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Clinical features, treatment strategies and outcomes of craniocervical junction arteriovenous fistulas: a cohort study of 193 patients

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Stroke & Vascular Neurology 2024年第1期9卷 18-29页

作者： Yongjie Ma Zihao Song Yinqing Wang Jiachen Wang Chuan He Guilin Li Peng Zhang tao hong Liyong Sun Peng Hu Ming Ye hongqi Zhang Department of Neurosurgery Xuanwu Hospital Capital Medical University

Background Craniocervical junction(CCJ)arteriovenous fistulas(AVFs)are *** current treatment strategies for AVFs with different angioarchitecture need to be *** present study aimed to analyse the correlation between angioarchitecture and clinical characteristics,share our experience in treating this disease and identify risk factors associated with subarachnoid haemorrhage(SAH)and poor *** A total of 198 consecutive patients with CCJ AVFs from our neurosurgical centre were retrospectively *** patients were grouped according to their clinical manifestations,and their baseline clinical characteristics,angioarchitecture,treatment strategies and outcomes were *** The patients’median age was 56 years(IQR 47–62 years).The majority of patients were men with 166(83.8%)*** most common clinical manifestation was SAH(52.0%),followed by venous hypertensive myelopathy(VHM)(45.5%).The most common CCJ AVFs type was dural AVF,with 132(63.5%)*** most frequent fistula location was C-1(68.7%)and dural branch of vertebral artery(70.2%)was the most involved arterial feeders for *** most common direction of venous drainage was descending intradural drainage(40.9%),followed by ascending intradural drainage(36.5%).Microsurgery was the most common treatment strategy applied for 151(76.3%)patients,15(7.6%)patients were treated with interventional embolisation only,and 27(13.6%)received both interventional embolisation and microsurgical *** learning curve for microsurgery only was analysed by cumulative summation method,and the turning point was the 70th case,and blood loss in post-group was lower than that in pre-group(p=0.034).At the last follow-up,there were 155(78.3%)patients with favourable outcomes(modified Rankin Scale(mRS)<3).Age≥56(OR 2.038,95%CI 1.039 to 3.998,p=0.038),VHM as the clinical manifestation(OR 4.102,95%CI 2.108 to 7.982,p<0.001)and pretreatment mRS≥3(OR 3.127,95%CI 1.617 to 6.047,p<0

关键词： patients treatment hypertensive

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The Uptake and Distribution Evidence of Nano-and Microplastics in vivo after a Single High Dose of Oral Exposure

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Biomedical and Environmental Sciences 2024年第1期37卷 31-41页

作者： hong tao SUN Wei DENG Yuan LYU Jian Da JIN Cui hong BAI Ying Long NA Jun ZHANG Rui GAO Yuan PAN Guo Wei YANG Zuo Sen YAN Ling Jun Research Center for Universal Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Pain Management Shengjing Hospital of China Medical UniversityShenyang 110004LiaoningChina Department of Toxicology School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Maternal and Child Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Institute of Preventive Medicine China Medical UniversityShenyang 110122LiaoningChina Institute of Chronic Diseases Liaoning Provincial Center for Disease Control and PreventionShenyang 110000LiaoningChina

Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in *** Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after *** was performed to corroborate these *** In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(P<0.05).In the 3μm group,the FI only increased in the lung at 2 h(P<0.05).In the 10μm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(P<0.05).The presence of nano-/microplastics in tissues was further verified by *** peak time of nanoplastic absorption in blood was *** Nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs.

关键词： Microplastics Nanoplastics IVIS Spectrum small-animal imaging system Tissue distribution Blood

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"Five steps four quadrants" modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in laparoscopic pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 503-510页

作者： Xiao-Si Hu Yong Wang hong-tao Pan Chao Zhu Shi-Lei Chen Hui-Chun Liu Qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People’s HospitalHefei 230041Anhui ProvinceChina

