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Determination of PAHs in atmospheric size-resolved particles by direct thermal desorption and comprehensive two dimensional gas chromatography coupled to quadrupole mass spectrometer

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Determination of PAHs in atmospheric size-resolved particles...

置入紫杉醇洗脱支架或裸金属支架后的不完全支架贴壁不良——TAXUSII随机试验的深入研究

30th International Symposium on Capillary Chromatography、4th GC×GC Symposium、16th National Symposium and Exhibition on Chromatography,i.e. 1st Dalian International Symposium and Exhibition on Chromatography

作者： leda,T. Ochiai,N. Sasamoto,k. Fushimi,A. Hasegawa,S. tanabe,k. k.bayashi,S. GERSTEL k.k. 2-13-18NakaneMeguro-kuTokyo 152-0031Japan GERSTEL k.k. 2-13-18NakaneMeguro-kuTokyo 152-0031Japan GERSTEL k.k. 2-13-18NakaneMeguro-kuTokyo 152-0031Japan National Institute for Environmental Studies 16-2OnogawaTsukuba 305-8506Japan National Institute for Environmental Studies 16-2OnogawaTsukuba 305-8506Japan National Institute for Environmental Studies 16-2OnogawaTsukuba 305-8506Japan National Institute for Environmental Studies 16-2OnogawaTsukuba 305-8506Japan

＜正＞Polycyclic aromatic hydrocarbons（PAHs）in atmospheric particles have received increased attention because some of these compounds have some potential to cause health ***,particle matters less than 100 nanometers in diameter are thought to pose the greatest health risk.because such small particles can reach deeply into the ***,quantification of size-resolved particles is important to determine their toxicity ***,sample amount of size-resolved particles is generally very sma11（μg level）so that highly sensitive analysis is essential.

关键词： k.Y WORDS GC×GC Direct thermal desorption PAHs Quadrupole mass spectrometer Atmospheric size-resolved particles

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世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 32-33页

作者： tanabe k. Serruys P.W. Degertek.n M. 孟欣 Thoraxcentre Erasmus MC Bd 406 Dr Molewaterplein 40 3015 GD Rotterdam Netherlands

Back.round The clinical impact of late incomplete stent apposition(ISA) for drug- eluting stents is unk.own. We sought to prospectively investigate the incidence and extent of ISA after the procedure and at 6- month follow- up of paclitaxel- eluting stents in comparison with bare metal stents(BMS) and survey the clinical significance of ISA over a period of 12 months. Methods and Results TAXUS II was a randomized, double- blind study with 536 patients in 2 consecutive cohorts comparing slow- release(SR; 131 patients) and moderate- release(MR; 135 patients) paclitaxel- eluting stents with BMS(270 patients). This intravascular ultrasound(IVUS) substudy included patients who underwent serial IVUS examination after the procedure and at 6 months(BMS, 240 patients; SR, 113; MR, 116). The qualitative and quantitative analyses of ISA were performed by an independent, blinded core laboratory. More than half of the instances of ISA observed after the procedure resolved at 6 months in all groups. No difference in the incidence of late- acquired ISA was observed among the 3 groups(BMS, 5.4% ; SR, 8.0% ; MR, 9.5% ; P=0.306), with a similar ISA volume(BMS, 11.4 mm3; SR, 21.7 mm3; MR, 8.5 mm3; P=0.18). Late- acquired ISA was the result of an increase of vessel area without change in plaque behind the stent. Predictive factors of late- acquired ISA were lesion length, unstable angina, and absence of diabetes. No stent thrombosis occurred in the patients diagnosed with ISA over a period of 12 months. Conclusions The incidence and extent of late- acquired ISA are comparable in paclitaxel- eluting stents and BMS. ISA is a pure IVUS finding without clinical repercussions.

关键词：紫杉醇洗脱支架 TAXUSII 不完全支架裸金属支架随机试验药物洗脱支架血管内超声不稳定型心绞痛病变长度临床影响

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用于旋翼飞机开发研究的多分野解析框架

Transactions of Nanjing University of Aeronautics and Astronautics 2024年第1期41卷 43-52页

作者： tanabe Yasutada SUGAWARA Hideak. k.MURA k.ita 日本宇宙航空研究开发机构航空技术部日本东京181-0015

介绍了日本宇宙航空研究开发机构研发的用于旋翼飞机的多分野解析框架。Heli Design是在各种旋翼飞机初期概念设计时使用的软件;rFlight可以提供在各种飞行条件下的平衡解析和线性化飞行模型;rBET/RMT是基于叶片要素理论的低保真度空力... 详细信息

介绍了日本宇宙航空研究开发机构研发的用于旋翼飞机的多分野解析框架。Heli Design是在各种旋翼飞机初期概念设计时使用的软件;rFlight可以提供在各种飞行条件下的平衡解析和线性化飞行模型;rBET/RMT是基于叶片要素理论的低保真度空力解析软件,和rMode提供的结构模型结合,可以推测旋转翼的弹性变形和各种飞行条件下的空力负载;rFlow3D是基于CFD计算的高保真度数值模拟软件;rGrid系列自动网格构造工具为其提供简单的网格生成;基于rFlow3D的计算结果,r Noise可以预测在任何观测点的噪声。这些软件已经广泛地被应用在各种新型旋翼飞机的开发研究中,其计算精度也已被各种实验结果所应证。

