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Mechanism of interactions betweenα-conotoxin RegIIA and carbohydrates at the humanα3β4 nicotinic acetylcholine receptor

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Marine Life Science & Technology 2022年第1期4卷 98-105页

作者： Meiling Zheng Han-Shen Tae Liang Xue tao jiang Rilei Yu Molecular Synthesis Center&Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao266003China Innovation Platform of Marine Drug Screening&Evaluation Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266100China Illawarra Health and Medical Research Institute(IHMRI) University of WollongongWollongongNSW2522Australia Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266003China

Conotoxins are marine peptide toxins from marine cone snails.Theα-conotoxin RegIIA can selectively act on human(h)α3β4 nicotinic acetylcholine receptor(nAChR),and is an important lead for drug development.The high-resolution cryo-electron microscopy structure of theα3β4 nAChR demonstrates several carbohydrates are located near the orthosteric binding sites,which may affectα-conotoxin binding.Oligosaccharide chains can modify the physical and chemical properties of proteins by changing the conformation,hydrophobicity,quality and size of the protein.The purpose of this study is to explore the effect of oligosaccharide chains on the binding modes and activities of RegIIA and its derivatives at hα3β4 nAChRs.Through computational simulations,we designed and synthesized RegIIA mutants at position 14 to explore the importance of residue H14 to the activity of the peptide.Molecular dynamics simulations suggest that the oligosaccharide chains affect the binding of RegIIA at the hα3β4 nAChR through direct interactions with H14 and by affecting the C-loop conformation of the binding sites.Electrophysiology studies on H14 analogues suggest that in addition to forming direct interactions with the carbohydrates,the residue might play an important role in maintaining the conformation of the peptide.Overall,this study further clarifies the structure–activity relationship ofα-conotoxin RegIIA at the hα3β4 nAChR and,also provides important experimental and theoretical basis for the development of new peptide drugs.

关键词： Oligosaccharide chains nAChR Conotoxin Action mechanism

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Digital-to-analog converter free architecture for digital reconfigurable intelligent surface

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Frontiers of Information Technology & Electronic Engineering 2023年第12期24卷 1752-1762页

作者： Miaoran PENG Jinhao KAN Lixia XIAO Guanghua LIU tao jiang Research Center of 6G Mobile Communications Huazhong University of Science and TechnologyWuhan430074China School of Cyber Science and Engineering Huazhong University of Science and TechnologyWuhan430074China School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhan430074China

This research investigates the digital-to-analog converter(DAC)free architecture for the digital reconfigurable intelligent surface(RIS)system,where the transmission lines are implemented for reflection coefficient(RC)control to reduce power consumption.In the proposed architecture,the radio frequency(RF)switch based phase shifter is considered.By using a single-pole four-throw(SP4T)switch to simultaneously control the RCs of a group of elements,a 2-bit phase shifter is realized for passive beam steering.A novel modulation scheme is developed to explore the cost effectiveness,which approaches the performance of traditional quadrature amplitude modulation(QAM).Specifically,to overcome the limitation of the phase shift bits,joint frequency-shift and phase-rotation operations are applied to the constellation points.The simulation and experimental results demonstrate that the proposed architecture is capable of providing an ideal transmission performance.Moreover,64-and 256-QAM modulation schemes could be implemented by expanding the elements and phase bits.

关键词： Reconfigurable intelligent surface Hardware implementation High-order modulation

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Numerical Simulation and Experimental Verification of Laser Multi‑Section Welding

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Chinese Journal of Mechanical Engineering 2022年第6期35卷 219-233页

作者： Jia Liu tao jiang Yan Shi Hongyin Zhu Yuchi Dai School of Electromechanical Engineering Changchun University of Science and TechnologyChangchun 130022China Engineering Research Center of Laser Processing for Universities of Jilin Province Changchun 130022China National Base of International Science and Technology Cooperation in Optics Changchun 130022China

