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Exploring the association between hypertension and cognitive impairment:Evidence-based insights

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Chronic Diseases and Translational Medicine 2024年第2期10卷 153-155页

作者： tarun Kumar Suvvari Rangaraya Medical College KakinadaAndhra PradeshIndia Squad Medicine and Research VizagAndhra PradeshIndia

To the Editor,Hypertension,also known as high blood pressure(BP),affects millions of people worldwide.Beyond its well-documented cardiovascular consequences,hypertension has been uncovered an association with cognitive impairment.1 This is a growing concern,as the number of people with hypertension is expected to increase in the coming years,particularly in developing countries.

关键词： hypertension impairment cardiovascular

Efficacy of stromal vascular fraction for knee osteoarthritis:A prospective,single-centre,non-randomized study with 2 years follow-up

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World Journal of Orthopedics 2024年第5期15卷 457-468页

作者： Madhan Jeyaraman Naveen Jeyaraman tarun Jayakumar Swaminathan Ramasubramanian Rajni Ranjan Saurabh Kumar Jha Ashim Gupta Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennaiTamil Nadu 600077India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201310India Department of Orthopaedics and Regenerative Medicine South Texas Orthopaedic Research InstituteLaredoTX 78045United States Department of Orthopaedics KIMS-Sunshine HospitalHyderabadTelangana 500032India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennaiTamil Nadu 600002India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Zoology Kalindi CollegeUniversity of DelhiNew Delhi 110008India Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301Uttar PradeshIndia Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States

BACKGROUND Current osteoarthritis(OA)treatments focus on symptom relief without addressing the underlying disease process.In regenerative medicine,current treatments have limitations.In regenerative medicine,more research is needed for intra-articular stromal vascular fraction(SVF)injections in OA,including dosage optimization,long-term efficacy,safety,comparisons with other treatments,and mechanism exploration.AIM To compare the efficacy of intra-articular SVF with corticosteroid(ICS)injections in patients with primary knee OA.METHODS The study included 50 patients with Kellgren-Lawrence grades II and III OA.Patients were randomly assigned(1:1)to receive either a single intra-articular SVF injection(group A)or a single intra-articular ICS(triamcinolone)(group B)injection.Patients were followed up at 1,3,6,12,and 24 months.Visual analog score(VAS)and International Knee Documentation Committee(IKDC)scores were administered before the procedure and at all followups.The safety of SVF in terms of adverse and severe adverse events was recorded.Statistical analysis was performed with SPSS Version 26.0,IBM Corp,Chicago,IL,United States.RESULTS Both groups had similar demographics and baseline clinical characteristics.Follow-up showed minor patient loss,resulting in 23 and 24 in groups A and B respectively.Group A experienced a notable reduction in pain,with VAS scores decreasing from 7.7 to 2.4 over 24 months,compared to a minor reduction from 7.8 to 6.2 in Group B.This difference in pain reduction in group A was statistically significant from the third month onwards.Additionally,Group A showed significant improvements in knee functionality,with IKDC scores rising from 33.4 to 83.10,whereas Group B saw a modest increase from 36.7 to 45.16.The improvement in Group A was statistically significant from 6 months and maintained through 24 months.CONCLUSION Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in patients with primary knee OA.More adequately powe

关键词： Knee osteoarthritis Adipose tissue Stromal vascular fraction Regenerative medicine Orthobiologics

Are case reports valuable?Exploring their role in evidence based medicine and patient care

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World Journal of Clinical Cases 2024年第24期12卷 5452-5455页

作者： tarun Kumar Suvvari Department of Clinical Research Squad Medicine and Research(SMR)Amadalavalasa 532185Andhra PradeshIndia Department of Medicine Rangaraya Medical CollegeKakinada 533001Andhra PradeshIndia

Case reports,often overlooked in evidence-based medicine(EBM),play a pivotal role in healthcare research.They provide unique insights into rare conditions,novel treatments,and adverse effects,serving as valuable educational tools and generating new hypothesis.Despite their limitations in generalizability,case reports contribute significantly to evidence-based practice by offering detailed clinical information and fostering critical thinking among healthcare professionals.By acknowledging their limitations and adhering to reporting guidelines,case reports can contribute significantly to medical knowledge and patient care within the evolving landscape of EBM.This editorial explores the intrinsic value of case reports in EBM and patient care.

