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Catalyzing Singlet Fission by Transition Metals:Second versus Third Row Effects

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Precision Chemistry 2023年第9期1卷 555-564页

作者： Yuxuan Hou Ilias Papadopoulos Yifan Bo Anna-Sophie Wollny Michael j.ferguson Lukas A.Mai Rik R.Tykwinski Dirk M.Guldi Department of Chemistry University of AlbertaEdmontonAlberta T6G 2G2Canada Department of Chemistry and Pharmacy&Interdisciplinary Center for Molecular Materials(ICMM) Friedrich-Alexander-University Erlangen-Nuremberg91058 ErlangenGermany Department of Applied Chemistry Graduate School of EngineeringCenter for Molecular Systems(CMS)Kyushu University744 Moto-okaNishi-kuFukuoka 819-0395Japan

The synthesis and characterization of platinum(II)and palladium(II)complexes bearing two(dimers Pt(L_(pc))_(2)Cl_(2)and Pd(L_(pc))_(2)Cl_(2)),one(monomers Pt(L_(pc))(L_(ref))Cl_(2)and Pd(L_(pc))(L_(ref))-Cl_(2)),or no(reference compounds Pt(L_(ref))_(2)Cl_(2)and Pd(L_(ref))_(2)Cl_(2))pentacene-based pyridyl ligands are *** properties of the dimers are probed by means of steady-state and time-resolved transient absorption measurements in compar-ison to the monomer and model *** results document that despite enhanced spin−orbit coupling from the presence of heavy atoms,intramolecular singlet fission(iSF)is not challenged by intersystem *** thus yields correlated triplet pairs and even uncorrelated triplet excited states upon ***,significant separation of the two pentacenyl groups facilitates decoupling of the two ***,the mechanism of iSF is altered depending on the respective metal center,that is,Pt(II)versus Pd(II).The dimer based on Pt(II),Pt(L_(pc))2Cl_(2),exhibits a direct pathway for the iSF and forms a correlated triplet pair with singlet−quintet spin-mixing within 10 ns in variable *** the other hand,the dimer based on Pd(II),Pd(L_(pc))_(2)Cl_(2),leads to charge transfer mixing during the population of the correlated triplet pair that is dependent on solvent ***,Pd(L_(pc))_(2)Cl_(2)gives rise to a stable equilibrium between singlet and quintet correlated triplet pairs with lifetimes of up to 170 *** differences in the size and polarizability,when contrasting platinum(II)with palladium(II),are the most likely rationale for the underlying trends.

关键词： metal complexes singlet fission pentacene dimers ultrafast spectroscopy electronic coupling

Overview of genetic signaling pathway interactions within cutaneous malignancies

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journal of Cancer Metastasis and Treatment 2020年第1期6卷 440-479页

作者： Brittany S.Maner Leonie Dupuis Ashley Su jeremy j jueng tanner P.Harding john Meisenheimer Ⅶ Fahad S.Siddiqui Mia R.Hardack Savina Aneja james A.Solomon Ross University School of Medicine MiramarFL 33027USA Ameriderm Research Ormond BeachFL 32174USA University of Central Florida College of Medicine OrlandoFL 32827USA University of South Florida Morsani College of Medicine TampaFL 33612USA Alabama College of Osteopathic Medicine DothanAL 36303USA Advanced Dermatology and Cosmetic Surgery OrlandoFL 32806USA Florida State University College of Medicine OrlandoFL 32304USA Kansas City University of Medicine&Biosciences Kansas CityMO 64106USA Carle-Illinois College of Medicine UrbanaIL 61820USA

