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Electrochemical regioselective synthesis of N-substituted/unsubstituted 4-selanylisoquinolin-1(2H)-ones

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Chinese Chemical Letters 2022年第3期33卷 1501-1504页

作者： Zhi-Lin Wu Jin-Yang Chen Xian-Zhi Tian Wen-tao ouyang Zhuo-tao Zhang Wei-Min He School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China

A novel and efficient electro-chemical initiated radical strategy was developed for the preparation of both N-substituted and N-unsubstituted 4-selanylisoquinolin-1(2H)-ones through selenylation of isoquinolin-1(2H)-o... 详细信息

关键词： Organodiselenide Electrochemistry Radical Atom economy Additives-free

Breast-conserving therapy and modified radical mastectomy for primary breast carcinoma:a matched comparative study

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Chinese Journal of Cancer Research 2015年第6期27卷 545-552页

作者： Lize Wang tao ouyang Tianfeng Wang Yuntao Xie Zhaoqing Fan Benyao Lin Jinfeng Li Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Breast Cancer Center Peking University Cancer Hospital & Institute

Background- To compare two types of therapy for primary breast carcinoma, breast-conserving therapy （BCT） and modified radical mastectomy （MRM）, in a matched cohort study. Methods： A series of 1,746 patients with primary breast cancer treated with BCT or MRM in a single Chinese institute between January 2000 and February 2009 were analyzed retrospectively to compare their outcomes with respect to the incidence of local recurrence （LR）, distant metastasis, and survival. The patients were matched with regard to age at diagnosis, spreading to axillary lymph nodes, hormone receptor status, the use of neoadjuvant chemotherapy and maximal tumor diameter. The match ratio was 1：1, and each arm included 873 patients. Results： The median follow-up period was 71 months. The 6-year disease-free survival （DFS） and 6-year distant disease-free survival （DDFS） rates differed significantly between two groups. The 6-year local recurrence-free survival （LRFS） rates were 98.2% [95% confidence interval （CI）： 0.973-0.989] in the BCT group and 98.7% （95% CI： 0.980-0.994） in the MRM group （P=0.182）, respectively. DFS rates in BCT and MRM groups were 91.3% （95% CI： 0.894-0.932） and 86.3% （95% CI： 0.840-0.886）（P〈0.001）, respectively, whereas the DDFS rates in BCT and MRM groups were 93.6% （95% CI： 0.922-0.950） and 87.7% （95% CI： 0.854-0.900）（P〈0.001）, respectively. Conclusions： BCT in eligible patients is as effective as MRM with respect to local tumor control, DFS and DDFS, and may result in a better outcome than MRM in Chinese primary breast cancer patients.

关键词： Breast carcinoma breast-conserving therapy (BCT) mastectomy recurrence survival

Ultrathin organic polymer with p-πconjugated structure for simultaneous photocatalytic disulfide bond generation and CO_(2)reduction

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Journal of Energy Chemistry 2023年第1期76卷 639-647,I0016页

作者： Linquan Hou Zhunyun Tang Guojiang Mao Shiheng Yin Bei Long tao ouyang Guo-Jun Deng Atif Ali Ting Song Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105HunanChina Hunan Key Laboratory for Micro-Nano Energy Materials and Device School of Physics and OptoelectronicsXiangtan UniversityXiangtan 411105HunanChina School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanChina Analytical and Testing Center South China University of TechnologyGuangzhou 510640GuangdongChina Department of Chemistry and State Key Laboratory of Synthetic Chemistry The University of Hong KongPokfulam RoadHong Kong 999077China

Combining photocatalytic organic reactions with CO_(2)reduction is an efficient solar energy utilization mode,but it is still limited by the organic species that can be matched and the low ***,ultrathin organic polymer with p-πconjugated structure(TPP)was rationally designed and prepared,and showed a high yield of CO(15.2 mmol g^(-1))and conversion of SAS coupled products(100%),far exceeding the organic polymer with P=O *** enhanced photoredox activity of TPP is ascribed to the orbital interaction between the p-orbital on phosphorus and theπ-orbitals of aromatic,which can accelerate the photoinduced charge carrier separation and improve the CO_(2)adsorption *** can also be used for the dehydrocoupling of various benzyl mercaptans to the corresponding SAS bond *** work provides a new concept for the efficient synthesis of disulfide bonds combined with CO_(2)reduction in a photoreaction system.