BACKGROUND Although en bloc dissection of hepatic hilum lymph nodes has many advantages in radical tumor treatment,the feasibility and safety of this approach for laparo-scopic pancreaticoduodenectomy(LPD)require further clinical evaluation and *** To explore the application value of the"five steps four quadrants"modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in LPD *** A total of 52 patients who underwent LPD via the"five steps four quadrants"modularized en bloc dissection technique for hepatic hilum lymph nodes from April 2021 to July 2023 in our department were analyzed *** patients'body mass index(BMI),preoperative laboratory indices,intraoperative variables and postoperative complications were *** relationships between preoperative data and intraoperative lymph node dissection time and blood loss were also *** Among the 52 patients,36 were males and 16 were females,and the average age was 62.2±11.0 *** were 26 patients with pancreatic head cancer,16 patients with periampullary cancer,and 10 patients with distal bile duct *** BMI was 22.3±3.3 kg/m²,and the median total bilirubin(TBIL)concentration was 57.7(16.0-155.7)µmol/*** patients successfully underwent the"five steps four quadrants"modularized en bloc dissection technique without lymph node clearance-related complications such as postoperative bleeding or lymphatic *** analysis revealed significant associations between preoperative BMI(r=0.3581,P=0.0091),TBIL level(r=0.2988,P=0.0341),prothrombin time(r=0.3018,P=0.0297)and lymph node dissection ***,dissection time was significantly correlated with intraoperative blood loss(r=0.7744,P<0.0001).Further stratified analysis demonstrated that patients with a preoperative BMI≥21.9 kg/m²and a TIBL concentration≥57.7μmol/L had significantly longer lymph node dissection times(both P<0.05).CONCLUSION The"five steps four quadrants

关键词： Five steps four quadrants Hepatic hilum lymph node Modularized en bloc clearance Laparoscopic pancreaticoduodenectomy

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Tourmaline geochemistry as genetic evolution and metallogenic potential indicators of pegmatites: a case study from the Tugeman Be-Li deposit， Middle Altun

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Journal of Earth Science 2024年

作者： Hang Li Xingwang Xu tao hong Qiang Ke Yince Ma Kai Kang Zhiquan Yang Changsheng Guo College of Architecture and Civil Engineering Sanming University Key Laboratory of Mineral Resources Institute of Geology and Geophysics Chinese Academy of Sciences University of Chinese Academy of Sciences Innovation Academy for Earth Science Chinese Academy of Sciences Guangdong Provincial Key Lab of Geodynamics and Geohazards School of Earth Sciences and Engineering Sun Yat-Sen University Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) No.3 Geological Party Xinjiang Bureau of Geology and Mineral Exploration and Development

Tourmaline is a common borosilicate mineral in granite and pegmatite， and it is also an important carrier to record the physicochemical evolution information of magmas. However， the genetic relationship between pegmatite-type rare metal mineralization potential and tourmaline-bearing pegmatites is not clear， and the tourmaline geochemical indication of the mineralization type of rare metals needs to be supplemented. In the middle Altun region， extensive tourmaline-bearing pegmatite dykes are prevalent within and surrounding the Tugeman complex. In this paper， the petrology and geochemical characteristics of tourmaline within the pegmatite of the Tugeman Be-Li deposit have been comprehensively analyzed. The research delves into the genetic evolution and metallogenic potential of the pegmatite， emphasizing the indicative role of tourmaline geochemistry in discerning mineralization types in the Tugeman Be-Li deposit. Major and trace element analysis of tourmaline reveals varying contents of FeO （9.37 wt.%–17.10 wt.%）， Al2O3（28.64 wt.%–35.22% wt.%）， and MgO （0.13 wt.%–2.47 wt.%） in the Tugeman Be–Li pegmatite. Li， Zn， and Sn contents range from 204 ppm to 1 590 ppm， 1 143 ppm to 4 089 ppm， and 74 ppm to 396 ppm， respectively. The tourmaline analyzed in this study is magmatic origin and belongs to schorl series， exhibits substitution relationships， including (Na， Fe2+)(X□， Al)-1， (Fe2+， Fe3+)（Mg， Al）-1， (Al，X□)(R2+， Na)-1，（Na， Mg）(X□， Al)-1andX□NaR2+-1. The trace element data of tourmaline show that lithium has four enrichment stages in different mineral crystallization phases. Notably， the tendency of tourmaline in the Tugeman Be-Li pegmatite to evolve towards elbaite implies a magmatic evolution sequence from low to high， transitioning through microcline-albite pegmatite， muscovite-microcline-albite pegmatite， albite pegmatite， and microcline pegmatite. Furthermore， we also propose that the Sc content in schorl can serve as an indicator of pegmatite mineralization typ

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Design to enhance sensing performance of ZIF-8 crystals

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Progress in Natural Science:Materials International 2024年第2期 240-250页

作者： Ya-Ru Li Xiuxiu Dong Shu-Yi Pan Lin Luo hong-tao Lei Zhen-Lin Xu Guangdong Provincial Key Laboratory of Food Quality and Safety College of Food Science South China Agricultural University Key Laboratory of Modern Agricultural Equipment and Technology (Jiangsu University) Ministry of Education School of Agricultural Engineering Jiangsu University

