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Genome-Wide Linkage and Positional Association Analyses Identify Associations of novel AFF3 and nTM Genes with Triglycerides:The GenSalt Study

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Journal of Genetics and Genomics 2015年第3期42卷 107-117页

作者： Changwei Li Lydia A.L.Bazzano Dabeeru C.Rao James E.Hixson Jiang He Dongfeng Gu Charles C.Gu Lawrence C.Shimmin Cashell E.Jaquish Karen Schwander De-Pei Liu Jianfeng Huang Fanghong Lu Jie Cao Shen Chong Xiangfeng Lu tanika n.kelly Department of Epidemiology Tulane University School of Public Health and Tropical Medicine Department of Medicine Tulane University School of Medicine Division of Biostatistics Washington University School of Medicine Department of Epidemiology Human Genetics and Environmental SciencesUniversity of Texas School of Public Health State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center of Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Division of Prevention and Population Sciences National HeartLungBlood Institute national Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine Shandong Academy of Medical Sciences Department of Epidemiology and Biostatistics Nanjing Medical University School of Public Health

We conducted a genome-wide linkage scan and positional association study to identify genes and variants influencing blood lipid levels among participants of the Genetic Epidemiology network of Salt-Sensitivity （GenSalt） study. The GenSalt study was conducted among 1906 participants from 633 Han Chinese families. Lipids were measured from overnight fasting blood samples using standard methods. Multipoint quantitative trait genome-wide linkage scans were performed on the high-density lipoprotein, low-density lipoprotein, and log- transformed triglyceride phenotypes. Using dense panels of single nucleotide polymorphisms （SnPs）, single-marker and gene-based association analyses were conducted to follow-up on promising linkage signals. Additive associations between each SnP and lipid phenotypes were tested using mixed linear regression models. Gene-based analyses were performed by combining P-values from single- marker analyses within each gene using the truncated product method （TPM）. Significant associations were assessed for replication among 777 Asian participants of the Multi-ethnic Study of Atherosclerosis （MESA）. Bonferroni correction was used to adjust for multiple testing. In the GenSalt study, suggestive linkage signals were identified at 2p11.2-2q12.1 [maximum multipoint LOD score （MML） = 2.18 at 2q11.2] and t lq24.3-11q25 （MML = 2.29 at 11q25） for the log-transformed triglyceride phenotype. Follow-up analyses of these two regions revealed gene-based associations of charged multivesicular body protein 3 （CHMP3）, ring finger protein 103 （RnF103）, AF4/FMR2 family, member 3 （AFF3）, and neurotrirnin （nTM） with triglycerides （P = 4 ×10^-4, 1.00 × 10^-5, 2.00 × 10^-5, and 1.00 × 10^-7, respectively）. Both the AFF3 and nTM triglyceride associations were replicated among MESA study participants（P = 1.00 × 10^-7 and 8.00× 10^-5, respectively）. Furthermore, nTM explained the linkage signal on chromosome 11, In conclusion, we identified novel genes associated with lipid

关键词： Lipids Linkage analysis Positional association analysis Gene-based analysis

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内皮系统基因与血压改变和高血压发病的关系:盐敏感遗传流行病学研究

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中华高血压杂志 2015年第10期23卷 998-998页

作者： Fangchao Liu Jiang He Dongfeng Gu Dabeeru C.Rao Jianfeng Huang James E.Hixson Cashell E.Jaquish Jichun Chen Changwei Li Xueli Yang Jianxin Li Treva K.Rice Lawrence C.Shimmin tanika n.kelly

研究者在一个纵向家庭研究中以单标记和新基因为基础的方法探讨内皮系统基因与血压改变和高血压发病率的关系。方法：盐敏感性的遗传流行病学随访研究共纳入633个汉族家庭的1768位成员。使用随机零点血压计,获取基线和随访调查的共9次... 详细信息

研究者在一个纵向家庭研究中以单标记和新基因为基础的方法探讨内皮系统基因与血压改变和高血压发病率的关系。方法：盐敏感性的遗传流行病学随访研究共纳入633个汉族家庭的1768位成员。使用随机零点血压计,获取基线和随访调查的共9次血压值。

关键词：遗传流行病学内皮系统盐敏感性高血压新基因发病率随访研究随访调查

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中国人基因变异和体力活动的相互作用与血压相关

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中华高血压杂志 2012年第2期20卷 198-198页

作者： May E.Montasser Lawrence C.Shimmin Charles Gu tanika n.kelly Cashell E.Jaquish Treva Rice Dabeeru C.Rao Paul K.Whelton James E.Hixson 罗冬梅叶鹏

维持血压动态平衡涉及遗传和非遗传因素之间复杂的相互作用，这对明确影响血压和高血压的遗传因素有巨大的挑战。该研究选取中国农村遗传基因相对均一的一人群队列，研究基因变异与体力活动相互作用对血压的影响。方法：根据是否进行体... 详细信息

