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Dynamic Forecasting of Traffic Event Duration in Istanbul:A Classification Approach with Real-Time Data Integration

Computers, Materials & Continua 2024年第8期80卷 2259-2281页

作者： Mesut Ulu Yusuf Sait Türkan kenan Menguc Ersin Namlı tar.k kucukdeniz occupational Health and Safety Department Bandirma Onyedi Eylul UniversityBalikesir10200Türkiye Department of Industrial Engineering Istanbul University-CerrahpasaIstanbul34320Türkiye Department of Industrial Engineering Istanbul Technical UniversityIstanbul34467Türkiye

Today,urban traffic,growing populations,and dense transportation networks are contributing to an increase in traffic *** incidents include traffic accidents,vehicle breakdowns,fires,and traffic disputes,resulting in long waiting times,high carbon emissions,and other undesirable *** is vital to estimate incident response times quickly and accurately after traffic incidents occur for the success of incident-related planning and response *** study presents a model for forecasting the traffic incident duration of traffic events with high *** proposed model goes through a 4-stage process using various features to predict the duration of four different traffic events and presents a feature reduction approach to enable real-time data collection and *** the first stage,the dataset consisting of 24,431 data points and 75 variables is prepared by data collection,merging,missing data processing and data *** the second stage,models such as Decision Trees(DT),k-Nearest Neighbour(kNN),Random Forest(RF)and Support Vector Machines(SVM)are used and hyperparameter optimisation is performed with *** the third stage,feature selection and reduction are performed and real-time data are *** the last stage,model performance with 14 variables is evaluated with metrics such as accuracy,precision,recall,F1-score,MCC,confusion matrix and *** RF model outperforms other models with an accuracy of 98.5%.The study’s prediction results demonstrate that the proposed dynamic prediction model can achieve a high level of success.

关键词： Traffic event duration forecasting machine learning feature reduction shapley additive explanations(SHAP)

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Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesica A López-Mora Valeria García-Zárate Ana Varela-Constantino Sergio U Villegas-De Leon Xitlaly J González-Leal Raúl del Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R Colunga-Pedraza olga G Cantú-Rodríguez César H Gutiérrez-Aguirre Luz tarín-Arzaga Elías E González-López David Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACkGRoUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:out-of-pocket(ooP),private insurance,and a federal Universal healthcare program“Seguro Popular”.outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(oS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,kaplan-Meier method,and Cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was ooP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in oS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

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MicroRNA-155 mediates endogenous angiotensin II type 1 receptor regulation:implications for innovative type 2 diabetes mellitus management

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世界糖尿病杂志:英文版(电子版) 2023年第9期14卷 1334-1340页

作者： konstantinos I Papadopoulos Alexandra Papadopoulou tar-Choon Aw Department of R&D THAI StemLifeBangkok 10310Thailand occupational and Environmental Health Services Feelgood LundLund 223-63SkåneSweden Department of Laboratory Medicine Changi General HospitalSingapore 529889SingaporeSingapore Department of Medicine National University of SingaporeSingapore 119228SingaporeSingapore

Type 2 diabetes mellitus(T2DM)is a lifelong condition and a threat to human *** understanding of its pathogenesis is acutely needed in order to devise innovative,preventative,and potentially curative pharmacological ***(miRNA),are small,non-coding,one-stranded RNA molecules,that can target and silence around 60%of all human genes through translational ***-155 is an ancient,evolutionarily well-conserved miRNA,with distinct expression profiles and multifunctionality,and a target repertoire of over 241 genes involved in numerous physiological and pathological processes including hematopoietic lineage differentiation,immunity,inflammation,viral infections,cancer,cardiovascular conditions,and particularly diabetes ***-155 Levels are progressively reduced in aging,obesity,sarcopenia,and ***,the loss of coordinated repression of multiple miR-155 targets acting as negative regulators,such as C/EBPβ,HDAC4,and SoCS1 impacts insulin signaling,deteriorating glucose homeostasis,and causing insulin resistance(IR).Moreover,deranged regulation of the renin angiotensin aldosterone system(RAAS)through loss of Angiotensin II Type 1 receptor downregulation,and negated repression of ETS-1,results in unopposed detrimental Angiotensin II effects,further promoting ***,loss of BACH1 and SoCS1 repression abolishes cytoprotective,anti-oxidant,anti-apoptotic,and anti-inflam matory cellular pathways,and promotesβ-cell *** contrast to RAAS inhibitor treatments that further decrease already reduced miR-155 Levels,strategies to increase an ailing miR-155 production in T2DM,e.g.,the use of metformin,mineralocorticoid receptor blockers(spironolactone,eplerenone,finerenone),and verapamil,alone or in various combinations,represent current treatment *** the future,direct tissue delivery of miRNA analogs is likely.

