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Failure mechanism and control technology of water-immersed roadway in high-stress and soft rock in a deep mine

International Journal of Mining Science and Technology 2017年第2期27卷 245-252页

作者： Yang Renshu li Yongliang Guo Dongming Yao Lan Yang Tongmao li taotao School of Mechanics and Architecture Engineering China University of Mining and TechnologyBeijing 100083China State Key Laboratory for Geomechanics and Deep Underground Engineering Beijing 100083China Faculty of Resources and Safety Engineering China University of Mining and TechnologyBeijing 100083China

Aiming at soft rock ground support issues under conditions of high stress and long-term water immersion, the ground failure mechanism is revealed by taking the deep-water sumps of Jiulong Mine as the engineering background and employing field investigation, tests of rock structure, mechanical properties and mineral composition. The main factors leading to the surrounding rock failure include the high and complex stress state of the water sumps, high-clay content and water-weakened rock, and the unreasonable support design. In this paper, the broken and fractured rock mass near roadway opening is considered as ground small-structure, and deep stable rock mass as ground large-structure. A support technology focusing on cutting off the water, strengthening the small structure of the rock and transferring the large structure of the rock is proposed. The proposed support technology of interconnecting the large and small structures, based on high-strength bolts, high-stiffness shotcrete layer plugging water,strengthening the small structure with deep-hole grouting and shallow-hole grouting, highpretensioned cables tensioned twice to make the large and small structures bearing the pressure evenly,channel-steel and high-pretensioned cables are used to control floor heave. The numerical simulation and field test show that this support system can control the rock deformation of the water sumps and provide technical support to similar roadway support designs.

关键词： High stress and soft rock Water immersion Failure mechanism Large and small structures Rework control

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Selection of a DNA aptamer for the development of fluorescent aptasensor for carbaryl detection

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Chinese Chemical Letters 2021年第6期32卷 1957-1962页

作者： Yuan liu Gaojian Yang taotao li Yan Deng Zhu Chen Nongyue He State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Hunan Provincial Key Lab of Dark Tea and Jin-Hua School of Materials and Chemical EngineeringHunan City UniversityYiyang 413000China Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China

An improved ssDNA library immobilized systematic evolution of ligands by enrichment(SELEX)was applied to select aptamers against *** nine selection rounds,a highly enriched ssDNA pool was *** Apta3 was demonstrated as the optimal aptame *** order to facilitate the modification of aptamer,the Apta3 was further truncated with the dissociation constant(K_(d))of 0.364±0.055μmol/L and a fluorescent aptasensor was *** linear range for carbaryl was from 100 nmol/L to1500 nmol/L,with the limit of detection was as low as 15.23 nmol/***,the biosensor was validated for the carbaryl spiked real samples,and the recoveries were between 97.7%and 107.3%.

关键词： Aptamer Fluorescence aptasensor SELEX Carbaryl Detection

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From lab to fab: path forward for 2D material electronics

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Science China(Information Sciences) 2023年第6期66卷 115-121页

作者： Hongkai NING Zhihao YU taotao li Haoliang SHEN Gen LONG Yi SHI Xinran WANG National Laboratory of Solid State Microstructures School of Electronic Science and Engineering and Collaborative Innovation Center of Advanced MicrostructuresNanjing University School of Integrated Circuits Nanjing University College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications Suzhou Laboratory

The increasing demand for computation requires the development of energy-efficient logic devices with reduced dimensions. Owing to their atomic thickness, 2D semiconductors are expected to provide possible solutions at the sub-1 nm technology node. Furthermore, taking advantage of the van der Waals nature, the low-temperature back-end of line integration with silicon may occur in the near future. In this perspective, vital progress in material synthesis, device engineering, and integration technologies toward integrated circuits based on 2D materials is reviewed. The challenges and important milestones on the roadmap for the next decade toward the fab adoption of 2D materials are outlined. Particularly, performance,power, area, cost, and equipment for further technology development in this area are proposed as key metrics and enablers.

