Hepatitis B core-related antigen:Are we near a treatment endpoint?

作     者：Tarana Gupta 

作者机构：MedicinePandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第27期

页      面：3532-3534页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Hepatitis B core-related antigen Chronic hepatitis B Covalently closed circular DNA Hepatitis B e antigen seroconversion Hepatitis B virus DNA Pregenomic RNA 

摘      要：Different serological and virological markers in chronic hepatitis B patients guide staging of viral infection,and initiation and response to *** to the persistence of intrahepatic covalently closed circular DNA(cccDNA)in the hepatocyte nucleus,hepatitis B is not *** after undetectable hepatitis B virus DNA levels,the persistence of hepatitis B surface antigen and novel markers such as hepatitis B core-related antigen(HBcrAg)indicate the persistence of intrahepatic *** this study,HBcrAg levels at baseline and after 24 and 48 wk of antiviral therapy predicted hepatitis B e antigen *** to the poor sensitivity of assays and detectable levels in HBsAg-negative patients,the long-term utility of HBcrAg needs future research.