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Comparison of incidence of acute kidney injury after robot-assisted radical prostatectomy with that after open retropubic and extraperitoneal laparoscopic radical prostatectomies in patients with prostate cancer

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CURRENT UROLOGY 2024年第2期18卷 139-143页

作者： Sato, Shunsuke tanaka, toshiaki Maehana, Takeshi Hashimoto, Kohei Kobayashi, Ko Masumori, Naoya Sapporo Med Univ Dept Urol S-1W-16Chuo ku Sapporo 0608543 Japan

Background: We retrospectively evaluated the postoperative renal function in patients who had undergone radical prostatectomy to compare the incidences of postoperative acute kidney injury (AKI) among the patients who had undergone robot-assisted radical prostatectomy (RARP), retropubic radical prostatectomy (RRP), and extraperitoneal laparoscopic radical prostatectomy (exLRP). Materials and methods: Patients with prostate cancer who had undergone radical prostatectomy at our institution between 2008 and 2014 were included. Robot-assisted radical prostatectomy was performed using an intraperitoneal approach in a 25-degree Trendelenburg position, whereas other procedures were performed with the patient in the supine position. We evaluated the serum creatinine levels and estimated glomerular filtration rates immediately after surgery and on postoperative day 1. We evaluated the incidence of AKI after prostatectomy using the Acute Kidney Injury Network criteria of the Kidney Disease: Improving Global Outcomes guidelines. Results: A total of 150 consecutive patients were included, with each of the 3 groups (RARP, RRP, and exLRP) comprising 50 patients. Postoperative AKI was observed in 15 (30.0%), 1 (2.0%), and 3 (6.0%) patients in the RARP, RRP, and exLRP groups, respectively. Stage 1 AKI was observed in all the patients except one. The incidence of AKI in RARP group was significantly higher than that in the other groups (p < 0.001). In the RARP group, the serum creatinine level was significantly elevated immediately after the surgery; however, it returned to baseline on postoperative day 1. Surgical procedures were the only independent factor associated with AKI incidence. Conclusions: This study suggest that compared with RRP and exLRP, RARP is associated with a higher incidence of postoperative AKI, although most patients recover rapidly. Intra-abdominal pneumoperitoneum may contribute to AKI onset.

关键词： Acute kidney injury Renal function Prostatectomy ACUTE-RENAL-FAILURE PERIOPERATIVE OUTCOMES RISK-FACTORS MORTALITY SURGERY PNEUMOPERITONEUM

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Which characteristics are associated with changes in medication status for lower urinary tract symptoms among patients with prostate cancer receiving external beam radiotherapy?

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CURRENT UROLOGY 2024年第2期18卷 122-127页

作者： Kyoda, Yuki Hashimoto, Kohei Takahashi, Atsushi Maehana, Takeshi Tachikawa, Kimihito Muranaka, Takashi Kato, Shuichi Kurisu, Tomoyo Fukuta, Fumimasa Kirisawa, Takahiro Okada, Manabu Kobayashi, Ko tanaka, toshiaki Hinotsu, Shiro Masumori, Naoya Sapporo Med Univ Sch Med Dept Urol S-1W-16Chuo Ku Sapporo 0608543 Japan Hakodate Goryoukaku Hosp Dept Urol Hakodate Japan Muroran City Gen Hosp Dept Urol Muroran Japan NTT East Sapporo Hosp Dept Urol Sapporo Japan Sunagawa City Med Ctr Dept Urol Sunagawa Japan Oji Gen Hosp Dept Urol Tomakomai Japan Steel Mem Muroran Hosp Dept Urol Muroran Japan Obihiro Kyokai Hosp Dept Urol Obihiro Japan Sapporo Med Univ Sch Med Dept Med Stat Sapporo Japan

BackgroundWe clarified the predictive factors for changes in the status of medications for lower urinary tract symptoms (LUTS) 2 years after local radiotherapy for nonmetastatic prostate cancer. Materials and methodsWe retrospectively included patients who underwent local external radiotherapy for nonmetastatic prostate cancer in 8 institutions between April 2001 and March 2016. Patients were divided into the medication and no-medication group based on the use of drugs for LUTS before radiotherapy. We defined improvement of LUTS as when the patient did not require medication for LUTS at 24 months after radiotherapy in the medication group and as deterioration when medication was required in the no-medication group. Logistic regression analysis was used to evaluate predictive factors for changes in medication status. ResultsAltogether, 505 patients were divided into a no-medication group (n = 352) and a medication group (n = 153). The number of patients with deterioration and improvement in LUTS was 49 (14%) and 36 (23%), respectively. In the multivariate analysis, the predictive variables for deterioration were the International Prostate Symptom Score (>= 8; odds ratio [OR], 2.21; p = 0.014) and the biopsy Gleason score (= 50%; OR, 2.530; p = 0.027) in the medication group. ConclusionsThese predictive factors for changes in the status of medications for LUTS at 2 years after external radiotherapy may help determine the definitive therapy for nonmetastatic prostate cancer.

