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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1910-1917页

作者： Akihiro Cho Satoshi Katagiri Masao Ota Shunsuke Onizawa Ryota Higuchi Toshiya Sugishita Yukiko Niwa takeshi Ishita Toshihiko Mouri akita Kato Moe Iwata Division of Gastroenterological Surgery Tokyo Women’s Medical UniversityYachiyo Medical CenterChiba 276-8524Japan

BACKGROUND Emergency pancreaticoduodenectomy(EPD)is a rare event for complex periam-pullary *** intraoperative blood loss is correlated with poor post-operative *** SUMMARY Two patients underwent EPD using a no-touch isolation technique,in which all arteries supplying the pancreatic head region were ligated and divided before manipulation of the pancreatic head and *** operative times were 220 and 239 min,and the blood loss was 70 and 270 g,*** patients were discharged on the 14^(th) and 10^(th) postoperative day,***-two patients underwent EPD for the treatment of neoplastic *** mean operative time was 361.6 min,and the mean blood loss was 747.3 *** comp-lication rate was 37.5%.The in-hospital mortality rate was 9.38%.CONCLUSION The no-touch isolation technique is feasible,safe,and effective for reducing intraoperative blood loss in EPD.

关键词： No-touch isolation technique Pancreaticoduodenectomy Emergency pancre-aticoduodenectomy Neoplastic bleeding Superior mesenteric artery first approach Case report

Targeting therapy for hepatocellular carcinoma by delivering microRNAs as exosomal cargo

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World Journal of Gastroenterology 2024年第17期30卷 2369-2370页

作者： takeshi Suda Department of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami Uonuma 949-7302NiigataJapan

Exosomes,the smallest extracellular vesicles,have gained significant attention as key mediators in intercellular communication,influencing both physiological and pathological processes,particularly in cancer progression.A recent review article by Wang et al was published in a timely manner to stimulate future research and facilitate practical developments for targeted treatment of hepatocellular carcinoma using exosomes,with a focus on the origin from which exosomes *** information about the mechanisms for delivering exosomes to specific cells is incorporated,the concept of targeted therapy for hepatocellular carcinoma using exosomes could be more comprehensively understood.

关键词： Exosomal delivery Therapeutic targets MicroRNAs Hepatocellular carcinoma

Dynamic Contact Problem for Slide Hinge

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Open Journal of Applied Sciences 2012年第4期2卷 82-86页

作者： Kazunori Shinohara Ryoji Takaki takeshi akita Faculty of Engineering Chiba Institute of Technology Chiba Japan Institute of Space and Astronautical Science (ISAS) Japan Aerospace Exploration Agency (JAXA) Sagamihara Japan JAXA's Engineering Digital Innovation Center (JEDI) Japan Aerospace Exploration Agency (JAXA) Sagamihara Japan

Contact analysis can be either static or dynamic. In static contact analysis, the position on the contact surface is constant. In dynamic contact analysis, the position on the contact surface changes at every time step. In static contact analysis, the computing results (stress, strain, etc.) of contact states have been verified through the Hertz contact problem in literature. On the other hand, there has been insufficient research into dynamic contact analysis. The contact algorithm is insufficiently constructed in finite element model (FEM) discretization. The gap between two objects cannot be calculated accurately. A contact method is demanded for artificial parameters. Inappropriate setting of artificial parameters causes artificial numerical oscillations on the contact surface between objects. To develop a high-reliability satellite, we started the development of FEM contact-friction modeling techniques in this study. A dynamic contact method was realized by using the appropriate parameters required in the contact analysis. We verified the reproducibility of the physical behavior of the contact friction via numerical simulation techniques by using a computational model of the hinge joints.

关键词： FEM Contact Friction Stress Joints Structural Analysis Advance/FrontSTR Dynamic Contact Analysis Static Contact Analysis

Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy

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World Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto Daisuke Tsugawa Masayuki akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun Ishida takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido Tetsuo Ajiki Takumi Fukumoto Division of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of *** use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative ***,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after *** To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after *** The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively *** were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower *** factors,including demographic data and perioperative D-dimer values,were compared between the two *** operating characteristic curve analysis was performed to determine the D-dimer cutoff *** and multivariate analyses were performed using logistic regression analysis to identify significant *** In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE *** the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after *** Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the

关键词： Hepatectomy Malignant tumor Postoperative complication D-dimer Early diagnosis Venous thromboembolism

Status and challenges of global antimicrobial resistance control: A dialogue between Professors Yonghong Xiao and takeshi Nishijima

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hLife 2024年第2期2卷 47-49页

作者： Yonghong Xiao takeshi Nishijima State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated HospitalZhejiang University School of MedicineZhejiangChina Antimicrobial Resistance Essential Medicines and Health TechnologiesDivision of Health Systems and ServicesWHO Regional Office for the Western PacificManilaPhilippines

Antimicrobial resistance(AMR)is one of the top 10 public health threats,which is not only related to human health,but also closely related to animal health and environmental *** health concept and framework are the core strategy to contain *** World Health Organization(WHO)has already issued the Global Action Plan to contain AMR,which includes surveillance,education,stewardship,and innovation of new diagnostics and *** Asia–Pacific region is the most populous area of WHO,and also a region with severe ***,***,a professional officer of AMR control from WHO Regional Office for the Western Pacific discussed with Professor Yonghong Xiao(Zhejiang University)about the epidemiology,socioeconomic impact of AMR globally and in Western Asia–Pacific region(WPRO),and they talked the actions and strategies,achievements and shortcomings in the control of AMR during the past years,introduced the initiative of quadripartite One *** outstanding results of China in AMR containment were recognized.

