检索结果-南通市图书馆

Homeotropic Alignment and Selective Adsorption of Nanoporous Polymer Film Polymerized from Hydrogen-bonded Liquid Crystal

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2020年第11期38卷 1185-1191,I0006页

作者： An-Qi Xiao Xiao-Lin Lyu Hong-Bing Pan Zhe-Hao tang Wei Zhang Zhi-Hao Shen Xing-He Fan Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Nano porous polymer film with a hexagonal colum nar(Coln)structure was fabricated by templated hydroge n-bonding discotic liquid crystals containing methacrylate functional *** supramolecular hydrogen-bonded complex T3Ph-L is composed of a 1,3/5-tris(1Hbenzo[d]imidazol-2-yl)benzene(T3Ph)core molecule as the hydrogen-bonding acceptor and 3,4,5-tris((11-(methacryloyloxy)undecyl)oxy)benzoic acid(L)peripheral molecules as *** the Colh structure is always retained after self-assembly,photo-crosslinking,and removal of the template *** nanoporous polymer film can retain the Colh phase even under the dry condition,which indicates more possibilities for practical applicati *** chemical modificati on of the inner wall of the nano pores,the nan oporous polymer film with pores of about 1 nm selectively adsorbs ionic dyes,and the adsorption process is spontaneous and exothermic in *** alignment can be obtained when the blend complex was sandwiched between two modified glasses after annealing by slow cooling,which shows that the nanoporous polymer film has potential in applications such as nanofiltration.

关键词： Liquid crystal Hydrogen bonding Homeotropic alignment Nanoporous polymer film Selective adsorption

Synthesis and biological evaluation of ^(99m)Tc-HEDTA/HYNIC-MPP4 complex for 5-HT_(1A) receptor imaging

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2009年第5期52卷 590-598页

作者： FAN WeiWei LIN Yan ZHANG XianZhong PANG Yan MA Cong tang ZhiGang ZHANG JunBo WANG XueBin Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China

5-HT_(1A)receptor is associated with a variety of pathophysiology of neuropsychiatric ***,we have synthesized a new 5-HT_(1A) receptor ligand(HYNIC-MPP4)and labeled it with^(99m)Tc using N-(2-hydroxyethyl)ethylenediaminetriacetic acid(HEDTA)as coligand.^(99m)Tc-HEDTA/HYNIC-MPP4 was prepared under pH 6 at room *** of^(99m)Tc-HEDTA/HYNIC-MPP4 in normal mice showed that this complex had moderate brain uptake(0.60%ID·g^(-1)at 2 min p.i.)and good *** hippocampus had the highest radioactivity uptake at 2 min p.i.(1.84%ID·g^(-1)).The ratio of Hipp/CB was 3.1 at 2 min *** increased to 4.4 at 60 min *** blocking with 8-hydroxy-2-(dipropylamino)tetralin,the uptake of hippocampus was decreased significantly from 1.84%ID·g^(-1) to 0.53%ID·g^(-1) at 2 min p.i.,while the cerebellum had no significant ***^(99m)Tc complex could be a potent agent for 5-HT_(1A) receptor imaging.

关键词： 5-HT_(1A)receptor ^(99m)Tc N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-(6-hydrazinyl)pyridyl carboxamide(HYNIC-MPP4) biodistribution

Modern research thoughts and methods on bio-active components of TCM formulae

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2022年第7期20卷 481-493页

作者： tang Yu-Ping XU Ding-Qiao YUE Shi-Jun CHEN Yan-Yan FU Rui-Jia BAI Xue Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drug ResearchShaanxi Collaborative Innovation Center of Chinese Medicinal Resource IndustrializationShaanxi University of Chinese MedicineXi’an 712046China

TCM formulae are the important guidances for clinical application of traditional Chinese medicines,which follow the principles of diagnosis and treatment in *** the bio-active components of TCM formulae is the key to the modernization and internationalization of traditional Chinese *** the rapid development of modern instruments and technology,many new theories,methods and strategies are emerging,which upgrade the research of TCM formulae into a higher *** when the medicinal efficacy,bio-active components,function mechanism of TCM formulae are understood,we can guarantee TCM safety and quality *** this paper,we summarized the latest modern research thoughts and methods on bio-active components of TCM formulae including formula decomposition study,serum pharmacology and serum pharmacochemistry,association analysis,biochro-matography,network pharmacology,metabolomics and proteomics,so as to provide reference for the research and development of TCM in the future.

