检索结果-南通市图书馆

Cleavable bimetallic-organic polymers for ROS mediated cascaded cancer therapy under the guidance of MRI through tumor hypoxia relief strategy

引用

Science China Chemistry 2020年第7期63卷 936-945页

作者： Haozhe He Lihua Du min tan Yali Chen Liejing Lu Yongcheng An Yong Wang Xiaoxia Li Bo Li Jun Shen Jun Wu Xintao Shuai PCFM Lab of ministry of Education School of Materials Science and EngineeringSun Yat-Sen UniversityGuangzhou 510260China Department of Radiology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510260China University of Laboratory of Interventional Radiology Department of Minimally Invasive Interventional Radiologyand Department of Radiologythe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China School of Biomedical Engineering State Key Laboratory of Oncology in South ChinaSun Yat-sen UniversityGuangzhou 510260China

Despite recent advances in tumor treatment, reactive oxygen species(ROS)-mediated therapy, such as photodynamic therapy(PDT) and chemical dynamic therapy(CDT), remains challenging mainly due to hypoxia in tumor microenviroment. Relieving the hypoxia of tumor tissue has been considered as an attractive strategy for enhancing efficacy of ROS-based cancer ***, one cascaded platform was developed to overcome tumor hypoxia and synergistically enhance the effect of ROSmediated therapy. This platform is based on cleavable bimetallic metal organic polymers(DOX@Fe/Mn-THPPTK-PEG). As an efficient Fenton-like material, it could not only produce cytotoxic ·OH by catalyzing the decomposition of intracellular H2O2, but also generate O2 to alleviate tumor hypoxia. In addition, the DOX-loaded metal organic polymers(MOPs could be disrupted after being exposed to laser irradiation or/and treated with H2O2, and then release the DOX for chemotherapy. Overall, 3 therapies(hypoxia-relieved PDT, photo-enhanced CDT, and ROS-mediated chemotherapy) could be achieved simultaneously by such a smart platform. Furthermore, T1-weighted MRI imaging ability of the MOPs could be greatly improved under H2O2 ***, total four robust functions were realized in a simple platform. These findings demonstrate great clinical potentials of the MOPs for cancer theranostics.

关键词： reactive oxygen species photodynamic therapy chemodynamic therapy ROS sensitive drug releases MRI imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure and Properties of Pure Cotton Low-Twist Single Yarn Based on Addition of Long-Staple Cotton

引用

Journal of Donghua University(English Edition) 2022年第2期39卷 115-119页

作者： WEN Run tan min XU Nuo ZHANG Ruiyin College of Textiles Donghua UniversityShanghai 201620China

Pure cotton low-twist single yarn has good softness,bulkiness,and wearing comfort,but its lower strength makes the yarn break easily during the spinning process,which seriously affects the spinning effect and *** addition of long-staple cotton helps to increase the average length and uniformity of the raw fiber,thereby improving the breaking load and spinnability of pure cotton low-twist single *** this study,the addition of long-staple cotton,the twist factor,and the twist direction were used as variables to spin 22 kinds of combed 14.6 tex pure cotton low-twist single yarn with spinnability,and the breaking load,the hairiness,and the unevenness of the yarn were *** result shows that the spinnability of pure cotton low-twist single yarn is mainly related to the breaking load,and with the increase of the twist factor,the breaking load of low-twist single yarn shows an obvious upward *** the proportion of long-staple cotton is 70%,the breaking load of low-twist single yarn is the largest,and the harmful hairiness index and unevenness of the yarn are significantly improved.

关键词： low twist single yarn long-staple cotton structure property

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel Trypsin Inhibitor-Like Cysteine-Rich Peptide from the Frog Lepidobatrachus laevis Containing ProteinaseInhibiting Activity

引用

Natural Products and Bioprospecting 2015年第4期5卷 209-214页

作者： Yu-Wei Wang Ji-min tan Can-Wei Du Ning Luan Xiu-Wen Yan Ren Lai Qiu-min Lu Life Sciences College of Nanjing Agricultural University Nanjing 210095JiangsuChina Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyKunming 650223YunnanChina

Various bio-active substances in amphibian skins play important roles in survival of the *** protease inhibitor peptides have been identified from amphibian skins,which are supposed to negatively modulate the activity of proteases to avoid premature degradation or release of skin peptides,or to inhibit extracellular proteases produced by invading ***,there is no information on the proteinase inhibitors from the frog Lepidobatrachus laevis which is unique in South *** this work,a cDNA encoding a novel trypsin inhibitor-like(TIL)cysteine-rich peptide was identified from the skin cDNA library of *** 240-bp coding region encodes an 80-amino acid residue precursor protein containing 10 *** sequence comparison and signal peptide prediction,the precursor was predicted to release a 55-amino acid mature peptide with amino acid sequence,*** mature peptide was named ***-TIL shares significant domain similarity with the peptides from the TIL supper *** and trypsin-inhibitory abilities of recombinant LL-TIL were *** LL-TIL showed no antimicrobial activity,while it had trypsin-inhibiting activity with aKi of 16.5178 *** results suggested there was TIL peptide with proteinase-inhibiting activity in the skin of frog *** the best of our knowledge,this is the first report of TIL peptide from frog skin.