关键词：旋翼飞机多分野解析高保真模拟设计工具

Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin(Ⅳ) prodrug delivery and enhanced colorectal cancer therapy

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Chinese Chemical Letters 2024年第4期35卷 280-286页

作者： Wenjia Wang Xingyue He Xiaojie Wang Tiantian Zhao Osamu Muraok. Genzoh tanabe Weijia Xie Tianjiao Zhou Lei Xing Qingri Jin Hulin Jiang State k.y Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Faculty of Pharmacy k.nk. University HigashiosakaOsaka 577-8502Japan State k.y Laboratory of Natural Medicines(Sk.NM)and Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 210009China School of Pharmacy Hangzhou Medical CollegeHangzhou 311399China College of Pharmacy Yanbian UniversityYanji 133002China

Oxaliplatin(Oxa) is the first-line chemotherapeutic drug for the treatment of colorectal cancer(CRC). However, long-term Oxa chemotherapy can induce inflammation and increase the levels of cyclooxygenase-2(COX-2) and prostaglandin E2(PGE2), which can promote tumor metastasis. Moreover,high glutathione(GSH) levels in CRC cells significantly reduce Oxa sensitivity and seriously restrict the clinical application of Oxa. Herein, an Oxa(Ⅳ) prodrug with anti-inflammatory properties(desmethyl naproxe, DN) and GSH-depleting cyclodextrin pseudo-polyrotaxane carriers were prepared and further self-assembled into micellar nanoparticles(designated DNPt@PPRI). The relesae of DN from DNPt@PPRI can reduce the level of PGE2 to inhibit inflammation and tumor metastasis by decreasing COX-2 protein,and also synergize with Oxa to inhibit tumor. More importantly, GSH depletion can reduce the detoxification of Oxa and further enhance chemotherapy-induced apoptosis. DNPt@PPRI have a good GSH depletion ability to enhance the sensitivity of Oxa, indicating a potential in the synergistic chemotherapy and chemo-sensitization of colorectal cancer.

关键词： Oxaliplatin Glutathione depletion Tetravalent platinum prodrug Synergistic therapy Colorectal cancer

Surgical strategies for challenging common bile duct stones in the endoscopic era: A comprehensive review of current evidence

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 305-317页

作者： Tharathorn Suwatthanarak.Vitoon Chinswangwatanak.l Asada Methasate Chainarong Phalanusitthepha Minoru tanabe k.iichi Ak.ta Thawatchai Ak.raviputh Minimally Invasive Surgery Unit Department of SurgeryFaculty of Medicine Siriraj HospitalMahidol UniversityBangkok Noi 10700BangkokThailand Graduate School of Medical and Dental Sciences Tokyo Medical and Dental UniversityBunkyo 113-8519TokyoJapan Department of Hepatobiliary and Pancreatic Surgery Tokyo Medical and Dental UniversityBunkyo 113-8519TokyoJapan Department of Clinical Anatomy Tokyo Medical and Dental UniversityBunkyo 113-8519TokyoJapan

While endoscopic retrograde cholangiopancreatography(ERCP)remains the primary treatment modality for common bile duct stones(CBDS)or choledocho-lithiasis due to advancements in instruments,surgical intervention,k.own as common bile duct exploration(CBDE),is still necessary in cases of difficult CBDS,failed endoscopic treatment,or altered *** evidence also supports CBDE in patients requesting single-step cholecystectomy and bile duct stone removal with comparable *** review elucidates relevant clinical anatomy,selection indications,and outcomes to enhance surgical *** selection between trans-cystic(TC)vs trans-choledochal(TD)approaches is described,along with stone removal techniques and ductal *** surgical techniques and strategies for both the TC and TD approaches,including instrument selection,is also ***,this review comprehensively addresses operation-specific complications such as bile leak.ge,stricture,and entrapment,and focuses on preventive measures and treatment *** review aims to optimize the management of CBDS through laparoscopic CBDE,with the goal of improving patient outcomes and minimizing risk..