关键词： Clinical cases Case reports Evidence based medicine Editorial Healthcare research

Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

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Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra Kashyap Nidhi Varshney tarun Prakash Verma Ajay Kumar Jain Debi Chatterji Vinod Kumar Amit Mishra Awanish Kumar Hem Chandra Jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(H.pylori)is the strongest known risk factor for gastric cancer(GC).H.pylori is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that H.pylori infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

Hybrid Bio-based Composites from Waste Chicken Feather and Betel Nut Fiber: A Study on the Mechanical and Thermal Properties

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Journal of Bionic Engineering 2022年第1期19卷 268-277页

作者： Gitashree Gogoi Chayanika Chowdhury tarun K.Maji Department of Chemical Sciences Tezpur UniversityAssam784028India

The present work is an attempt to develop bio-based hybrid composites by incorporating Betel nut Fiber(BF)and Chicken feather Fiber(CF)at different ratios in modified soybean oil matrix by compression molding technique.The ratio of the fiber and resin was taken as 30:70.Epoxidised soybean oil(ESO)was modified by using methacrylic acid and methacrylic anhydride.The ratio of CF and BF was varied from 2:1 to 1:2 respectively.The influence of hybrid fibers and fiber ratio on various properties of the composites was investigated.The obtained results showed that composites prepared with 1:1 ratio of CF and BF exhibited highest tensile strength compared to the other composites prepared by using different ratios of CF and BF.The surface morphology of the composites was studied by Scanning Electron Microscopy(SEM),where surface roughness was found to be decreased after incorporation of hybrid fibers.Thermogravimetric analysis was carried out to study the behaviour of the composites at high temperature,where thermal stability was found to enhance for hybrid composites compared to the composites prepared with single fibers.Also properties like water vapour uptake capacity and volumetric swelling were measured and found to be decreased for the hybrid composites.An overall improvement in properties was observed for composites having 1:1 ratio of CF:BF.Hence,it is concluded that 1:1 weight ratio of CF and BF is the optimum mixing ratio to enhance the various properties of the hybrid composites.

关键词： Hybrid composites Betel nut fiber Chicken feather fiber Mechanical properties Thermal properties

Encrusted cystitis and ascites due to urethral calculus

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Asian Journal of Urology 2022年第2期9卷 197-198页

作者： tarun Jindal Satyadip Mukherjee Department of Uro-oncology Tata Medical CentreKolkataIndia

Dear editor,A 55-year-old man presented with dyspnea and involuntary dribbling of urine for 1 month.He had history of straining during micturition and weak urinary stream for a year.On examination,he was disoriented and had abdominal distension.Ultrasound revealed marked ascites,pleural effusion,bilateral hydroureteronephrosis,and distended bladder with prostatic urethral calculus.A non-contrast computerized tomography scan additionally showed thickened bladder wall with florid mucosal calcification suggestive of encrusted cystitis and a 2.9 cm×2.5 cm calculus in the prostatic urethra extending to the bulbar urethra(Fig.1).His hemoglobin was 6 g/dL;urea and creatinine were elevated(114 mg/dL and 8.4 mg/dL,respectively);and the leucocyte count was 16.3×109/L.After initial resuscitation,ultrasound guided supra-pubic catheterization was performed.The urine pH was 8.4 while the microscopy revealed numerous pus cells,bacteria,and inorganic crystals.A nephrology consultation was taken and considering the clinical picture of encrusted cystitis,he started on intravenous vancomycin.He also received a session of hemodialysis.The patient died of cardiovascular collapse on the second post admission day.The urine culture report,obtained posthumously,revealed Corynebacterium urealyticum corroborating the diagnosis of encrusted cystitis.The strain was multidrug resistant and showed only sensitivity to teicoplanin and vancomycin.

