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"Five steps four quadrants" modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in laparoscopic pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 503-510页

作者： Xiao-Si Hu Yong Wang Hong-tao Pan Chao Zhu Shi-l.i Chen Hui-Chun liu Qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People’s HospitalHefei 230041Anhui ProvinceChina

BACKGROUND Although en bloc dissection of hepatic hilum lymph nodes has many advantages in radical tumor treatment,the feasibility and safety of this approach for laparo-scopic pancreaticoduodenectomy(lPD)require further clinical evaluation and *** To explore the application value of the"five steps four quadrants"modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in lPD *** A total of 52 patients who underwent lPD via the"five steps four quadrants"modularized en bloc dissection technique for hepatic hilum lymph nodes from April 2021 to July 2023 in our department were analyzed *** patients'body mass index(BMi),preoperative laboratory indices,intraoperative variables and postoperative complications were *** relationships between preoperative data and intraoperative lymph node dissection time and blood loss were also *** Among the 52 patients,36 were males and 16 were females,and the average age was 62.2±11.0 *** were 26 patients with pancreatic head cancer,16 patients with periampullary cancer,and 10 patients with distal bile duct *** BMi was 22.3±3.3 kg/m²,and the median total bilirubin(TBil)concentration was 57.7(16.0-155.7)µmol/*** patients successfully underwent the"five steps four quadrants"modularized en bloc dissection technique without lymph node clearance-related complications such as postoperative bleeding or lymphatic *** analysis revealed significant associations between preoperative BMi(r=0.3581,P=0.0091),TBil level(r=0.2988,P=0.0341),prothrombin time(r=0.3018,P=0.0297)and lymph node dissection ***,dissection time was significantly correlated with intraoperative blood loss(r=0.7744,Pified analysis demonstrated that patients with a preoperative BMi≥21.9 kg/m²and a TiBl concentration≥57.7μmol/l had significantly longer lymph node dissection times(both PlUSiON The"five steps four quadrants

关键词： Five steps four quadrants Hepatic hilum lymph node Modularized en bloc clearance laparoscopic pancreaticoduodenectomy

A cell transcriptomic profile p ovides insights into adipocytes of porcine mammary gland across development

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Journal of Animal Science and Biotechnology 2024年第1期15卷 182-200页

作者： Yongliang Fan long Jin Zhiping He Tiantian Wei Tingting luo Jiaman Zhang Can liu Changjiu Dai Chao A Yan liang Xuan tao Xuebin lv Yiren Gu Mingzhou li State Key laboratory of Swine and Poultry Breeding industry College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Key laboratory of Qinghai‑Tibetan Plateau Animal Genetic Resource Reservation and Utilization Southwest Minzu UniversityChengdu 610041China Animal Breeding and Genetics Key laboratory of Sichuan Province Sichuan Animal Science AcademyChengdu 610000China

Background Studying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous, and its physiological function dependents on the gene expression of mul.iple cell types. Most studies focused on epithelial cells, disregarding the role of neighboring *** Here, we constructed the largest transcriptomic dataset of porcine mammary gland cells thus far. The dataset captured 126,829 high-quality nucl.i from physiological mammary glands across five developmental stages(d 90 of gestation, G90;d 0 after lactation, l0;d 20 after lactation, l20;2 d post natural.involution, Pi2;7 d post natural.involution, Pi7). Seven cell types were identified, including epithelial cells, adipocytes, endothelial cells, fibroblasts cells, immune cells, myoepithelial cells and precursor cells. Our data indicate that mammary glands at different developmental stages have distinct phenotypic and transcriptional signatures. During late gestation(G90), the differentiation and proliferation of adipocytes were inhibited. Meanwhile, partly epithelial cells were completely differentiated. Pseudo-time analysis showed that epithelial cells undergo three stages to achieve lactation, including cellular differentiation, hormone sensing, and metabolic activation. During lactation(l0 and l20), adipocytes area accounts for less than 0.5% of mammary glands. To maintain their own survival, the adipocyte exhibited a poorly differentiated state and a proliferative capacity. Epithelial cells initiate lactation upon hormonal stimulation. After ful.il.ing lactation mission, their undergo physiological death under high intensity lactation. interestingly, the physiological dead cells seem to be actively cleared by immune cells via CCl21-ACKR4 pathway. This biological process may be an important mechanism for maintaining homeostasis of the mammary gland. During natural.involution(Pi2 and Pi7), epithelial cell populatio

