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A deep reinforcement learning approach to gasoline blending real-time optimization under uncertainty

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Chinese Journal of Chemical Engineering 2024年第7期71卷 183-192页

作者： Zhiwei Zhu Minglei Yang Wangli He Renchu He yunmeng Zhao Feng Qian Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

The gasoline inline blending process has widely used real-time optimization techniques to achieve optimization objectives,such as minimizing the cost of ***,the effectiveness of real-time optimization in gasoline blending relies on accurate blending models and is challenged by stochastic ***,we propose a real-time optimization algorithm based on the soft actor-critic(SAC)deep reinforcement learning strategy to optimize gasoline blending without relying on a single blending model and to be robust against *** approach constructs the environment using nonlinear blending models and feedstocks with *** algorithm incorporates the Lagrange multiplier and path constraints in reward design to manage sparse product *** abstracted states facilitate algorithm convergence,and the normalized action vector in each optimization period allows the agent to generalize to some extent across different target production *** these well-designed components,the algorithm based on the SAC outperforms real-time optimization methods based on either nonlinear or linear *** even demonstrates comparable performance with the time-horizon based real-time optimization method,which requires knowledge of uncertainty models,confirming its capability to handle uncertainty without accurate *** simulation illustrates a promising approach to free real-time optimization of the gasoline blending process from uncertainty models that are difficult to acquire in practice.

关键词： Deep reinforcement learning Gasoline blending Real-time optimization Petroleum Computer simulation Neural networks

Nanotherapeutics targeting autophagy regulation for improved cancer therapy

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2447-2474页

作者： yunmeng Liu Yaxin Wang Jincheng Zhang Qikai Peng Xingdong Wang Xiyue Xiao Kai Shi College of Pharmacy Nankai UniversityTianjin 300350China

The clinical efficacy of current cancer therapies falls short,and there is a pressing demand to integrate new targets with conventional ***,a highly conserved self-degradation process,has received considerable attention as an emerging therapeutic target for *** the rapid development of nanomedicine,nanomaterials have been widely utilized in cancer therapy due to their unrivaled delivery ***,considering the potential benefits of integrating autophagy and nanotechnology in cancer therapy,we outline the latest advances in autophagy-based *** on a brief background related to autophagy and nanotherapeutics and their impact on tumor progression,the feasibility of autophagy-based nanotherapeutics for cancer treatment is ***,emerging nanotherapeutics developed to modulate autophagy are reviewed from the perspective of cell signaling pathways,including modulation of the mammalian target of rapamycin(mTOR)pathway,autophagy-related(ATG)and its complex expression,reactive oxygen species(ROS)and mitophagy,interference with autophagosome-lysosome fusion,and inhibition of hypoxia-mediated *** addition,combination therapies in which nano-autophagy modulation is combined with chemotherapy,phototherapy,and immunotherapy are also ***,the prospects and challenges of autophagy-based nanotherapeutics for efficient cancer treatment are envisioned.

关键词： Autophagy regulation Nanotherapeutic Combination strategies Cancer therapy Signal transduction pathway Delivery strategies Dual effects Nanomaterials

All‑Covalent Organic Framework Nanofilms Assembled Lithium‑Ion Capacitor to Solve the Imbalanced Charge Storage Kinetics

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Nano-Micro Letters 2024年第6期16卷 246-260页

作者： Xiaoyang Xu Jia Zhang Zihao Zhang Guandan Lu Wei Cao Ning Wang yunmeng Xia Qingliang Feng Shanlin Qiao College of Chemistry and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018People’s Republic of China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China Hebei Engineering Research Center of Organic Solid Photoelectric Materials for Electronic Information Shijiazhuang 050018People’s Republic of China

Free-standing covalent organic framework(COFs)nanofilms exhibit a remarkable ability to rapidly intercalate/de-intercalate Li^(+) in lithium-ion batteries,while simultaneously exposing affluent active sites in *** development of these nanofilms offers a promising solution to address the persistent challenge of imbalanced charge storage kinetics between battery-type anode and capacitor-type cathode in lithium-ion capacitors(LICs).Herein,for the first time,custom-made COFBTMB-TP and COFTAPB-BPY nanofilms are synthesized as the anode and cathode,respectively,for an all-COF nanofilm-structured *** COFBTMB-TP nanofilm with strong electronegative–CF3 groups enables tuning the partial electron cloud density for Li^(+) migration to ensure the rapid anode kinetic *** thickness-regulated cathodic COFTAPB-BPY nanofilm can fit the anodic COF nanofilm in the *** to the aligned 1D channel,2D aromatic skeleton and accessible active sites of COF nanofilms,the whole COFTAPB-BPY//COFBTMB-TP LIC demonstrates a high energy density of 318 mWh cm^(−3) at a high-power density of 6 W cm^(−3),excellent rate capability,good cycle stability with the capacity retention rate of 77%after *** COFTAPB-BPY//COFBTMB-TP LIC represents a new benchmark for currently reported film-type LICs and even film-type *** being comprehensively explored via ex situ XPS,7Li solid-state NMR analyses,and DFT calculation,it is found that the COFBTMB-TP nanofilm facilitates the reversible conversion of semi-ionic to ionic C–F bonds during lithium ***-TP exhibits a strong interaction with Li^(+) due to the C–F,C=O,and C–N bonds,facilitating Li^(+) desolation and absorption from the *** work addresses the challenge of imbalanced charge storage kinetics and capacity between the anode and cathode and also pave the way for future miniaturized and wearable LIC devices.