关键词： Prostate cancer Radiotherapy Lower urinary tract symptoms Medications ANDROGEN DEPRIVATION THERAPY QUALITY-OF-LIFE RADIATION VOLUME MEN TOXICITY RELIEF

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Serum cystatin C can be used as a marker of renal function even in patients with intestinal urinary diversion

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Asian Journal of Urology 2015年第3期2卷 167-169页

作者： Masahiro Matsuki toshiaki tanaka Takeshi Maehana Koji Ichihara Masahiro Yanase Masanori Matsukawa Hideki Adachi Satoshi Takahashi Naoya Masumori Department of Urology Sapporo Medical UniversitySchool of MedicineSapporoJapan Sapporo Kidney Disease Treatment Forum SapporoJapan Department of Urology Sunagawa City Medical CenterSunagawaJapan Department of Urology Takikawa Municipal HospitalTakikawaJapan Department of Urology SaiseikaiOtaru HospitalOtaruJapan

Objective:Recently,serum cystatin C(CysC)has been used as a novel marker of renal ***,there is a lack of data on CysC levels in patients with intestinal urinary diversion(UD).Here we report CysC levels in such ***:We prospectively observed 38 patients who were diagnosed with bladder cancer and subsequently treated with radical cystectomy and UD at our institution in 2012 and *** creatinine(sCr)and CysC were obtained optionally at the same time at least 1 month after radical cystectomy and ***:The median CysC and sCr concentrations were 1.12 mg/L(range 0.75-2.47 mg/L)and 0.99 mg/dL(range 0.61-2.22 mg/dL),*** median estimated concentrations of glomerular filtration rate(GFR)based on CysC(eGFRcys)and GFR based on creatinine(eGFRcreat)were 61.08 mL/min/1.73 m^2(range 22.64e99.89 mL/min/1.73 m^2)and 58.01 mL/min/1.73 m^2(range 23.48e91.82 mL/min/1.73 m2),*** had a significant correlation with sCr(r=0.8607,p<0.0001)and eGFRcreat(r=-0.8993,p<0.0001).eGFRcys also had a significant correlation with eGFRcreat(r=0.8104,p<0.0001).Conclusion:The correlation between CysC and sCr was strong and the correlation coefficient was equivalent to that in patients without *** results suggest that CysC is not affected by UD and can be used as a marker of renal function similarly to sCr in patients with UD.

关键词： Renal function Cystatin C Urinary diversion

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Nomograms for colorectal cancer:A systematic review

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World Journal of Gastroenterology 2015年第41期21卷 11877-11886页

作者： Kazushige Kawai Eiji Sunami Hironori Yamaguchi Soichiro Ishihara Shinsuke Kazama Hiroaki Nozawa Keisuke Hata Tomomichi Kiyomatsu Junichiro tanaka toshiaki tanaka Takeshi Nishikawa Joji Kitayama toshiaki Watanabe Department of Surgical Oncology Graduate School of Medicinethe University of Tokyo

AIM: To assist in the selection of suitable nomograms for obtaining desired predictions in daily ***: We conducted electronic searches for journal articles on colorectal cancer(CRC)-associated nomograms using the search terms colon/rectal/colorectal/nomogram. Of 174 articles initially found, we retrieved 28 studies in which a nomogram for CRC was ***: We discuss the currently available CRCassociated nomograms, including those that predict the oncological prognosis, the short-term outcome of treatments, such as surgery or neoadjuvant chemoradiotherapy, and the future development of CRC. Developing nomograms always presents a dilemma. On the one hand, the desire to cover as wide a patient range as possible tends to produce nomograms that are too complex and yet have C-indexes that are not sufficiently high. Conversely, confining the target patients might impair the clinical applicability of constructed ***: The information provided in this review should be of use in selecting a nomogram suitable for obtaining desired predictions in daily clinical practice.