关键词： Angiotensin II Angiotensin II type 1 receptor Arginase 2 L-type calcium channel Mineralocorticoid receptor MiRNA-155 Renin-angiotensin aldosterone system Type 1/2 diabetes mellitus Verapamil

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Estimation of peak runoff and frequency in an ungauged stream of a forested watershed for flood hazard mapping

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Journal of Forestry Research 2019年第2期30卷 555-564页

作者： Refik karagül tar.k ?itgez Department of Forest Engineering Faculty of ForestryDuzce University Konuralp Campus

kaynasli District in the western Black Sea region of Turkey has long been vulnerable to frequent flood damage due to the establishment of settlements within and around stream channels without regard to fluctuating peakstreamflow frequencies. The aim of this research was to determine the measures needed to protect the towns and villages from this type of damage. Daily total precipitation data for 1975–2010 were analysed, and rainfall-runoff models developed to estimate the potential yearly maximum discharge from each stream of sub-watersheds dominated by forests and/or agriculture. This was then calculated for different frequencies of the yearly maximum discharge. Flood analysis and mapping was modified via the one-dimensional Hydrologic Engineering CentersRiver Analysis System software to produce potential maximum discharge and geometric data for kaynasli Creek. As the main creek of the sub-watershed, its crosssection was shown to be insufficient and incapable of containing the maximum discharge at the 100-year frequency presumed for the watershed, and subsequently was seen as having a high level of casualty risk. It was concluded that the one dimensional model could be useful, but 2D models were more suitable for these types of watersheds.

关键词： Flood frequency analysis Floodplain mapping Flow simulation Hydrologic Engineering Centers-River Analysis System(HEC-RAS) Soil Conservation Service Curve Number(SCS-CN)

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Severe Acute Hepatitis of Unknown origin in Children: What Do We know Today?

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 711-717页

作者： María Teresa Pérez-Gracia Antonio tarín-Pelló Beatriz Suay-García Área de Microbiología.Departamento de Farmacia Universidad Cardenal Herrera-CEU.CEU UniversitiesAlfara del Patri-arca(Valencia)Spain ESI International Chair@CEU-UCH Departamento de MatemáticasFísica y Ciencias TecnológicasUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del Patriarca(Valencia)Spain

In May 2022, the Uk International Health Regulations National Focal Point notified World Health organization of 176 cases of severe acute hepatitis of unknown etiology in children under 10 years of age. From that moment on, cases of severe acute hepatitis of unknown origin in children began to be reported in several countries. As of June 17, 2022, a total of 991 cases had been reported in 35 countries worldwide, 50 children needed a liver transplant and 28 patients died. According to information published by ECDC, 449 cases have been detected in 21 EU countries. The children were between 1 month and 16 years of age. Adenovirus was detected in 62.2% of the analyzed samples. So far, the cause of these cases is unknown and many hypotheses remain open, but hepatitis A-E viruses and CoVID-19 vaccines have been ruled out. A possible hypothesis has been published to explain the cause of these cases of severe hepatitis, according to which it could be a consequence of adenovirus infection in the intestine in healthy children previously infected with SARS-CoV-2. No other clear epidemiological risk factors have been identified to date. Thus, at this time, the etiology of the current cases of hepatitis remains under active investigation.

