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World Journal of Gastroenterology 2006年第13期12卷 2089-2094页

作者： Tetsuro Sekiguchi takeaki nagamine Hitoshi Takagi Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of Medicine MaebashiJapan School of Health Sciences Gunma University Graduate School of Medicine MaebashiJapan

AIM： To examine the hepatitis C virus （HCV） levels and immunological markers in cirrhotic patients after splenectomy. METHODS： HCV RNA titers as well as cellular and humoral immune markers were determined in 20 cirrhotic patients after splenectomy and in 32 cirrhotic controls with an intact spleen. RESULTS： Serum HCV RNA titers were lower in the splenectomized patients than in the controls （186 ± 225 × 10^3 copies/mL vs 541 ± 417×10^3 copies/mL, P〈0.01）. HCV RNA was judged to have been spontaneously eradicated in 4 splenectomized patients, but in none of the controls. Natural killer cell activity was higher in the splenectomized patients than in the controls （41.2 ± 19.3% vs 24.7 ± 15.3%, P〈 0.01）, and natural killer cell activity was negatively correlated to HCV RNA titers in the splenectomized patients except in those with serotype 2-related infection. The CEH/CD8 ratio was significantly lower in the splenectomized patients than in the controls. CONCLUSION： The findings suggest that splenectomy may diminish virus burden in cirrhotic patients with HCV infection at least in part, through augmentation of natural killer cell activity.

关键词： Hepatitis C virus Liver cirrhosis Natural killer cell Splenectomy

Autoimmune thrombocytopenia in response to splenectomy in cirrhotic patients with accompanying hepatitis C

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World Journal of Gastroenterology 2006年第8期12卷 1205-1210页

作者： Tetsuro Sekiguchi takeaki nagamine Hitoshi Takagi Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashiJapan School of Health Sciences Gunma University Graduate School of MedicineMaebashiJapan

AIM： To estimate the contribution of autoimmune thrombocytopenia to hepatitis C virus-related liver cirrhosis （type C cirrhosis）, we evaluated the influence of splenectomy upon platelet-associated immunoglobulin G （PAIgG） levels and platelet numbers. METHODS： PAIgG titers and immune markers were determined in 24 type C cirrhotic patients with an intact spleen, 17 type C cirrhotic patients submitted to splenectomy, and 21 non-C cirrhosis with an intact spleen. RESULTS： Thrombocytopenia （PLT〈15×10^4/μL） in type C cirrhosis was diagnosed in all patients with an intact spleen, 8 patients submitted to splenectomy, and in 19 non-C cirrhosis with intact spleen. Elevated titers of PAIgG at more than 25.0 ng/107cells were detected in all cirrhotic patients except for one splenectomized patient. PAIgG titers （ng/10^7cells） were significantly higher in the type C cirrhosis with an intact spleen （247.9 ± 197.0） compared with the splenectomized patients （125.6±87.8） or non-C cirrhosis （152.4± 127.4）. PAIgG titers were negatively correlated with platelet counts in type C cirrhotic patients with an intact spleen. In comparison with the type C cirrhosis with an intact spleen, the splenectomized patients had a reduced CD4/CD8 ratio and serum neopterin levels. The spleen index （cm^2） was negatively correlated with platelet counts in the non-C cirrhosis, but not in the type C cirrhosis. CONCLUSION： Our data indicate that the autoimmune mechanism plays an important role in thrombocytosis complicated by HCV-positive cirrhosis. In addition, splenectomy may impair T cells function through, at least in part, a reduction of CD4/CD8 ratio, consequently suppressing PAIgG production.

关键词： Platelet-associated immunoglobulin G Autoimmune thromboo/topenia Liver cirrhosis Hepatitis C virus Splenectomy CD4/CD8 ratio

Different outcomes of nosocomial infection with hepatitis C virus from the same origin

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World Journal of Gastroenterology 2006年第4期12卷 659-661页

作者： Satoru Kakizaki Hitoshi Takagi Yuichi Yamazaki Naondo Sohara Ken Sato takeaki nagamine Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashiGunma 371-8511Japan Department of Clinical Nursing Gunma University School of Health SciencesMaebashiGunma 371-8511Japan

The outcome of infection with hepatitis C virus （HCV） varies substantially from self-limiting infection to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma among the individuals. The mechanisms that determine the clearance or the persistence of HCV have not yet been clarified. Here, we experienced two cases of hospital-related infection with HCV from the same origin but with quite different outcomes. One case resolved after an episode of acute hepatitis, while the other case developed a chronic hepatitis although they were infected with HCV of the same origin. Although infected with the virus of the same origin, the clinical and virological courses were completely different. This suggests that host factors play a major role in conditioning the outcome of acute HCV infection.

