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Hepatitis B core-related antigen:Are we near a treatment endpoint?

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World Journal of Gastroenterology 2022年第27期28卷 3532-3534页

作者： tarana gupta Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

Different serological and virological markers in chronic hepatitis B patients guide staging of viral infection,and initiation and response to *** to the persistence of intrahepatic covalently closed circular DNA(cccDNA)in the hepatocyte nucleus,hepatitis B is not *** after undetectable hepatitis B virus DNA levels,the persistence of hepatitis B surface antigen and novel markers such as hepatitis B core-related antigen(HBcrAg)indicate the persistence of intrahepatic *** this study,HBcrAg levels at baseline and after 24 and 48 wk of antiviral therapy predicted hepatitis B e antigen *** to the poor sensitivity of assays and detectable levels in HBsAg-negative patients,the long-term utility of HBcrAg needs future research.

关键词： Hepatitis B core-related antigen Chronic hepatitis B Covalently closed circular DNA Hepatitis B e antigen seroconversion Hepatitis B virus DNA Pregenomic RNA

COVID-19 and the liver:Are footprints still there?

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World Journal of Gastroenterology 2023年第4期29卷 656-669页

作者： tarana gupta Hemant Sharma Department of Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

The coronavirus disease 2019(COVID-19)hit the entire world as a global pandemic and soon became the most important concern for all patients with chronic *** early trend in higher mortality in patients with acute respiratory distress attracted all researchers to closely monitor patients for the involvement of other *** soon became apparent that patients with chronic liver diseases are at increased risk of mortality given their cirrhosis-associated immune ***,liver function abnormalities were noted in patients with severe *** cytokine storm,direct viral infection,drugs and reactivation of viral infections were causes of deranged liver ***,we discuss the relation between COVID-19 and chronic liver disease,specifically cirrhosis,hepatitis B,hepatitis C,and non-alcoholic fatty liver disease(NAFLD),as well as the liver manifestations of *** metabolic syndrome,obesity,diabetes mellitus and NAFLD were found to worsen outcome in different studies reported *** cirrhosis should be considered a risk factor for death and severe ***,COVID-19 related cholangiopathy has also been reported with changes of secondary sclerosing *** long-term persistence of viral antigens in gut epithelia raises concern regarding the future risk of autoimmune liver diseases.

关键词： COVID-19 Chronic liver disease Cirrhosis Liver injury Transaminases Non-alcoholic fatty liver disease Post-acute COVID-19 syndrome

COVID-19 and liver disease: Are we missing something?

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World Journal of Hepatology 2022年第2期14卷 479-481页

作者： tarana gupta Department of Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

Since the coronavirus disease 2019(COVID-19)has hit the world as a pandemic,researchers all over the world have worked on its diagnostics,prognosticating factors,*** present study showed liver enzymes,especially aspartate aminotransferase(AST)levels,to be high in non-survivors with raised AST/alanine aminotransferase *** the non-specific nature of AST with its presence in organs other than liver such as muscle,heart,kidney and brain makes it difficult to *** pre-existing metabolic syndrome and non-alcoholic fatty liver disease are confounding factors for deranged liver functions detected during COVID-19 ***,the results of the study should be taken with caution.

关键词： COVID-19 Liver disease Transaminases Non-alcoholic fatty liver disease Hepatocytes Cholangiocytes

Hepatocellular carcinoma immune microenvironment and check point inhibitors-current status

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World Journal of Hepatology 2024年第3期16卷 353-365页

作者： tarana gupta Nikhil Sai Jarpula Division of Hepatology Department of MedicinePandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

Hepatocellular carcinoma(HCC)is the most common primary tumor of the liver and has a high mortality *** Barcelona Clinic Liver Cancer staging system in addition to tumor staging also links the modality of treatment available to a particular *** recent description of the tumor microenvironment(TME)in HCC has provided a new concept of immunogenicity within the *** HCC has been shown to be more immunogenic with higher expression of cytotoxic T lymphocytes and decreased elements for immunosuppression such as regulatory T *** immunogenic milieu provides a better response to immunotherapy especially immune checkpoint inhibitors(ICIs).In addition,the recent data on combining locoregional therapies and other strategies may convert the less immunogenic state of the TME towards higher ***,data are emerging on the use of combinations of locoregional therapy and ICIs in unresectable or advanced HCC and has shown better survival outcomes in this difficult population.