Melanoma and non-melanoma cutaneous malignancies are some of the leading causes of cancer-related death in the United *** melanoma is more known to have a high mortality rate,the total mortality per year is nearly equal for between melanoma and non-melanoma skin ***,the non-melanoma types of cutaneous malignancies have potential to become locally invasive and even metastasize with very little to no treatment options when *** development of these malignancies involves various genetic pathways through the four hallmarks of cancer development:malignant cell growth,apoptosis evasion,the use of supporting stroma and vascularization,and modulating and promoting an inadequate immune *** genetic signaling pathways of basal cell carcinoma,squamous cell carcinoma,verrucous carcinoma,basosquamous cell carcinoma,melanoma,and cutaneous T-cell lymphoma interact with each other through genetic predisposition as well as with environmental ***,solar ultraviolet radiation and chronic inflammatory states are found to initiate the progression of many of these cutaneous *** paper includes validated models of genetic pathways,emerging pathways,and crosstalk between genetic pathways through the four hallmarks of cancer ***,unlike most reviews addressing oncogenetics of the well-recognized,as well as newly discovered,genetic pathway mutations,this review stresses that these pathways are not fixed but rather exist in dynamic,interrelated,interactive,complex,and adaptive flux states.

关键词： Basal cell carcinoma squamous cell carcinoma verrucous carcinoma basosquamous cell carcinoma melanoma cutaneous T-cell lymphoma genetic pathways cancer hallmarks

Strategies supporting the prevention and control of neglected tropical diseases during and beyond the COVID-19 pandemic

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Infectious Diseases of Poverty 2020年第4期9卷 135-141页

作者： john P.Ehrenberg Xiao-Nong Zhou Gilberto Fontes Eliana M.M.Rocha Marcel tanner jürg Utzinger Avenida Cedro 9 #303CholulMeridaYucatanMexico Formerly World Health Organization Regional Office for the Western PacificManilaThe Philippines National Institute of Parasitic Diseases at the Chinese Center for Disease Control and Prevention&Chinese Center for Tropical Diseases Research ShanghaiPeople's Republic of China School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China Laboratory of Parasitology Central-West CampusFederal University of S(a)o Jo(a)o del ReiDivinopolisMinas GeraisBrazil Swiss Tropical and Public Health Institute BaselSwitzerland University of Basel BaselSwitzerland

Emerging and re-emerging zoonotic diseases represent a public health challenge of international *** include a large group of neglected tropical diseases(NTDs),many of which are of zoonotic *** disease 201g(COVID-19),another emerging zoonotic disease,has just increased the stakes *** NTDs are subject to the impact of some of the very same human-related activities triggering other emerging and re-emerging diseases,including COVID-19,severe acute respiratory syndrome(SARS),bird flu and swine *** is conceivable that COVID-19 will exacerbate the NTDs,as it will divert much needed financial and human *** is considerable concern that recent progress achieved with control and elimination efforts will be *** potential strategies will need to reconsider the determinants of health in NTDs in order to galvanize efforts and come up with a comprehensive,well defined programme that will set the stage for an effective multi-sectorial *** this Commentary,we propose areas of potential synergies between the COVID-19 pandemic control efforts other health and non-health sector initiatives and NTD control and elimination programmes.

关键词： COVID-19 Emerging and re-emerging diseases Multi-sectorial approaches Neglected tropical diseases Zoonotic diseases

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Novel Hollow Fibre Bioreactors for Growing Bulky Bone Tissue

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Novel Hollow Fibre Bioreactors for Growing Bulky Bone Tissue

Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status

第七届全国生物力学学术会议

作者： David j.P.ferguson james T.TRIFFITT Nuffield Department of Pathology Oxford University John Radcliffe Hospital Oxford UK Nuffield Department of Orthopaedic Surgery Oxford University Nuffield Orthopaedic Centre Oxford UK

＜正＞ Limitations in the size and amount of bone tissue produced in vitro via tissue engineering are mainly due to the lack of nutrient and oxygen supply to the cells some distance away from the surface. Our laboratory has investigated possibilities for growing bulky bone tissue using novel hollow fibre bioreactors. The hollow fibre membranes embedded in the three dimensional scaffold are porous and semi permeable, which can serve the function of arteries and veins. Foam-type polycaprolactone （PCL） was used as a 3D scaffold and cellulose acetate hollow fibre membranes were embedded within the 3-D constructs. Rat bone marrow fibroblastic （RBMF） cells were initially seeded onto PCL scaffolds and then

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World journal of Clinical Oncology 2021年第4期12卷 238-248页