关键词： Photocatalytic coupled reaction Disulfide bond CO_(2)reduction High activity Organic polymer

Sono-photocatalytic amination of quinoxalin-2(1H)-ones with aliphatic amines

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Chinese Chemical Letters 2024年第10期35卷 269-272页

作者： Wen-tao ouyang Jun Jiang Yan-Fang Jiang Ting Li Yuan-Yuan Liu Hong-tao Ji Li-Juan Ou Wei-Min He School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China School of Materials Science and Engineering Hunan Institute of TechnologyHengyang 421002China National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass Nanjing Forestry UniversityNanjing 210037China

The first example of sono-photocatalytic bond formation was *** both visible light and ultrasound wave as the energy,various 3-aminoquinoxalin-2(1H)-ones were efficiently obtained with good functional group tolerance in the absence of any additive or external *** with the conventional photocatalysis,sono-photocatalysis not only dramatically improved the reaction rates and yields,but also reduced energy consumption.

关键词： Sono-photocatalysis External photocatalyst-free Quinoxalin-2(1H)-ones Amination Aliphatic amines

Tunable bandgaps and flat bands in twisted bilayer biphenylene carbon

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Chinese Physics B 2021年第7期30卷 451-455页

作者： Ya-Bin Ma tao ouyang Yuan-Ping Chen Yue-E Xie School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Faculty of Science Jiangsu UniversityZhenjiang 212013China

Owing to the interaction between the layers,the twisted bilayer two-dimensional(2 D)materials exhibit numerous unique optical and electronic properties different from the monolayer counterpart,and have attracted tremendous interests in current physical research *** means of first-principles and tight-binding model calculations,the electronic properties of twisted bilayer biphenylene carbon(BPC)are systematically investigated in this *** results indicate that the effect of twist will not only leads to a phase transition from semiconductor to metal,but also an adjustable band gap in BPC(0 me V to 120 me V depending on the twist angle).Moreover,unlike the twisted bilayer graphene(TBG),the flat bands in twisted BPC are no longer restricted by"magic angles",i.e.,abnormal flat bands could be appeared as well at several specific large angles in addition to the small *** charge density of these flat bands possesses different local modes,indicating that they might be derived from different stacked modes and host different *** exotic physical properties presented in this work foreshow twisted BPC a promising material for the application of terahertz and infrared photodetectors and the exploration of strong correlation.

关键词： twisted bilayer biphenylene carbon adjustable band gap flat bands

Early prediction of pathological outcomes to neoadjuvant chemotherapy in breast cancer patients using automated breast ultrasound

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Chinese Journal of Cancer Research 2016年第5期28卷 478-485页

作者： Xinguang Wang Ling Huo Yingjian He Zhaoqing Fan Tianfeng Wang Yuntao Xie Jinfeng Li tao ouyang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Breast Center Peking University Cancer Hospital & Institute Beijing 100142 China

