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ⅢA-ⅡB multicomponent perovskite rare earth ferrites with promising electromagnetic wave absorption properties

Journal of Rare Earths 2024年第6期42卷 1118-1127,I0005页

作者： Yanyan He tao Chen Yanyu Pan Minzhong huang Kaixian Wang Liyan Xue Yazhu Li Fengzhi Tan Fan Yang Tongkuan Xu Heng Chen School of Light Industry and Chemical Engineering Dalian Polytechnic UniversityDalian116034China Xiamen Institute of Rare EarthMaterials Haixi InstitutesChinese Academy of SciencesXiamen36021China Fujian Institute of Research on the Structure of Matter Chinese Academyof SciencesFuzhou350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China Xiamen Key-Laboratoryof Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen361021China Key Laboratory of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou3410ooChina

Perovskite-type rare-earth ferrites(REFeO_(3))are promising materials for absorbing electromagnetic(EM)wave pollution.However,insufficient dielectric loss and poor impedance matching are key factors that limit the broader implementation of REFeO_(3).Herein,a series of multicomponent perovskite-type ferrites with strong EM wave absorption capabilities was prepared.Through the synergistic effect of chemical constitution regulation and entropy regulation,optimization of the dielectric loss and impedance matching is achieved by strengthening the structural defect mechanism,thus further adjusting the EM wave absorption performance.Compared with(LaGdSmNdBa)FeO_(3)(HE-1)and(LaGdPrSmNdBa)FeO_(3)(HE-2),(LaGdBa)FeO_(3)(ME-1)and(LaGdSmBa)FeO_(3)(ME-2)exhibit favorable performance,with optimal minimum reflection loss(RL_(min))of-56.35 dB(at 11.12 GHz)and-63.25 dB(at 7.22 GHz)and effective absorption bandwidth(EAB)of 4.46 and 4.72 GHz,respectively.This multicomponent design provides a new strategy for the development of EM wave absorption materials.

关键词： Rare earths Multicomponent design Rare earth ferrites Entropy regulation Electromagnetic wave absorption

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China's Rural Industrialization and Agricultural Mechanization

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China & World Economy 2023年第3期31卷 27-58页

作者： Xin Ma tao huang Guanghua School of Management Peking UniversityChina.

Rural industrialization provides nonfarm employment opportunities and financial support for farmers and may be a non-negligible cause of agricultural mechanization in China.However,there is a lack of empirical studies on this topic due to challenges in obtaining data and identifying causal relationships.In this paper,we use multiple data sources and construct an instrumental variable based on the number of handicraft production cooperatives in 1957 to test empirically the causal effect of rural industrialization on agricultural mechanization.The results show that rural industrialization contributes significantly and robustly to agricultural mechanization.A 10 percent increase in the average number of industrial enterprises per township was associated with a 1.05 percent increase in the agricultural machinery power per unit area of arable land.Both the demand effect and income effect played crucial roles in the interaction between these two phenomena.

关键词： agricultural mechanization handicraft production cooperatives rural industrialization township industrial enterprises

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Source apportionment of polycyclic aromatic hydrocarbons(PAHs) in a sediment core from Lake Dagze Co, Tibetan Plateau, China: Comparison of three receptor models

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Journal of Environmental Sciences 2022年第11期34卷 224-233页

作者： Yixin Bai Kunlin Shi Heyu Yu Nana Shang Weiyue Hao Chuan Wang tao huang Hao Yang Changchun huang School of Geography Nanjing Normal UniversityNanjing 210023China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing Normal UniversityNanjing 210023China Key Laboratory of Virtual Geographic Environment(Nanjing Normal University) Ministry of EducationNanjing 210023China State Key Laboratory Cultivation Base of Geographical Environment Evolution(Jiangsu Province) Nanjing 210023China