To address the problems of large welding deformation and splashing in the resistance spot welding of the lubricating oil cooler plate,the laser spot welding was employed,instead of the resistance spot welding,and a novel laser spot welding was proposed,i.e.,laser multi-section welding.The major processes involved in this study referred to a finite element model of pulsed laser lap welding built by adopting SYSWELD simulation software,as well as the laser welding of various welding methods.The effect of different welding methods on the welding quality was studied,the parameters of the average power and the duty cycle were optimized in line with the comparative analysis of the experimentally achieved results and the numerical simulation.As indicated from the experimentally achieved results,when the new 6-sections welding method was adopted,the resulting welded joint achieved the most uniform heat input and the largest welding fusion area,and the tensile properties exhibited by the welded joints were significantly enhanced,whereas some pores remained.By altering the duty cycle,pores could be eliminated to further improve the quality of the joint.The mentioned process method could tackle down the problems facing conventional resistance spot welding.Furthermore,it was capable of improving the uneven heat input of the laser spot welding.

关键词： Laser multi-section welding SYSWELD Finite element analysis Mechanical properties

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High-temperature CO_(2) sorbents with citrate and stearate intercalated Ca-Al hydrotalcite-like as precursor

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Chinese Journal of Chemical Engineering 2022年第10期50卷 177-184页

作者： tao jiang Fei Xiao Yujun Zhao Shengping Wang Xinbin Ma Key Laboratory for Green Chemical Technology School of Chemical Engineering and TechnologyCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin UniversityTianjin 300072China

CO_(2),one of the main components of greenhouse gases,increased rapidly because of the growing use of fossil fuels.And CaO sorbents possess the capability to be used in capture of CO_(2) at high temperature.In the work,Ca-Al complex oxides derived from citrate and stearate intercalated layered double hydroxides were fabricated and their CO_(2) adsorption capacity was compared with that from CO_(3)^(2-)intercalated layered double hydroxides.The results presented that the sorbents(Ca/Al=5)with Ca-Al-citrate layered double hydroxides as precursors performed best and displayed remarkable CO_(2) capture capacity of 52.0%(mass)at the carbonization temperature of 600℃without distinct recession during cycling adsorption/desorption tests.The excellent CO_(2) adsorption capacity of the sorbent was ascribed to its smaller crystallite size of calcinated particles,optimized pore size distribution as well as homogeneous distributed Ca and Al in the sorbent.

关键词： Layered doublehydroxides CO_(2)capture CaO-based Organic ions

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Fabricating biopolymer-inorganic hybrid microspheres for enzyme immobilization:Connect membrane emulsification with biomimetic mineralization

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Particuology 2022年第5期20卷 171-177页

作者： Jian Li Tiantian Feng Lin Han Min Zhang tao jiang College of Chemical Engineering and Materials Science Tianjin University of Science and TechnologyTianjin 300457China

The organic-inorganic hybrid composites displayed great potential for biotechnological and biomedical application.In this research,a gelatin/alginate/silica hybrid microsphere was developed by a synergy of membrane emulsification process and biomimetic mineralization method.The gelatin was mixed and complexed with alginate solutions(water phase).The water phase was extruded through a Shirasu Porous Glass(SPG)membrane,and then was crosslinked,which formed gelatin/alginate microspheres.The biomimetic mineralization was occurred in situ by immersing gelatin/alginate complex in a Na_(2)SiO_(3) solution,while silica was formed around the organic microspheres,resulting in the final gelatin/alginate/silica hybrid microspheres.These microspheres were characterized by SEM,TEM,EDS,TGA/DTA,and DSC.The hybrid microcapsules present a more than 40%mass fraction of the inorganic component,and displayed superior swelling resistance to biopolymer complex microspheres.Glycerol dehydrogenase(GlyDH)was immobilized in the obtained novel gelatin/alginate-silica hybrid microspheres as the model enzyme.Due to the protective effect of carriers,the pH tolerance stability,storage and recycling stability of the immobilized GlyDH were all improved in comparison with free GlyDH.

