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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 2-3页

作者： Hadziyannis S.J. tassopoulos n.c. Jenny Heathcote E. 李明 Department of Medicine Henry Dunant Hospital 107 Mesogion Ave. Athens 11526 Greece Dr.

BAcKGROUnD: Treatment with adefovir dipivoxil for 48 weeks resulted in histologic, virologic, and biochemical improvement in patients with hepatitis B e antigen (HBeAg)- negative chron.c.hepatitis B. We evaluated the effect of continued therapy as compared with cessation of therapy. METHODS: One hundred eighty-five HBeAgnegative patients with chron.c.hepatitis B were assigned to receive 10 mg of adefovir dipivoxil or placebo once daily for 48 weeks (ratio, 2 ∶ 1). After week 48, patients receiving adefovir dipivoxil were again randomly assigned either to receive an additional 48 weeks of the drug or to switch to placebo. Patients originally assigned to placebo were switched to adefovir dipivoxil. Patients treated with adefovir dipivoxil during weeks 49 through 96 were subsequently offered continued therapy. The primary end points were changes in hepatitis B virus (HBV) DnA and alanine aminotransferase levels. RESULTS: Treatment with adefovir dipivoxil resulted in a median decrease in serum HBV DnA of 3.47 log copies per milliliter (on a base-10 scale) at 96 weeks and 3.63 log copies per milliliter at 144 weeks. HBV DnA levels were less than 1000 copies per milliliter in 71 percent of patients at week 96 and 79 percent at week 144. In the majority of patients who were switched from adefovir dipivoxil to placebo, the benefit of treatment was lost (median.c.ange in HBV DnA levels from baseline, - 1.09 log copies per milliliter; only 8 percent of patients had levels below 1000 copies per milliliter at week 96). Side effects during weeks 49 through 144 were similar to those during the initial 48 weeks. Resistance mutations rtn236T and rtA181V were identified in 5.9 percent of patients after 144 weeks. cOncLUSIOnS: In patients with HBeAg-negative chron.c.hepatitis B, the benefits achieved from 48 weeks of adefovir dipivoxil were lost when treatment was discontinued. In patients treated for 144 weeks, benefits were maintained, with infrequent emergence of viral resistance.

关键词：乙型肝炎 HBeAg阴性韦长慢性乙肝阿德基线水平终点指标安慰剂周和耐药基因

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聚乙二醇干扰素α-2b和(或)拉米夫定治疗慢性乙型肝炎或HBeAg阴性患者病毒动力学研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 40-41页

作者： Sypsa V.-A. Mimidis K. tassopoulos n.c. A. Hatzakis 王志宇 Department of Hygiene and Epidemiology Athens University Medical School 75 Mikras Asias Street 15 27 Athens Greece Dr.

We studied viral dynamic parameters in 44 chron.c.hepatitis B/hepatitis B e antigen (HBeAg)(-) patients treated with pegylated interferon alfa-2b (PEG-IFn) 100 or 200 μg weekly or lamivudine 100 mg daily or the combination of PEG-IFn 100 or 200 μg with lamivudine. Patients receiving PEG-IFn monotherapy exhibited viral load oscillations between weekly injections, which were resolved by the addition of lamivudine. The median pharmacological delay was estimated at 4.1, 5.8, and 1.8 hours in PEG-IFn monotherapy, PEG-IFn 100/200 μg +lamivudine, and lamivudine monotherapy, respectively (P = .44). The median half-life of free virus was 12.7 hours (range, 2.4-69.2 hours). The mean antiviral effectiveness of PEG-IFn 100/200 μg monotherapy was lower than that of lamivudine (82.6%vs. 96.4%; P = .005). The mean effectiveness of PEGIFn 100 μg +lamivudine and PEG-IFn 200 μg +lamivudine was 92.8%and 94.4%, respectively. The half-life of infected cells ranged from 2.7 to 75 days. The median half-life of infected cells in patients receiving the combination regimens of PEG-IFn and lamivudine was similar to that of lamivudine patients (5.0 days vs. 6.0 days, P = .77). In.c.nclusion, the addition of pegylated interferon alfa-2b in lamivudine treatment was found to neither enhance the potency of blocking HBV production nor the decay rates of infected cells.

