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In Vivo Development of Fetal Pig Kidneys in Mature Monkeys under Clinically Approved Immunosuppressant Drugs

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Engineering 2022年第3期8卷 65-73页

作者： Tsuyoshi Takamura Kenji Matsui Naoto matsumoto Yatsumu Saito Toshinari Fujimoto Susumu Tajiri Shuichiro Yamanaka Kei matsumoto Akimitsu Kobayashi Izumi Yamamoto Hiroshi Sasaki Haruyuki Hirayama Hitomi Matsunari Kazuaki Nakano Hiroshi Nagashima Akihiko Kiyoshi Takao Kuroda Makoto Inoue Takeshi Miyawaki Takashi Yokoo Eiji Kobayashi Division of Nephrology and Hypertension Department of Internal MedicineThe Jikei University School of MedicineTokyo 105-8461Japan Department of Urology The Jikei University School of MedicineTokyo 105-8461Japan Department of Plastic and Reconstructive Surgery The Jikei University School of MedicineTokyo 105-8461Japan Meiji University International Institute for Bio-Resource Research Kanagawa 214-8571Japan Sumitomo Dainippon Pharma Co. Ltd.Osaka-fu 564-0053Japan Department of Kidney Regenerative Medicine The Jikei University School of MedicineTokyo 105-8461Japan

Controlling the immune response with only clinically approved immunosuppressant drugs is difficult in renal heterotra ns plantation from pigs to nonhuman ***,to the best of our knowledge,no reports exist on the use of fetal pigs as kidney *** study aimed to compare the degree of transplant rejection between neonatal and fetal kidneys,with genetically unmodified pigs as donors and cynomolgus monkeys as *** left kidneys of the recipient monkeys were removed,followed by transplantation of neonatal as well as fetal pig kidneys,which had undergone vascular anastomosis at the same site,into the *** was performed with only US Food and Drug Administration-approved *** fetal kidneys were transplanted into the omentum and paraaortic regions of cynomolgus ***,the engraftment and development of the transplanted tissues were pathologically examined by sampling over time(twice in each experiment).An acute rejection was observed after a few weeks in neonatal renal grafts with vascular ***,fetal pig kidneys were spared from rejection despite the administration of the same immunosuppressive protocol to the monkeys and the recipient blood vessels flowing into the fetal *** immunogenicity of fetal kidneys in pig-monkey renal heterotransplantation was lower than that of neonatal kidneys.

关键词： Cynomolgus monkey Pig Kidney Fetal kidney Immunosuppression

RANKL^(+) senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics

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International Journal of Oral Science 2023年第2期15卷 278-290页

作者： Yue Zhou Aki Nishiura Hidetoshi Morikuni Wenqi Deng Toru Tsujibayashi Yoshihiro Momota Yuki Azetsu Masamichi Takami Yoshitomo Honda Naoyuki matsumoto Department of Orthodontics Osaka Dental UniversityHirakataOsakaJapan Department of Physics Osaka Dental UniversityHirakataOsakaJapan Department of Anesthesiology Osaka Dental UniversityHirakataOsakaJapan Department of Pharmacology Showa University School of Dentistry1-5-8HatanodaiShinagawakuTokyoJapan Department of Oral Anatomy Osaka Dental University8-1 KuzuhahanazonochoHirakataOsakaJapan

In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely ***,we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate that mechanical stress-induced senescent cells aggravate apical root resorption,which was prevented by administering senolytics(a dasatinib and quercetin cocktail).

关键词： stress therapeutic ortho

Research　on　the　Conditions　of　Enzymatic　Saccharification　for　Sugarcane　Bagasse

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Chemical Research in Chinese Universities 1998年第1期14卷 46-52页

作者： Zheng, Cheng Kanji, matsumoto Guangzhou Univ Dept Light Chem Engn Guangzhou 510091 Peoples R China Yokohama Natl Univ Dept Mat Sci & Chem Engn Yokohama Kanagawa Japan

ＲｅｓｅａｒｃｈｏｎｔｈｅＣｏｎｄｉｔｉｏｎｓｏｆＥｎｚｙｍａｔｉｃＳａｃｃｈａｒｉｆｉｃａｔｉｏｎｆｏｒＳｕｇａｒｃａｎｅＢａｇａｓｓｅＺＨＥＮＧＣｈｅｎｇ（Ｄｅｐｔ，ｏｆＬｉｇｈｔＣｈｅｍ．Ｅｎｇ．，Ｃｕａｎｇｚ... 详细信息

ＲｅｓｅａｒｃｈｏｎｔｈｅＣｏｎｄｉｔｉｏｎｓｏｆＥｎｚｙｍａｔｉｃＳａｃｃｈａｒｉｆｉｃａｔｉｏｎｆｏｒＳｕｇａｒｃａｎｅＢａｇａｓｓｅＺＨＥＮＧＣｈｅｎｇ（Ｄｅｐｔ，ｏｆＬｉｇｈｔＣｈｅｍ．Ｅｎｇ．，ＣｕａｎｇｚｈｏｕＵｎｉｖｅｒｓｉｔｙ，Ｇｕａ...