关键词： Covalent organic frameworks Lithium-ion capacitor Charge storage kinetic

Electron delocalization-enhanced sulfur reduction kinetics on an MXene-derived heterostructured electrocatalyst

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Nano Research 2024年第8期17卷 7153-7162页

作者： yunmeng Li Yinze Zuo Xiang Li Yongzheng Zhang Cheng Ma Xiaomin Cheng Jian Wang Jitong Wang Hongzhen Lin Licheng Ling State Key Laboratory of Chemical Engineering Key Laboratory of Specially Functional Polymeric Materials and Related Technology(Ministry of Education)East China University of Science and TechnologyShanghai 200237China Institute of New Energy Materials and Engineering College of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Key Laboratory of Specially Functional Polymeric Materials and Related Technology(Ministry of Education) School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China i-Lab&CAS Key Laboratory of Nanophotonic Materials and Device Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123China Helmholtz Institute Ulm(HIU) D89081 UlmGermany

Lithium-sulfur(Li-S)batteries mainly rely on the reversible electrochemical reaction of between lithium ions(Li^(+))and sulfur species to achieve energy storage and conversion,therefore,increasing the number of free Li^(+)and improving the Li^(+)diffusion kinetics will effectively enhance the cell ***,Mo-based MXene heterostructure(MoS_(2)@Mo_(2)C)was developed by partial vulcanization of Mo_(2)C MXene,in which the introduction of similar valence S into Mo-based MXene(Mo_(2)C)can create an electron delocalization *** theoretical simulations and electrochemical characterisation,it is demonstrated that the MoS_(2)@Mo_(2)C heterojunction can effectively promote ion desolvation,increase the amount of free Li^(+),and accelerate Li^(+)transport for more efficient polysulfide *** addition,the MoS_(2)@Mo_(2)C material is also capable of accelerating the oxidation and reduction of polysulfides through its sufficient defects and vacancies to further enhance the catalytic ***,the Li-S battery with the designed MoS_(2)@Mo_(2)C electrocatalyst performed for 500 cycles at 1 C and still maintained the ideal capacity(664.7 mAh·g^(−1)),and excellent rate performance(567.6 mAh·g^(−1)at 5 C).Under the extreme conditions of high loading,the cell maintained an excellent capacity of 775.6 mAh·g^(−1)after 100 *** also retained 838.4 mAh·g^(−1)for 70 cycles at a low temperature of 0℃,and demonstrated a low decay rate(0.063%).These results indicate that the delocalized electrons effectively accelerate the catalytic conversion of lithium polysulfide,which is more practical for enhancing the behaviour of Li-S batteries.

关键词： delocalized electron lithium sulfur batteries MXene-based heterostructures catalytic desolvation multi-catalytic sites

An Efficient Fair Electronic Cash System

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High Technology Letters 2003年第3期9卷 1-5页

作者：郭涛 Li Zhitang tan yunmeng Wu Shizhong Department of Computer Science & Technology Huazhong University of Science and Technology Wuhan 430074 P.R.China Department of Communication Science & Technology Huazhong University of Science and TechnologyWuhan 430074 P.R.China China National Information Security Testing Evaluation & Certification Center Beijing 100091P.R.China

In this paper, an efficient fair e-cash system is presented. Based on the improved Brands’ e-cash scheme, it is expanded by adding two roles, government and judges. The user can keep unconditionally anonymous in normal transactions. Authorized by the judges, the government can remove the identity of an illegal user with the help of the bank. So such misuse as blackmailing or money laundering can be prevented. Therefore, this scheme is more efficient, more suitable for adopting pre-processing and post-processing and more practical. In the paper, the details of the scheme are described, its security is proved, and its efficiency is analyzed.

