检索结果-南通市图书馆

World Journal of Gastroenterology 2008年第14期14卷 2235-2240页

作者： Yun-Chun Li Tian-Zhi tan Jian-Guo zheng Chun Zhang Department of Nuclear Medicine West China Hospital Sichuan University 37 Guoxue Alley Chengdu 610041 Sichuan Province China

AIM:To explore and compare the radiochemical behavior and biological property of anti-sense oligonuc-leotide (ASON) labeled with technetium-99m using N-hydroxysuccinimidyl S-acetylmercaptoacetyltriglycl ine (NHS-MAG3) and hydrazinonictinamide derivative (HYNIC). METHODS:After HYNIC and NHS-MAG3 were synthesized, ASON was labeled with technetium-99m using HYNIC and NHS-MAG3 as a bifunctional chelator. The in vivo and in vitro stability, binding rates of labeled compounds to serum albumen, biodistribution of 99mTc-MAG3-ASON and 99mTc-HYNIC-ASON in BALB/C mouse and its HT29 tumor cellular uptake were compared. RESULTS:The labeling efficiency and stability of 99mTc-MAG3-ASON were significantly higher than those of 99mTc-HYNIC-ASON (P = 0.02, and P = 0.03, respectively). 99mTc-MAG3-ASON had a significantly lower rate of binding to serum albumen than 99mTc-HYNIC-ASON (P 0.05) and significantly higher in lung and kidney (P < 0.05). The HT29 tumor cellular uptake rate of 99mTc-MAG3-ASON was significantly higher than that of 99mTc-HYNIC-ASON (P < 0.05). CONCLUSION:99mTc-MAG3-ASON shows superior radiochemical behaviors and biological properties than 99mTc-HYNIC-ASON. 99mTc-MAG3-ASON is a potential radiopharmaceutical agent for in vivo application.

关键词： Anti-sense oligonucleotide Radiolabeling Technetium-99m N-hydroxysuccinimidyl S-acetylmercapt oacetyltriglycline Hydrazinonictionamide derivative

Reconstruction from contour lines based on bi-cubic Bézier spline surface

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第7期7卷 1241-1246页

作者： LI Zhong MA Li-zhuang tan Wu-zheng ZHAO Ming-xi Department of Mathematics and Science Zhejiang Sci-Tech University Hangzhou 310018 China Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

A novel reconstruction method from contours lines is provided. First, we use a simple method to get rid of redundant points on every contour, then we interpolate them by using cubic Bézier spline curve. For corresponding points of different con- tours, we interpolate them by the cubic Bézier spline curve too, so the whole surface can be reconstructed by the bi-cubic Bézier spline surface. The reconstructed surface is smooth because every Bézier surface is patched with G2 continuity, the reconstruction speed is fast because we can use the forward elimination and backward substitution method to solve the system of tridiagonal equations. We give some reconstruction examples at the end of this paper. Experiments showed that our method is applicable and effective.

关键词： Contour Surface reconstruction Bi-cubic Bézier surface G^2 continuity

Photoelectrochemistry of electrochemically deposited cadmium-rich cadmium mercury telluride films

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 1991年第1期9卷 40-44页

作者： tan zheng LI Jun MI Tian-Ying Changchun Institute of Applied Chemistry Academia SinicaChangchun 130022

The potentiostatic deposition of cadmium-rich CMT films onto Ti, Mo, Ni substrates from an aqueous bath was carried out. The photoelectrochemical properties of film electrodes were investigated when used in a solid-li... 详细信息

关键词： Photoelectrochemistry of electrochemically deposited cadmium-rich cadmium mercury telluride films

A tribute to Professor Yong Zhao

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2022年第1期13卷 1-3页

作者： zheng tan Jun tang Feng Wang Xiaocui Li Yanlian Chen Zhou Songyang Institute of Zoology Chinese Academy of Sciences(CAS)Beijing 100101China Xiamen Multi-Dimension Biomedical Technology Co. LtdXiamen 361000China School of Basic Medical Sciences Tianjin Medical UniversityTianjin 300203China School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China

Professor Yong Zhao was the Dean of School of Life Sciences at Sun Yat-sen University and a renowned biologist whose studies focused on the role of telomeres and telom-erase in cancer and ***'s postdoctoral mentor Professor Woodring ***(1949-2019)of University of Texas Southwestern Medical Center(UTSW)once remarked,“It will be hard for anyone else in my lab to match up to the superb performance of Yong Zhao.”

