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Zircon U–Pb geochronology and Hf isotope geochemistry of magmatic and metamorphic rocks from the Hida Belt, southwest Japan

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Geoscience Frontiers 2021年第4期12卷 185-201页

作者： Deung-Lyong Cho Tae-Ho Lee Yutaka Takahashi takenori Kato Keewook Yi Shinae Lee Albert Chang-sik Cheong Korea Institute of Geoscience and Mineral Resources Daejeon 34132Republic of Korea Geological Survey of Japan Tsukuba 305-8567Japan Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Korea Basic Science Institute Ochang Center Cheongju 28119Republic of Korea

Zircon U–Pb and Hf isotope data integrated in this study for magmatic and metamorphic rocks fromthe Hida Belt,southwest Japan,lead to a new understanding of the evolution of the Cordilleran arc system along the ancestral margins of present-day Northeast *** microprobe data for magmatic zircon domains from eight mafic tointermediate orthogneisses in the Tateyama and Tsunogawa areas yielded weighted mean 206Pb/238U ages spanning the entire Permian period(302–254 Ma).Under cathodoluminescence,primary magmatic growth zones in the zircon crystals were observed to be partially or completely replaced by inward-penetrating,irregularly curved featureless or weakly zoned secondary domains that mostly yielded U–Pb ages of 250–240 Ma and relatively high Th/U ratios(>0.2).These secondary domains are considered to have been formed by solid-state recrystallization during thermal overprints associated with intrusions of Hida *** whole-rock geochemical and Sr–Nd isotope data as well as zircon age spectra corroborate that the Hida Belt comprises the Paleozoic–Mesozoic Cordilleran arc system built upon the margin of the North China Craton,together with the YeongnamMassif in southern *** arcmagmatismalong this systemwas commenced in the Carboniferous and culminated in the Permian–Triassic transition *** positiveεHf(t)values(>+12)of late Carboniferous to early Permian detrital zircons in the Hida paragneisses indicate that there was significant input from the depleted asthenospheric mantle and/or its crustal derivatives in the early stage of arc *** the other hand,near-chondriticεHf(t)values(+5 to−2)of magmatic zircons from late Permian Hida orthogneisses suggest a lithospheric mantle *** isotopic differences between magmatic zircon cores and the secondary rims observed in some orthogneiss samples clearly indicate that the zircons were chemically open to fluids or melts during thermal *** highly positive zirconεHf(t)val

关键词： Hida Belt Zircon U–Pb age Hf isotope Cordilleran arc Yeongnam Massif

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Aluminum potassium sulfate and tannic acid sclerotherapy for Goligher Grades Ⅱ and Ⅲ hemorrhoids: Results from a multicenter study

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World Journal of Hepatology 2016年第20期8卷 844-849页

作者： Hidenori Miyamoto takenori Hada Gentaro Ishiyama Yoshito Ono Hideo Watanabe Department of Digestive and Pediatric Surgery Institute of Health Bioscience University of Tokushima Graduate School Department of Proctologic Surgery Shiseikai Miyamoto Hospital Division of Proctologic Surgery Onaka Clinic Oshiri Center Department of Anorectal Surgery Sapporo Ishiyama Hospital Department of Surgery Watanabe Hospital