关键词： Nosocomial infection Hepatitis C virus HLA

Application of virtual reality technology improves the functionality of brain networks in individuals experiencing pain

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World Journal of Clinical Cases 2025年第3期13卷 66-68页

作者： Takahiko nagamine Department of Psychiatric Internal Medicine Sunlight Brain Research CenterHofu 7470066YamaguchiJapan

Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and ***,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)*** has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been *** precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be ***,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain *** salience network is diminished,while the default mode network is ***,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and *** research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.

关键词： Virtual reality Pain Anxiety Salience network Default mode network

Rotational Motions Excited by Vertical Harmonic Motions

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 51-57页

作者： Tadokoro Chiharu Kadowaki Kei Mori Hiroki nagamine Takuo Department of Mechanical Engineering Saitama University Department of Mechanical Engineering Kyushu University

Rotation of a pair of wings was driven by the vertical harmonic motion of a pin inserted into the center hole of the *** elucidate the mechanism by which the rotational motion of the wings was excited,the relationship between the wings and the pin was examined by tracking their motions using both displacement measurements and high-speed *** motion modes occurred in this study were categorized into five types:slipping,rolling,jumping(without eccentricity),jumping(with eccentricity),and *** the case that the hole of the wings was located at a distance from the center of the wings,referred to as″with eccentricity,″the slipping,jumping(with eccentricity),and non-rotation modes *** experimental results showed that the mechanism of the jumping(with eccentricity)was different from that of the other modes(slipping,rolling,jumping(without eccentricity)),which are well known to be driven by the periodical reaction of the wings against the vertical vibration of the *** was found that the jumping(with eccentricity)was driven by the non-periodical force with the collision between the wing hole and the pin.

关键词： motion transformation rotation vibration hula-hoop

In vitro identification of nonalcoholic fatty liver diseaserelated protein hnRNPM

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World Journal of Gastroenterology 2015年第6期21卷 1784-1793页

作者： Jun-ichi Takino Kentaro nagamine Masayoshi Takeuchi Takamitsu Hori Department of Biochemistry Faculty of Pharmaceutical Sciences Hiroshima International University Department of Advanced Medicine Medical Research Institute Kanazawa Medical University

AIM:To study the formation of intracellular glyceraldehyde-derived advanced glycation end products(Glycer-AGEs)in the presence of high concentrations of ***:Cells of the human hepatocyte cell line Hep3B were incubated with or without fructose for five days,and the corresponding cell lysates were separated by two-dimensional gradient sodium dodecyl sulfate-polyacrylamide gel ***-AGEs were detected with the anti-Glycer-AGEs ***,the identification of the proteins that are modified by glyceraldehyde in the presence of high concentrations of fructose was conducted using matrixassisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS).The protein and m RNA levels were determined by Western blotting and realtime reverse transcription PCR,***:The results of the two-dimensional gradient sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated a greater amount of GlycerAGEs in the sample exposed to high concentrations of fructose than in the *** detected GlycerAGEs showed isoelectric points in the range of 8.0-9.0and molecular weights in the range of 60-80 k *** heterogeneous nuclear ribonucleoprotein M(hn RNPM),which plays an important role in regulating gene expression by processing heterogeneous nuclear RNAs to form mature m RNAs,was identified as a modified protein using *** the concentration of fructose in the medium induced a concentration-dependent increase in the generated ***,in an experiment using glyceraldehyde,which is a precursor of Glycer-AGEs,hn RNPM was found to be more easily glycated than the other ***:The results suggest that glyceraldehyde-modified hn RNPM alters gene *** change may cause adverse effects in hepatocytes and may serve as a target for therapeutic intervention.

关键词： Advanced glycation end-products Fructose Glycation

Facial aesthetics is shaped not only by genetic predispositions but also by the cultural norms and values

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World Journal of Clinical Cases 2024年第34期12卷 6684-6686页

作者： Takahiko nagamine Psychiatric Internal Medicine Sunlight Brain Research CenterHofu 7470066YamaguchiJapan

The positioning of teeth is of significant importance,both in terms of function and *** is a subjective matter,and there is often a discrepancy between the perceptions of patients and those of medical *** act of wearing a mask has been demonstrated to impair the ability to evaluate facial attractiveness,thereby reaffirming the visual importance of the oral cavity in the context of facial *** notion that a face perceived as beautiful is inherently exceptional is a *** average face is defined as one that exhibits characteristics that are common to the ***,cultural mutations occur at a faster rate than genetic *** regard to changes in facial aesthetics,cultural differences have a more immediate effect than genetic *** advent of the internet meme may herald the advent of an era in which the average face that defines a beautiful face is determined by the internet.