关键词： Colon Rectum Nomograms Prognosis Cancer

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Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy with taxanes

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World Journal of Gastrointestinal Oncology 2015年第11期7卷 285-291页

作者： Hironori Yamaguchi Joji Kitayama Hironori Ishigami Shinsuke Kazama Hiroaki Nozawa Kazushige Kawai Keisuke Hata Tomomichi Kiyomatsu toshiaki tanaka Junichiro tanaka Takeshi Nishikawa Kensuke Otani Koji Yasuda Soichiro Ishihara Eiji Sunami toshiaki Watanabe Department of Surgical Oncology the University of Tokyo

The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains ***,the intraperitoneal(IP) administration of taxanes [e.g.,paclitaxel(PTX) and docetaxel(DOC)] during the perioperative period has shown promising ***,we summarized the rationale and methodology for using IP chemotherapy with taxanes and reviewed the clinical *** administered taxanes remain in the IP space at an extremely high concentration for 48-72 *** drug directly infiltrates peritoneal metastatic nodules from the surface and then produces antitumor effects,making it ideal for IP *** are two types of perioperative IP chemotherapy with taxanes: neoadjuvant intraperitoneal and systemic chemotherapy and sequential perioperative intraperitoneal chemotherapy(SPIC).In SPIC,patients receive neoadjuvant IP chemotherapy and the same regimen of IP chemotherapy after cytoreductive surgery(CRS) until disease ***,a taxane dissolved in 500-1000 m L of saline at ordinary temperature is administered through an IP access port on an outpatient *** to phase Ⅰ?studies,the recommended doses(RD) are as follows: IP DOC,45-60 mg/m2; IP PTX [without intravenous(IV) PTX],80 mg/m2; and IP PTX(with IV PTX),20 mg/*** Ⅱ studies have reported a median survival time of 14.4-24.6 mo with a 1-year overall survival of 67%-78%.A phase Ⅲ study comparing S-1 in combination with IP and IV PTX to S-1 with IV cisplatin started in *** prognosis of patients who underwent CRS was better than that of those who did not; however,this was partly due to selection *** several phase Ⅱ studies have shown promising results,a randomized controlled study is needed to validate the effectiveness of IP chemotherapy with taxanes for PC of gastric cancer.

关键词： Taxane Paclitaxel Docetaxel Carcinoma Gastric canc

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利用TE10,TE20和TE30模的脊形窄壁定向耦合器

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无线电通信技术 1981年第9期 57-65+56页

作者： toshiaki tanaka 张士祥

简介——提出并分析一种紧凑的新型窄壁定向耦合器,其耦合区域是一个脊形波导,此波导的尺寸能够存在TE10,TE20和TE30模。耦合比及无反射条件分别由TE20与TE30模之间和TE10与TE30模了间的干扰程度确定。改变耦合缝的高度,这种耦合器就能... 详细信息

简介——提出并分析一种紧凑的新型窄壁定向耦合器,其耦合区域是一个脊形波导,此波导的尺寸能够存在TE10,TE20和TE30模。耦合比及无反射条件分别由TE20与TE30模之间和TE10与TE30模了间的干扰程度确定。改变耦合缝的高度,这种耦合器就能当作可变功率分配器使用。对于在16到19GHz频率范围内的3db耦合来说,能够获得在±0.5db内的功率分配误差、大于30db的隔离和30db以上的反射损耗。实验耦合结果表明与理论相当吻合。

关键词： TE 区域内工作原理波导馈电设备相移常数波长常数传输常数祸合器

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A single atom photocatalyst co-doped with potassium and gallium for enhancing photocatalytic hydrogen peroxide synthesis

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Nano Research 2024年第8期17卷 7027-7038页

作者： Wenan Cai Yuichiro tanaka Xing Zhu Teruhisa Ohno Department of Applied Chemistry Faculty of EngineeringKyushu Institute of TechnologyKitakyushu 804-8550Japan College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXi’an 710021China

Polymer carbon nitride(PCN)is widely used in ***,pristine PCN has disadvantages such as insufficient visible light absorption and low photogenerated carrier separation efficiency that greatly limited the photocatalytic *** a non-toxic metal,gallium has the potential to solve the defects of *** ions coordinated with nitrogen in carbon nitride to form Ga-N active sites and improved the photocatalytic *** doped potassium ions form a transmission channel for charge redistribution and transfer between adjacent layers,which is beneficial for better separation of photoexcited *** this study,a series of PCN co-doped with gallium and potassium(Ga-K-PCN)were *** experimental results indicated photocatalytic generation of hydrogen peroxide proceeds through the 2e−oxygen reduction reaction ***,Nyquist plots and photocurrent results further proved that the presence of Ga-N sites and potassium ion doping could significantly improve the separation/transfer of intra-planar and interlayer charge carriers and thus enhance photocatalytic *** Ga10-K3-PCN photocatalysts promoted yield of H_(2)O_(2),with reactivity at 28.2μmol/(g·h)and solar-to-chemical conversion efficiency at 0.64%,surpassed that of a typical photo-catalyst based on PCN(0.18%).