Receptor models are a useful tool for identifying sources of polycyclic aromatic hydrocarbons(PAHs) in multiple environmental media. In this study, three different receptor models(including the principal component analysis-multiple linear regression(PCA-MLR), positive matrix factorization(PMF), and Unmix models) were used to apportion the sources of 16 priority PAHs in a sediment core of Lake Dagze Co. The ΣPAHs(sum of all 16 measured PAHs) concentrations ranged from 51.89 to 132.82 ng/g with an average of 80.39 ng/g. TheΣ PAHs were dominated by 2-3 ring PAHs, accounting for 80.12% on average, thereby indicating that they mainly originated from biomass and coal combustion and/or from long-range atmospheric transportation. The three models produced consistent source apportionment results. The greatest contributor to ΣPAHs was biomass combustion, followed by coal combustion, vehicle emissions, and petrogenic sources. Moreover, the temporal variation of the common sources was well-correlated among models. The multi-method comparison and evaluation results showed that all three models were useful tools for source apportionment of PAHs, with the PMF model providing better results than the PCA-MLR and Unmix models. The temporal trends of factor contributions were verified by PAHs with different ring numbers. Significant correlations were found between the simulated concentrations of each source factor and the PAHs with different ring numbers(P0.05). This study can provide useful information for further investigation of source apportionment of PAHs in the sediment cores.

关键词： Polycyclic aromatic hydrocarbons(PAHs) Source apportionment Receptor models Sediment core Tibetan Plateau

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Coordination of networking and computing: toward new information infrastructure and new services mode

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Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 629-632页

作者： Xiaoyun WANG tao SUN Yong CUI Rajkumar BUYYA Deke GUO Qun huang Hassnaa MOUSTAFA Chen TIAN Shangguang WANG China Mobile Communications Corporation Beijing 100032China China Mobile Research Institute Beijing 100053China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China CLOUDS Lab School of Computing and Information SystemsUniversity of MelbourneMelbourneVIC 3010Australia National Key Laboratory of Information Systems Engineering National University of Defense TechnologyChangsha 410073China School of Computer Science Peking UniversityBeijing 100871China Intel Corporation Santa ClaraCA 95054USA State Key Laboratory for Novel Sofiware Technology Nanjing UniversityNanjing 210023China State Key Laboratory of Networking and Switching Technology Bejing University of Posts and TelecommunicationsBeijing 100876China

Computing,serving as the cornerstone of information processing,plays a pivotal role in the digital service era.The"network"and"computing,"responsible for information transmission and processing respectively,traditionally belong to different stakeholders and have evolved separately.However,the recent trend toward the coordination and integration of computing and networks has garnered significant attention from both industry and academia.Concepts such as"computility network"and"computing force network"have emerged,and the International Telecommunication Union-Telecommunication Standardization(ITU-T)has initiated efforts to develop standards for the coordination of networking and computing(CNC),focusing on the architecture and framework.

关键词： computing services network

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Pig H3K4me3,H3K27ac,and gene expression profiles reveal reproductive tissue-specific activity of transposable elements

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Zoological Research 2024年第1期45卷 138-151页

作者： tao Jiang Zhi-Min Zhou Zi-Qi Ling Qing Zhang Zhong-Zi Wu Jia-Wen Yang Si-Yu Yang Bin Yang Lu-Sheng huang National Key Laboratory of Pig Genetic Improvement and Germplasm Innovation Jiangxi Agricultural UniversityNanchangJiangxi 330045China

Regulatory sequences and transposable elements(TEs)account for a large proportion of the genomic sequences of species;however,their roles in gene transcription,especially tissue-specific expression,remain largely unknown.Pigs serve as an excellent animal model for studying genomic sequence biology due to the extensive diversity among their wild and domesticated populations.Here,we conducted an integrated analysis using H3K27ac ChIP-seq,H3K4me3 ChIP-seq,and RNA-seq data from 10 different tissues of seven fetuses and eight closely related adult pigs.We aimed to annotate the regulatory elements and TEs to elucidate their associations with histone modifications and mRNA expression across different tissues and developmental stages.Based on correlation analysis between mRNA expression and H3K27ac and H3K4me3 peak activity,results indicated that H3K27ac exhibited stronger associations with gene expression than H3K4me3.Furthermore,1.45%of TEs overlapped with either the H3K27ac or H3K4me3 peaks,with the majority displaying tissue-specific activity.Notably,a TE subfamily(LTR4C_SS),containing binding motifs for SIX1 and SIX4,showed specific enrichment in the H3K27ac peaks of the adult and fetal ovaries.RNA-seq analysis also revealed widespread expression of TEs in the exons or promoters of genes,including 4688 TE-containing transcripts with distinct development stage-specific and tissue-specific expression.Of note,1967 TE-containing transcripts were enriched in the testes.We identified a long terminal repeat(LTR),MLT1F1,acting as a testis-specific alternative promoter in SRPK2(a cell cycle-related protein kinase)in our pig dataset.This element was also conserved in humans and mice,suggesting either an ancient integration of TEs in genes specifically expressed in the testes or parallel evolutionary patterns.Collectively,our findings demonstrate that TEs are deeply embedded in the genome and exhibit important tissue-specific biological functions,particularly in the reproductive organs.