关键词： HBeAg阴性干扰素α 乙型肝炎阴性患者复制能力感染细胞平均有效率负荷波动

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Early Phases of Star Formation: Testing chemical Tools

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Research in Astronomy and Astrophysics 2024年第1期24卷 96-118页

作者： n.c.Martinez S.Paron cOn.c.T-Universidad de Buenos Aires.Instituto de Astronomía y Física del Espacio Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

Star-forming processes strongly influence the ISM ***,many high-quality databases are available at millimeter *** them,it is possible to carry out studies that review and deepen previous *** these studies involve large samples of sources,it is preferred to use direct tools to study the molecular *** the aim of testing these tools such as the use of the Hcn/Hnc ratio as a thermometer,and the use of H^(13)cO^(+),Hc_(3)n,n_(2)H^(+) and c_(2)H as "chemical clocks," we present a molecular line study toward 55 sources representing massive young stellar objects at different evolutionary stages:infrared dark clouds(IRDcs),highmass protostellar objects(HMPOs),hot molecular cores(HMcs) and ultracompact H II *** found that the use of the Hcn/Hnc ratio as a universal thermometer in the ISM should be taken with care because the Hcn optical depth is a big issue that can affect the ***,this tool should be utilized only after a careful analysis of the Hcn spectrum,checking that no line,neither the main nor the hyperfine ones,presents absorption *** point out that the analysis of the emission of H^(13)cO^(+),Hc_(3)n,n_(2)H^(+) and c_(2)H could be useful to trace and distinguish regions among IRDcs,HMPOs and *** molecular line widths of these four species increase from the IRDc to the HMc stage,which can be a consequence of the gas dynamics related to the starforming processes taking place in the molecular *** results not only contribute with more statistics,acting as a probe of such chemical tools,useful to obtain information in large samples of sources,but also complement previous works through the analysis of other types of sources.

关键词： stars:formation ISM:molecules ISM:clouds

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Imprints of a gravitational wave through the weak field deflection of photons

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chinese Physics c 2024年第8期48卷 240-245页

作者： Reggie c.Pantig Ali Övgün Physics Department Mapúa University658 Muralla St.IntramurosManila 1002Philippines Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkiye

In this study,we investigate the novel phenomenon of gravitational lensing experienced by gravitational waves traveling past a Schwarzschild black hole perturbed by a specific,first-order,polar gravitational *** apply the Gauss-Bonnet theorem,finding a topological contribution to the deflection of light rays passing near the black *** demonstrate that the deflection angle can be determined by analyzing a region entirely outside the path of the light ray,leading to a calculation based solely on the parameters of the perturbing wave(Legendre polynomial order,l;frequency,σ).This approach offers a unique perspective on gravitational lensing and expands our understanding of black hole interactions with gravitational waves.

关键词： supermassive black holes gravitational waves chaos weak deflection angle Gauss-Bonnet theorem

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HBeAg阴性的慢性乙型肝炎患者拉米夫定长期治疗的研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 54-54页

作者： Rizzetto M. tassopoulos n.c. Goldin R.D. 王铮 Exp. Department of Gastroenterology S. Giovanni Battista Hosp. C.So B. 88 10126 Torino Italy

The histological and clin.c.l outcome of lamivudine 100 mg/day was assessed in 76 HBeAg-negative chron.c.hepatitis B patients previously randomised to a double-blind comparison study of lamivudine and placebo. Paired liver biopsies were available before 1 year of randomised lamivudine treatment and after 2 years of further open-label treatment for 48 patients. Serum samples were analysed for hepatitis B markers and ALT levels (n=74). The histological activity index improved, remained unchanged andworsened in 64,32 and 5%, respectively, for patients without YMDD-variant HBV compared to 15, 54 and 31%with the variant. none of the 42/48 patients without cirrhosis at baseline progressed to cirrhosis. Of 24/48 patients without bridging fibrosis at pre-treatment, 83%(20/24) did not progress to bridging fibrosis. Median HBV DnA remained below the lower limit of detection and ALT ≤1 times the ULn for patients without the variant whereas levels gradually increased to 11.3 Meq/ml (bDnA assay) and 2 times the upper limit of normal by month 24 for patients with variant. The clin.c.l benefit of lamivudine is greatest for patients without YMDD variants over 2 years of extended treatment. Additional therapies should be considered for patients with YMDD variants.

关键词： HBeAg阴性乙型肝炎桥接纤维化活动性指标正常上限临床作用双盲对照血清样本安慰剂检测下限

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Mathematical modeling and simulations of stress mitigation by coating polycrystalline particles in lithium-ion batteries

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Applied Mathematics and Mechan.c.(English Edition) 2024年第6期45卷 947-962页

作者： n.IQBAL J.cHOI S.F.SHAH c.LEE S.LEE Department of Mechan.c.l Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A chemo-mechan.c.l model is developed to investigate the effects on the stress development of the coating of polycrystalline ni-rich LinixMn.c._(z)O_(2)(x≥0.8)(n.c.particles with poly(3,4-ethylenedioxythiophene)(PEDOT).The simulation results show that the coating of primary n.c.particles significantly reduces the stress generation by efficiently accommodating the volume change associated with the lithium diffusion,and the coating layer plays roles both as a cushion against the volume change and a channel for the lithium transport,promoting the lithium distribution across the secondary particles more ***,the lower stiffness,higher ion.c.conductivity,and larger thickness of the coating layer improve the stress *** paper provides a mathematical framework for calculating the chemo-mechan.c.l responses of anisotropic electrode materials and fundamental insights into how the coating of n.c.active particles mitigates stress levels.