作者： james Wei Tatt Toh Angela L ferguson Kevin j Spring Hema Mahajan Umaimainthan Palendira Division of Surgery and Anaesthesia Department of Colorectal SurgeryWestmead HospitalWestmead Clinical SchoolThe University of SydneyIngham Institute for Applied Medical ResearchWestmead 2145NSWAustralia Department of Infectious Diseases and Immunology School of Medical SciencesFaculty of Medicine and HealthHuman Viral&Cancer ImmunologyCentenary InstituteCharles Perkin CentreThe University of SydneySydney 2000NSWAustralia Medical Oncology Group Ingham Institute for Applied Medical ResearchLiverpool HospitalLiverpool Clinical SchoolUniversity of Western SydneySouth Western Clinical School UNSWLiverpool 2170NSWAustralia Department of Anatomical Pathology ICPMRWestmead HospitalWestmead 2145NSWAustralia Department of Immunology and Infectious Diseases School of Medical SciencesFaculty of Medicine and HealthThe University of SydneySydney 2000NSWAustralia

BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the potential role of T_(RM) cells in providing immunogenicity in CRC stratified by microsatellite instability(MSI) and BRAF *** Patients with known MSI and BRAF mutation status were eligible for inclusion in this study. CRC tumour sections stained with haematoxylin and eosin were microscopically reviewed and the images scanned prior to assessment for location of invading edge and core of tumour. Sequential sections were prepared for quantitative multiplex immunohistochemistry(IHC) staining. Opal Multiplex IHC staining was performed with appropriate positive and negative controls and imaged using a standard fluorescent microscope fitted with a spectral scanning camera(Mantra) in conjunction with Mantra snap software. Images were unmixed and annotated in in Form 2.2.0. Statistical analysis was performed using Graphpad Prism Version 7 and Stata Version *** Seventy-two patients with known MSI and BRAF status were included in the study. All patients were assessed for MSI by IHC and high resolution capillary electrophoresis testing and 44 of these patients successfully underwent quantitative multiplex IHC staining. Overall, there was a statistically significant increase in CD8+ T_(RM) cells in the MSI(BRAF mutant and wild type) group over the microsatellite stable(MSS) group. There was a statistically significant difference in CD8+ T_(RM) between high level MSI(MSI-H):BRAF mutant [22.57, 95% confidence interval(CI): 14.31-30.84] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0076 and MSI-H:BRAF wild type [16.18(95%CI: 10.44-21.93)] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0279. There was no statistically significant difference in CD8 T cells(both CD8+CD103-and CD8+CD103+T_(RM)) between MSI-H: BRAF mutant and wild type *** This study has

关键词： Tissue resident memory cells Resident memory T cells Colorectal cancer Microsatellite instability BRAF DNA mismatch repair Immunotherapy Prognosis

A stoichiometric terbium-europium dyad molecular thermometer: energy transfer properties

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Light(Science & Applications) 2018年第1期7卷 141-150页

作者： Guochen Bao Ka-Leung Wong Dayong jin Peter A.tanner Department of Chemistry Hong Kong Baptist UniversityKowloon TongHong Kong SARPeople’s Republic of China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW 2007Australia School of Mathematical and Physical Sciences Faculty of ScienceUniversity of Technology SydneySydneyNSW 2007Australia

The optical thermometer has shown great promise for use in the fields of aeronautical engineering,environmental monitoring and medical ***-referencing lanthanide thermo-probes distinguish themselves because of their accuracy,calibration,photostability,and temporal dimension of ***,the use of conventional lanthanidedoped materials is limited by their poor reproducibility,random distance between energy transfer pairs and interference by energy migration,thereby restricting their ***,a strategy for synthesizing hetero-dinuclear complexes that comprise chemically similar lanthanides is introduced in which a pair of thermosensitive dinuclear complexes,cycTb-phEu and cycEu-phTb,were *** structures were geometrically optimized with an internuclear distance of approximately 10.6Å.The sensitive linear temperature-dependent luminescent intensity ratios of europium and terbium emission over a wide temperature range(50–298 K and 10–200 K,respectively)and their temporal dimension responses indicate that both dinuclear complexes can act as excellent self-referencing *** energy transfer from Tb^(3+)to Eu^(3+)is thermally activated,with the most important pathway involving the ^(7)F_(1) Eu^(3+)j-multiplet at room *** energy transfer from the antenna to Eu^(3+)was simulated,and it was found that the most important ligand contributions to the rate come from transfers to the Eu^(3+)upper states rather than direct ligand–metal transfer to 5D1 or *** the first molecular-based thermometer with clear validation of the metal ratio and a fixed distance between the metal pairs,these dinuclear complexes can be used as new materials for temperature sensing and can provide a new platform for understanding the energy transfer between lanthanide ions.

