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Antimicrobial,antibiofilm,angiogenesis,anti-inflammatory,and wound healing activities of zinc nanoparticles green synthesized using Ferula macrecolea extract

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 259-268页

作者： sultan F.Alnomasy Department of Medical Laboratories Sciences College of Applied Medical SciencesShaqra UniversityAl-Quwayiyah 19257Saudi Arabia

Objective:To assess the antimicrobial,antibiofilm,anti-inflammatory,angiogenic,and wound healing activities of zinc nanoparticles(ZNPs)green synthesized using Ferula macrecolea ***:The green synthesis was conducted using the precipitation ***,the minimum inhibitory concentration(MIC),minimum bactericidal concentration(MBC),and minimum biofilm inhibition concentration 50%(MBIC50)of ZNPs against Staphylococcus aureus(***)and Pseudomonas aeruginosa(***)were *** effects of ZNPs on the gene expressions of Staphylococcus spp.[intracellular adhesion A(icaA)and D(icaD)]and ***(rhlI and rhlR)were investigated using quantitative real-time *** addition,the effects of ZNPs on wound healing,angiogenesis,and anti-inflammatory markers were ***:The green-synthesized ZNPs demonstrated significant antimicrobial efficacy against *** and *** biofilm formation in *** and *** was also inhibited by ZNPs with MBIC50 values of 3.30μg/mL and 2.08μg/mL,***,ZNPs downregulated the expression of biofilm-related genes icaA,icaD,rhlI,and rhlR in the tested *** also demonstrated promising in vitro wound healing effects by promoting fibroblast cell proliferation and wound closure in a dose-dependent manner.A significant increase in the expression of HLA-G5 and VEGF-A genes as well as a marked decrease in the expression of NF-κB,IL-1β,and TNF-αgenes were observed in cells treated with ZNPs compared to the control group(P<0.05).Conclusions:ZNPs display promising antibacterial effects against *** and *** and wound-healing effects by inhibiting biofilm formation,inducing angiogenesis,and reducing ***,further studies must be conducted to specify the accurate mechanisms of action and toxicity of ZNPs.

关键词： Wound healing Antibacterial Angiogenesis Nanomedicine Ferula macrecolea Inflammation

Effect of mitomycin C on the corneal endothelial cells of Saudi patients with myopia after transepithelial photorefractive keratectomy:a two-armed cohort study

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 909-915页

作者： sultan H Alrashidi Department of Ophthalmology College of MedicineQassim UniversityBuraidah 51452Saudi Arabia

AIM:To study the effect of mitomycin C(MMC)applied during transepithelial photorefractive keratectomy(TPRK)on the corneal endothelium one week(W1)and three months(M3)after surgery and its ***:In this two-armed cohort study conducted in 2022,eyes treated with MMC during TPRK(group 1)were compared with eyes not treated with MMC(group 2).The corneal endothelial cell(EC)count,EC density(ECD;cells/mm2),average(μm2),standard deviation(μm2),coefficient of variation(CV%),ECmax,ECmin,and EC percentage of hexagonality were estimated at W1 and *** postoperative changes in the EC count in the two groups were compared and correlated with the other independent ***:Group 1 had 26 eyes,and group 2 had 78 *** TPRK indices were significantly higher for the eyes in group 1 than for those in group *** MMC usage was not a significant predictor of the change in ECD(P=0.644),change in CV(P=0.374),and change in the percentage of hexagonality of EC(P=0.164)at ***,the use of MMC was a significant predictor of changes in CV(P=0.014)and the change in the percentage of hexagonality of EC(P=0.039)at *** duration of laser exposure and the size of the optical zone influenced the correlation of MMC use with the changes in EC indices,***:The use of MMC doesn’t affect ECD,CV,and percentage of hexagonality at W1 if other surgical indices are *** M3 after operating myopic eyes by TPRK,MMC significantly influence the CV and percentage of *** duration of the laser application and the size of the optical zone should be considered when determining the effect of MMC on the EC indices.

