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Genetic causal association between gut microbiota and sepsis: Evidence from a two-sample bidirectional Mendelian randomization analysis

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Journal of Intensive Medicine 2024年第3期4卷 362-367页

作者： Jungen tang man Huang Department of General Intensive Care Unit The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangChina

Background Sepsis is a severe and potentially life-threatening condition characterized by a dysregulated host response and organ *** causal relationship between intestinal microbiota and sepsis is *** A two-sample Mendelian randomization(MR)study was performed to proxy the causal association between gut microbiota and *** genome-wide association study(GWAS)data of sepsis and gut microbiome were collected from the Integrative Epidemiology Unit(IEU)OpenGWAS,with summary-level data obtained from the UK *** traditional methods were used to estimate the potential causal relationships between gut microbiota and sepsis,including the inverse-variance weighted method,weighted median method,MR-Egger regression,simple mode,and weighted *** MR analysis was performed on the bacteria that were found to be causally associated with sepsis in forward MR ***'s Q statistic was used to quantify the heterogeneity of instrumental *** The inverse-variance weighted estimate suggested that class Lentisphaeria(odds ratio[OR]=0.86,95%confidence interval[CI]:0.78 to 0.94,P=0.0017,q=0.1596)and order Victivallales(OR=0.86,95%CI:0.78 to 0.94,P=0.0017,q=0.1596)have a protective effect on *** genus Eubacterium eligens group(OR=1.34,95%CI:1.11 to 1.63,P=0.0029,q=0.1881)was positively associated with the risk of *** may be a significant risk factor for genus Odoribacter(OR=1.18,95%CI:1.10 to 1.39,P=0.0415,q=0.9849)and Phascolarctobacterium(OR=1.21,95%CI:1.00 to 1.46,P=0.0471,q=0.9849),but this effect was not statistically significant after false discovery rate *** was a suggestive association between sepsis and Faecalibacterium(OR=0.85,95%CI:0.73 to 0.98,P=0.0278)and Ruminococcus 1(OR=0.85,95%CI:0.73 to 1.00,P=0.0439),which were not significant after false discovery rate correction(q>0.2).Conclusions This study found that class Lentisphaeria,order Victivallales,and genus Eubacterium eligens group

关键词： Gut microbiota Sepsis Mendelian randomization

An AI-empowered indoor digital contact tracing system for COVID-19 outbreaks in residential care homes

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Infectious Disease Modelling 2024年第2期9卷 474-482页

作者： Jiahui Meng Justina yat Wa Liu Lin Yang man Sing Wong Hilda Tsang Boyu Yu Jincheng Yu Freddy man-Hin Lam Daihai He Lei Yang Yan Li Gilman Kit-Hang Siu Stefanos Tyrovolas Yao Jie Xie David man David H.K.Shum School of Nursing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Electronic and Information Engineering The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Research Centre of Textiles for Future Fashion The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Computing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Nutrition and Food Studies George Mason UniversityUSA Tung Wah College Hong Kong Special Administrative RegionChina Mental Health Research Centre The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

An AI-empowered indoor digital contact-tracing system was developed using a centralized architecture and advanced low-energy Bluetooth technologies for indoor positioning,with careful preservation of privacy and data *** analyzed the contact pattern data from two RCHs and investigated a COVID-19 outbreak in one study *** evaluate the effectiveness of the system in containing outbreaks with minimal contacts under quarantine,a simulation study was conducted to compare the impact of different quarantine strategies on outbreak containment within *** significant difference in contact hours between weekdays and weekends was observed for some pairs of RCH residents and staff during the two-week data collection *** significant difference between secondary cases and uninfected contacts was observed in a COVID-19 outbreak in terms of their demographics and contact *** results based on the collected contact data indicated that a threshold of accumulative contact hours one or two days prior to diagnosis of the index case could dramatically increase the efficiency of outbreak containment within RCHs by targeted isolation of the close *** study demonstrated the feasibility and efficiency of employing an AI-empowered system in indoor digital contact tracing of outbreaks in RCHs in the post-pandemic era.

关键词： COVID-19 Indoor contact tracing Contact pattern Outbreak containment Artificial intelligence

Knock-out of GhPDCT with the CRISPR/Cas9 system increases the oleic acid content in cottonseed oil

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Journal of Integrative Agriculture 2024年第10期23卷 3468-3471页

作者： Tingwan Li Lu Long Yingchao tang Zhongping Xu Guanying Wang man Jiang Shuangxia Jin Wei Gao National Key Laboratory of Cotton Bio-breeding and Integrated Utilization/School of Life Science Henan UniversityKaifeng475004China Hubei Hongshan Laboratory/National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan430070China

Cotton is a pivotal economic crop for natural textile fibers that also serves as an important source of edible oil(Long et al.2023).Cottonseed oil contains approximately14%oleic acid and 59%linoleic *** increase in monounsaturated fatty acids,particularly oleic acid,enhances the oxidative stability and nutritional value of edible oil(Chen et al.2021).