关键词： lithium-ion battery(LIB) polycrystalline particle coating finite element simulation ni-rich LinixMn.c._(z)O_(2)(x>0.8)(n.c.

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Empirical model for fusion.c.oss sections of ca-induced reactions

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chinese Physics c 2024年第3期48卷 126-132页

作者： Reddi Rani.L n.Sowmya K.n Sridhar H c.Manjunatha M.M.Armstrong Arasu Department of Physics St.Joseph's College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirappalli620002TNIndia Department of Physics Govt.First.Grade CollegeChikkaballapur-562101KarnatakaIndia Department of Physics Govt.First.Grade CollegeMalur-563160KarnatakaIndia Department of Physics Govt.First.Grade CollegeDevanahalli-562110KarnatakaIndia

A new empirical formula for the astrophysical S-factor has been suggested as a function of the coulomb interaction parameter,center of mass energy,and barrier *** 22 fusion reactions with ^(40,48)ca as projectiles were considered for different targets,leading to compound n.c.ei with atomic and mass numbers varying between 40≤Z≤≤Z≤112 and 88≤A≤27888≤A≤278,*** fusion.c.oss-sections have been estimated using the geometric factor,the Gamow-Sommerfield factor,and the empirical formula for the *** study's findings showed better agreement with those of available experiments when.c.mpared to Wong's *** present work leads to a smaller standard deviation value than Wong's formula when used to correlate the experimental data of calcium-induced fusion ***'s formula provides a good approximation of fusion.c.oss-sections when the center of mass energy is below the fusion barrier when.c.mpared to above the fusion barrier.

关键词： fusion.c.oss-sections Wong formula Gamow-Sommerfield-factor Geometric-factor S-factor

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Polio eradication surveillance in Sri Lanka,2019-2023

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.Y.Fernando n.S.Madarasinghe c.Rangana n.Weerasinghe D.c.U.D.Weligamage J.I.Abeynayake Department of Medical Microbiology and Immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillance carried out from January,2019 to May,2023 by the Polio Regional Reference Laboratory,Sri ***:This retrospective study analyzed all stool samples received under the acute flaccid paralysis(AFP)and immunodeficient vaccine-derived poliovirus(VDPV)surveillance at Polio Regional Reference Laboratory,Sri Lanka from January,2019 to May,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VDPV real time reverse tran.c.iptase polymerase chain reaction(ITD/VDPV rRTPcR)and sequencing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillance from Sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while Sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all years of the study,the non-polio AFP detection rate was>1/100000 in.c.ildren aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of receipt,ensuring timely reporting as per global ***:The Polio Regional Reference Laboratory,Sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VDPV during the study period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance Regional reference laboratory Polio eradication

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Automating selective area electron diffraction phase identification using machine learning

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Journal of Materiomics 2024年第4期10卷 896-905页

作者： M.Mika n.Tomczak c.Finney J.carter A.Aitkaliyeva n.c.ear Engineering Program in Department of Materials Science University of Florida100 Rhines HallGainesville32611FLUSA Department of Materials Science&Engineering Case Western Reserve University2111 Martin Luther King Jr DrCleveland44106OHUSA

Selective area electron diffraction(SAED)patterns can provide valuable insight into the structure of a ***,the manual identification of collected patterns can be a significant bottlen.c. in the overall phase classification *** this work,we utilize the recent advances in.c.mputer vision and machine learning(ML)to automate the indexing of SAED *** performance of six different ML algorithms is demonstrated using metallic plutonium-zirconium *** most successful approach trained a neural network(nn)to make a classification of the phase and zone axis,and then utilized a second nn to synthesize multiple independent predictions of different tilts in a single sample to make an overall phase *** results demonstrate that automated SAED phase identification using ML is a viable route to accelerate materials characterization.

关键词： Selective area electron diffraction Machine learning Phase identification Metallic fuels Pu alloys

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Airway management of a patient with linear immunoglobulin A bullous dermatosis:A case report

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World Journal of clin.c.l cases 2024年第13期12卷 2263-2268页

作者： Olga c nin Robert Hutnik neil n.c.heda David Hutchinson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BAcKGROUnD There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare mucocutaneous disorder that leads to the development of friable *** clin.c.l decision making is n.c.ssary when there is a risk of bleeding into the airway,and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios,especially when.c.nfronted with an unusual cause for *** SUMMARY A 45-year-old African American female presented to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous *** diagnosis of IgA dermatosis was recent,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required transfer to the intensive care unit where a multidisciplinary team was involved in her *** patient was extubated on postoperative day *** A multidisciplinary approach to treating this disease is the best course of action before a surgical *** our case,key commun.c.tion between the surgery,anesthesia,and dermatology teams led to the quick and safe treatment of our patient’s *** surgery should not be considered for these cases unless they are in full remission and there is no mucous membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisciplinary approach Outpatient procedure case report

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