouts is convenient and who benefits from their *** this aim,I scrutinize academic literature examining the impact of earnouts.I perform a systematic review of studies in both accounting and financial domains that provide empirical evidence of main consequences due to the use of earnouts in M&*** generally highlight a positive impact on the stock market performance of the acquirer in earnout-financed ***,the positive reaction of acquirers’investors is influenced by specific features to be *** issues are still uncovered and need further examination.

关键词： earnout merger and acquisition empirical evidence method of payment

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Reviving Ties

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Beijing Review 2024年第35期67卷 24-25页

作者： elisa Tirabassi Swiss Radiotelevision Italian Language

I talian Prime Minister Giorgia Meloni's official visit to China from July 27 to 31 was the first by a Western leader since the Third Plenary Session of the 20th Central Committee of the Communist Party of China(CPC),... 详细信息

关键词： comprehensive strategic official

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Tools for the diagnosis of hepatitis C virus infection and hepatic fibrosis staging

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World Journal of Gastroenterology 2014年第13期20卷 3431-3442页

作者： Verónica Saludes Victoria González Ramon Planas Lurdes Matas Vicente Ausina elisa Martró Institut d’ Investigació en Ciències de la Salut Germans Trias i Pujol Hospital Universitari Germans Trias i Pujol (Universitat Autònoma de Barcelona)08916 BadalonaSpain CIBER Epidemiología y Salud Pública (CIBERESP) 08003 BarcelonaSpain Centre for Epidemiological Studies on HIV/STI in Catalonia (CEEISCAT)-ICO 08916 BadalonaSpain Liver Unit Hospital Universitari Germans Trias i Pujol08916 BadalonaSpain Ramon Planas CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD)08036 BarcelonaSpain CIBER Enfermedades Respiratorias (CIBERES) 07110 BunyolaSpain

Hepatitis C virus(HCV)infection represents a major public health *** C can be cured bytherapy,but many infected individuals are unaware of their *** HCV screening,fast diagnosis and characterization,and hepatic fibrosis staging are highly relevant for controlling transmission,treating infected patients and,consequently,avoiding end-stage liver *** to HCV can be determined with high sensitivity and specificity with currently available third generation serology ***,the use of point-of-care tests can increase HCV screening ***,active HCV infection must be confirmed by direct diagnosis ***,HCV genotyping is required prior to starting any ***,high-volume clinical laboratories use different types of automated platforms,which have simplified sample processing,reduced hands-on-time,minimized contamination risks and human error and ensured full traceability of *** advances have also been made in the field of fibrosis stage assessment with the development of non-invasive methods,such as imaging techniques and serum-based ***,no single test is currently available that is able to completely replace liver *** review focuses on approved commercial tools used to diagnose HCV infection and the recommended hepatic fibrosis staging tests.

关键词： Hepatitis C virus Diagnosis Real-time polymerase chain reaction Serology Hepatitis C virus-RNA quantification Hepatitis C virus genotyping Hepatic fibrosis staging

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Overview of microRNAs as liquid biopsy biomarkers for colorectal cancer sub-type profiling and chemoresistance

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Cancer Drug Resistance 2021年第4期4卷 934-945页

作者： Alfred Buhagiar elisa Seria Miriana Borg Joseph Borg Duncan Ayers Faculty of Medicine and Surgery University of MaltaMsida 2080Malta Centre for Molecular Medicine and Biobanking University of MaltaMsida 2080Malta Faculty of medical sciences Newcastle UniversityNewcastle upon Tyne NE17RUUK Faculty of Health Sciences University of MaltaMsida 2080Malta Faculty of Biology Medicine and Health SciencesThe University of ManchesterManchester M139PLUK

Colorectal cancer(CRC)is the third most common cancer *** has also been demonstrated that over the last ten years the incidence of CRC among younger people below the age of 50 is also *** for colorectal cancer is of utmost importance;the rationale behind screening is to target the malignancy and reduce the incidence and mortality of the *** methods to screen for incidence or relapse are therefore a requisite to detect cancer as early as *** findings demonstrate that many deaths are due to lack of screening and therefore early identification will lead to greater *** colorectal cancer,diagnostic tests include liquid biopsy *** the discovery of microRNAs(miRNAs),many studies have demonstrated the relationship between miRNAs and the various sub-types of *** miRNAs have been identified after analysing serum or plasma samples in patients,and such miRNAs were found to be significantly *** findings place the possibility of miRNAs to be at the epicentre of novel diagnostic techniques for CRC identification and sub-type stratification,including other characteristics associated with CRC development such as patient *** following review serves to underline the latest findings for miRNAs with such potential for routine diagnostic employment in CRC diagnostics and treatments.