关键词： Adipocytes Cell–cell.interaction Development Mammary gland snRNA-seq

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紫外光活化亚硫酸盐降解水中卡马西平

环境科学 2024年第3期45卷 1553-1560页

作者：林涛苑宇杰河海大学环境学院南京210098

研究了紫外光活化亚硫酸盐高级氧化工艺降解水中典型新污染物——卡马西平(CBZ)的效能和降解机制.探究了不同溶解氧浓度[ρ(DO)]对紫外光活化亚硫酸盐降解CBZ的影响,并在模拟自然水体环境控制初始ρ(DO)为(8.0±0.2) mg·l^(-1)条件下,... 详细信息

研究了紫外光活化亚硫酸盐高级氧化工艺降解水中典型新污染物——卡马西平(CBZ)的效能和降解机制.探究了不同溶解氧浓度[ρ(DO)]对紫外光活化亚硫酸盐降解CBZ的影响,并在模拟自然水体环境控制初始ρ(DO)为(8.0±0.2) mg·l^(-1)条件下,考察了不同工艺参数(亚硫酸盐投加量、反应pH)与水环境要素(碳酸氢根离子、氯离子、腐殖酸)对CBZ降解效能的影响.结果表明,紫外光活化亚硫酸盐工艺可在30 min内降解85.3%的CBZ,降解过程遵循拟一级动力学,动力学常数为0.055 7 min^(-1).并采用电子顺磁共振波谱技术、活性物质淬灭实验和竞争反应动力学实验发现,CBZ的降解主要来自紫外光活化亚硫酸盐工艺中硫酸根自由基(SO_(4)^(-)·)与羟基自由基(·OH)等活性物质,且降解贡献率分别为43.9%和56.1%.而且CBZ降解率随HCO_(3)^(-)浓度升高而降低,但Cl-浓度变化对CBZ降解率影响不大,水中存在的腐殖酸可显著抑制CBZ的降解.反应过程中硫酸盐的积累量显著低于《生活饮用水卫生标准》(GB 5749-2022)限值,且亚硫酸盐消耗速率(0.004 4 min^(-1))显著低于CBZ的降解速率,说明亚硫酸盐可被紫外光高效活化用于降解水中存在的CBZ.

关键词：紫外光亚硫酸盐卡马西平活性物质降解

Effect of Al.icin on the Formation of Kidney Stones in Rats by Regulating the Expression of OPN and NF-κB Signaling Pathway

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Chinese Journal of Biomedical Engineering 2024年第2期33卷 76-84页

作者： TU tao ZHAO li-wen WU Qin-fu longyan First Affiliated Hospital of Fujian Medical University

Objective: To investigate the effect of al.icin on the formation of kidney stones in rats by regulating the expression of osteopontin(OPN) and nuclear factor-κB(NF-κB) signaling pathway. Methods: A total of 50 healthy adult male SD rats with SPF grade were selected and divided into five groups by random number and computer random combination, with 10 rats in each group. Except the blank group, the other four groups were given 2 m l/d mixed solution of 1% ethylene glycol+2% ammonium chloride to construct the nephrolith model. During the modeling process, the blank group and the model group were given normal saline by gavage. The positive group was given 600 mg/(kg·d) of potassium sodium hydrogen citrate granules by gavage, the low-dose group was given 7.5 mg/(kg·d) of al.icin by gavage, and the high-dose group was given 15 mg/(kg·d)of al.icin by gavage. After administration, renal function, urine related indicators, cal.ium oxalate crystal.ization score, OPN protein expression and NF-κB signaling pathwayrelated protein expression were observed and compared among the five groups of ***: There were significant differences in kidney index, urea nitrogen(BUN) and blood creatinine(Cr) levels among the five groups(Pifferences in kidney index, BUN and Cr levels between the high-dose group and the positive group(P>0.05), and were all lower than those in the model group and low-dose group(Pignificant differences in the levels of oxalic acid(OA), cal.ium(Ca),magnesium(Mg), and phosphorus(P) in the urine of five groups of rats(Pigh-dose group showed no difference in the levels of OA, Ca, Mg, and P compared to the positive control group(P>0.05), and all were lower than the model group and low-dose group(Pignificant differences in the scores of cal.ium oxalate crystal.ization and the expression of OPN protein in the five groups(Pifference in the scores of cal.ium oxalate crys