关键词： resistance globally shortcomings

Method to measure tree-ring width,density,elemental composition,and stable carbon and oxygen isotopes using one sample

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Journal of Forestry Research 2024年第3期35卷 167-174页

作者： Chenxi Xu Yaru Zhao Wenling An Qingyu Zhao Yucheng Liu Masaki Sano takeshi Nakatsuka Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029People's Republic of China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044People's Republic of China College of Earth Sciences University of Chinese Academy of SciencesBeijing 100049People's Republic of China Graduate School of Environment Studies Nagoya UniversityNagoya 4648601Japan

Tree-ring width(RW),density,elemental com-position,and stable carbon and oxygen isotope(δ^(13)C,δ^(18)O)are widely used as proxies to assess climate change,ecology,and environmental pollution;however,a specific pretreat-ment has been needed for each ***,we developed a method by which each proxy can be measured in the same ***,the sample is polished for ring width *** obtaining the ring width data,the sample is cut to form a 1-mm-thick wood *** sample is then mounted in a vertical sample holder,and gradually scanned by an X-ray ***,the count rates of the fluorescent photons of elements(for chemical characteriza-tion)and a radiographic grayscale image(for wood density)are obtained,*** density and the element content are ***,cellulose is isolated from the 1-mm wood plate by removal of lignin,and *** producing this cellulose plate,cellulose subsamples are separated by knife under the microscope for inter-annual and intra-annual stable carbon and oxygen isotope(δ^(13)C,δ^(18)O)*** on this method,RW,density,elemental composition,δ^(13)C,and δ^(18)O can be measured from the same sample,which reduces sample amount and treatment time,and is helpful for multi-proxy comparison and combination research.

关键词： Tree-ring width Tree-ring density Tree-ring elemental composition Tree-ring stable carbon and oxygenisotopes

A plant growth chamber system equipped with aerosol generators for studying aerosol-vegetation interactions

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Particuology 2024年第2期85卷 122-132页

作者： Masao Gen Seiji Ikawa Masahiro Yamaguchi Fong Zyin Lim takeshi Izuta I.Wuled Lenggoro Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai980-8577Japan Faculty of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasaki852-8521Japan Institute of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509 Japan Department of Applied Physics and Chemical Engineering Tokyo University of Agriculture and TechnologyKoganeiTokyo184-8588Japan Institute of Global Innovation Research Tokyo University of Agriculture and TechnologyFuchuTokyo183-8509Japan

Understanding aerosol-vegetation interactions is vital in ***,the interactions remain elusive partly due to the lack of suitable plant growth chamber ***,deposition of submicron particles on leaf surfaces is challenging due to its low deposition velocities compared to larger *** this work,we present a plant-growth chamber that was used to study the effect of sub-micron black carbon(BC)particles on the growth and photosynthesis of *** chamber system simultaneously enables the growth of multiple plants in pots and the deposition of submicron particles onto *** spraying methods assisted by ultrasonic and electrostatic forces were employed as aerosol generators to realize the particle *** flow regime inside the chamber was numeri-cally calculated to predict the transportation of aerosol particles,suggesting the optimal operating conditions of the *** gas-phase particle size distribution measurements showed that gener-ated BC particles were suspended in submicron diameter *** aerosol generators were examined in the chamber using three conductor and insulator substrates as a model of plant *** observations and spectroscopic analysis ascertained that submicron BC particles generated from our generators were deposited on all substrate *** the developed chamber system,systematic studies can be performed to advance the fundamental understanding of aerosol-vegetation interactions.

关键词： Aerosol Exposure chamber Spray drying Black carbon

Endoscopic hemostasis using self-expandable metal stent combinedwith PuraStat® for patient with high risk of post-endoscopicsphincterotomy bleeding (with video)

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 94-96页

作者： takeshi Ogura Yuki Uba Masahiro Yamamura Nobu Nishioka Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical UniversityOsakaJapan

To the Editor:Endoscopic sphincterotomy(EST)is an established technique for removal of bile duct stones and self-expandable metal stent(SEMS)***,bleeding can be considered an adverse event after EST,particularly for patients with high risk of bleeding such as those on *** the various techniques reported for obtaining endoscopic hemostasis[1-3].

关键词： bleeding stasis endoscopic

Roles of N-cadherin in cerebral cortical development:cooperation with membrane trafficking and actin cytoskeletal regulation

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Neural Regeneration Research 2025年第1期20卷 188-190页

作者： Shiho Ito takeshi Kawauchi Department of Adaptive and Maladaptive Responses in Health and Disease Graduate School of MedicineKyoto UniversityKyotoJapan Department of Physiology Keio University School of MedicineTokyoJapan

Cell adhesion plays pivotal roles in the morphogenesis of multicellular *** cells form several types of cell-to-cell adhesion,including zonula occludens(tight junctions),zonula adhaerens(adherens junctions),and macula adhaerens(desmosomes).Although these adhesion complexes are basically observed only in epithelial cells,cadherins,which are the major cell adhesion molecules of adherens junctions,are expressed in both epithelial and non-epithelial tissues,including neural tissues(Kawauchi,2012).The cadherin superfamily consists of more than 100 members,but classic cadherins.

关键词： cerebral skeletal cooperation

Derivation of Modified Stress-Strain Tensor for Wrinkled Membrane by Using Projection Matrix

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Derivation of Modified Stress-Strain Tensor for Wrinkled Mem...