关键词： transepithelial photorefractive keratectomy mitomycin-C corneal endothelium

Utilizing N-hydroxy-9-octadecenamide as a collector in flotation separation of bastnaesite and fluorite

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Journal of Rare Earths 2024年第8期42卷 1620-1628,I0008页

作者： Zhihao Guo sultan Ahmed Khoso Mengjie Tian Wei Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha410083China State Key Laboratory of Mineral Processing Bejing102600China Hubei Key Laboratory for Eficient Utilization and Agglomeration of Metallurgic Mineral Resources Wuhan430081China Key Laboratoryof Hunan Province for Cleanand Eficient Utilization of Strategic Calcium-containing Mineral Resources Central South University.Changsha410083China Department of Mining Engineering Mehran University of Engineering&TechnologyJamshoro76062Pakistan

Bastnaesite((Ce,La,Pr,Nd)CO_(3)F) is a significant light rare earth mineral found in nature,known for its fine-grained *** is commonly employed for the recovery of fine-grained bastnaesite *** serve as an essential flotation reagent that enhance the surface hydrophobicity of target minerals.A novel collector,N-hydroxy-9-octadecenamide(N-OH-9-ODA),was synthesised in this study.N-OH-9-ODA exhibits superior selectivity compared to the traditional collector oleic acid in the flotation separation of bastnaesite and *** experimental and co mputational results indicate that N-OH-9-ODA exhibits superior selectivity due to its higher adsorption affinity for bastnaesite surface compared to fluorite *** zeta potential and the binding energies of the Ce 3d peaks in the X-ray photoelectron spectrum(XPS) of bastnaesite surface exhibit significant ***,fluorite surface demonstrates minimal alterations in its zeta potential and the binding energies of the Ca 2p peaks in its XPS after its interaction with N-OH-9-ODA.

关键词： Bastnaesite Collector Hydroxamic acids N-hydroxy-9-octadecenamide Oleic acid Rare earths

Breaking wheat yield barriers requires integrated efforts in developing countries

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Journal of Integrative Agriculture 2015年第8期14卷 1447-1474页

作者： Saeed Rauf Maria Zaharieva Marilyn L Warburton ZHANG Ping-zhi Abdullah M AL-Sadi Farghama Khalil Marcin Kozak sultan A tariq Department of Plant Breeding & Genetics University College of Agriculture University of Sargodha National Agricultural University La Molina (UNALM) USDA ARS Corn Host Plant Resistance Research Unit Crop Research Institute Anhui Academy of Agricultural Sciences Department of Crop Science College of Agricultural and Marine Sciences Sultan Qaboos University Department of Botany Warsaw University of Life Sciences-SSGW Social Sciences Research Institute National Agriculture Research Council

Most yield progress obtained through the so called ＂Green Revolution＂, particularly in the irrigated areas of Asia, has reached a limit, and major resistance genes are quickly overcome by the appearance of new strains of disease causing *** plant stresses due to a changing environment are difficult to breed for as quickly as the changes *** is consequently a continual need for new research programs and breeding strategies aimed at improving yield potential, abiotic stress tolerance and resistance to new, major pests and *** advances in plant breeding encompass novel methods of expanding genetic variability and selecting for recombinants, including the development of synthetic hexaploid, hybrid and transgenic *** addition, the use of molecular approaches such as quantitative trait locus（QTL） and association mapping may increase the possibility of directly selecting positive chromosomal regions linked with natural variation for grain yield and stress *** present article reviews the potential contribution of these new approaches and tools to the improvement of wheat yield in farmer＇s fields, with a special emphasis on the Asian countries, which are major wheat producers, and contain the highest concentration of resource-poor wheat farmers.