关键词： two-dimensional materials transition-metaldichalcogenides equipment integrated circuits roadmap

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Synthesis of aptamer-functionalized Ag nanoclusters for MCF-7 breast cancer cells imaging

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Science China Chemistry 2017年第3期60卷 370-376页

作者： taotao li Jingjing Yang Zeeshan Ali Zunliang Wang Xianbo Mou Nongyue He Zhifei Wang State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Chemistry and Chemical Engineering Southeast UniversityNanjing 210096China

Aptamer-functionalized silver nanoclusters(Ag NCs) have been attracting a lot of interest as label-free probes which have been successfully applied to both cell imaging and molecular *** aptamer is an ssDNA aptamer that specifically binds to MUCl mucin which is a large transmembrane glycoprotein whose expression level increases at least 10-fold in primary and metastatic breast *** C4A4C3-linker-MUCl as template,the Ag NCs were synthesized through one-pot *** fluorescence intensity of Ag NCs was found to be closely related to the length and type(poly adenine or thymine) of the linker,the optimum linker being-AAAAA-.Using the C4A4C3-A5-MUC1 as the scaffold,the synthesized Ag NCs emitted fluorescence with high quantum yield(QY) of 66.5%.Based on the specific interaction between the MUCl aptamer and MUCl mucin,the C4A4C3-A5-MUC1-stabilized Ag NCs could recognize and differentiate the MCF-7 breast cancer cells from MDA-MB-231 breast cancer and A549 human lung cancer cells.

关键词： MCF-7 cells cell typing Ag NCs aptamer one-pot process

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A simple AuNPs-based colorimetric aptasensor for chlorpyrifos detection

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Chinese Chemical Letters 2022年第4期33卷 1913-1916页

作者： Yuan liu taotao li Gaojian Yang Yan Deng Xianbo Mou Nongyue He State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Hunan Provincial Key Lab of Dark Tea and Jin-Hua School of Materials and Chemical EngineeringHunan City UniversityYiyang 413000China Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China Medical School of Ningbo University Ningbo 315211China

In this work, a simple gold nanoparticles(Au NPs) based colorimetric biosensor was developed for chlorpyrifos(Chl) detection using an aptamer as the capture probe. The Chl-aptamer with low dissociation constant(Kd) of 58.59 ± 6.08 nmol/L was selected by ss DNA library immobilized systematic evolution of ligands by enrichment(SELEX). In the absence of Chl, the Chl-aptamer acted as the stabilizer for Au NPs in salt solution. In the presence of Chl, the highly specific Chl-aptamer bound with Chl targets immediately,thus a self-aggregation of Au NPs induced by salt was displayed. The fabricated colorimetric aptasensor exhibited an excellent sensitivity for Chl detection with the LOD as low as 14.46 nmol/L. In addition, the aptasensor was applied to test Chl in tap water, cucumber and cabbage samples, the excellent recoveries with acceptable RSD values below 5% demonstrated that the method can be considered as a promising tool for simple, rapid Chl detection.

关键词： Aptamer Colorimetric aptasensor SELEX Chlorpyrifos AuNPs

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Copper-Catalyzed Redox-Triggered Remote C--H Functionali- zation： Highly Selective Formation of C--CF3 and C--O Bonds

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Chinese Journal of Chemistry 2016年第5期34卷 490-494页

作者： taotao li Peng Yu Jin-Shun lin Yonggang Zhi Xin-Yuan liu Chengdu Institute of Organic Chemistry Chinese Academy ofSeienees Chengdu Sichuan 610041 China Department of Chemistry South University of Science and Technology of China Shenzhen Guang dong 518055 China

A Cu-catalyzed remote sp3 C--H/unactivated alkenes functionalization reaction for the concomitant construc- tion of C--CF3 and C--O bonds was described. An 1,5-H radical transfer involving an sp3 C--H bond adjacent to a nitrogen atom and an a-CF3-alkyl radical intermediate derived from unactivated alkenes was observed and demon- strated to proceed via the radical process.

关键词： alkenes radical trifluoromethylation 1,5-H radical transfer Togni's reagent

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SHY2 as a node in the regulation of root meristem development by auxin, brassinosteroids, and cytokinin

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Journal of Integrative Plant Biology 2020年第10期62卷 1500-1517页

作者： taotao li Xinke Kang Wei Lei Xiuhong Yao lijuan Zou Dawei Zhang Honghui lin Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment College of Life ScienceState Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610064China School of life Science and Engineering Henan University of Urban ConstructionPingdingshan 467044China Ecological Security and Protection Key Laboratory of Sichuan Province Mianyang Normal UniversityMianyang 621000China

In multicellular organisms,the balance be-tween cell division and differentiation determines organ size,and represents a central unknown in devel-opmental *** Arabidopsis roots,this balance is mediated between cytokinin and auxin through a reg-ulatory circuit converging on the IAA3/SHORT HYPO-COTYL 2(SHY2)***,we show that crosstalk between brassinosteroids(BRs)and auxin occurs in the vascular transition zone to promote root meristem *** found that BR increases root meristem size by up-regulating expression of the PINFORMED 7(PIN7)gene and down-regulating expression of the SHY2 *** addition,BES1 could directly bind to the pro-moter regions of both PIN7 and SHY2,indicating that PIN7 and SHY2 mediate the BR-induced growth of the root meristem by serving as direct targets of ***,the PIN7 overexpression and loss-of-function SHY2 mutant were sensitive to the effects of BR and could partially suppress the short-root phenotypes associated with deficient BR ***,BRs could inhibit the accumulation of SHY2 protein in response to *** together,these findings suggest that a complex equilibrium model exists in which regulatory interactions among BRs,auxin,and cytokinin regulate optimal root growth.