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空间啮齿类动物培养装置及实验技术研究进展

空间科学学报 2024年第3期44卷 544-555页

作者：张晶晶吕勇张涛刘方武中国地质大学自动化学院武汉430074 中国科学院上海技术物理研究所上海200083 复杂系统先进控制与智能自动化湖北省重点实验室武汉430074 地球探测智能化技术教育部工程研究中心武汉430074

空间动物实验是人类空间生命科学研究的重要组成部分.一直以来,空间动物实验为探索地球生物体在航天环境中的生命现象及活动规律、支持载人航天的可持续性发展做出了重要贡献.随着航天工程的发展,航天员在空间驻留的时间越来越长,为解... 详细信息

空间动物实验是人类空间生命科学研究的重要组成部分.一直以来,空间动物实验为探索地球生物体在航天环境中的生命现象及活动规律、支持载人航天的可持续性发展做出了重要贡献.随着航天工程的发展,航天员在空间驻留的时间越来越长,为解决人类在空间旅行中的健康问题,各国先后开展了空间啮齿类动物实验,研究空间环境给生命体带来的影响,为人类空间飞行提供重要的生理和医学数据.本文研究了国外主流的空间啮齿类动物培养装置,根据各类装置培养动物的存活情况及死亡原因,提出装置的不足与可改进之处;深入分析空间啮齿类动物实验发射前、在轨、返回地面阶段的相关实验技术,为中国空间啮齿类动物培养装置设计及动物实验提供参考.

关键词：空间飞行啮齿类动物培养装置实验技术

Simple-structured hydrophilic sensors for sweat uric acid detection with laser-engraved pol.imide electrodes and cellulose paper substrates

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Chinese Chemical letters 2024年第3期35卷 443-448页

作者： linhe Xu Xueshan Hu Shuang Zhou Ze Zhang Junxian Zhang Chao li Daxian Zuo Hao liu Gang Chen Jiayu Wan Jinsong tao State Key lab of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China Future Battery Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China

Accurate detection of uric acid(UA)is crucial for diagnosing gout,yet traditional sweat-based UA sensors continue to face challenges posed by complex and costly electrode fabrication methods,as well as weakly hydrophilic ***,we designed and developed simple,low-cost,and hydrophilic sweat UA detection sensors constructed by carbon electrodes and cellulose paper *** carbon electrodes were made by carbonized pol.imide films through a simple,one-step laser engraving *** electrodes are porous,possess a large specific surface area,and are flexible and *** substrates were composed of highly hydrophilic cellulose paper that can effectively collect,store,and transport *** constructed electrodes demonstrate high sensitivity of 0.4μA lμmol^(-1)cm^(-2),wide linear range of 2–100μmol/*** addition,our electrodes demonstrate high selectivity,excellent reproducibility,high flexibility,and outstanding stability against mechanical bending,temperature variations,and extended storage ***,our sensors have been proven to provide reliable results when detecting UA levels in real sweat and on real human *** envision that these sensors hold enormous potential for use in the prognosis,diagnosis,and treatment of gout.

关键词： laser-engraved carbon Pol.imide Cellulose paper Hydrophilicity Sweat uric acid

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基于相对零主观算法的机场智慧化程度评价

交通运输工程学报 2024年第2期24卷 232-242页

作者：张锐黄卫马涛东南大学智能运输系统(iTS)研究中心江苏南京211189 综合交通运输理论交通运输行业重点实验室(南京现代综合交通实验室) 江苏南京211100 东南大学交通学院江苏南京211189

为了解决机场智慧化程度评价过程中遇到的指标类型繁多、覆盖范围广泛,且指标间关系错综复杂、量纲不统一、难以进行定量分析的难题,优选了传统的评价方法,并将改进后的优劣解距离(TOPSiS)法和层次分析法(AHP)进行融合,提出了专门针对... 详细信息

