检索结果-南通市图书馆

Autofluorescence imaging endoscopy for identifi cation and assessment of inflammatory ulcerative colitis

World Journal of Gastroenterology 2011年第46期17卷 5110-5116页

作者： taro Osada Atsushi Arakawa Naoto Sakamoto Hiroya Ueyama Tomoyoshi Shibuya Tatsuo Ogihara Takashi Yao Sumio Watanabe Department of Gastroenterology Juntendo University School of Medicine Department of Human Pathology Juntendo University School of Medicine

AIM:To validate the clinical relevance of autofluores-cence imaging(AFI)endoscopy for the assessment of inflammatory ulcerative colitis(UC).METHODS:A total of 572 endoscopic images were se-lected from 42 UC patients:286 taken with white light imaging(WLI)and 286 with AFI from the same *** images were assessed for overall mucosal inflammation according to Mayo endoscopic subscore(MES),and for seven characteristic endoscopic ***,AFI photographs were scored according to relative abundance of red,green and blue color com-ponents within each image based on an RGB additive color *** and AFI endoscopic scores from the same sites were *** evaluation of biopsies was according to the Riley ***:Relative to red(r=0.52,P<0.01)or blue(r=0.56,P<0.01)color component,the green color component of AFI(r=-0.62,P<0.01)corresponded more closely with mucosal inflammation *** were signif icant differences in green color components between MES-0(0.396±0.043)and MES-1(0.340± 0.035)(P<0.01),and between MES-1 and ≥ MES-2(0.318±0.037)(P<0.01).The WLI scores for "vascu-lar patterns"(r=-0.65,P<0.01),"edema"(r=-0.62,P<0.01),histology scores for "polymorphonuclear cells in the lamina propria"(r=-0.51,P<0.01)and "crypt architectural irregularities"(r=-0.51,P<0.01)showed correlation with the green color component of *** were significant differences in green color components between limited(0.399± 0.042)and extensive(0.375±0.044)(P=0.014)polymorpho-nuclear cell inf iltration within *** the severity of the mucosal inflammation increased,the green color component of AFI *** AFI green color com-ponent was well correlated with the characteristic en-doscopic and histological inflammatory features of ***:AFI has application in detecting inflammatory lesions,including microscopic activity in the co-lonic mucosa of UC patients,based on the green color component of images.

关键词：溃疡性结肠炎荧光成像炎症评估颜色分量 COM组件镜身自体

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diffusion-weighted imaging might be useful for reactive lymphoid hyperplasia diagnosis of the liver: A case report

引用

World Journal of Clinical Cases 2020年第21期8卷 5313-5319页

作者： taro Tanaka Kazuhiro Saito Daisuke Yunaiyama Jun Matsubayashi Yuichi Nagakawa Maki Tanigawa Toshitaka Nagao Department of Radiology Tokyo Medical UniversityTokyo 1600023Japan Department of Anatomic Pathology Tokyo Medical UniversityTokyo 1600023Japan Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityTokyo 1600023Japan

BACKGROUND Reactive lymphoid hyperplasia(RLH)of the liver is a rare liver *** is considered difficult to differentiate radiologically from hepatocellular carcinoma,metastatic liver tumor and other *** SUMMARY A 54-year-old woman presented to our hospital with RLH of the *** patient had a diagnosis of metastatic carcinoma of the liver from an unknown origin and subsequently underwent partial ***,histopathological analysis revealed *** lesion showed perinodular enhancement in the arterial phase on contrast-enhanced computed tomography and magnetic resonance *** diffusion-weighted imaging(DWI),we encountered linear hyperintensity along the portal tract consecutive to the liver lesion,which is a new characteristic radiologic *** finding corresponded to the lymphoid cell infiltration of the portal ***,there was strongly restricted diffusion on the apparent diffusion coefficient *** used these characteristic radiologic findings to diagnose the lesion as a lymphoproliferative *** The linear hyperintensity consecutive to the liver lesion on DWI provided additional valuable diagnostic information.