AIM: To show that aluminum potassium sulfate and tannic acid(ALTA) sclerotherapy has a high success rate for Grade Ⅱ and Ⅲ ***: This study was based on the clinical data of 604 patients with hemorrhoids who underwent ALTA sclerotherapy between January 2009 and February 2015. The objective of this study was to assess the efficacy of this treatment for Grades Ⅱ and Ⅲ hemorrhoids. Preoperative and postoperative symptoms, complications and success rate were all assessed retrospectively. Follow-up consisted of a simple questionnaire, physical examination and an anoscopy. Patients were followed-up at one day, one week, two weeks, one month, one year, two years, three years, four years and five years after the ALTA ***: One hundred and sixty-nine patients were diagnosed with Grade Ⅱ hemorrhoids and 435 patients were diagnosed with Grade Ⅲ hemorrhoids. The one year, three year and five year cumulative success rates of ALTA sclerotherapy for Grades Ⅱ and Ⅲ hemo-rrhoids were 95.9% and 93.1%; 89.3% and 83.7%; and 89.3% and 78.2%, respectively. No significant differences were observed in the cumulative success rates after ALTA sclerotherapy between Grades Ⅱ and Ⅲ hemorrhoids(P = 0.09). There were forty-seven post-operative complications(low grade fever; anal pain; urinary retention; rectal ulcer; and others). No serious or life-threatening complications occurred and all cases improved through conservative treatment. At univariate analysis there were no predictive factors of ***: ALTA sclerotherapy has had a high success rate for Grade Ⅱ and Ⅲ hemorrhoids during five years of post-operative treatment. However, additional studies are needed to evaluate the efficacy of this ALTA sclerotherapy in the management of hemorrhoidal disease.

关键词： sclerotherapy Aluminum potassium sulfate and tannic acid Goligher grade Ⅲ Minimally invasive treatment Hemorrhoid

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Multiple excimer laser phototherapeutic keratectomies for Avellino corneal dystrophy:a case report

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 841-844页

作者： Chihiro Koiwa Satoru Nakatani takenori Inomata Masahiro Yamaguchi Satoshi Iwamoto Akira Murakami Department of Ophthalmology Juntendo University Faculty of MedicineBunyo-kuTokyo 1130033Japan Department of Strategic Operating Room Management and Improvement Juntendo University Faculty of MedicineBunkyo-kuTokyo 1130033Japan Department of Hospital Administration Juntendo University Graduate School of MedicineBunkyo-kuTokyo 1130033Japan

Dear Editor,I am Chihiro Koiwa,from the Department of Ophthalmology,Juntendo University Hospital.I am writing this letter to present a case of multiple excimer laser phototherapeutic keratectomies(PTKs)for Avellino corneal dystrophy(ACD).Corneal dystrophy is a common type of hereditary,noninflammatory,and bilateral corneal disorder that involves various pathological,histological,and clinical manifestations[1].Advanced molecular gene sequencing has identified specific mutations that are associated with most dystrophies of this ***,also known as granular corneal dystrophy typeⅡ[2],is autosomal dominant and associated with the R124H mutation of the transforming growth factor beta-induced(TGFBI)gene and characterized by deposits consistent with both discrete granular and lattice corneal opacities[3-4].An analysis of the TGFBI gene is essential to differentiate ACD because heterozygous R124H mutation carriers have minimal corneal abnormalities,whereas homozygotes have severe visual impairment,starting from early childhood,and early postoperative recurrence of corneal opacity.

关键词： laser excimer starting

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Kinase and non-kinase activities of myosin lightchain kinase of smooth muscle

Kinase and non-kinase activities of myosin lightchain kinase...

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第三届中日双边药理学和临床药理学学术会议

作者： kohama Kazuhiro Department of Molecular ＆ Cellular Pharmacology Gunma University Graduate School of MedicineGunma 371-8511Japan

＜正＞AIM Myosin light-chain kinase （MLCK） regulates smooth muscle contraction by phosphorylating 20- kDa myosin light chain （MLC20） of smooth muscle myo- sin to activate the actin-myosin （A-M） ***- though this mode of action is well-established,there are numerous reports of the contraction that is not associated with MLC20 *** domain structure of MLCK is composed of the central kinase activity,the N- terminal actin-binding activity,and C-terminal myosin- binding activity.I will overview that the actin-and myo- sin-binding domains may regulate the A-M interaction. METHODS The eDNA from bovine stomach was expressed in *** and then purified by the affinity *** actin-binding and myosin-binding fragments from the both terminals were also expressed and *** MLCK devoiding the kinase activity was produced by mutating the ATP-binding sequence of the kinase *** MLCK exerted stimulatory and inhibitory effects on the A-M interaction with the un- phosphorylated and phosphorylated myosins of smooth mus- cle,*** effects were also evident with the mutant MLCK devoiding the kinase activity,indicating that the effect was not attributable to phosphorylate MLC20.I confirmed the stimulatory and inhibitory effects with the myosin-and actin-binding fragments,respective- *** MLCK exerts regulatory activity through its myosin-and actin-binding activities.

