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Journal of Modern Transportation 2016年第3期24卷 177-186页

作者： Yanning Zhao Toshiyuki Yamamoto takayuki Morikawa Department of Civil Engineering Nagoya University Institute of Materials and Systems for Sustainability Nagoya University Institute of Innovation for Future Society Nagoya University

This paper examines older driver＇s automotive trip （abbreviation： trip） characteristics which include trip frequency, trip length, destination distribution, and non- home-based （NHB） trips. A two-month experiment of 108 participants was carried out to collect GPS tracking data in Aichi Prefecture, Japan. To identify the effect of living area, a comparative analysis between older drivers and others is conducted in densely inhabited district （DID, i.e., urban） and other areas （non-DID, i.e., suburban, rural, etc）, separately. The present study found that there was no sig- nificant difference between the trip characteristics of older drivers and others who were living in DID. Thus, we suggest that the education of safety driving and the rec- ommendation of public transportation should be given to DID-living older drivers. However, the results of non-DID reflected that older drivers＇ trip frequency, trip length, destination, and NHB trips rate were shorter and lower than others＇. This implies that electric vehicles may be suit- able for promotion among older drivers in suburban and rural area. Furthermore, the regression analysis confirmed that ＂older driver＂ was a significant independent variable on trip frequency, trip length, and NHB trips, and there were interaction effects between ＂older driver＂ and ＂living areas＂ on all trip characteristics.

关键词： Older driver Travel behavior Living areaTrip frequency - Trip length Destination distribution Non-home-based (NHB) trips

An analysis on older driver＇s driving behavior by GPS tracking data： Road selection, left/right turn, and driving speed

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第1期5卷 56-65页

作者： Yanning Zhao Toshiyuki Yamamoto takayuki Morikawa Department of Civil Engineering Nagoya University Nagoya 464-8603 Japan Institute of Materials and Systems for Sustainability Nagoya University Nagoya 464-8603Japan Institute of Innovation for Future Society Nagoya University Nagoya 464-8603Japan

With the high older-related accident ratio and increasing population aging problem, understanding older drivers＇ driving behaviors has become more and more important for building and improving transportation system. This paper examines older driver＇s driving behavior which includes road selection, left/right turn and driving speed. A two-month experiment of 108 participants was carried out in Aichi Prefecture, Japan. Since apparently contradictory statements were often drawn in survey-based or simulators-based studies, this study collected not only drivers＇ basic information but also GPS data. Analysis of road selection demonstrates that older drivers are reluctant to drive on expressway not only in short trips but also in long trips. The present study did not find significant difference be- tween older drivers and others while turning at the intersections. To investigate the impact factors on driving speed, a random-effects regression model is constructed with explan- atory variables including age, gender, road types and the interaction terms between age and road types. Compared with other variables, it fails to find that age （60 years old or over） has significant impact on driving speed. Moreover, the results reflect that older drivers drive even faster than others at particular road types： national road and ordinary municipal road. The results in this study are expected to help improve transportation planning and develop driving assistance systems for older drivers.

关键词： Older driver Driving behavior Road selection Left/right turn Driving speed

Metabolomics-assisted refinement of the pathways of steroidal glycoalkaloid biosynthesis in the tomato clade

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Journal of Integrative Plant Biology 2014年第9期56卷 864-875页

作者： Kevin Schwahn Leonardo Perez de Souza Alisdair R.Fernie takayuki Tohge University of Potsdam AG BioinformaticsInstitute for Biochemistry and Biology MaxPlanck-Institute of Molecular Plant Physiology

Steroidal glycoalkaloids（SGAs） are nitrogen-containing secondary metabolites of the Solanum species,which are known to have large chemical and bioactive diversity in *** recent effort and development on LC/MS techniques for SGA profiling have elucidated the main pathways of SGA metabolism in tomato,the problem of peak annotation still remains due to the vast diversity of chemical structure and similar on overlapping of chemical *** we provide a case study of peak classification and annotation approach by integration of species and tissue specificities of SGA accumulation for provision of comprehensive pathways of SGA *** order to elucidate natural diversity of SGA biosynthesis,a total of 169 putative SGAs found in eight tomato accessions（Soianum lycopersicum, ***, ***, ***, ***,***,***,***） and four tissue types were used for correlation *** results obtained in this study contribute annotation and classification of SGAs as well as detecting putative novel biosynthetic branch *** such this represents a novel strategy for peak annotation for plant secondary metabolites.