关键词： size auxin roots

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Electrochemical sensor for Cd2+ and Pb2+ detection based on nano-porous pseudo carbon paste electrode

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Chinese Chemical Letters 2019年第12期30卷 2211-2215页

作者： Yuan liu taotao li Chuxuan ling Zhu Chen Yan Deng Nongyue He State Key Laboratory of Bioelectronics Southeast UniversityNanjing 210096China Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China Hunan Provincial Key Lab of Dark Tea and Jin-Hua School of Materials and Chemical EngineeringHunan City UniversityYiyang 413000China School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China

An electrochemical sensor based on self-made nano-porous pseudo carbon paste electrode(nano-PPCPE)has been successfully developed,and used to detect Cd^2+ and Pb^2+.The experimental results showed that the electrochemical performance of nanoPPCPE is evidently better than both glassy carbon electrode(GCE)and pure carbon paste electrode(CPE).Then the prepared nano-PPCPE was applied to detect Cd^2+ and Pb^2+in standard solution,the results showed that the electrodes can quantitatively detect trace Cd^2+ and Pb^2+,which has great significance in electrochemical analysis and *** linear ranges between the target ions concentration and the D PASV current were from 0.1-3.0 μmol/L,0.05-4.0 μmol/L for Cd^2+ and Pb^2+,*** the detection limits were 0.0780 μmol/L and 0.0292 μmol/L,***,the preparation of the nano-PPCPE is cheap,simple and has important practical value.

关键词： Nano-porous pseudo carbon paste electrode (nano-PPCPE) Cadmium ions Lead ions Sensor Detection

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Principal element design of pyrochlore-fluorite dual-phase medium-and high-entropy ceramics

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Journal of Materials Science & Technology 2022年第12期107卷 149-154页

作者： Wei Fan Yu Bai Yanfen liu taotao li Binmao li Lei Zhang Chenmin Gao Shiyu Shan Haocen Han State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China School of Energy and Power Engineering North University of ChinaTaiyuan 030051China School of Mechanical Engineering North University of ChinaTaiyuan 030051China

*** Rare earth zirconate(REZrO,RE=La-Lu,Y or Sc)is a kind of significantly important structural or functional ceramic[1,2].It possesses extensive application in numerous fields,such as in thermal barrier coatings(TBCs)[3–5],high-level radioactive wastes[6–8],etc.,due to the excellent thermal stability,low thermal conductivity and low oxygen ion *** phase structure of conventional rare earth zirconate is strongly linked with the ionic radius ratio of REto Zr[7,9].

关键词： thermal phase earth

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Displacement damage effects in MoS_(2)-based electronics

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Journal of Semiconductors 2024年第12期45卷 152-158页

作者： Kaiyue He Zhanqi li taotao li Yifu Sun Shitong Zhu Chao Wu Huiping Zhu Peng Lu Xinran Wang Maguang Zhu School of Integrated Circuits Nanjing UniversitySuzhou 215000China Suzhou Laboratory Suzhou 215000China School of Electronic Science and Engineering and Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210000China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Jihua Laboratory Foshan 528200China

Owing to the unique characteristics of ultra-thin body and nanoscale sensitivity volume,MoS_(2)-based field-effect tran-sistors(FETs)are regarded as optimal components for radiation-hardened integrated circuits(ICs),which is exponentially grow-ing demanded especially in the fields of space exploration and the nuclear *** researches on MoS_(2)-based radiation tolerance electronics focused on the total ionizing dose(TID)effect,while few works concerned the displacement damage(DD)effects,which is more challenging to measure and more crucial for practical *** first conducted measurements to assess the DD effects of MoS_(2) FETs,and then presented the stopping and ranges of ions in matter(SRIM)simulation to analysis the DD degradation mechanism in MoS_(2) *** monolayer MoS_(2)-based FETs exhibit DD radiation tolerance up to 1.56×1013 MeV/g,which is at least two order of magnitude than that in conventional radiation hardened *** exceptional DD radiation tolerance will significantly enhance the deployment of MoS_(2) integrated circuits in environments characterized by high-energy solar and cosmic radiation exposure.

关键词： MoS_(2) field effect transistor displacement damage effect radiation hardness proton radiation

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