关键词： Transposable elements Porcine Histone modification Alternative promoter TE-containing transcript

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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu huang Qiuyu Pang Lexin Zheng Jiaxi Lin Hanxi Li Lingbo Wan tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and myelination.Cholesterol plays a key role in the establishment and maintenance of the central nervous system.The brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and efflux.Certain brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental consequences.Therefore,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system diseases.Intracerebral hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and morbidity.Historical cholesterol levels are associated with the risk of intracerebral hemorrhage.Moreover,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell death.Intracellular cholesterol accumulation in the brain has been found after intracerebral hemorrhage.In this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell death.We also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

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Evaluation of the safety and efficiency of cytotoxic T cell therapy sensitized by tumor antigens original from T-ALL-iPSC in vivo

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Cancer Innovation 2024年第1期3卷 50-60页

作者： Weiran Li Meiling Zhou Lu Wang Liying huang Xuemei Chen Xizhuo Sun tao Liu Department of Tumor Immunotherapy Shenzhen Luohu People's HospitalThe Third Affiliated Hospital of Shenzhen UniversityShenzhenGuangdongChina Cell Quality Testing Laboratory of Shenzhen Luohu Hospital Group ShenzhenGuangdongChina

Background:Since RNA sequencing has shown that induced pluripotent stem cells(iPSCs)share a common antigen profile with tumor cells,cancer vaccines that focus on iPSCs have made promising progress in recent years.Previously,we showed that iPSCs derived from leukemic cells of patients with primary T cell acute lymphoblastic leukemia(T-ALL)have a gene expression profile similar to that of T-ALL cell lines.Methods:Mice with T-ALL were treated with dendritic and T(DC-T)cells loaded with intact and complete antigens from T-ALL-derived iPSCs(T-ALL-iPSCs).We evaluated the safety and antitumor efficiency of autologous tumor-derived iPSC antigens by flow cytometry,cytokine release assay,acute toxicity experiments,long-term toxicity experiments,and other methods.Results:Our results indicate that complete tumor antigens from T-ALL-iPSCs could inhibit the growth of inoculated tumors in immunocompromised mice without causing acute and long-term toxicity.Conclusion:T-ALL-iPSC-based treatment is safe and can be used as a potential strategy for leukemia immunotherapy.

关键词： adoptive cell therapy drug safety evaluation IPSCs T-ALL

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Evaluation of genetic response of mesenchymal stem cells to nanosecond pulsed electric fields by whole transcriptome sequencing

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World Journal of Stem Cells 2024年第3期16卷 305-323页

作者： Jian-Jing Lin Tong Ning Shi-Cheng Jia Ke-Jia Li Yong-Can huang Qiang Liu Jian-Hao Lin Xin-tao Zhang Department of Sports Medicine and Rehabilitation Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Institute of Medical Science The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina Department of Biomedical Engineering Institute of Future TechnologyPeking UniversityBeijing 100871China Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijing 100044China