关键词： Reactive lymphoid hyperplasia Pseudolymphoma Magnetic resonance imaging Diffusion-weighted imaging Perinodular enhancement Portal tract infiltration Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

InGaAs/InAlAs Five Layer Asymmetric Coupled Quantum Well (FACQW) for Ultra-Wideband Ultrafast Optical Modulators

引用

光学学报 2003年第S1期23卷 343-344页

作者： taro Arakawa Ryuji Iino Tetsuya Ishie Terumasa Kawabata Kunio Tada Graduate School of Engineering Yokohama National University 79-5 Tokiwadai Hodogaya-ku Yokohama 240-8501JapanGraduate School of Engineering Yokohama National University 79-5 Tokiwadai Hodogaya-ku Yokohama 240-8501JapanGraduate School of Engineering Yokohama National University 79-5 Tokiwadai Hodogaya-ku Yokohama 240-8501JapanGraduate School of Engineering Yokohama National University 79-5 Tokiwadai Hodogaya-ku Yokohama 240-8501JapanGraduate School of Engineering Yokohama National University 79-5 Tokiwadai Hodogaya-ku Yokohama 240-8501Japan

An InGaAs/InAlAs five-layer asymmetric coupled quantum well (FACQW) is expected to show very large electrorefractive index change . n in a wideband transparency region. Band structures of the FACQW are analyzed with L... 详细信息

关键词： InGaAs/InAlAs Five Layer Asymmetric Coupled Quantum Well for Ultra-Wideband Ultrafast Optical Modulators FACQW

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Egalitarian Policies, Effective Demand, and Globalization： Considering Budget Constraint

引用

International Relations and Diplomacy 2016年第3期4卷 189-202页

作者： taro Abe Nagoya Gakuin University Aichi Japan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intussusception due to hematogenous metastasis of hepatocellular carcinoma to the small intestine:A case report

引用

World Journal of Gastroenterology 2020年第42期26卷 6698-6705页

作者： taro Mashiko Yoshihito Masuoka Akira Nakano Kota Tsuruya Shunji Hirose Kenichi Hirabayashi Tatehiro Kagawa Toshio Nakagohri Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 2591193KanagawaJapan Department of Gastroenterology Tokai University School of MedicineIsehara 2591193KanagawaJapan Department of Pathology Tokai University School of MedicineIsehara 2591193KanagawaJapan

BACKGROUND The commonest sites of extrahepatic metastases from hepatocellular carcinoma(HCC)are the lungs,bones,adrenal glands,and regional lymph *** metastasis to the gastrointestinal(GI)tract is a rare condition in patients with HCC,and the prognosis is usually *** report,herein,an extremely rare case of a patient with intussusception due to hematogenous metastasis of HCC to the ileum and his long-term survival with multidisciplinary *** SUMMARY The patient was a 71-year-old man with a history of chronic hepatitis B,who had undergone three surgeries for *** was treated with sorafenib for peritoneal metastases of *** was admitted to our hospital with chief complaints of abdominal pain and *** contrast-enhanced computed tomography imaging revealed a small intestinal tumor,presenting with intussusception and small bowel *** treatment was started,but due to repeated exacerbation of symptoms,surgery was planned on the 28th d of *** ileal resection without reducing the intussusception and end-to-end anastomosis was *** histological examination,tumor cells were not observed on the serosal surface,but intravascular invasion of tumor cells was *** was positive for immunohistochemical markers,and a diagnosis of hematogenous metastasis of HCC to the ileum was *** remains alive 82 mo after the first *** Prognosis of HCC patients with GI tract metastasis is usually poor,but in some cases,multidisciplinary therapy may prolong survival.

关键词： Hepatocellular carcinoma Hematogenous metastases Extrahepatic metastasis Small intestinal metastasis Intussusception Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis

引用

World Journal of Gastroenterology 2009年第28期15卷 3480-3485页

作者： Daisuke Asaoka Akihito Nagahara Masako Oguro Yuko Izumi Akihiko Kurosawa taro Osada Masato Kawabe Mariko Hojo Michiro Otaka Sumio Watanabe Department of Gastroenterology Juntendo University School of Medicine

AIM:To explore the pathological flndings in the entire esophagus in rats with reflux esophagitis, and the effects of ecabet sodium(ES).METHODS:A rat model of chronic acid reflux esophagitis was *** the treatment group, ES was administered after surgery(n = 16).No drug was administered postoperatively to the esophagitis group(n = 9).Shamoperated rats were used as a control group(n = 5).Rats were sacriflced on day 7 after the *** epithelial thickness and leukocyte inflltration were examined in the upper, middle and lower areas of the *** survival rate, incidence of esophageal ulcer, and mean surface area and number of esophageal ulcers were determined in the esophagitis and ES *** histology was assessed in all three ***:Leukocyte infiltration in the esophagitis group was 26.3 ± 22.0 in the middle esophagus and 8.2 ± 4.9 in the upper esophagus, which was signiflcantly greater than that in the controls(1.3 ± 1.1 and 1.4 ± 1.0, respectively)(P < 0.05).The thickness of the epithelium in the esophagitis group was 210.8 ± 47.7 μm in the lower esophagus and 204.2 ± 60.1 μm in the middle esophagus, which was significantlygreater than that in the controls(26.0 ± 5.5 and 21.0 ± 6.5 μm, respectively)(P < 0.05).The mean number of ulcers per animal in the ES group in the entire esophagus was 5.4 ± 2.5, which was signiflcantly less than that in the esophagitis group(9.0 ± 3.5)(P < 0.05).The epithelial thickness in the ES group was 97.5 ± 32.2 μm in the lower esophagus, which was decreased compared with that in the esophagitis group(210.8 ± 47.7 μm)(P < 0.05).CONCLUSION:Mucosal inflammation extended to the upper esophagus close to the *** study suggested that ES may have a useful defensive role in reflux esophagitis.