关键词： doctor renowned Southwestern

在线全文

学校读者我要写书评

暂无评论

金沙江下游梯级水库提前蓄水策略

长江科学院院报 2024年第1期41卷 1-8页

作者：龚文婷曹瑞谭政宇邢龙王玮玉朱文丽李帅中国长江三峡集团有限公司流域枢纽运行管理中心湖北宜昌443133

随着长江上游水库群汛末集中蓄水问题日益突出,在确保防洪安全的前提下,提前抬升水库运行水位,有序衔接防洪与蓄水调度显得尤为重要。以金沙江下游乌东德、白鹤滩、溪洛渡、向家坝梯级水库为研究对象,选取发电量和水资源利用率为评价指... 详细信息

随着长江上游水库群汛末集中蓄水问题日益突出,在确保防洪安全的前提下,提前抬升水库运行水位,有序衔接防洪与蓄水调度显得尤为重要。以金沙江下游乌东德、白鹤滩、溪洛渡、向家坝梯级水库为研究对象,选取发电量和水资源利用率为评价指标,探究汛期7—8月份梯级水库提前蓄水策略。研究结果表明:①平水(50%频率)、枯水(75%频率)和特枯(90%频率)来水条件下,乌东德、白鹤滩梯级水库应尽可能提前抬升运行水位,且优先抬升乌东德库水位。②7月份平水、8月份平水或枯水条件下,应优先将乌东德库水位抬升至960 m以上;7月份枯水、8月份平水或枯水条件下,应优先将乌东德库水位抬升至954 m以上。③不同来水条件下,溪洛渡水库应尽可能抬升库水位,但最高不超过585 m。

关键词：提前蓄水策略金沙江下游梯级水库防洪库容综合效益

维普期刊数据库博看期刊

Determination of DNA single-strand breaks by low-energy heavy ion and analysis of dose-effect curves

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1999年第8期44卷 711-715页

作者： Yanhua Du Shenghai Huang zheng tan Yingzhi Lin Guanying Qiu Wuhan Univ Coll Life Sci Wuhan 430072 Peoples R China

Calf thymus DNA was exposed to low-energy heavy ions (N+) and 60Co-γ-rays, and the dose-effect on DNA single-strand breaks (SSB) has been investigated. The results indicate that the dose-effect curve by N+ irradiation is different from that of conventional ionizing radiation. While the curve from γ-irradiation follows exponential type, the effect curve produced by N+ ion is of 'saddle type'. The yield of DNASSB per dose unit per DNA unit remained at a certain level under different doses of γ-rays. In contrast, the DNASSB at low dosage region of N+ showed an obvious peak before it decreased rapidly to a lower level.

关键词： ion implantation γ-rays 'saddle types' curve DNA single-strand breaks curve fitting.

Ten cases of intradiaphragmatic extralobar pulmonary sequestration:a single-center experience

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatric Surgery 2022年第2期5卷 5-10页

作者： Yue Gao Xu Han Jie Jin zheng tan Department of Paediatric Thoracic Surgery The Children's HospitalZhejang University School of MedicineNational Clinical Research Center for Child HealthNational Regional Medical Center for ChildrenHangzhouZhejiangChina Clinical laboratory The Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Regional Medical Center for ChildrenHangzhouZhejiangChina

Background Intradiaphragmatic extralobar pulmonary sequestration(IDEPS)is a rare type of pulmonary sequestration(PS).The purpose of this study is to assess diagnosis and operative treatment of *** Patients with PS who were diagnosed and treated in our center from January 2015 to December 2020 were analyzed retrospectively to identify patients with *** Totally,215 patients with PS were treated surgically,including 10 cases with *** ultrasounds and postnatal-enhanced CT showed the presence of IDEPS in four cases and in seven cases,*** three-dimensional(3D)reconstruction software was performed perfectly to identify the location of the lesions in 10 *** surgeries were performed smoothly by laparoscopic surgery in one case,video-assisted thoracic surgery(VATS)in five cases and Da Vinci robot-assisted thoracoscopic surgery(DVRATS)in four *** the VATS group,the average operative duration,intraoperative blood loss volume,length of stay after operation,and postoperative thoracic catheter indwelling duration were 48 min,3.8 mL,6.4 days and 2.2 days,*** of the DVRATS group were 80 min,3.5 mL,4.3 days and 1.5 days,*** side effects had *** The 3D reconstruction software was proven to be capable in assisting the assessment of *** suggested early surgery to treat IDEPS,and the best path was accessing the mass from the *** DVRATS and VATS for the treatment of an IDEPS are safe,feasible,and ***,DVRATS provides a 3D magnified view,more flexibility and precision.