关键词： Orthodontics Mask Genetics Culture Average face

Merits and demerits of administering esketamine in preventing postpartum depression following cesarean section

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World Journal of Clinical Cases 2024年第36期12卷 6883-6886页

作者： Takahiko nagamine Department of Psychiatric Internal Medicine Sunlight Brain Research CenterHofu 7470066YamaguchiJapan

Emergency cesarean section is associated with the development of postpartum *** has been demonstrated to have a rapid onset of antide-pressant *** controlled trials and meta-analyses have demon-strated the efficacy of esketamine in preventing postpartum depression after ce-ssarean ***,the data included in these analyses were derived from elective cesarean sections and differed in the dose and timing of esketamine *** is a dissociative anesthetic with a dose-dependent risk of inducing psychotic symptoms,including *** the setting of cesarean section,esketamine should be administered with caution and only if the potential benefits outweigh the risks.

关键词： Esketamine Cesarean section Depression Adverse event Medial prefrontal cortex

Contribution of the toxic advanced glycation end-productsreceptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma

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World Journal of Hepatology 2015年第23期7卷 2459-2469页

作者： Jun-ichi Takino Kentaro nagamine Takamitsu Hori Akiko Sakasai-Sakai Masayoshi Takeuchi Department of Biochemistry Faculty of Pharmaceutical Sciences Hiroshima International University Department of Advanced Medicine Medical Research Institute Kanazawa Medical University

Hepatocellular carcinoma(HCC) is one of the most common malignancies worldwide. The main etiologies of HCC are hepatitis B virus and hepatitis C virus(HCV), and non-hepatitis B/non-hepatitis C HCC(NBNCHCC) has also been identified as an etiological factor. Although the incidence of HCV-related HCC in Japan has decreased slightly in recent years, that of NBNC-HCC has increased. The onset mechanism of NBNC-HCC, which has various etiologies, remains unclear; however, nonalcoholic steatohepatitis(NASH), a severe form of nonalcoholic fatty liver disease, is known to be an important risk factor for NBNC-HCC. Among the different advanced glycation end-products(AGEs) formed by the Maillard reaction, glyceraldehyde-derived AGEs, the predominant components of toxic AGEs(TAGE), have been associated with NASH and NBNC-HCC, including NASH-related HCC. Furthermore, the expression of the receptor for AGEs(RAGE) has been correlated with the malignant progression of HCC. Therefore, TAGE induce oxidative stress by binding with RAGE may, in turn, lead to adverse effects, such as fibrosis and malignant transformation, in hepatic stellate cells and tumor cells during NASH or NASH-related HCC progression. The aim of this review was to examine the contribution of the TAGE-RAGE axis in NASH-related HCC.

关键词： Hepatocellular carcinoma Nonalcoholic steatohepati

Localized type 1 autoimmune pancreatitis superimposed upon preexisting intraductal papillary mucinous neoplasms

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World Journal of Gastroenterology 2013年第47期19卷 9127-9132页

作者： Takahiro Urata Yoshiki Naito Yoshihiro Izumi Yoshi Takekuma Hiroshi Yokomizo Michiko nagamine Seiji Fukuda Kenji Notohara Michio Hifumi Department of Gastroenterology Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan Department of Pathology Kurume University School of MedicineKurume CityFukuoka 830-0011Japan Department of Surgery Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan Department of Pathology Japanese Red Cross Kumamoto HospitalKumamoto 861-8520Japan Department of Anatomic Pathology Kurashiki Central HospitalKurashiki CityOkayama 701-01Japan

A 70-year-old woman was found to have 2 cystic lesions in the head of the pancreas on abdominal ultrasonography during a routine medical *** ultrasonography(EUS)and magnetic resonance cholangiopancreatography showed multilocular cysts in the head of the pancreas without dilation of the main pancreatic *** patient was followed-up semiannually with imaging studies for suspected branch duct-type intraductal papillary mucinous neoplasm(IPMN).At 3 years after initial presentation,hypoechoic lesions were observed around each pancreatic cyst by ***-weighted imaging showed high-intensity regions corresponding to these ***,a diagnosis of invasive carcinoma derived from IPMN could not be excluded,and subtotal stomach-preserving pancreaticoduodenectomy was *** macroscopic examination of the surgical specimen showed whitish solid masses in the head of the pancreas,with multilocular cysts within each ***,each solid mass consisted of inflammatory cells such as lymphocytes and plasma ***,immunochemical staining revealed immunoglobulin G4-positive cells,and many obliterating phlebitides were *** cysts consisted of mucus-producing epithelial cells and showed a papillary growth *** on these findings,we diagnosed multiple localized type 1 autoimmune pancreatitis occurring only in the vicinity of the branch ducttype IPMN.

关键词： Autoimmune pancreatitis Intraductal papillary mucinous neoplasm Immunoglobulin G4 Endoscopic ultrasonography Diffusion-weighted imaging