关键词：特征和食管大鼠病理钠

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Long-term dexamethasone treatment diminishes store-operated Ca^(2+) entry in salivary acinar cells

引用

International Journal of Oral Science 2019年第1期11卷 25-32页

作者： Yuichiro Kusuda Yusuke Kondo Yuta Miyagi Takashi Munemasa Yusuke Hori Fumiko Aonuma Shintaro Tsuka taro Mukaibo Chihiro Masaki Ryuji Hosokawa Division of Oral Reconstruction and Rehabilitation Kyushu Dental University

Corticosteroids are used in the treatment of many diseases; however, they also induce various side effects. Dexamethasone is one of the most potent corticosteroids, and it has been reported to induce the side effect of impaired salivary gland function. This study aimed to evaluate the effects of dexamethasone on mouse submandibular gland function to gain insight into the mechanism of dexamethasone-induced salivary hypofunction. The muscarinic agonist carbachol(CCh) induced salivary secretion and was not affected by short-term dexamethasone treatment but was decreased following long-term dexamethasone administration. The expression levels of the membrane proteins Na^+-K^+-2 Cl-cotransporter, transmembrane member 16 A, and aquaporin 5 were comparable between the control and long-term dexamethasone treatment groups. The CCh-induced increase in calcium concentration was significantly lower in the presence of extracellular Ca^(2+) in the long-term dexamethasone treatment group compared to that in the control group. Furthermore, CCh-induced salivation in the absence of extracellular Ca^(2+) and Ca^(2+) ionophore A23187-induced salivation was comparable between the control and long-term dexamethasone treatment ***, salivation induced by the Ca^(2+) -ATPase inhibitor thapsigargin was diminished in the long-term dexamethasone treatment group. In summary, these results demonstrate that short-term dexamethasone treatment did not impair salivary gland function, whereas long-term dexamethasone treatment diminished store-operated Ca^(2+) entry, resulting in hyposalivation in mouse submandibular glands.

关键词： Corticosteroids carbachol(CCh)induced

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Programmed cell death-1 inhibitor-related sclerosing cholangitis:A systematic review

引用

World Journal of Gastroenterology 2020年第3期26卷 353-365页

作者： Takumi Onoyama Yohei Takeda taro Yamashita Wataru Hamamoto Yuri Sakamoto Hiroki Koda Soichiro Kawata Kazuya Matsumoto Hajime Isomoto Division of Medicine and Clinical Science Department of Multidisciplinary Internal MedicineFaculty of MedicineTottori UniversityTottori prefecture 683-8504Japan Internal Medicine Irisawa Medical ClinicShimane prefecture 690-0025Japan

BACKGROUND Programmed cell death-1(PD-1)inhibitor has been indicated for many types of ***,these inhibitors also cause immune-related adverse *** disorder is a phenotype of immune-related adverse event affecting 0%–4.5%of patients treated with PD-1 *** studies have reported PD-1 inhibitor-related sclerosing cholangitis(SC);however,the associated clinical and pathological features are *** To evaluate the clinical and pathological features of PD-1 inhibitor-related SC through a systematic review of the *** The review,conducted using electronic databases in PubMed,was restricted to the period from January 2014 to September 2019 and focused on case reports/series on PD-1 inhibitor-related SC published in *** scanned the references of the selected literature to identify any further relevant *** cases previously studied by us,including three that have not yet been published,were included in this *** Thirty-one PD-1 inhibitor-related SC cases were *** age of patients was 67 years(range,43–89),with a male to female ratio of 21:*** main disease requiring PD-1 inhibitor treatment was non-small cell lung *** that caused PD-1 inhibitor-related SC were nivolumab(19 cases),pembrolizumab(10 cases),avelumab(1 case),and durvalumab(1 case).The median number of cycles until PD-1 inhibitor-related SC onset was 5.5(range,1–27).Abdominal pain or discomfort(35.5%,11/31)was the most frequent *** serum tests identified liver dysfunction with a notable increase in biliary tract enzymes relative to hepatic enzymes,and a normal level of serum immunoglobulin *** dilation without obstruction(76.9%,20/26),diffuse hypertrophy of the extrahepatic biliary tract(90.5%,19/21),and multiple strictures of the intrahepatic biliary tract(30.4%,7/23)were *** 11/23(47.8%)cases,pathological examination indicated that CD8+T cells were the dominant inflammatory cells i

