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Regenerative Biomaterials 2021年第3期8卷 45-56页

作者： Hannah A.Pearce Yu Seon Kim Emma Watson Kiana Bahrami Mollie M.Smoak Emily Y.Jiang Michael Elder tate shannon Antonios G.Mikos Department of Bioengineering Rice University6500 Main StreetHoustonTX 77030USA

The field of biomaterials has advanced significantly in the past *** the growing need for high-throughput manufacturing and screening,the need for modular materials that enable streamlined fabrication and analysis of tissue engineering and drug delivery schema has *** are a powerful platform that have demonstrated promise in enabling these technologies without the need to modify a bulk *** building block paradigm of using microparticles within larger scaffolds to control cell ratios,growth factors and drug release holds *** microparticles(GMPs)are a well-established platform for cell,drug and growth factor *** of the challenges in using GMPs though is the limited ability to modify the gelatin *** the present work,we hypothesized that by thiolating gelatin before microparticle formation,a versatile platform would be created that preserves the cytocompatibility of gelatin,while enabling post-fabrication *** thiols were not found to significantly impact the physicochemical properties of the ***,the thiolated GMPs were demonstrated to be a biocompatible and robust platform for mesenchymal stem cell ***,the thiolated particles were able to be covalently modified with a maleimide-bearing fluorescent dye and a peptide,demonstrating their promise as a modular platform for tissue engineering and drug delivery applications.

关键词： gelatin microparticles thiolated gelatin microparticles click chemistry cell delivery drug delivery tissue engineering biomaterials

Impact of COVID-19 on Safety Performance for Motorcycles: Pre-and during-Pandemic Conditions

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Journal of Transportation Technologies 2024年第3期14卷 390-401页

作者： Hongyun Chen Amelia Lawson Charles Hurda Madalyn Smith tate Grant Civil Engineering Department Embry-Riddle Aeronautical University Daytona Beach FL USA

Florida has the highest number of motorcycle fatalities in the United States and contains the second largest population of registered motorcycles. The COVID-19 pandemic influenced the roads, traffic, and driving behavior in the continental United States. Motorcycle crashes decreased during the COVID-19 years (2020 and 2021) while the fatality rates increased. The purpose of this study is to 1) investigate motorcycle crashes before and during the Pandemic period to understand the impacts on motorcycle safety and contributing factors to the crash severity levels;2) develop the crash predictive model for different degrees of severity in motorcycle crashes in Florida. Florida statewide crash data were collected. T tests have been conducted to compare the contributing factors between two periods. The injury severities are significantly different among all five levels between those during normal period and the Pandemic period. A crash predictive model has been developed to determine the facts to injury severity levels for motorcycle crashes. A total of eight variables are found to significantly increase the injury severity levels for motorcycle crashes during the Pandemic period.

关键词： Motorcycle Crash Pandemic Injury Severity Contributing Factors

MAGNA CARTA AND THE FUNDAMENTAL RIGHT TO DUE PROCESS

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Frontiers of Law in China-Selected Publications from Chinese Universities 2016年第2期11卷 236-242页

作者： Joshua C. tate SMU Dedman School of Law Dallas US

The 800th anniversary of Magna Carta has been marked by much pageantry and celebration. Some scholars have taken this opportunity to point out that the myth of Magna Carta is far greater than what the actual 1215 Charter managed to accomplish. Nevertheless, Magna Carta did make a meaningful and concrete contribution to due process in 1215, as shown by certain provisions that are seemingly overlooked by critics eager to downplay the Charter＇s importance. This article highlights two lesser known clauses of Magna Carta that had real contemporary significance in guaranteeing the availability of jury trial for some categories of civil litigation. The ringing promises of Clauses 39 and 40 may have inspired great jurists and founders of nations, but the more humble Clauses 17 and 18 -- specifying the proper location and manner of hearing certain civil cases -- must also be taken into account in assessing the Charter＇s importancc.