Metal-organic frameworks（MOFs） are a large class of crystalline porous materials that composed of organic ligands and metal ions,of which zeolitic imidazolate frameworks（ZIFs） are a broad *** most wellknown ZIF-like material is ZIF-8 crystals,which have been the subject of extensive research for ***-8 crystals have been synthesized under various conditions for application in the fields of sensing,drug delivery,and *** paper provides a brief introduction to the preparation methods,formation processes,and formation mechanisms of ZIF-8 crystals in different media,and then explains the effects of different precursor conditions(type of Zn2+,ratio of raw materials,and type of solvent) on ZIF-8 crystals in terms of formation ***,current reports on the application of ZIF-8-based chemiresistive gas sensors,electrochemical,fluorescent and colorimetric sensors are also ***,ZIF-8 crystals with good catalytic properties will be obtained based on rational design for promoting the application in different fields of the sensors.

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Sinomenine increases osteogenesis in mice with ovariectomyinduced bone loss by modulating autophagy

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World Journal of Stem Cells 2024年第5期16卷 486-498页

作者： Hai-Xiang Xiao Lei Yu Yu Xia Kai Chen Wen-Ming Li Gao-Ran Ge Wei Zhang Qing Zhang hong-tao Zhang De-Chun Geng Department of Orthopedics The Fourth Affiliated Hospital of Soochow UniversitySuzhou Dushu Lake HospitalMedical Centre of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Orthopedics Jingjiang People’s Hospital Affiliated to Yangzhou UniversityJingjiang 214500Jiangsu ProvinceChina Department of Orthopedics The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Orthopedics Hai’an People’s HospitalHai’an 226600Jiangsu ProvinceChina Department of Orthopedics The Affiliated Huai’an Hospital of Xuzhou Medical UniversityHuai’an Second People’s HospitalXuzhou 223002Jiangsu ProvinceChina Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND A decreased autophagic capacity of bone marrow mesenchymal stromal cells(BMSCs)has been suggested to be an important cause of decreased osteogenic differentiation.A pharmacological increase in autophagy of BMSCs is a potential therapeutic option to increase osteoblast viability and ameliorate *** To explore the effects of sinomenine(SIN)on the osteogenic differentiation of BMSCs and the underlying *** For in vitro experiments,BMSCs were extracted from sham-treated mice and ovariectomized mice,and the levels of autophagy markers and osteogenic differentiation were examined after treatment with the appropriate concen-trations of SIN and the autophagy inhibitor *** vivo,the therapeutic effect of SIN was verified by establishing an ovariectomy-induced mouse model and by morphological and histological assays of the mouse *** SIN reduced the levels of AKT and mammalian target of the rapamycin(mTOR)phosphorylation in the phosphatidylinositol 3-kinase(PI3K)/AKT/mTOR signaling pathway,inhibited mTOR activity,and increased autophagy ability of BMSCs,thereby promoting the osteogenic differentiation of BMSCs and effectively alleviating bone loss in ovariectomized mice in *** The Chinese medicine SIN has potential for the treatment of various types of osteoporosis,bone homeostasis disorders,and autophagy-related diseases.

关键词： Sinomenine Osteogenesis Autophagy Ovariectomy Osteoporosis

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“Hepatic hilum area priority,liver posterior first”:An optimized strategy in laparoscopic resection for type Ⅲ-Ⅳ hilar cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2167-2174页

作者： Xiao-Si Hu Yong Wang hong-tao Pan Chao Zhu Shi-Lei Chen Shuai Zhou Hui-Chun Liu Qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People's HospitalHefei 230041Anhui ProvinceChina

BACKGROUND In recent years,pure laparoscopic radical surgery for Bismuth-Corlette type Ⅲ and Ⅳ hilar cholangiocarcinoma(HCCA)has been preliminarily explored and applied,but the surgical strategy and safety are still worthy of further improvement and *** To summarize and share the application experience of the emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”in pure laparoscopic radical resection for patients with HCCA of Bismuth-Corlette types Ⅲ and *** The clinical data and surgical videos of 6 patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ who underwent pure laparoscopic radical resection in our department from December 2021 to December 2023 were retrospectively *** Among the 6 patients,4 were males and 2 were *** average age was 62.2±11.0 years,and the median body mass index was 20.7(19.2-24.1)kg/m^(2).The preoperative median total bilirubin was 57.7(16.0-155.7)μmol/*** patient had Bismuth-Corlette type Ⅲa,4 patients had Bismuth-Corlette type Ⅲb,and 1 patient had Bismuth-Corlette type Ⅳ.All patients successfully underwent pure laparoscopic radical resection following the strategy of“hepatic hilum area dissection priority,liver posterior separation first”.The operation time was 358.3±85.0 minutes,and the intraoperative blood loss volume was 195.0±108.4 *** of the patients received blood transfusions during the perioperative *** median length of stay was 8.3(7.0-10.0)*** bile leakage occurred in 2 patients,and all patients were discharged without serious surgery-related *** The emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”is safe and feasible in pure laparoscopic radical surgery for patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ.This strategy is helpful for promoting the modularization and process of pure laparoscopic radical surgery for complicated HCCA,shortens the learning curve,and