关键词： Nivolumab Pembrolizumab Avelumab Durvalumab Atezolizumab Programmed cell death-1 inhibitor Immune-related adverse events Cholangitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of the Long-Term Interaction between Intracellular Reactive Oxygen Species and Oxidative DNA Damage in Murine Lin<sup>-</sup>/Sca-1<sup>+</sup>Cells Exposed to Ionizing Radiation

引用

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 95-105页

作者： Junya Ishikawa taro Morisaki Department of Medical Radiologic Technology Kyorin University Mitaka Japan Department of Environmental Health Science Oita University of Nursing and Health Sciences Oita Japan

Mutations in the Sfpi1 gene are essential for the development of radia-tion-induced acute myeloid leukemia. In this study, we investigated long-term interaction among immature hematopoietic cell number, intra-cellular reactive oxygen species contents, and oxidative DNA damage fre-quency after irradiation. Lin-/Sca-1+ cells were isolated from C3H/HeN mice on days 1 - 400 after 0 - 3 Gy total body irradiation. On days 1 - 7, the number of surviving cells decreased and reached a minimum;however, the number of cells gradually recovered until day 200. Intracellular reactive oxygen species contents significantly increased from day 1 to day 30. In addition, the frequency of oxidative DNA damage tended to increase from day 1 and day 30, and that at day 30 was significantly increased in the 3 Gy group compared with that in the control group. In contrast, decreased cell number, increased intracellular reactive oxygen species content, and decreased oxidative DNA damage frequency were observed on day 400. These results suggested that oxidative DNA damage was involved in intracellular reactive oxygen species generation induced by cell proliferation to compensate for cell death after irradiation.

关键词： Acute Myeloid Leukemia Oxidative DNA Damage Reactive Oxygen Species

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extraction of items identifying hiesho(cold disorder)and their utility in young males and females

引用

Journal of Integrative Medicine 2016年第1期14卷 36-43页

作者： Shunji Sakaguchi Hiroshi Kuge Hidetoshi Mori Junji Miyazaki Tim Hideaki Tanaka KazuyoHanyu taro Takeda Kazuro Sasaki Research Division of Acupuncture and Moxibustion Kansai University of Health Sciences Osaka 590-0482 Japan Department of Anesthesiology Osaka Medical College Hospital Osaka 569-8686 Japan Faculty of Health Sciences Course of Acupuncture and Moxibustion Tsukuba University of TechnologyTsukuba 305-0821 Japan Takarazuka University of Medical and Health Care Takarazuka 666-0162 Japan Graduate School of Life and Environmental Sciences University of Tsukuba Tsukuba 305-8572 Japan Department of Clinical Acupuncture and Moxibustion Meiji University of Integrative Medicine Kyoto629-0301 Japan Department of Acupuncture Medicine Faculty of Oriental Medicine Suzuka University of Medical Science Suzuka 510-0293 Japan

OBJECTIVE： Hie （cold sensation） is one of the most common health complaints in Japan. Those who suffer from severe hie are considered as having hiesho （cold disorder）. However, exact hiesho symptoms have not been defined clearly and the decision as to whether a person suffers from hiesho is subjective and based on self-awareness. The study was conducted in attempt to develop a standardized hiesho diagnostic scale. METHODS： Subjects comprised 1 146 students. From the self-awareness of hiesho symptoms, males and females were divided into hiesho and non-hiesho groups. Physical, behavioral and adaptive characteristics were compared using the 24-item questionnaire （four-grade survey） and indicators for hiesho symptoms were extracted. Based on the scores, a receiver operating characteristic curve was drawn for the total ordinal scale score of the extracted items in relation to the presence and absence of hiesho symptoms, and an optimal cutoff value was determined. RESULTS： The self-awareness of having hiesho was found in 23.2% males and in 55.6% females. The sensitivity was 84.5% for males and 83.3% for females in the hiesho groups, and the specificity was 86.0% for males and 85.2% for females in the non-hiesho groups. CONCLUSION： A questionnaire consisting of the extracted items may be useful to identify hiesho in young males and females with a high level of accuracy.

关键词： cold hypersensitivity questionnaires ROC curve

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：