关键词： Membrane emulsification Immobilized enzyme Biomimetic mineralization Gelatin Alginate Microspheres

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Whole-Brain Connectome of GABAergic Neurons in the Mouse Zona Incerta

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Neuroscience Bulletin 2022年第11期38卷 1315-1329页

作者： Yang Yang tao jiang Xueyan Jia Jing Yuan Xiangning Li Hui Gong Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsMoE Key Laboratory for Biomedical PhotonicsHuazhong University of Science and TechnologyWuhan 430074China Research Unit of Multimodal Cross Scale Neural Signal Detection and Imaging Chinese Academy of Medical SciencesHUST-Suzhou Institute for BrainsmaticsJITRISuzhou 215123China

The zona incerta(ZI)is involved in various functions and may serve as an integrative node of the circuits for global behavioral modulation.However,the long-range connectivity of different sectors in the mouse ZI has not been comprehensively mapped.Here,we obtained whole-brain images of the input and output connections via fluorescence micro-optical sectioning tomography and viral tracing.The principal regions in the input-output circuits of ZI GABAergic neurons were topologically organized.The 3D distribution of cortical inputs showed rostro-caudal correspondence with different ZI sectors,while the projection fibers from ZI sectors were longitudinally organized in the superior colliculus.Clustering results show that the medial and lateral ZI are two different major functional compartments,and they can be further divided into more subdomains based on projection and input connectivity.This study provides a comprehensive anatomical foundation for understanding how the ZI is involved in integrating different information,conveying motivational states,and modulating global behaviors.

关键词： Zona incerta GABAergic neurons Whole-brain connectome Input circuit Output circuit Topological connection

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Alamouti code based on block repetition in FBMC/OQAM systems

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Digital Communications and Networks 2022年第1期8卷 58-63页

作者： Dejin Kong Xing Zheng Yukang Tian tao jiang Yue Zhang School of Electronic and Electrical Engineering Wuhan Textile UniversityWuhanChina State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhanChina Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanChina Department of Engineering University of LeicesterLeicesterLEI 7RHUK

In this paper,we address the Alamouti code in Filter-Bank Multicarrier with Offset Quadrature Amplitude Modulation(FBMC/OQAM)and propose a novel block-wise Alamouti code,in which a repeated block is designed to eliminate the imaginary interference among FBMC/OQAM symbols.The proposed approach exhibits a higher spectral efficiency than the conventional block-wise Alamouti scheme,as only one column of zero symbols is used as a guard interval instead of two.Furthermore,compared to the conventional scheme,the bit error ratio is improved in the proposed block-wise Alamouti,as the assumption on channel invariance at two adjacent sub-carriers is not required.Simulation results indicate that,with a significantly reduced overhead,the proposed Alamouti scheme achieves better performance over the conventional block-wise Alamouti scheme.

关键词： Alamouti Filter-bank multicarrier Block repetition Imaginary interference

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Role of the tumor microenvironment in shaping IDH-wildtype glioma plasticity,and potential therapeutic strategies

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Cancer Biology & Medicine 2022年第10期19卷 1423-1427页

作者： Lingxiang Wu Ruichao Chai Zheng Zhao Qianghu Wang tao jiang Department of Bioinformatics Nanjing Medical UniversityNanjing 211166China Institute for Brain Tumors Jiangsu Collaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing 211166China Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China Chinese Glioma Genome Atlas Network(CGGA) Beijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Diffuse glioma is the most common primary malignant brain tumor in adults.Currently,the prognosis of glioma remains dismal,and almost all patients with glioma experience recurrence even after comprehensive treatment including maximal surgical resection,radiotherapy,and/or chemotherapy1.Gliomas can be stratified according to their IDH mutation status.As we have previously reported2,3,the genetic characteristics,pathogenesis,and chemotherapy response are distinct between IDH-mutant and IDH-wildtype tumors.For instance,IDH-wildtype tumors are associated with poor prognosis and frequently have genomic alterations,including a gain of chromosome 7 and loss of chromosome 10.IDHmutant tumors often show findings including CpG island hypermethylation and MET alterations.

关键词： glioma chemotherapy IDH

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Evaluation of the diagnostic value of serum-based proteomics for colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1562-1573页

作者： Hui-Juan Wang Yi-Bin Xie Peng-Jun Zhang tao jiang Department of Respiratory and Critical Care Medicine Beijing Chao-Yang HospitalBeijing Institute of Respiratory MedicineCapital Medical UniversityBeijing 100020China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Interventional Therapy DepartmentPeking University Cancer Hospital and InstituteBeijing 100142China Medical Innovation Research Division of Chinese PLA General Hospital Beijing 100853China