关键词： genetic diversity heterosis hybrid wheat synthetic hexaploid wheat yield potential

Novel Framework for an Intrusion Detection System Using Multiple Feature Selection Methods Based on Deep Learning

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Tsinghua Science and Technology 2024年第4期29卷 948-958页

作者： A.E.M.Eljialy Mohammed Yousuf Uddin sultan Ahmad Department of Information Systems College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharjSaudi Arabia Department of Computer Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharjSaudi Arabiaand also with University Center for Research and Development(UCRD)Department of Computer Science and EngineeringChandigarh UniversityPunjabIndia

Intrusion detection systems (IDSs) are deployed to detect anomalies in real time. They classify a network’s incoming traffic as benign or anomalous (attack). An efficient and robust IDS in software-defined networks is an inevitable component of network security. The main challenges of such an IDS are achieving zero or extremely low false positive rates and high detection rates. Internet of Things (IoT) networks run by using devices with minimal resources. This situation makes deploying traditional IDSs in IoT networks unfeasible. Machine learning (ML) techniques are extensively applied to build robust IDSs. Many researchers have utilized different ML methods and techniques to address the above challenges. The development of an efficient IDS starts with a good feature selection process to avoid overfitting the ML model. This work proposes a multiple feature selection process followed by classification. In this study, the Software-defined networking (SDN) dataset is used to train and test the proposed model. This model applies multiple feature selection techniques to select high-scoring features from a set of features. Highly relevant features for anomaly detection are selected on the basis of their scores to generate the candidate dataset. Multiple classification algorithms are applied to the candidate dataset to build models. The proposed model exhibits considerable improvement in the detection of attacks with high accuracy and low false positive rates, even with a few features selected.

关键词： random forest feature selection decision tree software-defined network logistic regression intrusion detection system XGB classifier AdaBoost

Multiple thoracic and abdominal foregut duplication cysts:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1504-1509页

作者： Tuqa Adil Alsinan tariq Ibrahim Altokhais Department of Pediatric Surgery Prince Sultan Military Medical CityRiyadh 12233Saudi Arabia Devision of Pediatric Surgery Department of SurgeryCollege of MedicineKing Saud UniversityRiyadh 4545Saudi Arabia

BACKGROUND Congenital enteric duplication cysts are tubular or cystic structures that normally lie alongside the gastrointestinal(GI)*** duplication cysts are typically solitary lesions that occur anywhere near the GI tract from the neck to the rectum,but having multiple duplication cysts is rare,and presentation within the pancreas is extremely *** SUMMARY We herein demonstrate a case of esophageal,gastric,and gastric-type duplication cyst of the pancreas in a seventeen-month-old girl who presented with failure to thrive,abdominal pain,vomiting,hematemesis,and melena since the age of three *** cysts were excised by thoracoscopy and laparoscopy in the same *** our knowledge,no such case has been *** Enteric duplications can occur throughout the entire alimentary *** they occur in the pancreas,they present a formidable challenge in both diagnosis and *** to the risk of complications and malignant transformation,surgical removal is the recommended treatment of all duplication cysts.

关键词： Congenital Duplication cyst Foregut duplication Gastric duplication Pancreas Case report

A rare presentation of unicentric Castleman's disease in the thigh:A case report and review of literature

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World Journal of Clinical Cases 2024年第19期12卷 4003-4009页

作者： sultan AlSheikh Abdulmajeed Altoijry Husain Al-Mubarak Ofays Dakkam Alsallum Fadi Alakeel tariq Alanezi Division of Vascular Surgery Department of SurgeryCollege of MedicineKing Saud UniversityRiyadh 11322Saudi Arabia Division of Vascular Surgery Department of SurgeryKing Khalid Hospital NajranNajran 11321Saudi Arabia Department of Pathology College of MedicineKing Saud UniversityRiyadh 11322Saudi Arabia

