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心肌模型和分析软件的研发及其在心肌SPECT显像标准化中作用的多中心研究

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中华核医学与分子影像杂志 2017年第8期37卷 523-523页

作者：唐军 takayuki shibutani Masahisa Onoguchi Tetsuro Katafuchi Seigo Kinuya 苏州大学附属第二医院核医学科 215004 Department of Quantum Medical Technology Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan

目的该课题组自主研发了一款心肌模型和分析软件，通过标准化的定量指标来客观评价显像质量。研究目的是明确该模型和软件是否适用于显像的标准化。方法为对心肌SPECT显像进行标准化，课题组研发了心肌显像的评价分析软件（EMIT）和模... 详细信息

目的该课题组自主研发了一款心肌模型和分析软件，通过标准化的定量指标来客观评价显像质量。研究目的是明确该模型和软件是否适用于显像的标准化。方法为对心肌SPECT显像进行标准化，课题组研发了心肌显像的评价分析软件（EMIT）和模型，利用该模型对胸部进行模拟，其内设置了肺和心脏。心肌模型包括5个放射性正常区域和8个放射性缺损区域。

关键词： EMIT模型心肌SPECT显像标准化显像质量评价

Tissue and bone regeneration material for alveolar bone defects.

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Tissue and bone regeneration material for alveolar bone defe...

Inflammation-based factors and prognosis in patients with colorectal cancer

第十次全国牙周病学学术会议

作者： Toshiaki shibutani Department of Periodontology Asahi University School of Dentistry

Tissue and bone regeneration around periodontal tissue and periImplant tissue is indicated to compose growth factors,stem cells and *** study for this area focus to the growth factors,such as bone morphogenic proteins(BMPs),transforming growth factor beta(TGF-β),and fibroblast growth factors(FGFs)*** cells,iPScells,ES cells,bone marrow stem cells.

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World Journal of Gastrointestinal Oncology 2015年第8期7卷 111-117页

作者： Kiyoshi Maeda Masatusne shibutani Hiroshi Otani Hisashi Nagahara Tetsuro Ikeya Yasuhito Iseki Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of MedicineOsaka 545-8585 Japan

Several parameters for predicting survival in patients with colorectal cancer have been identified, including the performance status, age, gender and tumor-nodemetastasis(TNM) stage. Although the TNM stage is important and useful for predicting the prognosis and determining the appropriate treatment, it is well known that the survival time varies widely, even in patients with the same stage of disease. Therefore, the identification of new parameters capable of more precisely predicting patient survival is needed to help select the optimal treatment, especially in patients in the advanced stage of disease. Although the TNM stage reflects the tumor characteristics, cancer progression and survival are not determined solely based on the local characteristics of the tumor, but also the host systemic immune/inflammatory response. Therefore, using a combination of parameters that reflect both tumor characteristics and the host systemic inflammatory status is thought to be important for accurately predicting patient survival.

关键词： Colorectal cancer Platelet-to-lymphocyteratio Prognosis Glasgow Prognostic Score C-reactiveprotein Neutrophil-to-lymphocyte ratio Inflammationbasedfactor Nutritional Prognostic Index

Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer

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World Journal of Gastroenterology 2015年第34期21卷 9966-9973页

作者： Masatsune shibutani Kiyoshi Maeda Hisashi Nagahara Hiroshi Ohtani Katsunobu Sakurai Sadaaki Yamazoe Kenjiro Kimura Takahiro Toyokawa Ryosuke Amano Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of Medicine

AIM:To evaluate the prognostic significance of the lymphocyte to monocyte ratio(LMR) in patients with unresectable metastatic colorectal cancer who received palliative ***:A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy,while posttreatment LMR values were measured eight weeks after the initiation of ***:The median pre-treatment LMR was 4.16(range:0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38,66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate(P = 0.0011). Moreover,patients who demonstrated low pre-treatment LMR and normalization after treatmentexhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR ***:The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy.