BACKGROUND Colorectal cancer(CRC)is a highly malignant cancer with a high incidence and mortality in China.It is urgent to find a diagnostic marker with higher sensitivity and specificity than the traditional approaches for CRC diagnosis.AIM To provide new ideas for the diagnosis of CRC based on serum proteomics.METHODS Specimens from 83 healthy people,62 colon polyp(CRP)patients,and 101 CRC patients were analyzed by matrix-assisted laser desorption/ionization time-offlight mass spectrometry.The diagnostic value of the profiles of differentially expressed proteins was then analyzed.RESULTS Compared with the healthy control group,CRC patients had elevated expression of 5 proteins and reduced expression of 14 proteins.The area under the curve(AUC)for a differentially expressed protein with a mass-to-charge ratio of 2022.34 was the largest;the AUC was 0.843,which was higher than the AUC of 0.717 observed with carcinoembryonic antigen(CEA),and the sensitivity and specificity of this identified marker were 75.3%and 79.5%,respectively.After cross-validation,the accuracy of diagnosis using levels of this differentially expressed protein was 82.37%.Compared with the CRP group,the expression of 3 proteins in the serum of CRC patients was elevated and 11 proteins were expressed at reduced levels.Proteins possessing mass-to-charge ratio values of 2899.38 and 877.3 were selected to establish a classification tree model.The results showed that the accuracy of CRC diagnosis was 89.5%,the accuracy of CRP diagnosis was 81.6%,and the overall accuracy of this approach was 86.3%.The overall sensitivity and specificity of diagnosis using the proteomics approach were 81.8%and 66.75%,respectively.The sensitivities and specificities of diagnoses based on CEA and carbohydrate antigen 19-9 expression were 55.6%and 91.3%and 65.4%and 65.2%,respectively.CONCLUSION We demonstrated that serum proteomics may be helpful for the detection of CRC,and it may assist clinical practice for CRC diagnosis.

关键词： Colorectal cancer Colorectal polyps Serum Proteomics Diagnostic value

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Otolith microchemical evidence revealing multiple spawning site origination of the anadromous tapertail anchovy(Coilia nasus)in the Changjiang(Yangtze)River Estuary

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Acta Oceanologica Sinica 2023年第1期42卷 120-130页

作者： Zhongya Xuan tao jiang Hongbo Liu Xiubao Chen Jian Yang Wuxi Fisheries College Nanjing Agricultural UniversityWuxi214081China Key Laboratory of Fishery Ecological Environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River Freshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxi214081China

The estuarine tapertail anchovy(Coilia nasus)is a high-value commercial fish.Estimating the spawning site or hatchery origin and habitat is essential for its conservation.This study aimed to determine the habitat use and life history characteristics of C.nasus from the Changjiang River Estuary.We investigated the environmental signatures of strontium(Sr)and calcium(Ca)in the otoliths of the collected specimens using electron probe microanalysis;additionally,we examined their gonadal maturity stage.Our results indicate that the 31 adult C.nasus specimens used in this study could be classified into two types based on their otolith Sr:Ca concentration ratios and their gonadal maturity stage.The long freshwater early life history type(Type LF)had wider central region in the otolith with low Sr:Ca concentration ratios ranging from 1.24±0.62 to 1.92±0.78 and a bluish pattern of low Sr content level.These fish are of riverine origin and had a relatively long early life history in freshwater and low gonadal maturation when captured.The short freshwater early life history type(Type SF)had a shorter central region in the otolith with low Sr:Ca concentration ratios ranging from 1.35±0.5 to 2.82±0.97 and a correspondingly bluish pattern.These fish also had a relatively short-term early life history in freshwater and high gonadal maturation when captured.The results of the otolith microchemical analysis indicated that Type LF and Type SF originated in spawning/hatching sites far from and close to the estuary,respectively.The mature gonads of Type SF fish indicated that they may breed in areas close to the estuary,whereas the immature gonads of Type LF fish indicated that they may breed in areas far from the estuary.This study is the first to reveal that the Changjiang River Estuary contains stocks of anadromous C.nasus originating in different spawning sites during the same season.The estuarine habitat plays a critical role in the connectivity between freshwater recruitment and the marine resources available to adult spawners

关键词： Coilia nasus otolith migration connectivity spawning site

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