关键词： Conditions Enzymatic Sugarcane Saccharification

Enzyme replacement therapy in two patients with classic Fabry disease from the same family tree:Two case reports

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World Journal of Clinical Cases 2023年第15期11卷 3542-3551页

作者： Yuki Harigane Issei Morimoto O Suzuki Jumpei Temmoku takayuki Sakamoto Kohichiro Nakamura Kazuo Machii Masayuki Miyata Department of Urology Fukushima Medical UniversityFukushima 960-1295Japan Otsuki Sleep Clinic Fukushima 960-8044Japan Department of Diagnostic Pathology Fukushima Medical UniversityFukushima 960-1295Japan Center of Internal Medicine for Rheumatology and Collagen Disease Fukushima Red Cross HospitalFukushima 960-8530Japan Department of Cardiology Fukushima Red Cross HospitalFukushima 960-8530Japan Department of Neurology Fukushima Red Cross HospitalFukushima 960-8530Japan Machii Cardiology and Internal Medicine Clinic Fukushima 960-8530Japan

BACKGROUND The pathophysiology of Fabry disease(FD)-induced progressive vital organ damage is *** progression can be delayed using enzyme replacement therapy(ERT).In patients with classic FD,sporadic accumulation of globotriaosylceramide(GL-3)in the heart and kidney begins in utero;however,until childhood,GL-3 accumulation is mild and reversible and can be restored by *** current consensus is that ERT initiation during early childhood is ***,complete recovery of organs in patients with advanced FD is *** SUMMARY Two related male patients,an uncle(patient 1)and nephew(patient 2),presented with classic *** patients were treated by *** 1 was in his 50s,and ERT was initiated following end-organ damage;this was subsequently *** developed cerebral infarction and died of sudden cardiac *** 2 was in his mid-30s,and ERT was initiated when the patient was diagnosed with FD,during which the damage to vital organs was not overtly *** he had left ventricular hypertrophy at the beginning of this treatment,the degree of hypertrophy progression was limited to a minimal range after>18 years of *** We obtained discouraging ERT outcomes for older patients but encouraging outcomes for younger adults with classic FD.

关键词： Enzyme replacement therapy Fabry disease Pedigree Left ventricular hypertrophy α-galactosidase Case report

Influence of sputtering power on properties of ZnO thin films fabricated by RF sputtering in room temperature

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Science China(Information Sciences) 2012年第4期55卷 951-955页

作者： Satoru matsumoto Department of Electrical Engineering Keio UniversityTokyoJapan

High mobility and c-axis orientated ZnO thin films were deposited on glass substrates using RF sputtering method at room *** properties of ZnO thin films were investigated by X-ray diffraction (XRD).Surface morphology and roughness were studied with scanning electron microscopy (SEM) and atomic force microscopy (AFM).Electrical properties were measured at room temperature using a Hall effect measurement *** influence of sputtering power on characteristics of ZnO thin films is *** results indicate that the sputtering powers have great influence on the crystal quality and mobility of ZnO thin *** using optimized sputtering conditions,high crystal quality ZnO thin films with Hall mobility of 34 cm 2 /V·s at room temperature were obtained.

关键词： ZnO thin film transparent oxide semiconductor sputtering power room temperature process

Effects of bottom bracings on torsional dynamic characteristics of horizontally curved twin I-girder bridges with different curvatures

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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 149-162页

作者： Robiul Awall Toshiro Hayashikawa Takashi matsumoto Graduate School of Engineering Hokkaido University Faculty of Engineering Hokkaido University

Curved twin I-girder bridges (CTIGBs) have low torsional stiffness that makes them vulnerable to dynamic loads. This study investigates the effects of bottom bracings on the torsional dynamic characteristics of CTIGBs. Five types of bottom bracings are designed to investigate their effects on the dynamic characteristics of CTIGBs with different curvatures under free and forced vibrations. To perform numerical investigations, three-dimensional (3-D) finite element (FE) bridge and vehicle models are established using commercial ANSYS code, and then a vehicle-bridge interaction analysis approach is proposed. Road roughness profiles generated from power spectral density and cross spectral functions are also taken into account in the analyses. The numerical results show that torsional frequencies increase significantly after providing bottom bracings, and the increasing rate depends on the type of bottom bracings and their locations of installation. Bottom bracings can act as load transmitting members from one main girder to the others. Large negative bearing forces that have occurred in bridges with small radii of curvatures can be remarkably reduced by providing bottom bracing systems. It is found that the performances of several bottom bracing systems are effective in improving the torsional dynamic characteristics of the bridges in this study.