关键词： myosin light-chain kinase actin-and myosin-binding domains regulation of contraction

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新疆阿勒泰红柱石-矽线石型递增变质带特征及其PT条件研究

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矿物岩石 2005年第4期25卷 45-51页

作者：郑常青徐学纯 Masaki ENAMI takenori KATO 吉林大学地球科学学院吉林长春130061 Deparment of Earth and Planetary Sciences Nagoya UniversityNagoya 464-8602Japan

新疆阿勒泰地区发育了红柱石-矽线石型递增变质带,由绿泥石-黑云母带、黑云母-石榴石带、石榴石-十字石带、十字石-红柱石带和矽线石带组成,根据石榴石成分环带、变质与变形关系、矿物共生组合演化等特征,将变质作用分为峰前期、峰期和... 详细信息

新疆阿勒泰地区发育了红柱石-矽线石型递增变质带,由绿泥石-黑云母带、黑云母-石榴石带、石榴石-十字石带、十字石-红柱石带和矽线石带组成,根据石榴石成分环带、变质与变形关系、矿物共生组合演化等特征,将变质作用分为峰前期、峰期和峰后期3个演化阶段。峰前期、峰期为连续的递增变质过程,形成典型的中-低压过渡型递增变质带,峰后期属于退变质过程。据石榴石-斜长石-黑云母-白云母-石英组合内部一致地质温压计估算出峰期温度-压力:T=580℃～670℃,P=0.4GPa～0.5GPa。变质作用演化具有顺时针的PTt轨迹,代表陆壳有一定程度的构造增厚,但幅度不大,没有大规模的陆壳俯冲或拆沉作用,这种增厚可能以陆壳的构造叠置机制为主。总体相当于地体间斜向走滑兼有一定垂直分量的拼合过程的地球动力学机制。

关键词：红柱石-矽线石型递增变质作用 PT条件阿勒泰

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Choroidal folds associated with carotid cavernous fistula:a case report

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1881-1884页

作者： Yasutsugu Akasaki takenori Inomata Jaemyoung Sung Megumi Ito Hiroaki Kobayashi Ryosuke Kuwana Hidenori Oishi Akira Murakami Department of Ophthalmology Juntendo University Graduate School of Medicine3-1-3 HongoBunkyo-kuTokyo 113-0033Japan Department of Digital Medicine Juntendo University Graduate School of Medicine3-1-3 HongoBunkyo-kuTokyo 113-0033Japan Department of Strategic Operating Room Management and Improvement Juntendo University Graduate School of Medicine3-1-3 HongoBunkyo-kuTokyo 113-0033Japan Department of Hospital Administration Juntendo University Graduate School of Medicine3-1-3HongoBunkyo-kuTokyo 113-0033Japan Morsani College of Medicine University of South Florida560 Channelside DrTampaFL 33602USA Kuwana Ophthalmology Neurosurgery Clinic 27-1 KumaidenShimizu-choSunto-gunShizuoka 411-0911Japan Department of Neuroendovascular Therapy Juntendo UniversityFaculty of Medicine3-1-3HongoBunkyo-kuTokyo 113-0033Japan Department of Neurosurgery Juntendo University Faculty of Medicine3-1-3 HongoBunkyo-kuTokyo 113-0033Japan

Dear Editor,I am Yasutsugu Akasaki, from the Department of Ophthalmology, Juntendo University Hospital. I am writing this letter to present a case of choroidal folds associated with carotid cavernous fistula(CCFs).