Objective： Early assessment of response to neoadjuvant chemotherapy （NAC） for breast cancer allows therapy to be individualized. The optimal assessment method has not been established. We investigated the accuracy of automated breast ultrasound （ABUS） to predict pathological outcomes after NAC. Methods： A total of 290 breast cancer patients were eligible for this study. Tumor response after 2 cycles of chemotherapy was assessed using the product change of two largest perpendicular diameters （PC） or the longest diameter change （LDC）. PC and LDC were analyzed on the axial and the coronal planes respectively. Receiver operating characteristic （ROC） curves were used to evaluate overall performance of the prediction methods. Youden＇s indexes were calculated to select the optimal cut-off value for each method. Sensitivity, specificity, positive and negative predictive values （PPV and NPV） and the area under the ROC curve （AUC） were calculated ***： ypT0/is was achieved in 42 patients （14.5%） while ypT0 was achieved in 30 patients （10.3%） after NAC. All four prediction methods （PC on axial planes, LDC on axial planes, PC on coronal planes and LDC on coronal planes） displayed high AUCs （all〉0.82）, with the highest of 0.89 [95% confidence interval （95% CI）, 0.83-0.95] when mid-treatment ＆BUS was used to predict final pathological complete remission （pCR）. High sensitivities （85.7%-88.1%） were observed across all four prediction methods while high specificities （81.5%-85.1%） were observed in two methods used PC. The optimal cut-off values defined by our data replicate the WHO and the RECIST criteria. Lower AUCs were observed when mid-treatment ABUS was used to predict poor pathological outcomes. Conclusions：ABUS is a useful tool in early evaluation of pCR after NAC while less reliable when predicting poor pathological outcomes.

关键词： Automated breast ultrasound breast neoplasms drug monitoring neoadjuvant therapy pathologicalcomplete remission ultrasonography

Breast Cancer Subtypes and Survival in Chinese Women with Operable Primary Breast Cancer

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Chinese Journal of Cancer Research 2011年第2期23卷 134-139页

作者： Zhao-sheng Li Lu Yao Yi-qiang Liu tao ouyang Jin-feng Li Tian-feng Wang Zhao-qing Fan Tie Fan Ben-yao Lin Yun-tao Xie Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Breast Center Department of Pathology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective： To investigate the associations between the different breast cancer subtypes and survival in Chinese women with operable primary breast cancer. Methods： A total of 1538 Chinese women with operable primary breast cancer were analyzed in this study, the median follow-up was 77 months. Estrogen receptor （ER）, progesterone receptor （PR）, and HER2 status were available for these patients. Results： Luminal A （ER＋ and/or PR＋, HER2-） had a favorable disease-free survival （DFS） and overall survival （OS） compared with other subtypes in the entire cohort. Using the luminal A as a reference, among the patients with lymph node positive disease, HER2＋（ER-, PR-, HER2＋） had the worst DFS （hazard ratio, HR=1.80, 95% CI 1.11 to 2.91, P=0.017） and luminal B （ER＋ and/or PR＋, HER2＋） had the worst OS （HR=2.27, 95% CI 1.50 to 3.45, P0.001）; among the patients with lymph node negative disease, triple-negative （ER-, PR-, HER2-） had the worst DFS （HR=2.21, 95% CI 1.43 to 3.41, P0.001）, whereas no significant difference in DFS between HER2＋ and luminal B or luminal A was observed. Conclusion： As compared with luminal A, luminal B and HER2＋ have the worst survival in patients with lymph node positive disease, but this is not the case in patients with lymph node negative disease; triple-negative subtype has a worse survival in both lymph node positive and lymph node negative patients.

关键词： Breast cancer Subtypes Disease-free survival Overall survival

Association between HER2 status and response to neoadjuvant anthracycline followed by paclitaxel plus carboplatin chemotherapy without trastuzumab in breast cancer

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Chinese Journal of Cancer Research 2015年第6期27卷 553-561页

作者： Lu Yao Juan Zhang Yiqiang Liu tao ouyang Jinfeng Li Tianfeng Wang Zhaoqing Fan Tie Fan Benyao Lin Yuntao Xie Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Breast Center Beijing Cancer Hospital & Institute Peking University Cancer Hospital Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Pathology Beijing Cancer Hospital & Institute Peking University Cancer Hospital