关键词： Trypsin inhibitor Cysteine-rich peptide Amphibian Skin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于知识的机器人视觉测量分类与进展

引用

控制与决策 2010年第4期25卷 481-486,492页

作者：徐德谭民中国科学院自动化研究所复杂系统与智能科学重点实验室北京100190

提出了基于知识的视觉测量的观点,将传统的立体视觉看作一种基于摄像机知识的视觉测量,并对当前其他的视觉测量方式按所采用知识的不同进行了分类.分别简要介绍了基于点、线、面、统计特性等目标知识的视觉测量,讨论了基于运动知识的视... 详细信息

提出了基于知识的视觉测量的观点,将传统的立体视觉看作一种基于摄像机知识的视觉测量,并对当前其他的视觉测量方式按所采用知识的不同进行了分类.分别简要介绍了基于点、线、面、统计特性等目标知识的视觉测量,讨论了基于运动知识的视觉测量和基于环境知识的视觉测量.在对视觉测量所采用知识的表达和获取进行初步探讨的基础上,给出了视觉测量的几个值得深入研究的发展方向.

关键词：视觉测量仿人视觉机器人知识获取知识表达

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CMRC——多DSP并行结构机器人控制器的研究

引用

自动化学报 2001年第3期27卷 411-416页

作者：胡健谭民中国科学院自动化研究所北京100080

用并行结构实现多机器人协调系统的控制任务是多机器人协调系统研究的重要内容之一 .文中提出了一种新型多 DSP并行结构机器人控制器的思想 ,阐述了系统的硬、软件结构 ,并对系统的主要性能进行了分析。

关键词：多机器人协调机器人控制器数字信号处理器并行结构 CMRC DSP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beijing Jeep Takes Thirty Years in One Step

引用

China Today 1995年第1期44卷 28-30页

作者： $$$$staff reporter tan min

ＢｅｉｊｉｎｇＪｅｅｐＴａｋｅｓＴｈｉｒｔｙＹｅａｒｓｉｎＯｎｅＳｔｅｐＢｙｓｔａｆｆｒｅｐｏｒｔｅｒＴＡＮＭＩＮＴＨＥＦＩＲＳＴｆｏｕｒ－ｗｈｅｅｌｄｅｉｖｅ，ｃｒｏｓｓ－ｃｏｕｎｔｒｙｖｅｈｉｃｌｅｉｎｔｈｅｗｏ... 详细信息

ＢｅｉｊｉｎｇＪｅｅｐＴａｋｅｓＴｈｉｒｔｙＹｅａｒｓｉｎＯｎｅＳｔｅｐＢｙｓｔａｆｆｒｅｐｏｒｔｅｒＴＡＮＭＩＮＴＨＥＦＩＲＳＴｆｏｕｒ－ｗｈｅｅｌｄｅｉｖｅ，ｃｒｏｓｓ－ｃｏｕｎｔｒｙｖｅｈｉｃｌｅｉｎｔｈｅｗｏｒｌｄ－ｔｈｅｊｅｅｐ－ｗａｓ１９...

关键词： Beijing Jeep Takes Thirty Years in One Step

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

QUANTITATIVE CHARACTERIZATION OF CROSS-SECTION SHAPE OF DUMBBELL-LIKE FIBER BY IMAGE ANALYSIS

QUANTITATIVE CHARACTERIZATION OF CROSS-SECTION SHAPE OF DUMB...