关键词： folds letter fistula

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Crowd-sourcing materials-science challenges with the NOMAD 2018 Kaggle competition

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npj Computational Materials 2019年第1期5卷 150-160页

作者： Christopher Sutton Luca M.Ghiringhelli takenori Yamamoto Yury Lysogorskiy Lars Blumenthal Thomas Hammerschmidt Jacek R.Golebiowski Xiangyue Liu Angelo Ziletti Matthias Scheffler Fritz Haber Institute of the Max Planck Society BerlinGermany Research Institute for Mathematical and Computational Sciences(RIMCS) YokohamaJapan ICAMS Ruhr-Universität BochumBochumGermany EPSRC Centre for Doctoral Training on Theory and Simulation of Materials Department of PhysicsImperial College LondonLondonUK Thomas Young Centre for Theory and Simulation of Materials Department of MaterialsImperial College LondonLondonUK

A public data-analytics competition was organized by the Novel Materials Discovery(NOMAD)Centre of Excellence and hosted by the online platform Kaggle by using a dataset of 3,000(Al_(x)GayIn_(1-x-y))_(2)O_(3) *** aim was to identify the best machinelearning(ML)model for the prediction of two key physical properties that are relevant for optoelectronic applications:the electronic bandgap energy and the crystalline formation ***,we present a summary of the top-three ranked ML *** first-place solution was based on a crystal-graph representation that is novel for the ML of properties of *** second-place model combined many candidate descriptors from a set of compositional,atomic-environment-based,and average structural properties with the light gradient-boosting machine regression *** third-place model employed the smooth overlap of atomic position representation with a neural *** Pearson correlation among the prediction errors of nine ML models(obtained by combining the top-three ranked representations with all three employed regression models)was examined by using the Pearson correlation to gain insight into whether the representation or the regression model determines the overall model *** relatively decorrelated models(based on the Pearson correlation)leads to an even higher prediction accuracy.

关键词： energy prediction overlap

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Investigation of charge interaction between fullerene derivatives and single-walled carbon nanotubes

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InfoMat 2019年第4期1卷 559-570页

作者： Clément Delacou Il Jeon Keigo Otsuka Taiki Inoue Anton Anisimov takenori Fujii Esko I.Kauppinen Shigeo Maruyama Yutaka Matsuo Department of Mechanical Engineering The University of TokyoTokyoJapan KU-KIST Green School Graduate School of Energy and Environment Korea UniversitySeoulSouth Korea Nanoscale Quantum Photonics Laboratory RIKENSaitamaJapan Canatu Ltd HelsinkiFinland Cryogenic Research Center The University of TokyoTokyoJapan Department of Applied Physics Aalto University School of ScienceAaltoFinland Energy NanoEngineering Laboratory National Institute of Advanced Industrial Science and Technology(AIST)TsukubaJapan Institutes of Innovation for Future Society Nagoya UniversityNagoyaJapan

The charge interaction and corresponding doping effect between single-walled carbonnanotubes (SWNTs) and various fullerene derivatives, namely, C60, phenyl-C61-butyricacid methyl ester (PC61BM), methano-indenefullerene (MIF), 10,100,40,400-tetrahydrodi[1,4]methanonaphthaleno[5,6]fullerene (ICBA), 1,4-bis(dimethylphenylsilylmethyl)[60]fullerene (SIMEF-1), and dimethyl(orthoanisyl) silylmethyl(dimethylphenylsilylmethyl)[60]fullerene (SIMEF-2), are investigated. A variety of analytical techniques,including field-effect transistors (FETs) made of horizontally aligned arrays ofSWNTs, is used as a means of investigation. Data from different measurements haveto be used to obtain a concrete evaluation for the fullerene-applied SWNTs. The datacollectively points toward the conclusion that fullerenes with high molecular orbitalenergy levels, namely, MIF, SIMEF-1, SIMEF-2, and PC61BM, induce p-type doping,while fullerenes with low molecular orbital energy levels, namely, ICBA and C60,induce n-type doping on the carbon nanotubes. Nevertheless, the SWNTs retained ptypecharacteristics because n-doping induced by the fullerenes are weak compared tothe p-doping of the water and oxygen on carbon nanotubes. This means that fullerenederivatives have the ability to fine-tune the energy levels of carbon nanotubes, whichcan play a crucial role in carbon nanotube-based electronics, such as solar cells, lightemittingdevices, and FETs.