关键词： Colorectal cancer Prognosis Unresectable Chemother

Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss

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International Journal of Oral Science 2015年第4期7卷 242-249页

作者： Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh shibutani Department of Biochemistry and Molecular Biology Nihon University School of Dentistry at Matsudo Research Institute of Oral Health Nihon University School of Dentistry at Matsudo Department of Oral Health Graduate School of DentistryKanagawa Dental University Department of Dental Hygiene Howon University Department of Preventive and Public Oral Health Nihon University School of Dentistry at Matsudo Department of Anesthesiology Nihon University School of Dentistry at Matsudo Department of Infection Control Division of MicrobiologyKanagawa Dental University Department of Radiopraxis Science Kanagawa Dental University

Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors. Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases. Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride （NaF） on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. NaF strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin （IL）-1β, matrix metalloproteinase 9 （MMP9）, and tartrate-resistant acid phosphatase, which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect, NaF inhibited osteoclast formation caused by the differentiation factor RANKL （receptor activator of nuclear factor KB ligand） and macrophage colony-stimulating factor （M-CSF）. The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells （NFAT） cl was also abrogated by NaF. Taken together, our data demonstrate that NaF inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATcl, ultimately leading to the suppressed expression of cathepsin K and MMP9. The in vivo effect of NaF on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of NaF for treating periodontal diseases.

关键词： alveolar bone loss osteoclasts Porphyromonas gingivalis sodium fluoride

用大量余震震源机制估计2000年鸟取县西部地震区域的应力场

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世界地震译丛 2007年第6期38卷 5-19页

作者： Y. Yukutake Y. Iio H. Katao T. shibutani 万永革（译）吕春来（校）不详防灾科技学院

根据大量震源机制估计了2000年鸟取县西部地震(MW=6.6)前后的区域应力场。为约束主震前的应力场,我们比较了主震产生的静态应力变化与主震后应力场的空间分布。在余震区的北部和中部,推测主震前的偏应力量值太大,不会受到静态应力变化... 详细信息

根据大量震源机制估计了2000年鸟取县西部地震(MW=6.6)前后的区域应力场。为约束主震前的应力场,我们比较了主震产生的静态应力变化与主震后应力场的空间分布。在余震区的北部和中部,推测主震前的偏应力量值太大,不会受到静态应力变化的影响。主震前的最大主应力轴的方向与构造应力场一致。而在余震区南部,主震滑动较大的地区及其周围,发现由于静态应力变化较大,主震后应力场的空间分布很不均匀。在断层南端附近,静态应力变化的空间分布与余震的P轴方位角一致,推测主震前的偏应力量值小到足以受到静态应力变化(5MPa)影响的地步。断层南端原有余震断层面的强度可能特别弱。发现主震前的应力场在小于主震断层长度的尺度上是不均匀的。

关键词：区域应力场地震区域震源机制鸟取县余震西部估计应力变化

由精确震源机制推断的日本海岸地震带的局部应力集中:板内地震断层应力积累过程的意义

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世界地震译丛 2009年第1期40卷 28-41页

作者： R．Kawanishi Y．Iio Y．Yukutake T．shibutani H．Katao 李洁波（译）万永革（校）吕春来（复校）不详防灾科技学院

在日本西南的板内地区发现了最大主应力轴(σ1)方位角的空间变化。根据大量精确震源机制进行应力反演推测,沿日本海岸地震带的σ1轴方位角取向为N110°E～N130°E,而在周边地区几乎为东西方向,即N90°E～N100°E。沿南海海沟内陆板块的... 详细信息

在日本西南的板内地区发现了最大主应力轴(σ1)方位角的空间变化。根据大量精确震源机制进行应力反演推测,沿日本海岸地震带的σ1轴方位角取向为N110°E～N130°E,而在周边地区几乎为东西方向,即N90°E～N100°E。沿南海海沟内陆板块的地壳浅部广泛观测到东西方向的最大水平压应力。然而,在该地震带上仅观测到WNW—ESE方向的最大水平应力。用该地震带之下下地壳中的无震断层或延性断层带的形变解释了该地震带内及其周围应力场的这种空间变化。

关键词：局部应力集中地震断层震源机制地震带积累过程日本板内海岸

熊胆粉对DEN + PBO诱发大鼠肝癌早期阶段的影响研究

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中国实验动物学报 2023年第9期31卷 1148-1155页

作者：董锐张梅洪泽宣唐倩邹昕羽贾贵阳倪元萍涉谷淳金美兰西南大学动物医学院重庆400715 东京农工大学农学研究科动物生命科学部兽医病理学研究室东京183-8509 西南大学实验动物中心重庆400715

目的为了解明熊胆粉在肝癌早期阶段的抑制作用,利用大鼠短期致癌模型进行了熊胆粉(bear bile powder, BBP)的抗癌药效实验。方法 40只5周龄雄性SD大鼠分成4组:DEN单独组(DEN-alone),模型组(DEN+PBO),低剂量组(DEN+PBO+BBP-L)(200 mg/k... 详细信息