关键词： Magna Carta legal history trials access to justice property fundamental rights

Detailed bed topography and sediment load measurements for two stepdown flows in a laboratory flume

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International Journal of Sediment Research 2022年第3期37卷 287-298页

作者： Daniel Wren Roger Kuhnle tate Mc Alpin David Abraham Keaton Jones United States Department of Agriculture Agricultural Research Service National Sedimentation Laboratory U.S.Army Research and Development Center Coastal and Hydraulics Laboratory

Streams and rivers, particularly smaller ones, often do not maintain steady flow rates for long enough to reach equilibrium conditions for sediment transport and bed topography. In particular, streams in small watersheds may be subject to rapidly changing hydrographs, and relict bedforms from previous high flows can cause further disequilibrium that complicates the prediction of sediment transport rates. In order to advance the understanding of how bedforms respond to rapid changes in flow rate, a series of flume experiments were performed where the flow was reduced rapidly from equilibrium *** transport rates and bed elevation data across the flume and over a 15-meter-long test section were collected during the experiments to allow detailed examination of evolving bedform dynamics. It was found that relict bedforms stopped moving completely after flow reductions, and the mode of sediment transport was shifted to small bedforms that arose rapidly over dune stoss sections throughout the test section. The changes in sediment transport with time as the sand bed adjusted to the new flow rate was found to agree with predictions based on the relations proposed in Wren et al.(2020). Wavelet analysis is used to visualize changes in length and amplitude scales during the bed transition process.

关键词： Sediment transport Bedforms Dunes Wavelets

COMPLEXITY OF SYSTEM MAINTAINABILITY ANALYSIS BASED ON THE INTERPRETIVE STRUCTURAL MODELING METHODOLOGY： TRANSDISCIPLINARY APPROACH

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Journal of Systems Science and Systems Engineering 2016年第2期25卷 254-268页

作者： A. Ertas M.W. Smith D. tate W.D. Lawson T.B. Baturalp Department of Mechanical Engineering Texas Tech University Lubbock TX USA 79410 Department of Industrial Design Xi 'an Jiaotong-Liverpool University Suzhou 215123 Jiangsu China Department of Civil Engineering Texas Tech University Lubbock TX USA 79410

This paper outlines a diagnostic approach to quantify the maintainability of a Commercial off-the-Shelf （COTS）-based system by analyzing the complexity of the deployment of the system components. Interpretive Structural Modeling （ISM） is used to demonstrate how ISM supports in identifying and understanding interdependencies among COTS components and how they affect the complexity of the maintenance of the COTS Based System （CBS）. Through ISM analysis we have determined which components in the CBS contribute most significantly to the complexity of the system. With the ISM, architects, system integrators, and system maintainers can isolate the COTS products that cause the most complexity, and therefore cause the most effort to maintain, and take precautions to only change those products when necessary or during major maintenance efforts. The analysis also clearly shows the components that can be easily replaced or upgraded with very little impact on the rest of the system.

关键词： COTS Based System maintainability complexity Interpretive Structural Modeling

A multiwavelength view of the ISM in the merger remnant galaxy Fornax A

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Research in Astronomy and Astrophysics 2013年第8期13卷 885-898页

作者： Swati Pralhadrao Deshmukh Bhagorao Tukaram tate Nilkanth Dattatray Vagshette Sheo Kumar Pandey Madhav Khushalrao Patil Department of Physics Institute of Science Department of Physics Balbhim Arts Science and Commerce College School of Physical Sciences Swami Ramanand Teerth Marathwada University School of Studies in Physics & Astrophysics Pandit Ravishankar Shukla University

We present multi-wavelength imagery of the merger remnant galaxy NGC 1316 with an objective to study the dust content and its association with the other phases of the interstellar medium. Color-index maps as well as extinction maps derived for this galaxy reveal an intricate and complex dust morphology in NGC 1316, i.e. there is a prominent lane in the inner part, while at about 6-7 kpc it apparently takes the form of an arc-like pattern extending along the northeast direction. In addition to this, several other dust clumps and knots are also evident in this galaxy. The dust emission mapped using Spitzer data at 8 μm indicates even more complex morphological structures of the dust in NGC 1316. The extinction curve derived over the optical to near-IR bands closely follows the standard Galactic curve, suggesting similar properties of the dust grains. The dust content of NGC 1316, estimated from optical extinction, is ,- 2.13 × 10^5 M⊙. This is a lower limit compared to that estimated using the IRAS flux densities of ,-5.17× 10^6 M⊙ and the flux densities at 24, 70 and 160 p.m from MIPS ,-3.2× 10^7 M⊙. High resolution Chandra observations of this merger remnant system have provided an unprecedented view of the complex nature exhibited by the distribution of hot gas in NGC 1316, which closely matches the morphology of ionized gas and to some extent also the dust. X-ray color-color plots for the resolved sources within the optical D25 extent of NGC 1316 have enabled us to separate them into different classes.