维持血压动态平衡涉及遗传和非遗传因素之间复杂的相互作用，这对明确影响血压和高血压的遗传因素有巨大的挑战。该研究选取中国农村遗传基因相对均一的一人群队列，研究基因变异与体力活动相互作用对血压的影响。方法：根据是否进行体力活动将3142名入选者进行分组（体力活动组与非体力活动组），应用广义估计方程分析收缩压和舒张压与血压调控通路中24个基因表型改变的关系[包括196单核苷酸多态性（single-nucleotide polymorphisms，SnP）]。

关键词：体力活动血压动态相互作用基因变异中国农村非遗传因素单核苷酸多态性广义估计方程

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Switchgrass Biochar Effects on Plant Biomass and Microbial Dynamics in Two Soils from Different Regions

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Pedosphere 2015年第3期25卷 329-342页

作者： Charlene n.kelly Francisco C.CALDERón Verónica ACOSTA-MARTínEZ Maysoon M.MIKHA Joseph BEnJAMIn David W.RUTHERFORD Colleen E.ROSTAD Western Carolina University Department of Geosciences and Natural Resources331 Stillwell HallCullowheeNC 28723 (USA) U.S.Geological Survey Denver CO 80225 (USA) USDA-ARS Akron CO 80720 (USA) USDA-ARS Lubbock TX 79403 (USA)

Biochar amendments to soils may alter soil function and fertility in various ways, including through induced changes in the microbial community. We assessed microbial activity and community composition of two distinct clayey soil types, an Aridisol from Colorado （CO） in the U.S. Central Great Plains, and an Alfisol from Virginia （VA） in the southeastern USA following the application of switchgrass （Panicum virgatum） biochar. The switchgrass biochar was applied at four levels, 0%,0, 2.5%, 5%, and 10%, approximately equivalent to biochar additions of 0, 25, 50, and 100 t ha^-1, respectively, to the soils grown with wheat （Triticum aestivum） in an eight-week growth chamber experiment. We measured wheat shoot biomass and nitrogen （n） content and soil nutrient availability and n mineralization rates, and characterized the microbial fatty acid methyl ester （FAME） profiles of the soils. net n mineralization rates decreased in both soils in proportion to an increase in biochar levels, but the effect was more marked in the VA soil, where net n mineralization decreased from -2.1 to -38.4 mg kg^-1. The 10% biochar addition increased soil pH, electrical conductivity, Mehlich- and bicarbonate-extractable phosphorus （P）, and extractable potassium （K） in both soil types. The wheat shoot biomass decreased from 17.7 to 9.1 g with incremental additions of biochar in the CO soil, but no difference was noted in plants grown in the VA soil. The FAME recovery assay indicated that the switchgrass biochar addition could introduce artifacts in analysis, so the results needed to be interpreted with caution. non-corrected total FAME concentrations indicated a decline by 457o and 34% with 10% biochar addition in the CO and VA soils, respectively, though these differences became nonsignificant when the extraction efficiency correction factor was applied. A significant decline in the fungi：bacteria ratio was still evident upon correction in the CO soil with biochar. Switchgrass biochar had the p

关键词： correction factor extraction efficiency fatty acid methyl ester profile nitrogen mineralization soil microbial community soil nutrient availability wheat

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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InVESTIGATIOn OF THE ATRP OF n-BUTYL METHACRYLATE USInG THE Cu(I)/n,n,n',n",n"-PEnTAMETHYLDIETHYLEnETRIAMInE CATALYST SYSTEM

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Chinese Journal of Polymer Science 2004年第2期22卷 195-204页

作者： kelly A. Davis Krzysztof Matyjaszewski Center for Macromolecular Engineering Department of Chemistry Carnegie Mellon University 4400 Fifth Ave.Pittsburgh Pennsylvania 15213 USACenter for Macromolecular Engineering Department of Chemistry Carnegie Mellon University 4400 Fifth Ave.Pittsburgh Pennsylvania 15213 USA

The polymerization of n-butyl methacrylate was investigated using the Atom Transfer Radical Polymerization technique with CuBr and CuCl/n,n,n',n',n'-pentamethyldiethylenetriamine catalytic systems. Various combinations of catalyst systems and initiators were utilized in order to optimize the polymerization conditions and to obtain well-defined polymers (i.e. controlled molecular weights and low polydispersities). It has been found that the optimal initiator for this system is a chlorine-based initiator, when the catalyst used is a salt in conjunction with the n,n,n',n',n'- pentamethyldiethylenetriamine ligand. Bromine-based initiators tend to result in large amounts of initial termination, leading to polymers with less than ideal chain end functionality, even if CuCl is used as the species to invoke the halogen exchange. Additionally, the effects of the polymerization temperature, species and the initiator structure were determined.

关键词： ATRP Atom transfer radical polymerization Controlled/living radical polymerization Butyl methacrylate Pentamethyldiethylenetriamine

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David VC Brito Clévio nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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