关键词： Hepatitis Children Unknown origin SARS-CoV-2 Adenovirus

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Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment

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World Journal of Gastroenterology 2020年第37期26卷 5543-5560页

作者： Abdullah tar.k Aslan Hatice Yasemin Balaban Department of Internal Medicine Gölhisar State HospitalBurdur 15100Turkey Department of Gastroenterology Hacettepe University Faculty of MedicineAnkara 06100Turkey

The hepatitis E virus(HEV)is the fifth known form of viral hepatitis and was first recognized as the cause of an epidemic of unexplained acute hepatitis in the early ***,it is one of the most frequent causes of acute viral *** majority of HEV infections are asymptomatic and lead to the spontaneous clearance of the *** the eight different genotypes identified to date,HEV genotype 1(HEV1),HEV2,HEV3,and HEV4 are the most frequent genotypes causing infections in ***1 and HEV2 are prevalent in developing regions and able to result in large-scale outbreaks originating from contaminated water *** are also responsible for severe hepatitis in pregnant patients and *** contrast,HEV3 and HEV4 are zoonotic,and the transmission of these genotypes to humans occurs mainly through the fecal contamination of water and consumption of contaminated meat from infected *** main reservoir is the pig,and they are mostly encountered in developed *** major risk groups for HEV infection and its ensuing adverse consequences are pregnant women,infants,older people,immunocompromised individuals,patients with underlying chronic liver diseases,and workers that come into close contact with HEV-infected *** the clinical perspective,HEV infections have diverse clinical manifestations including acute and self-limiting hepatitis,acute-on-chronic liver disease,chronic hepatitis,cirrhosis,and liver *** HEV mainly results in acute selflimiting infection,chronic HEV infection may occur among immunocompromised patients(e.g.,solid-organ transplant recipients).Additionally,HEV-associated extrahepatic manifestations involving various organs have been reported in the last decade,although the causal link for many of them still needs to be *** and interferon-alpha are the most widely used agents for the treatment of HEV infections with a certain level of ***,ribavirin is contraindicated in pregnan

关键词： Hepatitis E Hepatitis E virus Extrahepatic manifestations Zoonotic infection Chronic hepatitis Acute hepatitis

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Periodic orbits for Some Systems of Delay Differential Equations

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Acta Mathematica Sinica,English Series 2008年第2期24卷 267-274页

作者： Jaume LLIBRE Alexandrina-Alina tar■A Departament de Matemàtiques Universitat Autònoma de Barcelona 08193 Bellaterra Barcelona Spain Department of Applied Mathematics Babe■-Bolyai University1 Kogalniceanu str. 400084 Cluj-Napoca Cluj Romania

We provide sufficient conditions for the existence of periodic orbits of some systems of delay differential equations with a unique delay. We extend kaplan-Yorke＇s method for finding periodic orbits from a delay diff... 详细信息

关键词： delay differential system periodic orbit

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Too hard to die:Exercise training mediates specific and immediate SARS-CoV-2 protection

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World Journal of Virology 2022年第2期11卷 98-103页

作者： konstantinos I Papadopoulos Warachaya Sutheesophon tar-Choon Aw THAI StemLife Bangkok 10310BangkokThailand Laboratory THAI StemLifeBangkok 10310BangkokThailand Laboratory Medicine Changi General HospitalSingapore 529889SingaporeSingapore Department of Medicine National University of SingaporeSingapore 119228SingaporeSingapore

Several mechanisms may explain how exercise training mechanistically confers protection against coronavirus disease 2019(CoVID-19).Here we propose two new perspectives through which cardiorespiratory fitness may protect against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).Physical exercise-activated adenosine monophosphate(AMP)-activated protein kinase(AMPk)signaling induces endothelial nitric oxide(No)synthase(eNoS),increases No bio-availability,and inhibits palmitoylation,leading to specific and immediate SARS-CoV-2 *** signaling also induces angiotensin 1-7 release and enhances eNoS activation thus further mediating cardio-and ***,a myokine released from skeletal muscles during aerobic exercise,also participates in the AMPk/Akt-eNoS/No pathway,protects mitochondrial functions in endothelial cells,and antagonizes renin angiotensin system proinflammatory action leading to reductions in genes associated with severe CoVID-19 ***,all the above findings point to the fact that increased AMPk and irisin activity through exercise training greatly benefits molecular processes that mediate specific,immediate,and delayed SARS-CoV-2 *** regular physical activity levels is a safe and affordable lifestyle strategy against the current and future pandemics and may also mitigate against obesity and cardiometabolic disease *** more because a moving target is harder to kill.

