检索结果-南通市图书馆

Study roadmap for high-throughput development of easy to use and affordable biomarkers as diagnostics for tropical diseases:a focus on malaria and schistosomiasis

引用

Infectious Diseases of Poverty 2017年第1期6卷 1149-1156页

作者： Kokouvi Kassegne Ting Zhang Shen-Bo Chen Bin Xu Zhi-Sheng Dang Wang-Ping Deng Eniola Michael Abe Hai-Mo Shen Wei Hu takele geressu guyo Solomon Nwaka Jun-Hu Chen Xiao-Nong Zhou National Institute of Parasitic Diseases(NIPD) Chinese Centre for Disease Control and PreventionShanghai 200025People’s Republic of China WHO Collaborating Centre for Tropical Diseases National Centre for International Research on Tropical DiseasesKey Laboratory of Parasite and Vector Biology of the Chinese Ministry of HealthShanghai 200025People’s Republic of China Department of Microbiology and Microbial Engineering School of Life ScienceFudan UniversityShanghai 200433People’s Republic of China African Network for Drugs&Diagnostics Innovation(ANDI) Addis AbabaEthiopia

Background:Interventions are currently being used against‘infectious diseases of poverty’,which remain highly debilitating and deadly in most endemic countries,especially malaria,schistosomiasis,echinococcosis and African sleeping ***,major limitations of current‘traditional’methods for diagnosis are neither simple nor convenient for population surveillance,and showed low sensitivity and *** to novel technologies for the development of adequate and reliable tools are expressly needed.A collaborative project between African Network for Drugs and Diagnostics Innovation and partner institutions in Africa and China aims to screen suitable serological biomarkers for diagnostic pipelines against these‘diseases of the poor’.Methods:Parasite-specific exposed versus unexposed individuals were screened and sera or urine/stools were collected through case-control studies in China and African *** genes/open reading frames were selected,then will be cloned and cell-free expressed,quantified and *** antigens/epitopes will be probed and screened with sera from exposed or unexposed individuals using a high-throughput antigen screening platform as the study *** specificity and sensitivity of highly immunoreactive biomarkers will be evaluated as well,using enzyme-linked immunosorbent assays or ***:This roadmap explicitly unfolds the integrated operating procedures with focus on malaria and schistosomiasis,for the identification of suitable biomarkers that will aid the prioritization of diagnostics for population ***,there is need to further validate any new diagnostic through comparison with standard methods in field deployable tests for each *** expectations for the future are to seek regulatory approval and promote the use of diagnostics in endemic areas.

关键词： Malaria Schistosomiasis Neglected tropical diseases Immunoproteomics Protein microarray Serological biomarker Diagnosis

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：