关键词： galaxies individual (NGC 1316) - galaxies: ISM - X-rays: ISM - (ISM:) dust - extinction - galaxies: elliptical and lenticular, cD

Accommodating the bacterial decoding release factor as an alien protein among the RNAs at the active site of the ribosome

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Cell Research 2007年第7期17卷 591-607页

作者： Elizabeth S Poole David J Young Marjan E Askarian-Amiri Debbie-Jane G Scarlett Warren P tate Department of Biochemistry University of OtagoP.O.Box 56 DunedinNew Zealand

The decoding release factor (RF) triggers termination of protein synthesis by functionally mimicking a tRNA to spanthe decoding centre and the peptidyl transferase centre (PTC) of the ribosome. Structurally, it must fit into a site craftedfor a tRNA and surrounded by five other RNAs, namely the adjacent peptidyl tRNA carrying the completed polypeptide,the mRNA and the three rRNAs. This is achieved by extending a structural domain from the body of the protein thatresults in a critical conformational change allowing it to contact the PTC. A structural model of the bacterial terminationcomplex with the accommodated RF shows that it makes close contact with the first, second and third bases of the stopcodon in the mRNA with two separate loops of structure: the anticodon loop and the loop at the tip of helix α5. Theanticodon loop also makes contact with the base following the stop codon that is known to strongly influence termina-tion efficiency. It confirms the close contact of domain 3 of the protein with the key RNA structures of the PTC. ThemRNA signal for termination includes sequences upstream as well as downstream of the stop codon, and this may reflectstructural restrictions for specific combinations of tRNA and RF to be bound onto the ribosome together. An unbiasedSELEX approach has been investigated as a tool to identify potential rRNA-binding contacts of the bacterial RF in itsdifferent binding conformations within the active centre of the ribosome.

关键词： release factor protein synthesis termination tRNA functional mimicry molecular mimicry SELEX ribosome

Marked elevation of B-type natriuretic peptide in patients with heart failure and preserved ejection fraction

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The Journal of Biomedical Research 2014年第4期28卷 255-261页

作者： Samuel tate Andrea Griem Blythe Durbin-Johnson Clifton Watt Saul Schaefer Department of Internal Medicine Division of Cardiovascular MedicineUniversity of California DavisDavisCAUSA Department of Public Health Sciences Division of BiostatisticsUniversity of California DavisDavisCAUSA Cardiology Section Department of Veteran AffairsNorthern California Health Care SystemMatherCAUSA

Marked elevations of B-type natriuretic peptide （BNP） are not generally seen in patients with heart failure and preserved ejection fraction （HFpEF）. The objective of this study was to examine the clinical and laboratory characteristics of a large cohort of patients with HFpEF and markedly elevated BNP. A retrospective examination of 421 inpatients at a university hospital admitted with a diagnosis of HFpEF was performed. Clinical and echocardiographic data in 4 groups of patients with levels of BNP ≤ 100 pg/mL, 100-400 pg/mL, 400-1,000 pg/mL and 〉 1,000 pg/mL were compared. Patients with HFpEF and BNP 〉 1,000 pg/mL （28% of the population） were characterized by impaired renal function and greater use of anti-hypertensive medications. A subset of these patients with BNP 〉 1,000 pg/mL had normal renal function （21%） and were significantly older, more frequently female, and tended to have lower ejection fractions. Conversely, patients with HFpEF and BNP ≤100 pg/mL were younger and had preserved renal function. BNP was inversely related to the likelihood of subsequent admission for heart failure, but not to myocardial infarction or death. In conclusion： BNP 〉 1,000 pg/mL is seen in almost 1/3 of patients hospitalized with HFpEF. This elevation of BNP often reflects impaired renal function, but can also be seen in patients with preserved renal function but relatively impaired systolic function.