关键词： bladder urine ascites

Liver dysfunction during COVID-19 pandemic:Contributing role of associated factors in disease progression and severity

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World Journal of Hepatology 2022年第6期14卷 1099-1110页

作者： tarun Sahu Babita Pande Manasa PL Henu Kumar Verma Department of Physiology All India Institute of Medical SciencesRaipur 492001ChhattisgarhIndia Center for Basic Sciences Pt.Ravishankar Shukla UniversityRaipur 492001ChhattisgarhIndia Department of Immunopathology Institute of Lungs Health and ImmunityMunich 85764BavariaGermany

In December 2019,a new strain of coronavirus was discovered in China,and the World Health Organization declared it a pandemic in March 2020.The majority of people with coronavirus disease 19(COVID-19)exhibit no or only mild symptoms such as fever,cough,anosmia,and headache.Meanwhile,approximately 15%develop a severe lung infection over the course of 10 d,resulting in respiratory failure,which can lead to multi-organ failure,coagulopathy,and death.Since the beginning of the pandemic,it appears that there has been consideration that preexisting chronic liver disease may predispose to deprived consequences in conjunction with COVID-19.Furthermore,extensive liver damage has been linked to immune dysfunction and coagulopathy,which leads to a more severe COVID-19 outcome.Besides that,people with COVID-19 frequently have abnormal liver function,with more significant elevations in alanine aminotransferase and aspartate aminotransferase in patients with severe COVID-19 compared to those with mild/moderate disease.This review focuses on the pathogenesis of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection in the liver,as well as the use of liver chemistry as a prognostic tool during COVID-19.We also evaluate the findings for viral infection of hepatocytes,and look into the potential mechanisms behind SARS-CoV-2-related liver damage.

关键词： SARS-CoV-2 COVID-19 Liver function Hepatic injury Viral infection

Concurrent laparoscopic management of giant adrenal myelolipoma and contralateral renal cell carcinoma

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Asian Journal of Urology 2022年第1期9卷 97-98页

作者： tarun Jindal Pravin Pawar Neeraj Subedi Department of Uro-oncology Tata Medical CentreKolkataIndia

Dear editor,Myelolipomas are uncommon,benign tumors of the adrenal gland that can occasionally attain a large size.These tumors,very rarely,can occur along with renal cell carcinoma[1].We describe the first case of a giant right sided adrenal myelolipoma co-existent with a contralateral renal cell carcinoma,both of which could be operated laparoscopically in the same sitting.

关键词： adrenal renal laparoscopic

Early and aggressive presentation of wild-type transthyretin amyloid cardiomyopathy:A case report

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World Journal of Cardiology 2022年第12期14卷 657-664页

作者： Ilham Boda Hassan Farhoud tarun Dalia Amandeep Goyal Zubair Shah Andrija Vidic Department of Internal Medicine University of Kansas Medical CenterKansas CityKS 66160United States School of Medicine University of Kansas Medical CenterKansas CityKS 66160United States Department of Cardiovascular Medicine University of Kansas Medical CenterKansas CityKS 66160United States

BACKGROUND Wild-type transthyretin amyloidosis(ATTRwt)is the most common form of transthyretin amyloid cardiomyopathy,occurring mostly over age of 60 years(mean age of 80 years).Mean survival without treatment is 3.6 years,making early detection imperative.We report an unusual case of a 58-year-old patient with ATTRwt cardiomyopathy requiring heart transplantation.CASE SUMMARY A 58-year-old male presented with progressive fatigue,shortness of breath,weight gain,leg swelling,orthopnoea,and paroxysmal nocturnal dyspnoea for several months.Approximately ten months before this clinical presentation,the patient had first received a diagnosis of heart failure with reduced ejection fraction(EF)of 15% to 20%.The patient was started on appropriate guidelinedirected medical therapy with only mild improvement in his EF.Upon further investigation,echocardiogram,technetium pyrophosphate scan(Tc PYP),and cardiac magnetic resonance imaging(cMRI)suggested a diagnosis of amyloidosis,and ATTRwt was subsequently confirmed with native heart tissue biopsy,congo red staining,liquid chromatography-tandem mass spectrometry,and genetic testing.The patient was successfully treated with heart transplantation and is doing well post-transplant.CONCLUSION Wild-type ATTR amyloidosis should be kept on differentials in all patients(even less than 60 years old)with non-ischemic cardiomyopathy,especially in the setting of increased ventricular wall thickness and other classic echocardiogram,cMRI,and Tc PYP findings.Early diagnosis and management can be consequential in improving patient outcomes.

关键词： Wild-type Transthyretin Amyloidosis Young Heart failure Heart transplant Case report