Autofluorescence imaging endoscopy for identifi cation and assessment of inflammatory ulcerative colitis

作     者：Taro Osada Atsushi Arakawa Naoto Sakamoto Hiroya Ueyama Tomoyoshi Shibuya Tatsuo Ogihara Takashi Yao Sumio Watanabe 

作者机构：Department of GastroenterologyJuntendo University School of Medicine Department of Human PathologyJuntendo University School of Medicine 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第46期

页      面：5110-5116页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Japan Society for the Promotion of Science  JSPS: 23591023 

主　　题：Autofluorescence imaging endoscopy En-doscopic activity Histological activity Microscopic in-flammation Green color component 

摘      要：AIM:To validate the clinical relevance of autofluores-cence imaging(AFI)endoscopy for the assessment of inflammatory ulcerative colitis(UC).METHODS:A total of 572 endoscopic images were se-lected from 42 UC patients:286 taken with white light imaging(WLI)and 286 with AFI from the same *** images were assessed for overall mucosal inflammation according to Mayo endoscopic subscore(MES),and for seven characteristic endoscopic ***,AFI photographs were scored according to relative abundance of red,green and blue color com-ponents within each image based on an RGB additive color *** and AFI endoscopic scores from the same sites were *** evaluation of biopsies was according to the Riley ***:Relative to red(r=0.52,P0.01)or blue(r=0.56,P0.01)color component,the green color component of AFI(r=-0.62,P0.01)corresponded more closely with mucosal inflammation *** were signif icant differences in green color components between MES-0(0.396±0.043)and MES-1(0.340± 0.035)(P0.01),and between MES-1 and ≥ MES-2(0.318±0.037)(P0.01).The WLI scores for vascu-lar patterns(r=-0.65,P0.01),edema(r=-0.62,P0.01),histology scores for polymorphonuclear cells in the lamina propria(r=-0.51,P0.01)and crypt architectural irregularities(r=-0.51,P0.01)showed correlation with the green color component of *** were significant differences in green color components between limited(0.399± 0.042)and extensive(0.375±0.044)(P=0.014)polymorpho-nuclear cell inf iltration within *** the severity of the mucosal inflammation increased,the green color component of AFI *** AFI green color com-ponent was well correlated with the characteristic en-doscopic and histological inflammatory features of ***:AFI has application in detecting inflammatory lesions,including microscopic activity in the co-lonic mucosa of UC patients,based on the green color component of images.