关键词： Adenosine monophosphate-activated protein kinase Irisin Physical exercise Nitric oxide Endothelial nitric oxide synthase Severe acute respiratory syndrome coronavirus-2

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Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties

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Neural Regeneration Research 2014年第21期9卷 1884-1890页

作者： Aras Adem Bozkurt Guven Mustafa Akman tar.k ozkan Adile Sen Halil Murat k?l?coglu Mesut kalkan Y?ld?ray Silan Coskun Cosar Murat Department of Neurosurgery ?anakkale Onsekiz Mart UniversityCanakkaleTurkey Department of Neurology ?anakkale Onsekiz Mart UniversityCanakkaleTurkey Department of Medical Biochemistry Ondokuz May?s UniversitySamsunTurkey Deparment of Histology and Embryology Faculty of MedicineRecep Tayyip Erdo?an UniversityRizeTurkey Department of Pharmacology ?anakkale Onsekiz Mart UniversityCanakkaleTurkey

There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondi-adehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These ifndings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.

关键词： nerve regeneration syringaldehyde brain ischemia neuroprotective effects inflammatory oxidative stress apoptosis neural regeneration

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Age and genotype dependent erythropoietin protection in CoVID-19

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World Journal of Stem Cells 2021年第10期13卷 1513-1529页

作者： konstantinos I Papadopoulos Warachaya Sutheesophon Somjate Manipalviratn tar-Choon Aw Department of Research and Development THAI StemLifeBangkok 10310Thailand Laboratory Department THAI StemLifeBangkok 10310Thailand Department of Reproductive Endocrinology Jetanin Institute for Assisted ReproductionBangkok 10330Thailand Department of Laboratory Medicine Changi General HospitalSingapore 529889Singapore Department of Medicine National University of SingaporeSingapore 119228Singapore

Erythropoietin(EPo)is the main mediator of erythropoiesis and an important tissue protective hormone that appears to mediate an ancestral neuroprotective innate immune response mechanism at an early *** the young brain is threatened-prematurity,neonatal hyperbilirubinemia,malaria-EPo is hypersecreted disproportionately to any concurrent anemic *** eons of severe malarial selection pressure,neuroprotective EPo augmenting genetic determinants such as the various hemoglobinopathies,and the angiotensin converting enzyme(ACE)I/D polymorphism,have been positively *** malarial and other cerebral threats abate and the young child survives to adulthood,EPo *** high ACE and angiotensin II(Ang II)levels through the ACE D allele in adulthood may then become detrimental as witnessed by epidemiological *** ubiquitous renin angiotensin system(RAS)influences theα-klotho/fibroblast growth factor 23(FGF23)circuitry,and both are interconnected with *** we propose that at a young age,EPo augmenting genetic determinants through ACE D allele elevated Ang II levels in some or HbE/beta thalassemia in others would increase EPo levels and shield against coronavirus disease 2019,akin to protection from malaria and dengue *** evolution may use ACE2 as a“bait”for severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)to gain cellular entry in order to trigger an ACE/ACE2 imbalance and stimulate EPo hypersecretion using tissue RAS,uncoupled from hemoglobin *** subjects without EPo augmenting genetic determinants at any age,ACE2 binding and internalization upon SARS-CoV-2 entry would trigger an ACE/ACE2 imbalance,and Ang II oversecretion leading to protective EPo *** children,low nasal ACE2 Levels would beneficially augment this imbalance,especially for those without protective genetic *** the other hand,in predisposed adults with the ACE D allele,ACE/ACE2 imbalance,may lead to uncontrolled RAS overactiv

关键词： Erythropoietin Angiotensin converting enzyme Angiotensin II Hemoglobinopathy Malaria Coronavirus disease 2019 Fibroblast growth factor 23

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