引用

第十一届北京分析测试学术报告会暨展览会(BCEIA 2005)

作者： Zhengmin LI min tan Laboratory & Equipment Management Department Shandong University of Technology College of Physics Shandong University of Technology

Compared with circle cross-section fiber,dumbbell-like one has many special properties,such as *** cross-section shape has closely relationship with fiber properties and technique to produce ***,cross-section shape of fiber was qualitatively observed by *** profiled degree has been proposed and used to represent the degree

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

可变生产率的两级串行生产线可靠性分析

引用

控制理论与应用 2000年第2期17卷 255-258,239页

作者：孙钰谭民中国科学院自动化研究所复杂系统工程学开放实验室北京100080

制造系统的生产线由多个机器组合而成 ,可以有多种表现形式 ,各机器可以根据生产的实际情形改变生产率 .从系统可靠性的角度出发 ,当机器以较低的生产率工作时可靠性较高 .这样 ,提出一种能提高系统可靠性同时又能使各机器相互协调而提... 详细信息

制造系统的生产线由多个机器组合而成 ,可以有多种表现形式 ,各机器可以根据生产的实际情形改变生产率 .从系统可靠性的角度出发 ,当机器以较低的生产率工作时可靠性较高 .这样 ,提出一种能提高系统可靠性同时又能使各机器相互协调而提高生产线性能的策略就显得十分必要 .本文讨论了可变生产率的串行生产线模型 ,对机器、缓冲区及生产线的运行状态进行了研究 ,从机理上分析了生产线的运行状况 ,得到了分析生产线性能指标的解析解 :稳态生产率 ,并以稳态生产率为指标对这种生产线加以控制 ,从而进行优化 .

关键词：制造系统变生产率串行生产线可靠性分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

旋转流体中的二维惯性重力波-涡相互作用

引用

地球物理学报 2007年第4期50卷 1040-1052页

作者：王赟谈哲敏南京大学大气科学系中尺度灾害性天气教育部重点实验室南京210093

本文利用f-平面浅水模型讨论了二维情况下快速惯性重力波与平衡涡旋之间的相互作用问题.当快速的惯性重力波传入涡旋区域后,波-涡之间发生了相互作用,涡旋可被加深,涡旋区域的风场等可以出现非对称分布,当惯性重力波全部传出涡旋区域并... 详细信息

本文利用f-平面浅水模型讨论了二维情况下快速惯性重力波与平衡涡旋之间的相互作用问题.当快速的惯性重力波传入涡旋区域后,波-涡之间发生了相互作用,涡旋可被加深,涡旋区域的风场等可以出现非对称分布,当惯性重力波全部传出涡旋区域并远离之后,涡旋恢复到其初始状态,但此时惯性重力波可以出现非对称结构,这与一维情况不同.在波-涡发生相互作用过程中,其物理量变化的最大区域分布基本与波动传播方向一致,在波动进入或移出涡旋时,相对应存在两个最大物理量变化区域,此外,相互作用导致的物理量的最大变化与波动结构、强度、传播方向以及涡旋特性有关.非线性条件下的波-涡相互作用要强于线性过程.

关键词：惯性重力波涡旋相互作用旋转流体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Expression of albumin, IGF-1, IGFBP-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma patients with cirrhosis

引用

World Journal of Gastroenterology 2005年第27期11卷 4272-4276页

作者： Shi-min Luo Wei-min tan Wei-Xiong Deng Si-min Zhuang Jian-Wei Luo Department of Cadre Surgery The First Municipal People's Hospital of Guangzhou Guangzhou 510180 Guangdong Province China

AIM： To explore the expression of albumin （ALB）, insulinlike growth factor （IGF）-I, and insulin-like growth factor binding protein （IGFBP）-3 in tumor tissues and adjacent non-tumor tissues of hepatocellular carcinoma （HCC） patients with ***： Twenty-four HCC patients with cirrhosis who underwent hepatectomy were studied. ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA in liver tissues （including tumor tissues and adjacent non-tumor tissues） were detected by reverse transcriptase-polymerase chain reaction（RT-PCR）. Liver Ki67 immunohistochemistry staining was studied. At the same time, 12 patients with cholelithiasis or liver angioma who underwent operation were segregated as normal ***： In HCC patients with cirrhosis, hepatic ALB mRNA, IGF-1 mRNA, and IGFBP-3 mRNA of tumor tissues or adjacent non-tumor tissues were lower than the normal liver tissues, while in tumor tissues, hepatic ALB mRNA and IGFBP-3 mRNA were lower, hepatic IGF-1 mRNA was higher than in adjacent non-tumor tissues. Liver Ki67 labeling index （Ki67 LI） in tumor tissues or adjacent nontumor tissues were higher than that in the normal liver tissues, while in tumor tissues it was higher than that in adjacent non-tumor ***： Imbalance of IGF-1 and IGFBP-3 may play a role in hepatocarcinogenesis and tumor development of liver cirrhosis patients.

关键词： Hepatocellular carcinoma Insulin growth factor-i Insulin-like growth factor binding protein-3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：