关键词： B-type natriuretic peptide diastolic heart failure chronic kidney disease

Traceability, international standardization programs,and world-wide reference systems in laboratory medicine

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中华检验医学杂志 2008年第3期31卷 250-252页

作者： Francesco Dati Jill tate IVD-Consulting Pappelweg 18 D-35041 Marburg Germany Pathology Queensland Chemical Pathology Royal Brisbane and Women's Hospital Herstan Queensland 4029 Australia

随着科学与技术的发展，临床检验近年出现了许多新的检验项目，尤其是利用免疫学原理对某些浓度很低的特殊蛋白的检测，但这些检测的结果可以是方法特异的，一种方法结果可能无法与其他方法结果相比较。为实现标准化或一致化，不同免疫... 详细信息

随着科学与技术的发展，临床检验近年出现了许多新的检验项目，尤其是利用免疫学原理对某些浓度很低的特殊蛋白的检测，但这些检测的结果可以是方法特异的，一种方法结果可能无法与其他方法结果相比较。为实现标准化或一致化，不同免疫分析的方法设计需具有可比性，校准物需溯源至同一参考物质。新的欧盟法规要求体外诊断产品的校准物和控制物的定值需具有溯源性，此要求适用所有体外诊断产品，对全球制造商和临床实验室产生影响。溯源原理基于EN ISO 17511，方法间结果的可比性有赖于合理设计的参考系统。此参考系统包括下列基本要素：足够明确的分析物定义，参考测量程序，适当的一级和次级参考物质，经过认可的参考实验室网络，临床溯源性相关信息，以及测量不确定度表述等。溯源性通过不间断的校准链（溯源链）实现，后者由交替出现的测量程序和校准物质组成。SI溯源链始于分析物的SI单位定义，随后通过一级参考测量程序和一级参考物质传递SI单位。量值的准确性或正确性源于一级参考测量程序和一级参考物质，但由于一级参考物质价格昂贵，一级参考测量程序无法在常规检测中应用，尚需中间的校准物和方法将准确性传递至产品校准物，最终至患者样品。每一次传递都会增加误差或不确定度，因此溯源链的传递步骤越少越好。正确的传递链要求每一测量程序的检测特异性和每一校准品的互通性，达不到这些要求会使溯源链中断。制造商还需确定校准品定值的不确定度并将这一信息提供给用户，在计量学上不确定度与定值同样重要。临床实验室位于溯源链的终端，结果的溯源性有赖于制造商所使用和描述的参考测量程序和参考物质。建立校准物的溯源性和改进检验结果的可比性需要标准化计划，这意味着使检测结果尽可能接近上一级参考测量程序得到的真值。采用较低级别的公认方法为特定的参考物质定值时，上述过程表述为“一致化”，而不是“标准化”，因为一致的结果不一定是真值。为整理和公布检验医学现有较高级别参考物质、参考测量程序和参考实验室，国际计量局（BIPM）、国际临床化学联合会（IFCC）和国际实验室认可协会（ILAC）成立检验医学溯源联合委员会（简称JCTLM）。JCLTM的主要任务是通过实施参考系统，建立检验结果溯源性，改进其可比性，从而提高医疗卫生质量并降低费用。JCTLM设立工作框架，按照国际标准（ISO 17511，15193，15194）建立参考物质和参考测量程序认定步骤。工作任务被很快确立并付诸实施，包括建立参考物质和参考测量程序列表，建立参考实验室网络，建立新的参考物质和参考测量程序的审批程序，以及合作研发新的参考物质和参考测量程序。

关键词：参考标准校准临床检验参考物质参考测量程序实验室检验参考系统溯源性

Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ’long-haulers’?

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Chronic Diseases and Translational Medicine 2021年第1期7卷 14-26页

作者： Emily Wood Katherine H.Hall Warren tate Department of Biochemistry Health Sciences DivisionUniversity of OtagoDunedinNew Zealand Department of General Practice and Rural Health Otago Medical School-Dunedin CampusUniversity of OtagoDunedinNew Zealand

A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, oxidative stress and antioxidants may play in the understanding of the pathophysiology and treatment of chronic fatigue. It describes what is known about the dysfunctional pathways which can develop in mitochondria and their relationship to chronic fatigue. It also reviews what is known about oxidative stress and how this can be related to the pathophysiology of fatigue, as well as examining the potential for specific therapy directed at mitochondria for the treatment of chronic fatigue in the form of antioxidants. This study identifies areas which require urgent, further research in order to fully elucidate the clinical and therapeutic potential of these approaches.

关键词： Chronic fatigue syndrome Mitochondria Oxidative stress Antioxidants SARS-CoV-2