关键词： doping field-effect transistors fullerene single-walled carbon nanotubes thin films

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Characterization of macrophage mutants established by their resistance to LPS and cycloheximide-induced apopotic cell death

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Advances in Bioscience and Biotechnology 2012年第6期3卷 770-781页

作者： Fumio Amano Shoko Tsukabe Reiko Teshima Keiko Waku Kiyoko kohama Laboratory of Biodefense & Regulation Osaka University of Pharmaceutical Sciences Osaka Japan

Macrophages are activated by bacterial lipopolysaccharide (LPS) to produce inflammatory cytokines such as TNF-α or reactive oxygen species such as nitric oxide or superoxide anion. However, in the presence of an inhibitor of protein synthesis, cyclohex-imide (CHX), at 10 μg/mL, LPS at 100 ng/mL induced macrophage apoptosis rapidly without producing phenotypes of activated macrophages. In order to understand the mechanism underlying LPS-induced cytotoxicity toward macrophages, we isolated mutant cells from a macrophage-like cell line, J774.1, as clones resistant against the cytotoxic effects of LPS + CHX by using a somatic cell genetics protocol. All of the mutant clones, designated as LCR mutants, showed resistance to the cell death induced by LPS + CHX as well as to that induced by higher doses of LPS alone, as did the LPS1916 mutant cell line, which had been previously established by its resistance to 100 μg/mL LPS. Characterization of the activated macrophage phenotypes revealed that these mutants showed reduced production of TNF-α and nitric oxide in response to LPS. Further analysis showed a much reduced amount of [125I]LPS-binding and lower CD14 expression on the cell surface, in spite of an adequate intracellular expression of CD14 molecules. Besides, the molecular weight of CD14 on these mutants was around 40-48 kDa, smaller than that of the wild-type JA-4 cells (around 50-55 kDa), suggesting impaired CD14 maturation in these mutants. However, expression of Toll-like receptor 4 (TLR4) and Myd 88 on the cell surface was not different between the wild type and the mutant cells. These results suggest that LCR mutants have common phenotypes of mal-expression of CD14 molecules on the macrophage cell surface, leading to not only reduced responses to LPS-mediated macrophage activation but acquisition of resistance to LPS-induced apoptotic cell death in the presence of CHX.

关键词： Macrophage J774.1 Cell Line LPS Apoptosis CD14

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新疆阿尔泰冲乎尔地区蓝晶石-夕线石型变质带独居石CHIME二叠纪年龄及其地质意义

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高校地质学报 2007年第3期13卷 566-573页

作者：郑常青徐学纯 takenori KATO Masaki ENAMI 吉林大学地球科学学院吉林长春130061 Deparment of Earth and Planetary Sciences Nagoya University Nagoya 464-8602Japan

新疆冲乎尔地区的蓝晶石-夕线石型递增变质带由绿泥石-黑云母带、黑云母-石榴石带、石榴石-十字石带、十字石-蓝晶石带和夕线石带组成;递增变质作用峰期温度、压力分别为T=520～640℃,p=(4.5～5.8)×108Pa;十字石-蓝晶石带和夕线石带变... 详细信息

新疆冲乎尔地区的蓝晶石-夕线石型递增变质带由绿泥石-黑云母带、黑云母-石榴石带、石榴石-十字石带、十字石-蓝晶石带和夕线石带组成;递增变质作用峰期温度、压力分别为T=520～640℃,p=(4.5～5.8)×108Pa;十字石-蓝晶石带和夕线石带变质岩中含有丰富的独居石,而且Th-U-Pb含量比较高,适合电子探针独居石CHIME法定年,独居石CHIME法确定的变质时代为268±10～261±20Ma,与阿勒泰地区发育的红柱石-夕线石型(低压型)变质带形成时代(262±10～264±22Ma)一致,说明阿尔泰造山带蓝晶石-夕线石型和红柱石-夕线石型递增变质带是同一次大规模的构造热事件的产物,时代为二叠纪中期。

关键词：蓝晶石-夕线石型变质带独居石CHIME 二叠纪冲乎尔

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