关键词： Hepatocellular carcinoma Tumor immune microenvironment Immune checkpoint inhibitor Atezolizumab Bevacizumab Pembrolizumab

Predictors of Mortality at 28-days in Infection associated Acute Kidney Injury in Cirrhosis

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World Journal of Hepatology 2022年第3期14卷 592-601页

作者： tarana gupta Naveen Ranga Sandeep Kumar Goyal Department of Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Independent Researcher Kangra 176056Himachal PradeshIndia

BACKGROUND Acute kidney injury(AKI)in cirrhosis is important complication with poor *** infections are common cause for acute *** in cirrhosis lead to acute deterioration of hemodynamics leading to precipitation of *** To study predictors of mortality in patients with infection-associated AKI in *** This was a prospective,observational study conducted at Tertiary care centre from January 2018 till April *** 119 participants with cirrhosis of liver presenting with AKI were included into the *** was defined as per international club of Ascites-AKI criteria *** were grouped into infection AKI and non-infection ***-infection AKI included patients with diuretic induced AKI and pre-renal *** regression analysis was used to determine predictors of mortality at *** Out of 119 patients,alcohol(n=104)was most common etiology of *** infection AKI included 67(56%)patients and non-infection AKI(n=52)included pre-renal AKI in 36(30%)and diuretic-induced AKI in 16(14%)*** AKI had significantly higher bilirubin,higher international normalized ratio(INR),low serum sodium,higher total leukocyte count(TLC)and higher prevalence of hepatic encephalopathy(HE)as compared to non-infection *** AKI had higher progression of AKI(19/67 vs 2/52;P=0.01)and 28-d mortality(38/67 vs 4/5;P≤0.01)as compared to non-infection *** 28-d,non-survivors(n=42)had significantly higher bilirubin,higher INR,low serum sodium,higher TLC and higher prevalence of HE as compared to survivors(n=77).On subgroup analysis of Infection AKI group,on multivariate analysis,serum bilirubin as well as presence of HE were independent predictors of 28-d *** was no significant difference of mortality at 90-d between two *** Infection AKI in cirrhosis has a dismal prognosis with higher 28-d mortality as compared to noninfection *** bilirubin and presence of HE predict

关键词： Infection Acute kidney injury Mortality Cirrhosis Bilirubin Hepatic encephalopathy

Chronic Liver Failure-Sequential Organ Failure Assessment is better than the Asia-Pacific Association for the Study of Liver criteria for defining acute-on-chronic liver failure and predicting outcome

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World Journal of Gastroenterology 2014年第40期20卷 14934-14941页

作者： Radha K Dhiman Swastik Agrawal tarana gupta Ajay Duseja Yogesh Chawla Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh 160012 India

AIM: To compare the utility of the Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF-SOFA) and Asia-Pacific Association for the Study of Liver (APASL) definitions of acute-on-chronic liver failure (ACLF)... 详细信息

关键词： Cirrhosis Acute decompensation Mortality Prognosis Acute on chronic liver failure

Non-invasive assessment of esophageal varices:Status of today

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World Journal of Hepatology 2024年第2期16卷 123-125页

作者： tarana gupta Department of Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

With increasing burden of compensated cirrhosis,we desperately need noninvasive methods for assessment of clinically significant portal *** use of liver and spleen stiffness measurement helps in deferring unnecessary endoscopies for low risk esophageal *** would reduce cost and patient ***,these special techniques may not be feasible at remote areas where still we need only biochemical *** prospective studies validating the non-invasive risk prediction models are definitely needed.

关键词： Compensated cirrhosis Spleen stiffness measurement Liver stiffness measurement High-risk esophageal varices Clinically significant portal hypertension

Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

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Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： Morteza Abyadeh Vivek gupta Yuyi You Joao A.Paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

A Comprehensive Survey on Federated Learning Applications in Computational Mental Healthcare

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 49-90页

作者： Vajratiya Vajrobol Geetika Jain Saxena Amit Pundir Sanjeev Singh Akshat Gaurav Savi Bansal Razaz Waheeb Attar Mosiur Rahman Brij B.gupta Institute of Informatics and Communication University of DelhiDelhi110021India Maharaja Agrasen College University of DelhiDelhi110096India Computer Engineering Ronin InstituteMontclairNJ 07043USA Department of Research and Innovation Insights2TechinfoJaipur302001India University Centre for Research and Development(UCRD) Chandigarh UniversityChandigarh140413India Management Department College of Business AdministrationPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia CCRI&Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India

Mental health is a significant issue worldwide,and the utilization of technology to assist mental health has seen a growing *** aims to alleviate the workload on healthcare professionals and aid *** applications have been developed to support the challenges in intelligent healthcare ***,because mental health data is sensitive,privacy concerns have *** learning has gotten some *** research reviews the studies on federated learning and mental health related to solving the issue of intelligent healthcare *** explores various dimensions of federated learning in mental health,such as datasets(their types and sources),applications categorized based on mental health symptoms,federated mental health frameworks,federated machine learning,federated deep learning,and the benefits of federated learning in mental health *** research conducts surveys to evaluate the current state of mental health applications,mainly focusing on the role of Federated Learning(FL)and related privacy and data security *** survey provides valuable insights into how these applications are emerging and evolving,specifically emphasizing FL’s impact.

关键词： Depression emotional recognition intelligent healthcare systems mental health federated learning stress detection sleep behaviour