关键词： Hilar cholangiocarcinoma Bismuth-Corlette types Ⅲ and Ⅳ Laparoscopy Radical resection Strategy

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问题与新解:刑事电子数据的最佳证据规则--基于486份裁判文书的实证分析

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交大法学 2024年第4期 146-159页

作者：洪涛浙江大学光华法学院

由于电子数据具有虚拟性、可复制性、相对独立性等特点,传统最佳证据规则难以顺畅适用。通过对486份裁判文书的实证分析,可发现刑事司法实践中主要以扣押、封存原始存储介质来满足最佳证据规则。但该做法不仅与电子数据特性相冲突,还会... 详细信息

由于电子数据具有虚拟性、可复制性、相对独立性等特点,传统最佳证据规则难以顺畅适用。通过对486份裁判文书的实证分析,可发现刑事司法实践中主要以扣押、封存原始存储介质来满足最佳证据规则。但该做法不仅与电子数据特性相冲突,还会造成诉讼活动的障碍,从长远来看,也背离数据司法的趋势。证据材料说和原件规则是造成电子数据最佳规则适用现状的根本缘由。学界提出的拟制原件说、置换原件说等不同观点,可划归为优化原件规则和重新解读最佳证据规则两条路径。鉴于最佳证据的概念可塑性强,故有必要重新解读该规则,但应辅以“电子数据信息完整”的新标准。新标准下具备原始性和完整性的电子数据即为最佳证据,审查时可采用比对完整性校验值、区块链存证等方法,而扣押、封存原始存储介质仅是诸多方法之一,具体如何选择应由司法人员结合“成本、准确性、效率”标准确定。

关键词：电子数据最佳证据规则信息完整原始存储介质

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烦恼障:《红楼梦》的儒佛冲突、翻译难关和跨文化解读

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红楼梦学刊 2024年第2期 49-80页

作者：洪涛香港中文大学新亚书院

《红楼梦》多次写人物情绪激动,行为决绝,贾政、柳湘莲和金鸳鸯的故事中都有断发情节。古人不轻言落发,这是汉文化中的孝道使然(儒家)。《红楼梦》中“烦恼丝”和“烦恼鬓毛”等说法缘自佛教观念,剃去“烦恼丝”有特定的象征意义。这类... 详细信息

《红楼梦》多次写人物情绪激动,行为决绝,贾政、柳湘莲和金鸳鸯的故事中都有断发情节。古人不轻言落发,这是汉文化中的孝道使然(儒家)。《红楼梦》中“烦恼丝”和“烦恼鬓毛”等说法缘自佛教观念,剃去“烦恼丝”有特定的象征意义。这类跨文化解读的难点,令一些国外学者(尤其翻译家)应对失措。贾宝玉的心灵发展历程与最终结局也值得思考。我们还将探讨个别译者面对文化难题时怎样避重就轻,西方学者为达到跨文化解读的效果使用了什么策略。

关键词：跨文化佛教儒家孝道翻译策略合理化

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应对“两个温差”调整新周期消费政策的思考

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河北经贸大学学报 2024年第3期45卷 31-40页

作者：洪涛北京工商大学商业经济研究所北京100048

2023年中国进入消费全面恢复的一年,大多数消费指标超过了2019年,中国经济进入新的消费经济周期,消费进入常态化阶段。但当前我们正面临“两个温差”:一是宏观经济形势“温和”,但有些人感到“偏寒”;二是全国消费“回暖”,但有些人仍... 详细信息

2023年中国进入消费全面恢复的一年,大多数消费指标超过了2019年,中国经济进入新的消费经济周期,消费进入常态化阶段。但当前我们正面临“两个温差”:一是宏观经济形势“温和”,但有些人感到“偏寒”;二是全国消费“回暖”,但有些人仍感到消费“偏冷”。为此,应加大对经济形势和消费形势的科学和客观宣传,应坚持“消费对经济发展的基础性作用”政策思路,将政府在疫情期间刺激经济和消费的政策回归为常态化的经济政策,从而保持我国经济和消费的可持续发展。

关键词：消费经济周期扩大消费两个温差消费常态化新周期消费政策

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