关键词： CRISPR/Cas9 fibers system

Optimal operation of Internet Data Center with PV and energy storage type of UPS clusters

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Global Energy Interconnection 2024年第1期7卷 61-70页

作者： man Chen Yuxin Zhao Yuxuan Li Peng Peng Xisheng tang CSG PGC Energy Storage Research Institute Guangzhou 510000P.R.China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China

With the development of green data centers,a large number of Uninterruptible Power Supply(UPS)resources in Internet Data Center(IDC)are becoming idle assets owing to their low utilization *** revitalization of these idle UPS resources is an urgent problem that must be *** on the energy storage type of the UPS(EUPS)and using renewable sources,a solution for IDCs is proposed in this ***,an EUPS cluster classification method based on the concept of shared mechanism niche(CSMN)was proposed to effectively solve the EUPS control ***,the classified EUPS aggregation unit was used to determine the optimal operation of the *** IDC cost minimization optimization model was established,and the Quantum Particle Swarm Optimization(QPSO)algorithm was ***,the economy and effectiveness of the three-tier optimization framework and model were verified through three case studies.

关键词： Three-tier optimization framework Energy storage type of the UPS EUPS cluster classification method Quantum Particle Swarm Optimization

YTE-17 inhibits colonic carcinogenesis by resetting antitumor immune response via Wnt5a/JNK mediated metabolic signaling

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Journal of Pharmaceutical Analysis 2024年第4期14卷 525-541页

作者： Hua Sui Wanli Deng Qiong Chai Bing Han Yuli Zhang Zhenzhen Wei Zan Li Ting Wang Jiling Feng man Yuan Qingfeng tang Hongxi Xu Medical Experiment Center Jiading Branch of Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai201803China Translational Medicine Research Center for Cancer Prevention and Treatment Shanghai General Hospital Jiading Branch-School of Pharmacy of Shanghai University of Traditional Chinese Medicine Joint LaboratoryShanghai201803China Department of Medical Oncology Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai201203China The Second Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450000China Shanghai University of Traditional Chinese Medicine Shanghai201203China Precision Research Center for Refractory Diseases Institute for Clinical ResearchShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai201620China

The density and composition of lymphocytes infiltrating colon tumors serve as predictive factors for the clinical outcome of colon *** previous studies highlighted the potent anti-cancer properties of the principal compounds found in Garcinia yunnanensis(YTE-17),attributing these effects to the regu-lation of multiple signaling ***,knowledge regarding the mechanism and effect of YTE-17 in the prevention of colorectal cancer is *** this study,we conducted isobaric tags for relative and absolute quantification(iTRAQ)analysis on intestinal epithelial cells(IECs)exposed YTE-17,both in vitro and in vivo,revealing a significant inhibition of the Wnt family member 5a(Wnt5a)/c-Jun N-terminal kinase(JNK)signaling ***,we elucidated the influence and mechanism of YTE-17 on the tumor microenvironment(TME),specifically focusing on macrophage-mediated T helper 17(Th17)cell induction in a colitis-associated cancer(CAC)model with Wnt5a ***,we performed the single-cell RNA sequencing(scRNA-seq)on the colonic tissue from the Wnt5a-deleted CAC model to characterize the composition,lineage,and functional status of immune mesenchymal cells during different stages of colorectal cancer(CRC)***,our findings demon-strate a significant reduction in M2 macrophage polarization and Th17 cell phenotype upon treatment with YTE-17,leading to the restoration of regulatory T(Treg)/Th17 cell balance in azoxymethane(AOM)/dextran sodium sulfate(DSS)***,we also confirmed that YTE-17 effectively inhibited the glycolysis of Th17 cells in both direct and indirect co-culture systems with M2 ***,our study shed light on potential mechanisms linking the non-canonical Wnt5a/JNK signaling pathway and well-established canonical b-catenin oncogenic pathway in ***,we proposed that Wnt5a/JNK signaling activity in IECs promotes the development of cancer stem cells with b-catenin activity within

关键词： Tumor microenvironment Intestinal epithelial cells Treg/Th17 cells Metabolism Wnt5a/JNK signaling Tumorigenesis

Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2581-2597页

作者： Hongliang Qiu Sihui Huang Yuting Liu Libo Liu Fengming Guo Yingying Guo Dan Li Xianfeng Cen Yajie Chen Meng Zhang Yan Che man Xu Qizhu tang Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Hubei Key Laboratory of Metabolic and Chronic Diseases Wuhan 430060China

Doxorubicin(DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients,but related pharmacotherapeutic measures are relatively *** was recently identified as a major mechanism of DOX-induced ***,a novel ferroptosis inhibitor,is a well-described clinical drug widely ***,its role and pathological mechanism in DOX-induced cardiotoxicity are still *** this study,we demonstrated the effects of idebenone on DOX-induced cardiotoxicity and elucidated its underlying mechanism.A single intraperitoneal injection of DOX(15 mg/kg)was administrated to establish DOX-induced *** results showed that idebenone significantly attenuated DOX-induced cardiac dysfunction due to its ability to regulate acute DOX-induced Fe^(2+)and ROS overload,which resulted in *** and BLI further revealed that idebenone's anti-ferroptosis effect was mediated by ***,idebenone increased FSP1 protein levels but did not affect Fsp1 mRNA levels in the presence of *** could form stable hydrogen bonds with FSP1 protein at K355,which may influence its association with *** results confirmed that idebenone stabilized FSP1 protein levels by inhibiting its ubiquitination *** conclusion,this study demonstrates idebenone attenuated DOX-induced cardiotoxicity by inhibiting ferroptosis via regulation of FSP1,making it a potential clinical drug for patients receiving DOX treatment.