关键词： Choledocholithiasis Common bile duct stone Difficult common bile duct stone Common bile duct exploration Laparoscopic common bile duct exploration

日本人群中冠状动脉疾病患者颈动脉狭窄的患病率

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 55-55页

作者： Tanimoto S. Ik.ri Y. tanabe k. 刘凯 Department of Interventional Cardiology Thorax Center Dr. Molewaterplein 40 3015 GD Rotterdam Netherlands.Dr

Back.round and Purpose -Prevalence of carotid artery stenosis in patients with coronary artery disease (CAD) is unk.own in Japanese population. Methods -The study populations consisted of 632 consecutive patients who underwent coronary angiography because of suspicion of CAD. All patients underwent carotid ultrasonography to screen carotid artery stenosis before coronary angiography. We define d echographic carotid stenosis as area stenosis of >50%or peak.systolic velocit y of >200 cm/s. Results -Echographic carotid stenosis was observed in 124 patie nts (19.6%). Coronary angiography revealed 433 patients had CAD. Prevalence of echographic carotid artery stenosis was 14 of 199 (7.0%), 18 of 124 (14.5%), 2 8 of 131 (21.4%), and 64 of 178 (36.0%) in patients with 0-, 1-, 2-, and 3 -vessel CAD, respectively (P < 0.0001). The prevalence rate with carotid stenos is and CAD was 25.4%. Multivariate stepwise logistic regression analysis showed that age and the extent of CAD were independently related to the presence of ca rotid stenosis (P=0.0002 and < 0.0001, respectively). Conclusions -Prevalence o f carotid stenosis in patients with CAD is high in Japan as well as in Western c ountries. Screening of carotid artery stenosis is recommended especially in olde r patients with multivessel CAD.

关键词：患病率 CAD 颈动脉狭窄患者冠状动脉疾病

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前哨淋巴结活检诊断转移性基底细胞癌

世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 15-15页

作者： Harwood M. tanabe k. Bercovitch L. 张莹 Dr. 851 Main St SouthWeymouthMA 02190 United States

Although commonly used in the treatment of melanoma, sentinel lymph node biopsy has not yet been successfully used to detect lymphatic metastasis of basal cell carcinoma because of exceedingly low rates of metastasis. We describe the use of lymphatic mapping and sentinel lymph node biopsy in a patient after basal cell carcinoma was identified within a lymphatic vessel in the primary excisional specimen. As a result, the patient was found to have clusters of basal cell carcinoma in a sentinel lymph node resected from the right deltopectoral groove. Although metastatic basal cell carcinoma is exceedingly rare, we conclude that sentinel lymph node biopsy may be useful for certain high- risk.lesions, such as lesions demonstrating histologic evidence of lymphatic invasion. Further experience is necessary to determine the clinical usefulness of sentinel node biopsy in these patients and its effect on patient survival.

关键词：前哨淋巴结活检基底细胞癌黑色素瘤淋巴管转移患者存活率淋巴转移集簇转移率在原

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多层CT心脏成像检查中的心外发现

世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 56-页

作者： Onuma Y. tanabe k. Nak.zawa G. 赵君 Division of Cardiology Mitsui Memorial Hospital Tokyo Japan Dr.

Objectives: We investigated the frequency of the noncardiac findings in cardiac imaging with multidetector computed tomography(MDCT). Back.round: Multidetector computed tomography is an accepted new tool to evaluate the heart. In cardiac MDCT scans, organs other than the heart are also irradiated, but usually not assessed. Methods: A total of 503 patients underwent cardiac imaging with 16-or 64-slice MDCT. Cardiologists assessed the heart, while radiologists reviewed the other organs. Results: A total of 346 new, noncardiac findings were identified in 292 patients(58.1%). A total of 114 patients(22.7%) had clinically significant findings including 4 cases of malignancy(0.8%). Conclusions: There were a significant number of noncardiac findings in cardiac MDCT. To avoid missing clinically important findings, physicians who analyze cardiac MDCT scan-either radiologists or cardiologists-should carefully evaluate all the organs irradiated in the scan.

关键词：心脏成像 CT DCT

The role of protein phosphorylation in the regulation of class switch recombination

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BIOCELL 2020年第4期44卷 545-558页

作者： k.NO tanabe RYUTARO k.JIHARA Department of Medical Technology Faculty of Health ScienceKumamoto Health Science UniversityKumamoto861-5598Japan Department of Biomedical Laboratory Sciences Faculty of Life SciencesKumamoto UniversityKumamoto862-0976Japan Center for Immunotherapy Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA

Antibody is an important part of adaptive immune system and is produced only by B *** are five main classes(IgM,IgD,IgG,IgA,IgE)and some subclasses in *** and IgD are produced by mature naïve B *** the other hand,IgG,IgA and IgE are produced by activated antigen-specific B cells via class switch recombination(CSR).CSR is the irreversible DNA rearrangement from upstream to downstream classes in immunoglobulin heavy chain ***-stimulations of CD40 ligand(CD40L)and cytok.nes are required for induction of CSR by activating several transcription *** signal transduction pathways involve many protein *** or dephosphorylation of cellular protein is an important k.nd of post-translational protein modification in intracellular signal *** the fact,more than one third of the intracellular proteins are said to be transiently phosphorylated in human.A protein k.nase is an enzyme that catalyzes the addition of phosphate to substrate ***,a protein phosphatase catalyzes the removal of phosphate from the *** review focuses on the mechanism of CSR controlled by protein phosphorylation and *** provide the role of protein k.nase and phosphatase in the regulation of class switch recombination.

关键词： Antibody k.nase Phosphatase Signal Transduction