BACKGROUND Mesenchymal stem cells(MSCs)modulated by various exogenous signals have been applied extensively in regenerative medicine research.Notably,nanosecond pulsed electric fields(nsPEFs),characterized by short duration and high strength,significantly influence cell phenotypes and regulate MSCs differentiation via multiple pathways.Consequently,we used transcriptomics to study changes in messenger RNA(mRNA),long noncoding RNA(lncRNA),microRNA(miRNA),and circular RNA expression during nsPEFs application.AIM To explore gene expression profiles and potential transcriptional regulatory mechanisms in MSCs pretreated with nsPEFs.METHODS The impact of nsPEFs on the MSCs transcriptome was investigated through whole transcriptome sequencing.MSCs were pretreated with 5-pulse nsPEFs(100 ns at 10 kV/cm,1 Hz),followed by total RNA isolation.Each transcript was normalized by fragments per kilobase per million.Fold change and difference significance were applied to screen the differentially expressed genes(DEGs).Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to elucidate gene functions,complemented by quantitative polymerase chain reaction verification.RESULTS In total,263 DEGs were discovered,with 92 upregulated and 171 downregulated.DEGs were predominantly enriched in epithelial cell proliferation,osteoblast differentiation,mesenchymal cell differentiation,nuclear division,and wound healing.Regarding cellular components,DEGs are primarily involved in condensed chromosome,chromosomal region,actin cytoskeleton,and kinetochore.From aspect of molecular functions,DEGs are mainly involved in glycosaminoglycan binding,integrin binding,nuclear steroid receptor activity,cytoskeletal motor activity,and steroid binding.Quantitative real-time polymerase chain reaction confirmed targeted transcript regulation.CONCLUSION Our systematic investigation of the wide-ranging transcriptional pattern modulated by nsPEFs revealed the differential expression of 263 mRNAs,2 miRNAs,and 65 lncRNAs.Our study demons

关键词： Nanosecond pulsed electric fields Whole transcriptome sequencing Mesenchymal stem cells Genetic response Stem cell engineering

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Overexpression of Hepcidin Alleviates Steatohepatitis and Fibrosis in a Diet-induced Nonalcoholic Steatohepatitis

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 577-588页

作者： Hui Chen Wenshan Zhao Xuzhen Yan tao huang Aiting Yang Digestive Department Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Experimental and Transla-tional Research Center Beijing Friendship HospitalCapital Medical UniversityBeijingChina National Clinical Research Center of Digestive Diseases BeijingChina Beijing Clinical Medicine Institute BeijingChina

Background and Aims:Iron overload can contribute to the progression of nonalcoholic fatty liver disease(NAFLD)to nonalcoholic steatohepatitis(NASH).Hepcidin(Hamp),which is primarily synthesized in hepatocytes,is a key reg-ulator of iron metabolism.However,the role of Hamp in NASH remains unclear.Therefore,we aimed to elucidate the role of Hamp in the pathophysiology of NASH.Methods:Male mice were fed a choline-deficient L-amino acid-defined(CDAA)diet for 16 weeks to establish the mouse NASH model.A choline-supplemented amino acid-defined(CSAA)diet was used as the control diet.Recombinant adeno-asso-ciated virus genome 2 serotype 8 vector expressing Hamp(rAAV2/8-Hamp)or its negative control(rAAV2/8-NC)was administered intravenously at week 8 of either the CDAA or CSAA diet.Results:rAAV2/8-Hamp treatment markedly decreased liver weight and improved hepatic steatosis in the CDAA-fed mice,accompanied by changes in lipogenesis-related genes and adiponectin expression.Compared with the control group,rAAV2/8-Hamp therapy attenuated liver damage,with mice exhibiting reduced histological NAFLD inflammation and fibrosis,as well as lower levels of liver enzymes.Moreover,α-smooth muscle actin-positive acti-vated hepatic stellate cells(HSCs)and CD68-postive mac-rophages increased in number in the CDAA-fed mice,which was reversed by rAAV2/8-Hamp treatment.Consistent with the in vivo findings,overexpression of Hamp increased adi-ponectin expression in hepatocytes and Hamp treatment inhibited HSC activation.Conclusions:Overexpression of Hamp using rAAV2/8-Hamp robustly attenuated liver stea-tohepatitis,inflammation,and fibrosis in an animal model of NASH,suggesting a potential therapeutic role for Hamp.

关键词： Liver fibrosis Hepatic stellate cell Hepcidin NASH CDAA

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Impacts of COVID-19 Pandemic on Italian Electricity Demand and Markets

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CSEE Journal of Power and Energy Systems 2023年第2期9卷 824-827页

作者： Mahmood Hosseini Imani Ettore Bompard Pietro Colella tao huang Politecnico di Torino Dipartimento EnergiaTurin10129Italy

In this paper,the short-,medium-,and long-term effects of the COVID-19 pandemic on the Italian power system,particularly electricity consumption behavior and electricity market prices,are investigated by defining various metrics.The investigation reveals that COVID-19 lockdown caused a drop in load consumption and,consequently,a decrement in day-ahead market prices and an increase in ancillary service prices.

关键词： Ancillary service market price COVID-19 day-ahead market price Italian electricity markets load consumption

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