目的为了解明熊胆粉在肝癌早期阶段的抑制作用,利用大鼠短期致癌模型进行了熊胆粉(bear bile powder, BBP)的抗癌药效实验。方法 40只5周龄雄性SD大鼠分成4组:DEN单独组(DEN-alone),模型组(DEN+PBO),低剂量组(DEN+PBO+BBP-L)(200 mg/kg),高剂量组(DEN+PBO+BBP-H)(400 mg/kg)。实验开始时,大鼠腹腔注射200 mg/kg二乙基亚硝胺(diethylnitrosamine, DEN),模型组、低剂量组及高剂量组动物饲喂了0.5%胡椒基丁醚(piperonyl butoxide, PBO)粉末饲料。低剂量组和高剂量组动物同时灌胃200或400 mg/kg BBP 8周。结果饲喂PBO粉末饲料的动物绝对及相对肝重量显著大于DEN单独组。但是,DEN+PBO+BBP-L组的GST-P阳性病灶的数量和面积与DEN+PBO组相比显著减少。同时,因DEN和PBO处理显著增加的Ki-67阳性细胞率在BBP处理组显著减少。但是,细胞周期相关的Ccne1、Cdkn1b和细胞凋亡相关的Caspase 8、Caspase 9仅在DEN+PBO+BBP-H组中显著增加,在DEN+PBO+BBP-L组中没有变化。结论 BBP在肝癌形成早期阶段通过抑制癌前病灶发挥抑制作用,且它的抗癌机制中包含着抑制细胞增殖活性和诱导细胞凋亡作用。同时,高剂量的BBP可能影响其抗癌前病灶作用。

关键词：熊胆粉肝癌早期阶段癌前病灶抑制作用

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熊胆粉及熊去氧胆酸对肝癌癌前病变的作用

中国实验动物学报 2024年第11期32卷 1424-1432页

作者：贾贵阳倪元萍王梦茹涉谷淳金美兰西南大学动物医学院重庆400715 东京农工大学农学研究科动物生命科学部兽医病理学研究室东京183-8509 西南大学实验动物中心重庆400715

目的为了探究熊胆粉(bear bile powder,BBP)及其熊去氧胆酸(chenodeoxycholic acid,UDCA)在肝癌癌前病变的发生发展中的影响,利用短期致癌动物模型探索了BBP和UDCA的抗氧化作用及它在抗癌前病变中的影响。方法SPF级SD大鼠40只随机分4组... 详细信息

目的为了探究熊胆粉(bear bile powder,BBP)及其熊去氧胆酸(chenodeoxycholic acid,UDCA)在肝癌癌前病变的发生发展中的影响,利用短期致癌动物模型探索了BBP和UDCA的抗氧化作用及它在抗癌前病变中的影响。方法SPF级SD大鼠40只随机分4组:对照(Control)组,模型(DEN)组,熊胆粉(DEN+BBP)组(200 mg/kg),熊去氧胆酸(DEN+UDCA)组(30 mg/kg),每组10只。实验开始除Control组外所有大鼠腹腔注射100 mg/kg二乙基亚硝胺(diethylnitrosamine,DEN),每周一次,共3周。从实验开始到结束,DEN+BBP组每天灌胃200 mg/kg BBP水溶剂,DEN+UDCA组每天灌胃30 mg/kg UDCA悬浮溶液。结果DEN组,DEN+BBP组,DEN+UDCA组的体重和肝重量,3组之间无显著性差异。DEN组的肝组织中丙二醛(malondialdehyde,MDA)的水平显著增高,谷胱甘肽(glutathione,GSH)、超氧化物歧化酶(superoxide dismutase,SOD)的水平显著降低。但UDCA处理显著降低了MDA的水平,显著增加了GSH、SOD的水平。相反,BBP处理在血清中发挥同样的作用。DEN+BBP组和DEN+UDCA组的谷胱甘肽-S-转移酶(glutathione S-transferase,GST-P)阳性病变数量及面积和Ki-67阳性细胞率显著低于DEN组,且在DEN+UDCA组中更为明显。同时,DEN+UDCA组中的Caespase-9表达量显著高于DEN组。结论BBP和UDCA对DEN诱导的肝癌癌前病变的发生均发挥显著的抑制作用,且对DEN诱导的氧化应激也有抗氧化作用,但它们的作用方式不同。同时,这些抗氧化作用是否参与抗癌作用需进一步研究。

关键词：熊胆粉熊去氧胆酸肝癌癌前病变氧化应激