关键词： bottom bracing CTIGB FE model torsional stiffness dynamic response negative bearing force

Selective excitation of two-wave structure depending on crystal orientation under shock compression

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Science China(Physics,Mechanics & Astronomy) 2020年第11期63卷 59-71页

作者： QiLin Xiong Takahiro Shimada takayuki Kitamura ZhenHuan Li Department of Mechanics Huazhong University of Science&TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment Wuhan 430074China Department of Mechanical Engineering and Science Kyoto UniversityKyoto 615-8540Japan

Single crystals subjected to shock compression exhibit responses with distinct two-wave structures for certain crystal ***,little is known to date regarding how the shock response depends on crystal orientation,and especially why the two-wave structure depends on the crystal *** this work,molecular dynamics simulations of shock compressions in copper single crystals are performed to investigate the orientation dependence of shock responses and the corresponding deformation *** copper single crystals with[001],[011],[012],and[123]crystal orientations along the depth direction are ***[011],[012],and[123]crystal orientations of copper single crystals show distinct two-wave structures in their shock responses,while such a two-wave structure in the shock response is not seen for those orientations having a[001]crystal *** potential causes are analyzed by considering the propagation velocities of both elastic and plastic *** develop a technique for identifying twin structures in face-centered cubic crystals and this technique can effectively identify the twin *** morphology of shock-induced defects(e.g.,dislocations and twins)shows the significant dependence of crystal orientation and the mechanisms behind these are discussed in ***,the Johnson-Cook constitutive model describing dynamic deformations at high temperatures and high strain rates is used to analyze the relationships between the shock responses and microscopic *** predictions of the Johnson-Cook constitutive model are consistent with the results of the molecular dynamics simulations.

关键词： orientation-dependent two-wave structure shock compression copper molecular dynamics

Urban climate in the Tokyo metropolitan area in Japan

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Journal of Environmental Sciences 2017年第9期29卷 54-62页

作者： Jun matsumoto Fumiaki Fujibe Hideo Takahashi Research Center for Climatology Department of Geography Tokyo Metropolitan University Department of Coupled Ocean-Atmosphere-Land Processes Research JAMSTEC

Long-term climate changes related with urbanization in Tokyo, Japan, and recent temperature and heavy rainfall distribution in the Tokyo metropolitan area are reviewed. A relatively high temperature increase in annual mean temperature at the rate of 3.0°C/century was detected in Tokyo for the period 1901–2015. Some observational evidence showed the existence of both thermal and mechanical effects of urbanization on recent heavy rainfall occurrences, and modeling studies also support precipitation enhancement. Urban influences were recognized in other climatological elements, such as number of fog days, relative humidity, and wind circulation.

关键词： Heat island Cool island Heavy rainfall Fog Humidity Sea breeze

IMPROVEMENT OF BUBBLE MODEL FOR CAVITATING FLOW SIMULATIONS

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Journal of Hydrodynamics 2009年第1期21卷 41-46页

作者： TAMURA Y. matsumoto Y. Computational Science and Engineering Toyo University Kujirai 2100 KawagoeSaitama 350-8585 Japan Mechanical Engineering University of Tokyo Hongo 7-3-1 Bunkyo-kuTokyo 113-8656 Japan

In the present research, a bubble dynamics based model for cavitating flow simulations is extended to higher void fraction region for wider range of applications. The present bubble model is based on the so-called Rayleigh-Plesset equation that calculates a temporal bubble radius with the surrounding liquid pressure and is considered to be valid in an area below a certain void fraction. The solution algorithm is modified so that the Rayleigh-Plesset equation is no more solved once the bubble radius （or void fraction） reaches at a certain value till the liquid pressure recovers above the vapor pressure in order to overcome this problem. This procedure is expected to stabilize the numerical calculation. The results of simple two-dimensional flow field are presented compared with the existing bubble model.

关键词： cavitation model Computational Fluid Dynamics (CFD) cavitation flow Rayleigh-Plesset equation