关键词： photocatalysis gallium oxygen reduction reaction H_(2)O_(2) production

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Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 557-562页

作者： toshiaki Tsurui Yuya Hirasawa Yutaro Kubota Kiyoshi Yoshimura Takuya Tsunoda Department of Medical Oncology Showa UniversityTokyo 1428555Japan Department of Clinical Immuno Oncology Clinical Research Institute of Clinical Pharmacology and TherapeuticsShowa UniversityTokyo 1578577Japan

BACKGROUND Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer(CRC).Effective drainage is often im-possible before initiating systemic chemotherapy,owing to the liver’s diffuse metastatic ***,an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently *** SUMMARY The patient,a man in his 50s,presented with progressive fatigue and severe *** tomography revealed multiple hepatic masses with thick-ened walls in the sigmoid colon,which was pathologically confirmed as a well-differentiated *** RAS or BRAF mutations were *** Eastern Cooperative Oncology Group(ECOG)performance status(PS)score was *** drainage was impossible due to the absence of a dilated bile duct,and panitumumab monotherapy was promptly ***,the bilirubin level decreased and then normalized,and the patient’s PS improved to zero ECOG score after four cycles of therapy without significant adverse *** Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS wild-type CRC and hepatic metastases with severe hyperbilirubinemia.

关键词： Colorectal neoplasms Panitumumab Chemotherapy Hyperbilirubinemia Jaundice Case report

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Fabrication of Mie-resonant silicon nanoparticles using laser annealing for surface-enhanced fluorescence spectroscopy

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Microsystems & Nanoengineering 2024年第2期10卷 133-141页

作者： Tatsuya Fukuta Ryo Kato Takuo tanaka Taka-aki Yano Institute of Post-LED Photonics Tokushima University2-1 Minami-JosanjimaTokushima770-8506Japan Innovative Photon Manipulation Research Team RIKEN Center for Advanced PhotonicsWakoSaitama351-0198Japan Metamaterials Laboratory RIKEN Cluster for Pioneering ResearchWakoSaitama351-0109Japan

Silicon nanostructures with unique Mie resonances have garnered considerable attention in the field of ***,we present a simple and efficient method for the fabrication of silicon(Si)nanoparticle substrates using continuous-wave(CW)laser *** resulting silicon nanoparticles exhibit Mie resonances in the visible region,and their resonant wavelengths can be precisely ***,laser-annealed silicon nanoparticle substrates show a 60-fold enhancement in *** tunable and fluorescence-enhancing silicon nanoparticle platform has tremendous potential for highly sensitive fluorescence sensing and biomedical imaging applications.

关键词： nanoparticles annealing resonant

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Metabolomics in liver diseases: A novel alternative for liver biopsy?

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World Journal of Hepatology 2024年第1期16卷 12-16页

作者： Yasuo tanaka Department of Gastroenterology National Center for Global Health and MedicineTokyo 162-8655Japan

Hepatitis C virus(HCV)remains a significant public health problem as it can cause acute and chronic *** HCV infection is a major cause of liver fibrosis,and evaluation of liver fibrosis is essential because the prognosis of patients with chronic HCV infection is closely related to the stage of *** fibrosis is traditionally evaluated based on pathological analysis of biopsy specimens,which is considered the gold ***,liver biopsy is invasive and susceptible to sampling error and inter-and intraobserver variation in pathological interpretation;it is also ***,noninvasive diagnostic investigations have been developed,including the use of fibrotic markers,scoring systems based on routine blood tests,and transient elastography with magnetic resonance imaging or ***,metabolomics,an emerging technology,has been used to detect the fibrosis *** this editorial,I comment on the article titled“Metabolomics in chronic hepatitis C:Decoding fibrosis grading and underlying pathways”by Ferrasi et al published in the recent issue of the World Journal of Hepatology.I discuss previous studies on the use of metabolome analysis for the diagnosis of HCV-related liver fibrosis and the potential development of biopsy-free diagnostic techniques.

关键词： Metabolomics Hepatitis C virus Liver fibrosis Liver cirrhosis Serum biomarker

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