关键词： temperature. lanthanide transfer

Direct laser writing of volumetric gradient index lenses and waveguides

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Light(Science & Applications) 2020年第1期9卷 89-102页

作者： Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar tanner j.Garcia jorik van de Groep jung-Hwan Song Austin j.Cyphersmith Andrew Rhode Andrea N.Perry Alexander j.Littlefield jinlong Zhu Dajie Xie Haibo Gao jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint jr Lynford L.Goddard Paul V.Braun Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaILUSA Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Materials Science and Engineering Stanford UniversityStanfordCAUSA Carl R.Woese Institute for Genomic Biology University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA

Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer ***,these printed structures are limited to the refractive index and dispersive properties of the ***,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica *** the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic *** SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible ***’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing *** also has the potential to form multicomponent optics by cascading optical elements within a *** a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous ***,an all-pass ring resonator was coupled to a subsurface 3D *** measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple *** is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports.

关键词： index refractive render

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大豆结瘤和固氮的现代遗传学与生物技术学

自然杂志 2009年第6期31卷 320-326页

作者： Peter M.Gresshoff Brett j.ferguson Arief Indrasumunar 江群益澳大利亚豆科综合研究中心昆士兰大学

大豆(Glycinemax)是一种重要的供给粮食和动物饲料的主要农作物。作为豆科植物的一员,大豆与一种被称之为根瘤菌的土壤细菌形成了复杂的共生关系,结果导致新的根器官——根瘤的形成。在这个吸引人的新器官中,被植物所囚禁的根瘤菌能把... 详细信息

大豆(Glycinemax)是一种重要的供给粮食和动物饲料的主要农作物。作为豆科植物的一员,大豆与一种被称之为根瘤菌的土壤细菌形成了复杂的共生关系,结果导致新的根器官——根瘤的形成。在这个吸引人的新器官中,被植物所囚禁的根瘤菌能把空气中的氮气转换为可利用的氮肥。在巴西,有助于增加种子收成的细菌菌株借助微生物学手段已经被分离出来。目前,现代遗传学、生物技术学、生理学、生物化学和基因组学使得分离根瘤形成过程中的关键基因成为现实。综合这些研究发现了诱导,并随后控制细胞分裂的一种新的分子机制。笔者所在的研究小组已经在大豆中克隆到了根瘤菌结瘤因子信号的关键受体,以及一些在复杂的根—茎—根信号传递途径中的分子组分,这些组分涉及到肽类激素,受体激酶和小的信号代谢产物。上述发现表明提高大豆产量和抗逆性的大豆改良进入一个新的阶段。

关键词：共生关系干细胞氮肥生物燃料蛋白供给可持续发展

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虚拟存贮器与变换存贮器的区别

计算机工程 1977年第4期 60-65页

作者： G.j.tanner 姚立申

二种扩大计算机存贮器容量的方法,其名称常被混淆。这是二种完全不同的方法,各有优点和缺点许多计算机使用者、销售者甚至分析者,对“变换存贮器”和“虚拟存贮器”就象附属于计算机的其它器件一样,常相混淆。不明确的地方在于这二种... 详细信息

二种扩大计算机存贮器容量的方法,其名称常被混淆。这是二种完全不同的方法,各有优点和缺点许多计算机使用者、销售者甚至分析者,对“变换存贮器”和“虚拟存贮器”就象附属于计算机的其它器件一样,常相混淆。不明确的地方在于这二种存贮器各做些什么工作和如何区别。许多厂把变换存贮器说成虚拟存贮器,是并不奇怪的,因这二种设计一般都包含变换的概念。

关键词：存贮器系统数组页面操作系统用户存贮系统计算机系统额外开销地址翻译寄存器