Background： We recently showed HER2-positive breast cancers are less likely to respond to neoadjuvant anthracycline chemotherapy. Here, we investigated whether HER2-positive breast cancers responded to sequential neoadjuvant anthracycline followed by paclitaxel plus carboplatin regimen in the absence of trastuzumab. Methods： Women （n=372） with operable primary breast cancer initially received two cycles of neoadjuvant anthracyclines, the clinical tumor response was assessed, then patients were received four cycles of paelitaxel plus carboplatin regimen. All the patients did not received trastuzumab treatment in the neoadjuvant setting. HER2 status was determined by immunohistochemistry and/or by fluorescence in situ hybridization in core- biopsy breast cancer tissue obtained before the neoadjuvant chemotherapy. Results： Eighteen percent （67/372） of patients achieved a pathologic complete response （pCR） in their breast. HER2-positive tumors had a significant higher pCR rate than HER2-negative tumors （33.0% versus 13.5%, P〈0.001） in this cohort of 372 patients, and positive HER2 status remained an independent favorable predictor of pCR in a multivariate analysis [odds ratio （OR）, 2.26; 95% confidence interval （CI）, 1.18 to 4.36, P=0.015]. Furthermore, patients who responded to initial anthracycline regimens were more likely to respond to paclitaxel plus carboplatin than patients who did not （pCR, 27.2% versus 14.6%, P=0.005）. Patients with HER2-positive tumors exhibited a significant higher pCR rate than did patients with HER2- negative tumors in both anthracycline response group （40.5% versus 20.0%, P=0.025） and anthracycline non-response group （28.3% versus 11.3 %, P=0.002）. Conclusions： Under the circumstance of no trastuzumab treatment, women with HER2-positive cancers derive a large benefit from paclitaxel-carboplatin-based neoadjuvant chemotherapy.

关键词： HER2 breast cancer neoadjuvant chemotherapy paclitaxel carboplatin

Value of pre-treatment biomarkers in prediction of response to neoadjuvant endocrine therapy for hormone receptor-positive postmenopausal breast cancer

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Chinese Journal of Cancer Research 2013年第4期25卷 397-404页

作者： Min Ying Yingjian He Meng Qi Bin Dong Aiping Lu Jinfeng Li Yuntao Xie Tianfeng Wang Benyao Lin tao ouyang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Breast Cancer Center Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education)Department of Pathological Peking University Cancer Hospital&Institute

Objective： To determine the predictive ability of biomarkers for responses to neoadjuvant endocrine therapy （NET） in postmenopausal breast cancer. Methods： Consecutive 160 postmenopausal women with T 1-3 N 0-1 M 0 hormone receptor （HR）-positive invasive breast cancer were treated with anastrozole for 16 weeks before surgery. New slides of tumor specimens taken before and after treatment were conducted centrally for biomarker analysis and classified using the Applied Imaging Ariol MB-8 system. The pathological response was evaluated using the Miller ＆ Payne classification. The cell cycle response was classified according to the change in the Ki67 index after treatment. Multivariable logistic regression analysis was used to calculate the combined index of the biomarkers. Receiver operating characteristic （ROC） curves were used to determine whether parameters may predict response. Results： The correlation between the pathological and cell cycle responses was low （Spearman correlation coefficient =0.241, P〈0.001; Kappa value =0.119, P=0.032）. The cell cycle response was significantly associated with pre-treatment estrogen receptor （ER） status （P=0.001）, progesterone receptor （PgR） status （P〈0.001）, human epidermal growth factor receptor 2 （Her-2） status （P=0.050） and the Ki67 index （P〈0.001）, but the pathological response was not correlated with these factors. Pre-treatment ER levels [area under the curve （AUC） =0.634, 95% confidence interval （95% CI）, 0.534-0.735, P=0.008] and combined index of pre-treatment ER and PgR levels （AUC =0.684, 95% CI, 0.591-0.776, P〈0.001） could not predict the cell cycle response, but combined index including per-treatment ER/PR/Her-2/Ki67 expression levels could （AUC =0.830, 95% CI, 0.759-0.902, P〈0.001）. Conclusions： The combined use of pre-treatment ER/PgR/Her-2/Ki67 expression levels, instead of HR expression levels, may predict the cell cycle response to NET.

关键词： Breast cancer neoadjuvant endocrine therapy (NET) responsiveness predictive value