关键词： MicroRNA miRNA liquid biopsy biomarkers colorectal cancer cancer

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Relative volume measured with magnetic resonance imaging is an articular collapse predictor in hematological pediatric patients with femoral head osteonecrosis

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World Journal of Radiology 2016年第8期8卷 750-756页

作者： Davide Ippolito Alessandro masetto Cammillo Talei Franzesi Pietro A Bonaffini Alessandra Casiraghi Sandro Sironi Department of Diagnostic Radiology School of MedicineSan Gerardo HospitalUniversity of Milano-Bicocca

AIM To assess the potential value of femoral head(FH) volume measurements to predict joint collapse, as compared to articular surface involvement, in posttreatment osteonecrosis(ON) in pediatric patients affected by lymphoproliferative *** Considering 114 young patients with lymphoproliferative diseases undergone a lower-limbs magnetic resonance imaging(MRI) examination between November 2006 and August 2012 for a suspected post-treatment ON, we finally considered a total of 13 cases(7 males, mean age 15.2 ± 4.8 years), which developed a FH ON lesions(n = 23). The MRI protocol included coronal short tau inversion recovery and T1-weighted sequences, from the hips to the ankles. During the follow-up(elapsed time: 9.2 ± 2 mo), 13/23 FH articular surface(FHS)developed articular deformity. The first MRI studies with diagnosis of ON were retrospectively analyzed, measuring FH volume(FHV), FHS, ON volume(ONV) and the articular surface involved by ON(ONS). The relative involvement of FHS, in terms of volume [relative volume(RV): ONV/FHV] and articular surface [relative surface(RS): ONS/FHS], was then *** By using receiver operating characteristic curve analysis(threshold of 23% of volume involvement), RV predicted articular deformity in 13/13 FHS [sensitivity 100%, specificity 90%, accuracy 95%, positive predictive value(PPV) 93%, negative predictive value(NPV) 100%]. Considering a threshold of 50% of articular involvement, RS predicted articular deformity in 10/13 femoral heads(sensitivity 77%, specificity 100%, accuracy 87%, PPV 100%, NPV 77%).CONCLUSION RV might be a more reliable parameter than RS in predicting FH deformity and could represent a potential complementary diagnostic tool in the follow-up of femoral heads ON lesions.

关键词： Osteonecrosis Volume Articular surface Lymphoproliferative diseases Femoral head Magnetic resonance imaging

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Groundwater Management in Urban-coastal Aquifers of Developing Countries:Geochemical Based Study of the Region of Dakar(Senegal)

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地学前缘 2009年第S1期16卷 8-9页

作者： Viviana Re elisa Sacchi Seynabou Cissé-Faye Giovanni Maria Zuppi Department of Environmental Sciences University Ca' Foscari of Venice Department of Earth Sciences University of Pavia Department of Geology University Cheikh Anta Diop of Dakar CNR-Institution of Environmental Geology and Geoingeneering

The rapid increase of urban population in coastal areas of developing countries is nowadays a widespread phenomenon that has several environmental, economical and social *** migration, spread of informal suburban sett... 详细信息

关键词： groundwater coastal aquifers isotopes water management Senegal

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Inflammation as a cause of acute myocardial infarction in patients with myeloproliferative neoplasm

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World Journal of Cardiology 2024年第2期16卷 58-63页

作者： Amedeo Tirandi elisa Schiavetta Elia Maioli Fabrizio Montecucco Luca Liberale Department of Internal Medicine University of GenoaGenoa 16132Italy IRCCS Ospedale Policlinico San Martino Genoa–Italian Cardiovascular NetworkGenoa 16132Italy

Myeloproliferative neoplasms(MPN)are a group of diseases characterized by the clonal proliferation of hematopoietic progenitor or stem *** are clinically classifiable into four main diseases:chronic myeloid leukemia,essential thrombocythemia,polycythemia vera,and primary *** pathologies are closely related to cardio-and cerebrovascular diseases due to the increased risk of arterial thrombosis,the most common underlying cause of acute myocardial *** evidence shows that the classical Virchow triad(hypercoagulability,blood stasis,endothelial injury)might offer an explanation for such ***,patients with MPN might have a higher number and more reactive circulating platelets and leukocytes,a tendency toward blood stasis because of a high number of circulating red blood cells,endothelial injury or overactivation as a consequence of sustained inflammation caused by the neoplastic clonal *** abnormal cancer cells,especially when associated with the JAK2V617F mutation,tend to proliferate and secrete several inflammatory *** sustains a pro-inflammatory state throughout the *** direct consequence is the induction of a pro-thrombotic state that acts as a determinant in favoring both venous and arterial thrombus ***,MPN patients need to be carefully evaluated to be treated not only with cytoreductive treatments but also with cardiovascular protective strategies.

关键词： Inflammation Myeloproliferative neoplasm Acute coronary syndrome Myocardial infarction Thrombosis Cancer

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Update on cardiomyopathies and sudden cardiac death

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Forensic Sciences Research 2019年第3期4卷 202-210页

作者： Stefania Rizzo elisa Carturan Monica De Gaspari Kalliopi Pilichou Gaetano Thiene Cristina Basso Cardiovascular Pathology Department of Cardio-Thoracic-Vascular Sciences&Public Health and Azienda OspedalieraUniversity of Padua Medical SchoolPaduaItaly

Sudden cardiac death (SCD) remains a leading mode of death in western *** SCD can be the first and last clinical presentation of the underlying disease,autopsy could be the only medical examination available for early diagnosis and it should be performed according to the guidelines of the Association for European Cardiovascular *** the vast majority of SCD are due to coronary artery disease,non-ischemic causes of SCD do exist and are prevalent in young people with structural (***,hypertrophic and inflammatory cardiomyopathy) and non-structural (ion channel diseases)cardiomyopathies,accounting for up to one half of cases.A standardized autopsy protocol,in combination with blood sampling to ensure feasibility of postmortem molecular testing if needed,is *** pathologist is called to provide the correct diagnosis and to advice the relatives on the need of a cascade clinical and genetic screening in the presence of a heredo-familial disease.

关键词： Forensic sciences forensic pathology autopsy cardiomyopathies genetics sudden death

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