关键词：有效公平电子货币系统电子支付电子商务 Internet 交易安全

Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1661-1676页

作者： Junhui Chen Qian Zhang Jinan Guo Di Gu Jing Liu Piao Luo yunmeng Bai Jiayun Chen Xinzhou Zhang Sheng Nie Chunbo Chen Yulin Feng Jigang Wang National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine Jiangxi University of Chinese MedicineNanchang 330006China Department of Pulmonary and Critical Care Medicine Shenzhen Institute of Respiratory Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalFirst Affiliated Hospital of Southern University of Science and TechnologySecond Clinical Medical College of Jinan UniversityShenzhen 518020China School of Traditional Chinese Medicine and School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Urology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Nephrology Nanfang Hospitalthe First Affiliated Hospital of Southern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China State Key Laboratory for Quality Esurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Oncology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

Diabetic nephropathy(DN)is a severe complication of diabetes,characterized by changes in kidney structure and *** natural product rosmarinic acid(RA)has demonstrated therapeutic effects,including anti-inflammation and anti-oxidative-stress,in renal damage or *** this study,we characterized the heterogeneity of the cellular response in kidneys to DN-induced injury and RA treatment at single cell *** results demonstrated that RA significantly alleviated renal tubular epithelial injury,particularly in the proximal tubular S1 segment and on glomerular epithelial cells known as podocytes,while attenuating the inflammatory response of macrophages,oxidative stress,and cytotox-icity of natural killer *** findings provide a comprehensive understanding of the mechanisms by which RA alleviates kidney damage,oxidative stress,and inflammation,offering valuable guidance for the clinical application of RA in the treatment of DN.

关键词： Rosmarinic acid Diabetic nephropathy scRNA sequencing Injury Oxidative stress Infiammation Proteomics

Influence of ambient temperature on the CO_(2)emitted of light-duty vehicle

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Journal of Environmental Sciences 2024年第6期140卷 59-68页

作者： Dan tan Yachao Wang Jianwei tan Jiachen Li Changyu Wang Yunshan Ge School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China

Because of global warming,people have paid more attention to greenhouse gas emitted by *** quantify the impact of temperature on vehicle CO_(2)emissions,this study was conducted using the world light vehicle test cycle on two light-duty E10 gasoline vehicles a ambient temperatures of-10,0,23,and 40℃,and found that CO_(2)emission factors of Vehicle1 in the low-speed phase were 22.07%and 20.22%higher than those of Vehicle 2 at cold star and hot start under-10℃.The reason was vehicle 1 had a larger displacement and more friction pairs than vehicle *** was the highest CO_(2)emission at the low-speed phase due to low average speed,frequent acceleration,and *** CO_(2)temperature factor and the ambient temperature had a strong linear correlation(R2=0.99).According to CO_(2)temperature factors and their relationships,CO_(2)emission factors of other ambien temperatures could be calculated when the CO_(2)emission factor of 23℃was obtained,and the method also could be used to obtain the CO_(2)temperature factors of different *** separate the effect of load setting and temperature variation on CO_(2)emission quantitatively a method was *** results showed that the load setting was dominant for the CO_(2)emission *** with 23℃,the CO_(2)emission for vehicle 1 caused by load setting variation were 62.83 and 47.42 g/km,respectively at-10 and 0℃,while those fo vehicle 2 were 45.01 and 35.63 g/km,respectively.

关键词： CO_(2)emission Ambient temperature E10 gasoline Light-duty vehicle WLTC

Best Paper Award 2022

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Building Simulation 2024年第1期17卷 1-2页

作者： Gang tan College of Civil Engineering and Architecture Zhejiang University HangzhouZhejiang 310058China

I am pleased to announce that the following paper has been awarded the Best Review Paper 2022,which stands out from the 24 review papers published by Building Simulation from 2018(Volume 11)to 2022(Volume 15):Yuejing Zhao&Bin Zhao."Emissions of air pollutants from Chinese cooking:A literature review."Building Simulation,2018,11(5):977-995.

关键词： cooking stands award

Preface to the Special Issue:AI Applications in Atmospheric and Oceanic Science:Pioneering the Future(Part I)

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Advances in Atmospheric Sciences 2024年第7期41卷 1279-1280页

作者： Zhemin tan Key Laboratory of Mesoscale Severe Weather Ministry of Educationand School of Atmospheric SciencesNanjing UniversityNanjing 210023China

As AI continues to establish itself as a cornerstone technology across various industries and scientific disciplines,its profound impact on atmospheric and oceanic science is becoming increasingly *** advantages of AI in surmounting obstacles within our field are undeniable,as evidenced by breakthroughs in weather forecasting(e.g.,Bi et al.,2023),climate prediction(e.g.,Ham et al.,2019),AI-based parameterization schemes(e.g.,Rasp et al.,2018;Wang and tan,2023),and *** the transformative potential of AI in atmospheric and oceanic science,this special issue endeavors to explore the extensive applications of AI in our domain.

关键词： weather forecasting prediction