关键词： Idebenone DOX-induced cardiotoxicity Ferroptosis FSP1 Ubiquitination Lipid peroxidation Iron overload Clinical translation

Exploring a novel class tryptophan hydroxylase 1 inhibitor derived from Sambucus williamsii Hance for the osteoporosis treatment

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Acupuncture and Herbal Medicine 2024年第1期4卷 102-112页

作者： Yu-Xin Zhu Zi-Ling tang Lu Lu Zuo-Cheng Qiu Dabo Pan Yang Yu Hui-Hui Xiao man-Sau Wong State Key Laboratory of Chinese Medicine and Molecular Pharmacology(Incubation) The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhenChina Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhouChina Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong KongChina Research Center for Chinese Medicine Innovation The Hong Kong Polytechnic UniversityHong KongChina

Objective:Gut-derived serotonin strongly inhibits bone formation by inhibiting osteoblast *** previous study demonstrated that the lignan-rich fraction prepared from Sambucus willimasii Hance,a folk herbal medicine used to treat bone fractures and joint diseases in China,exerted bone-protective effects,and its actions were modulated by suppressing the synthesis of gut-derived serotonin via the inhibition of intestinal tryptophan hydroxylase 1(TPH-1).However,there is no direct evidence for the action of lignans on *** study aimed to verify the direct action of lignans on the TPH-1 and its influence on serotonin synthesis and bone ***:Molecular docking and surface plasmon resonance were performed to determine the affinities of lignans to *** cell viability and the protein activity and expression of TPH-1 were measured in RBL2H3 *** serum serotonin level and bone mineral density upon lignan treatment in ovariectomized mice were ***:The lignans showed high binding scores and binding affinities to TPH-1,inhibited the activity and protein expression of TPH-1,suppressed the serum serotonin levels in ovariectomized mice as well as promoted bone mineral ***:This is the first study to report that lignans are novel TPH-1 inhibitors and that these lignans could be potential agents for the management of serotonin-related diseases,including osteoporosis.

关键词： Lignan Osteoporosis Sambucus williamsii Hance Serotonin TPH-1 inhibitor

Cronkhite-Canada syndrome with esophagus involvement and sixyear follow-up:A case report

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World Journal of Gastroenterology 2024年第8期30卷 984-990页

作者： Yu-Chen tang Department of Endocrinology The First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare,noninherited disease characterized by gastrointestinal polyposis with diarrhea and ectodermal *** polyps are distributed through the whole digestive tract,and they are common in the stomach and colon but very uncommon in the *** SUMMARY Here,we present a case of a 63-year-old man with skin hyperpigmentation accompanied by diarrhea,alopecia,and loss of his *** data indicated anemia,hypoalbuminemia,hypocalcemia,hypokalemia,and positive fecal occult *** showed numerous polyps scattered throughout the digestive tract,including the *** was treated with nutritional support and glucocorticoids with remission of his *** Comprehensive treatment led by hormonal therapy can result in partial or full remission of clinical *** should be individualized for each patient according to their therapy *** endoscopy is necessary for assessing mucosal disease activity and detecting malignant transformation.

关键词： Cronkhite-Canada syndrome Gastrointestinal polyposis Hormonal therapy Prognosis Case report

失能老人长期照护体系的构建与公共健康治理创新

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上海大学学报（社会科学版） 2024年第3期41卷 108-123页

作者：唐贤兴唐曼复旦大学国际关系与公共事务学院上海200433

失能老人的长期照护不仅对医学提出了难题,更对当前的社会治理和公共政策形成了严峻挑战。需要从公共健康治理的视角重新审视,基于价值、结构、工具维度建构分析框架,识别公共健康治理的价值共识、协同共治结构和政策工具。以青岛和上... 详细信息

失能老人的长期照护不仅对医学提出了难题,更对当前的社会治理和公共政策形成了严峻挑战。需要从公共健康治理的视角重新审视,基于价值、结构、工具维度建构分析框架,识别公共健康治理的价值共识、协同共治结构和政策工具。以青岛和上海试点的长护险制度为例,探索其背后呈现的公共健康治理的逻辑可以发现,健康议题的价值回归驱动了公共健康治理创新,治理权向多元化主体的扩散形成了健康问题协同共治的基础,长护险制度及其所包含的多元化政策工具使用共同促进了健康服务的共同生产。

关键词：公共健康治理失能老人长期照护长护险制度