关键词： Chinese medicine TCM formulae Bio-active component Morden research methods

A new alkaloid from Castanea mollissima Blume

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第7期19卷 832-834页

作者： Dong Song Zhang Hui Yuan Gao Xiao Mei Song Zhi Shu tang Li Jun Wu School of Traditional Chinese Medicines Shenyang Pharmaceutical University Shenyang 110016 China School of Shanxi University of Chinese Medicines Xianyang 712046 China

A new alkaloid, named 6-（2＇,3＇-dihydroxy-4＇-hydroxymethyl-tetrahydro-furan-1＇-yl）cyclopentadiene[c]pyrrole-1,3-diol, was isolated from the seeds of Castanea mollissima Blume. The structure was elucidated based o... 详细信息

关键词： Castanea mollissima Blume Alkaloid 6-(2',3'-Dihydroxy-4'-hydroxylmethyl-tetrahydro-furan-1'-yl)cyclopentadiene[c]pyrrole-1,3-diol

在线全文

学校读者我要写书评

暂无评论

CCl_4导致肝硬化和门脉高压的机制

世界华人消化杂志 2005年第2期13卷 235-238页

作者：许永乐蔡大勇唐朝枢北京大学医学部生理学与病理生理学系北京市100083

用溶于食用油的CCl4来诱导肝硬化是最经典、最确切的实验模型.CCl4进入体内后,被细胞色素P450代谢产生活性物质,通过脂质过氧化、共价结合等机制引起选择性肝损伤:同时许多恢复因子也参与了肝硬化发生.血管活性物质对肝脏血流的调控在... 详细信息

用溶于食用油的CCl4来诱导肝硬化是最经典、最确切的实验模型.CCl4进入体内后,被细胞色素P450代谢产生活性物质,通过脂质过氧化、共价结合等机制引起选择性肝损伤:同时许多恢复因子也参与了肝硬化发生.血管活性物质对肝脏血流的调控在门脉高压的发生中起重要作用.

关键词： CCl4 肝硬化门脉高压肝损伤

Polymeric assembled nanoparticles through kinetic stabilization by confined impingement jets dilution mixer for fluorescence switching imaging

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2023年第4期56卷 89-96页

作者： Jingran Liu Yue Wu Jie tang Tao Wang Feng Ni Qiumin Wu Xijiao Yang Ayyaz Ahmad Naveed Ramzan Yisheng Xu State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Shyndec Pharmaceutical Co. LtdShanghai 200040China Department of Chemical Engineering Muhammad Nawaz Sharif University of Engineering and TechnologyMultanPakistan Faculty of Chemical Metallurgicaland Polymer EngineeringUniversity of Engineering&TechnologyLahorePakistan

Traditional fluorescence switching molecules achieving the state change between on and off states commonly based on UV irradiation. However, it is worth noting that UV irradiation is harmful to both the cancer cells and the normal cells. To achieve fluorescence switching under visible wavelength and avoid complicate molecular design, a fluorophore of 2,4,5,6-tetrakis(carbazol-9-yl)-1,3-dicyanobenzene(4Cz IPN) and a quencher of diarylethene(DAE) were physically incorporated within the biocompatible block copolymer poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)(PLGA-b-PEG) to form 4Cz IPNDAE nanoparticles(NPs) through flash nanoprecipitation(FNP). By using the FNP method, the NPs were prepared within milliseconds in a confined impingement jets dilution(CIJ-D) mixer. Quenching and recovery of fluorescence could achieve in the presence of DAE under 475 nm and 560 nm *** structure and fluorescent properties of the nanoparticles can be tuned by external conditions for their efficient fluorescence resonance energy transfer(FRET) in a kinetic stabilization process. This NPs formation process was further optimized by varying the dilution ratio, Reynolds number(Re) and polymer concentration to modulate the mixing and particle nucleation and growth process. The size and fluorescence switching properties of the NPs were systematically investigated in solution and in cellular uptake experiments. This work is anticipated to provide a simple and highly effective engineering strategy for the modulation of fluorescence switching nanoparticles and beneficial to its engineering application.

关键词： Preparation Kinetic stabilization Flash nanoprecipitation Nanoparticles Fluorescence switch

流域生态环境治理体系构建研究——以南流江为例

在线全文

学校读者我要写书评

暂无评论

地理空间信息 2024年第3期22卷 55-58页

作者：姜代炜谭太恒陈婉莹唐长增广西壮族自治区自然资源信息中心广西南宁530023

针对河流污染问题,以南流江为例,探讨了流域生态环境信息化治理体系构建方法。阐述了流域生态环境立体监测、三维实景重建、水质时空模拟与预警、信息服务拆分与聚合等关键技术,集成多源时空信息数据,科学布设环境防污设施,提供流域时... 详细信息

