Different outcomes of nosocomial infection with hepatitis C virus from the same origin

作     者：Satoru Kakizaki Hitoshi Takagi Yuichi Yamazaki Naondo Sohara Ken Sato Takeaki Nagamine Masatomo Mori 

作者机构：Department of Medicine and Molecular ScienceGunma University Graduate School of MedicineMaebashiGunma 371-8511Japan Department of Clinical NursingGunma University School of Health SciencesMaebashiGunma 371-8511Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第4期

页      面：659-661页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Nosocomial infection Hepatitis C virus HLA 

摘      要：The outcome of infection with hepatitis C virus （HCV） varies substantially from self-limiting infection to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma among the individuals. The mechanisms that determine the clearance or the persistence of HCV have not yet been clarified. Here, we experienced two cases of hospital-related infection with HCV from the same origin but with quite different outcomes. One case resolved after an episode of acute hepatitis, while the other case developed a chronic hepatitis although they were infected with HCV of the same origin. Although infected with the virus of the same origin, the clinical and virological courses were completely different. This suggests that host factors play a major role in conditioning the outcome of acute HCV infection.