关键词： operative diagnosis treatment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于多传感器的干式变压器故障诊断系统设计

国外电子测量技术 2024年第9期43卷 173-181页

作者：韩文文谭政张昆毛雕胡立忠三峡金沙江云川水电开发有限公司昆明651512

为实现对电力系统中的干式变压器的状态监测及早期故障诊断,结合声发射传感器、温度传感器、湿度传感器等多类传感器对干式变压器进行状态监测和故障诊断,开发一套基于LabVIEW的干式变压器故障诊断系统。针对声发射、温度、湿度等数据,... 详细信息

为实现对电力系统中的干式变压器的状态监测及早期故障诊断,结合声发射传感器、温度传感器、湿度传感器等多类传感器对干式变压器进行状态监测和故障诊断,开发一套基于LabVIEW的干式变压器故障诊断系统。针对声发射、温度、湿度等数据,采用基于金豺优化算法的变分模态分解方法,提取出数据趋势,根据趋势的变化规律识别出潜在的早期故障;针对高采样率的声发射数据,采用基于多尺度Teager能量算子(TEO)的特征提取方法,提取出早期故障的微弱特征。仿真和应用表明,系统对信噪比为-10 dB左右的微弱早期故障信号具有优越的识别和诊断能力。系统的优点是结合声发射对材料劣化的敏感性和趋势及微弱特征分析方法,可在故障早期进行预警,而无须完全依赖指标阈值。

关键词：干式变压器声发射传感器 LabVIEW 变分模态分解

HMGB1 from Astrocytes Promotes EAE by Influencing the Immune Cell Infiltration-Associated Functions of BMECs in Mice

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第11期38卷 1303-1314页

作者： Junyu Shi Yifan Xiao Na Zhang Mengya Jiao Xuhuan tang Chan Dai Chenchen Wang Yong Xu zheng tan Feili Gong Fang zheng Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationNHC Key Laboratory of Organ TransplantationKey Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430030China Department of Pathology and Pathophysiology School of MedicineJianghan UniversityWuhan 430056China

High mobility group box 1(HMGB1)has been reported to play an important role in experimental autoimmune encephalomyelitis(EAE).Astrocytes are important components of neurovascular units and tightly appose the endothelial cells of microvessels by their perivascular endfeet and directly regulate the functions of the blood-brain *** express more HMGB1 during EAE while the exact roles of astrocytic HMGB1 in EAE have not been well ***,using conditional-knockout mice,we found that astrocytic HMGB1 depletion decreased morbidity,delayed the onset time,and reduced the disease score and demyelination of ***,there were fewer immune cells,especially pathogenic T cells infiltration in the central nervous system of astrocytic HMGB1 conditional-knockout EAE mice,accompanied by up-regulated expression of the tight-junction protein Claudin5 and down-regulated expression of the cell adhesion molecules ICAM1 and VCAM1 in *** vitro,HMGB1 released from astrocytes decreased Claudin5 while increased ICAM1 and VCAM1 expressed by brain microvascular endothelial cells(BMECs)through TLR4 or *** together,our results demonstrate that HMGB1 derived from astrocytes aggravates EAE by directly influencing the immune cell infiltration-associated functions of BMECs.

关键词： HMGB1 Astrocytes Experimental autoimmune encephalomyelitis Blood-brain barrier

The Changing Planning Concept of Postwar Hong Kong:Contract,Welfare,and Space

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China City Planning Review 2017年第1期26卷 62-72页

作者： tan zheng Liu Jinxin(译) tang Yan(校) College of Architecture and Urban Planning Tongji UniversityShanghaiP.R.China 不详

Accommodating high-density economic activities,the cellular urban structure of Hong Kong has a certain origin in the New Town Movement of post-war *** the post-war era,the planning practice of Hong Kong,as a response to a series of urban crises,transformed the European new town ideal into a unique structure of Asian vertical"Garden City."This paper starts with the refl ection on the relationship between planning system and planning theory,thereby revisiting the"welfare state"tradition hidden behind the cityscape of Hong *** a brief review of the history of planning exchanges between Hong Kong and mainland cities like Shenzhen,it points out that the"collectivism"tradition was somehow overlooked in the urban design guidelines of mainland cities.

关键词： planning by contract New Town Movement social subsidy quasi-welfare state cellular city