针对河流污染问题,以南流江为例,探讨了流域生态环境信息化治理体系构建方法。阐述了流域生态环境立体监测、三维实景重建、水质时空模拟与预警、信息服务拆分与聚合等关键技术,集成多源时空信息数据,科学布设环境防污设施,提供流域时空信息、水环境预警与污染决策支持服务,为管理者开发流域生态环境监管系统,为调查者开发污染源实时上报系统,建立全要素、全过程、全流域生态环境协同治理模式。该模式已推广至广西钦州江、九洲江流域。

关键词：流域生态环境立体监测三维实景时空信息协同治理

Bright White Organic Light-emitting Device Based on 1,2,3,4,5,6-Hexakis(9,9-diethyl-9H-fluoren-2-yl)benzene

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2009年第4期25卷 590-594页

作者： MA Tao YU Jun-sheng LOU Shuang-ling tang Xiao-qing JIANG Ya-dong ZHANG Qing State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 610054 P. R. China Department of Polymer Science School of Chemistry and Chemical Technology Shanghai Jiaotong University Shanghai 200240 P. R. China

Organic light-emitting devices（OLEDs） with the structure of indium-tin-oxide（ITO）/N,N＇-bis-（1-naphthyl）-N,N＇-diphenyl-（1,1＇-biphenyl）-4,4＇-diamine（NPB）/2,9-dimenthyl-4,7-diphenyl-1,10-phenanthroline（BCP）/tris（8-hydroxyquinoline）aluminum（Alq3）/Mg：Ag or that of ITO/NPB/1,2,3,4,5,6-hexakis（9,9-diethyl-9H-fluoren-2-yl）benzene（HKEthFLYPh）/Alq3/Mg：Ag were *** light emission was achieved with the two devices when the thicknesses of BCP and HKEthFLYPh were 1.5 nm（device B） and 5 nm（device Ⅱ）,*** obvious difference was that the EL spectrum of device Ⅱ was not sensitive to the thickness of HKEthFLYPh compared to that of BCP ***,the maximum luminance of device Ⅱ was about 1000 cd/m^2 higher than that of device B at a forward bias of 15 V,and it exhibited a maximum power efficiency of 1.0 lm/W at 5.5 V,which is nearly twice that of device *** performance of device Ⅱ using a novel star-shaped hexafluorenylbenzene organic material was improved compared with that of BCP.

关键词： Organic light-emitting diode Star-shaped hexafluorenylbenzene White light BCP Energy transfer

Efficacy and Safety of Lianhua Qingwen for Patients with COVID-19: A Systematic Review and Meta-Analysis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2022年第7期28卷 650-660页

作者： SUN Xiao-hu ZHANG Shuo YANG Zhen CHEN Zhen-lin YUE Shi-jun ZHANG Sai tang Yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for Traditional Chinese Medicine Compatibility Shaanxi University of Chinese MedicineXi'an 712046China Nanjing Bestform Pharmaceutical Technology Co. Ltd.Nanjing 210032China Cardiovascular Department Guang'anmen HospitalSchool of Clinical MedicineBeijing University of Chinese MedicineBeijing 100029China School of Public Health Shaanxi University of Chinese MedicineXi'an 712046China International Programs Office Shaanxi University of Chinese MedicineXi'an 712046China

Background: Corona virus disease 2019(COVID-19) has spread around the world since its outbreak, and there is no ascertained effective drug up to now. Lianhua Qingwen(LHQW) has been widely used in China and overseas Chinese, which had some advantages in the treatment of COVID-19. Objective: To evaluate the efficacy and safety of LHQW for COVID-19 by conducting a systematic review with meta-analysis. Methods: A comprehensive literature search was conducted in 12 electronic databases from their establishment to October 30, 2021. Note Express 3.2.0 was used for screening of trials, and the data was independently extracted in duplicate by 2 researchers. The risk of bias of randomized controlled trials(RCTs) and retrospective studies were assessed by using the Cochrane collaboration tool and Newcastle Ottawa Scale, respectively, followed by data analysis using RevMan 5.3. The RCTs or retrospective studies to treat COVID-19 using LHQW were included. The intervention measures in the experimental group were LHQW alone or combined with chemical drugs(LCWC), and that in the control group were chemical drugs(CDs). Outcome measures included computed tomography(CT) recovery rate, disappearance rates of primary(fever, cough, fatigue), respiratory, gastrointestinal and other symptoms, exacerbation rate and adverse reaction. Subgroup analysis was conducted according to whether LHQW was combined with CDs and the different treatment methods in the control group. Results: Nine trials with 1,152 participants with COVID-19 were included. The CT recovery rates of LHQW and LCWC were 1.36 and 1.32 times of CDs, respectively(P0.05). Conclusions: LHQW was more

关键词： Lianhua Qingwen COVID-19 2019-nCoV systematic review meta-analysis Chinese medicine