BACKGROUND Castleman's disease(CD)is a rare lymphoproliferative,emulating both benign and malignant *** diagnosis of CD is formulated upon the combination of clinical and laboratory criteria and ultimately confirmed by histopathological *** to its rarity,CD presents a challenge in treatment selection,with available options encompassing surgery,chemotherapy,and autologous stem cell ***,studies suggest that surgical resection of the lesion is the most effective treatment modality,especially for unicentric CD(UCD).CASE SUMMARY Here,we describe the case of a 25-year-old woman who presented with painless left thigh swelling for 10 *** had been following a low-fat diet to lose weight and had normal laboratory *** resonance imaging revealed a wellcircumscribed,demarcated cystic lesion located in the left inguinal region with eccentrically positioned signal void vascular structures,measuring 4.3 cm×3 cm×3.2 cm,likely of lymphoid *** patient underwent surgical resection,and the final histopathology showed a vascular proliferation and hyalinization of the vessel walls,along with atretic germinal centers traversed by penetrating vessels,consistent with *** patient was discharged home one day after the procedure in good condition,with a follow-up appointment scheduled in our outpatient *** Although surgical resection is the mainstay for UCD,a multidisciplinary approach is needed due the lack of specific diagnostic features and treatments.

关键词： Castleman’s disease Lymph nodes Surgical resection Lymphoproliferative disorder Case report

Enabling Efficient Data Transmission in Wireless Sensor Networks-Based IoT Application

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Computers, Materials & Continua 2024年第6期79卷 4197-4218页

作者： Ibraheem Al-Hejri Farag Azzedin sultan Almuhammadi Naeem Firdous Syed Information and Computer Science Department King Fahd University of Petroleum andMineralsDhahran31261Saudi Arabia Center for Cyber Resilience and Trust(CREST) Deakin UniversityGeelong3220Australia

The use of the Internet of Things(IoT)is expanding at an unprecedented scale in many critical applications due to the ability to interconnect and utilize a plethora of wide range of *** critical infrastructure domains like oil and gas supply,intelligent transportation,power grids,and autonomous agriculture,it is essential to guarantee the confidentiality,integrity,and authenticity of data collected and ***,the limited resources coupled with the heterogeneity of IoT devices make it inefficient or sometimes infeasible to achieve secure data transmission using traditional cryptographic ***,designing a lightweight secure data transmission scheme is becoming *** this article,we propose lightweight secure data transmission(LSDT)scheme for IoT *** consists of three phases and utilizes an effective combination of symmetric keys and the Elliptic Curve Menezes-Qu-Vanstone asymmetric key agreement *** design the simulation environment and experiments to evaluate the performance of the LSDT scheme in terms of communication and computation *** and performance analysis indicates that the LSDT scheme is secure,suitable for IoT applications,and performs better in comparison to other related security schemes.

关键词： IoT lightweight computation complexity communication overhead cybersecurity threats threat prevention secure data transmission Wireless Sensor Networks(WSNs) elliptic curve cryptography

Back to the drawing board:Overview of the next generation of combination therapy for inflammatory bowel disease

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World Journal of Gastroenterology 2024年第25期30卷 3182-3184页

作者： Jeffrey A Lowell Michael J Farber Keith sultan Department of Medicine Zucker School of Medicine at HofstraNorth Shore University Hospital-Long Island Jewish Medical CenterManhassetNY 11030United States Preclinical Studies New York Institute of Technology College of Osteopathic MedicineGlen HeadNY 11545United States Division of Gastroenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States

Inflammatory bowel disease(IBD)is entering a potentially new era of combined *** et al provide an insightful review of the current state of combination therapy,with a focus on the use of a combined biologic and immunomodulator,as well as emerging data on the future potential of dual-biologic therapy(DBT).While current evidence for DBT is limited,encouraging safety profiles and ongoing trials suggest a brighter future for this *** importance of controlled trials should be stressed in establishing new treatment *** prospective randomized trials of DBT and perhaps future combinations of biologics and small molecule therapies will hopefully guide the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Immunomodulators Dual-therapy Combination therapy