为了解决机场智慧化程度评价过程中遇到的指标类型繁多、覆盖范围广泛,且指标间关系错综复杂、量纲不统一、难以进行定量分析的难题,优选了传统的评价方法,并将改进后的优劣解距离(TOPSiS)法和层次分析法(AHP)进行融合,提出了专门针对机场智慧化程度评价的相对零主观(ZR)算法;为确保评价结果的准确,利用专家意见与客观判断结果对机场智慧化程度评价体系中的功能指标权重进行了计算,基于江苏省某机场通过ZR算法进行了机场智慧化程度评价。研究结果表明:2018年某机场智慧化程度评分为65.64,2022年某机场智慧化程度评分为77.08,说明机场内各项智慧智能设备在不断更新迭代,机场智慧化程度也在不断提高;2022年,机场应急保障下的二级安全运行监测指标较2018年提高了65.7%,人身安全检查指标提高了17.1%,应急与安全指标提高了16.2%,主要原因在于某机场近年来大力发展人工智能分析系统,引进了航站楼出入口人脸识别系统,完善了站坪作业安全监控平台,在一定程度上提高了机场安全的智慧化程度;陆侧交通指标2018年评分为2.34,2022年为2.54,评分变化较小,因此,智慧化程度发展迟缓,在未来的建设中需进一步加强资源投入。

关键词：民用机场智慧化程度评价相对零主观算法改进TOPSiS法权重计算

Rare earth element-modified MOF materials:synthesis and photocatalytic applications in environmental remediation

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Rare Metals 2024年第4期43卷 1390-1406页

作者： Shu-Kun le Qi-Jie Jin Jia-Ao Han Hua-Cong Zhou Quan-Sheng liu Fu Yang Jie Miao Pei-Pei liu Cheng-Zhang Zhu Hai-tao Xu inner Mongolia Key laboratory of High-Value Functional Utilization of low Rank Carbon Resources Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot010050China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing210009China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212100China institut National de la Recherche Scientifique-Énergie Matériaux et Télécommunications MontrealQCJ3X 1P7Canada

Metal-organic framework-like materials(MOFs)have been developed in the fields of photocatalysis for their excellent optical properties and physicochemical properties,including environmental remediation,CO_(2)photoreduction,water splitting,and so *** their important roles in various fields,rare earth elements have received growing interests from *** MOFs with rare earth elements for modification allows broadening the absorption spectrum,while the active electrons on their empty 4f orbitals can act as traps to capture photoexcited carriers to inhibit the recombination of electron-hole pairs,thus promoting photocatalytic ***,rare earth elements modified MOFs provide an attractive way to achieve their high value *** this mini-review,the synthesis of rare earth element-modified MOFs photocatalysts and corresponding applications in the removal of antibiotics,CO_(2)reduction,and hydrogen production are constructively summarized and ***,the latest advancements and current difficul.ies of these materials as well as the application prospects are also provided.

关键词： Rare earth metals MOFs Photocatalytic CO_(2) reduction Environmental remediation Water splitting

混合动力汽车发动机启停工况扭振自适应模糊控制

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重庆大学学报 2024年第1期47卷 104-114页

作者：陈龙陶磊太原理工大学机械与运载工程学院太原030024 吉林大学汽车仿真与控制国家重点实验室长春130025

混合动力汽车(hybrid electric vehicle,HEV)发动机启停过程伴随的转矩脉动,易诱发车辆传动系扭振,导致车辆动力不平顺。为解决上述问题,提出并验证基于电磁阻尼自适应模糊控制的传动系扭振主动控制方法。建立行星混联式混合动力汽车发... 详细信息

混合动力汽车(hybrid electric vehicle,HEV)发动机启停过程伴随的转矩脉动,易诱发车辆传动系扭振,导致车辆动力不平顺。为解决上述问题,提出并验证基于电磁阻尼自适应模糊控制的传动系扭振主动控制方法。建立行星混联式混合动力汽车发动机启停工况动力学仿真模型和发动机启停控制逻辑,提出发动机启停扭振自适应模糊控制策略,开展2种运行状态下发动机启停工况仿真,对比分析无控制和自适应模糊控制下传动系扭转振动响应曲线。结果表明,自适应模糊控制相比无控制状态:定置停车时发动机启动和停机工况扭振平均衰减率分别为23.8%和30.1%,车辆行进间发动机启动和停机工况扭振平均衰减率分别为12.1%和23.6%。该方法可有效衰减发动机启停工况传动系扭转振动,提升混合动力汽车发动机启停工况NVH(noise,vibration,and harshness)性能。

关键词：行星混联传动系启停工况扭转振动主动控制自适应模糊控制