关键词： Fruit ripening glycoalkaloids secondary metabolite Solanum lycopersicum tomato accessions

Intragingival injection of Porphyromonas gingivalis-derived lipopolysaccharide induces a transient increase in gingival tumour necrosis factor-a, but not interleukin-6,in anaesthetised rats

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International Journal of Oral Science 2015年第3期7卷 155-160页

作者： Hiroko Taguchi Yuri Aono takayuki Kawato Masatake Asano Noriyoshi Shimizu Tadashi Saigusa Department of Orthodontics Nihon University School of Dentistry Department of Pharmacology Nihon University School of Dentistry at Matsudo Department of Pharmacology Nihon University School of Dentistry Department of Oral Health Sciences Nihon University School of Dentistry Department of Pathology Nihon University School of Dentistry

This study used in vivo microdialysis to examine the effects of intragingival application of lipopolysaccharide（LPS） derived from Porphyromonas gingivalis（Pg-LPS） on gingival tumour necrosis factor（TNF）-a and interleukin（IL）-6 levels in rats. A microdialysis probe with an injection needle attached to the surface of the dialysis membrane was implanted into the gingiva of the upper incisor. For comparison, the effects of LPS derived from Escherichia coli（Ec-LPS） on IL-6 and TNF-a levels were also analysed. Pg-LPS（1 mg/1 m L） or Ec-LPS（1 or 6 mg/1 m L） was applied by microsyringe, with gingival dialysates collected every hour. Enzyme-linked immunosorbent assay（ELISA） revealed that gingival dialysates contained approximately 389 pg？m L21 of IL-6 basally; basal TNF-a levels were lower than the detection limit of the ELISA. Pg-LPS failed to alter IL-6 levels but markedly increased TNF-a levels, which remained elevated for 2 h after treatment. Neither IL-6 nor TNF-a were affected by Ec-LPS. Reverse transcriptase-polymerase chain reaction（RT-PCR） analysis revealed that the gingiva expresses Toll-like receptor（TLR） 2 and TLR4 m RNA. Immunohistochemical examination showed that TLR2 and TLR4 are expressed by gingival epithelial cells. The present study provides in vivo evidence that locally applied Pg-LPS, but not Ec-LPS, into the gingiva transiently increases gingival TNF-a without affecting IL-6. The present results suggest that TLR2 but not TLR4 expressed on gingival epithelial cells may mediate the Pg-LPS-induced increase in gingival TNF-a in rats.

关键词： Porphyromonas gingivalis lipopolysaccharide gingiva tumour necrosis factor-a microdialysis

Reactive lymphoid hyperplasia of the liver:A case report and review of literature

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World Journal of Gastroenterology 2007年第40期13卷 5403-5407页

作者： Takuro Machida Toshiyuki Takahashi Tomoo Itoh Michiaki Hirayama takayuki Morita Shoichi Horita Department of Internal Medicine Hokkaido Gastroenterology HospitalSapporoHokkaido 065-0041Japan Department of Pathology Hokkaido Gastroenterology HospitalSapporoHokkaido 065-0041Japan Department of Pathology Hokkaido University HospitalSapporoHokkaido060-8648Japan Department of Surgery Hokkaido Gastroenterology HospitalSapporoHokkaido 065-0041Japan

A case of a 53-year-old female patient with reactive lymphoid hyperplasia （RLH）, clinically designated as pseudolymphoma of the liver is described in this article. The patient was admitted to our hospital for further evaluation of hepatic tumors incidentally discovered at another hospital. Various diagnostic methods, including ultrasonography （US）, computerized tomography （CT）, magnetic resonance imaging （MRI） and hepatic angiography displayed three small lesions in the liver with outstanding findings consistent with hepatocellular carcinoma （HCC）. Surgical resection was performed and the three lesions were microscopically diagnosed as RLH of the liver. The lesions comprised a massive infiltration of lymphoid cells with follicles and hyalinized inter- follicular spaces. Immunohistochemical examination revealed that infiltrating lymphocytes had no prominent nuclear atypia and polyclonality. RLH of the liver is a very rare condition and only twelve cases have been reported in the English literature. Majority of the reported cases were middle-aged women and about half of them had some immunologic abnormalities such as autoimmune thyroiditis, Sjogren＇s syndrome, primary immunodeficiency, primary biliary cirrhosis. Since they are olden clinically misdiagnosed as HCC, surgery is the choice of treatment for these patients. Although their pathology resembles malignant lymphoma, the clinical course is completely benign. The authors propose that RLH of the liver can be discriminated from HCC by its clinical features.

关键词： Reactive lymphoid hyperplasia Pseudo lymphoma Hepatocellular carcinoma Autoimmunethyroiditis Immunohistochemistry

A case of conjunctival intraepithelial neoplasia with spheroidal degeneration:a clinicopathological study

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1401-1403页

作者： Shoichiro Ota Satoru Kase takayuki Tanaka Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan

Dear Editor,I am Shoichiro Ota from Hokkaido University hospital,*** intraepithelial neoplasia(CIN)is a disease concept that includes dysplasia and carcinoma in ***,CIN is characterized by tumor cell proliferation located within the epithelium with preservation of the basement membrane[1].In addition to histological diagnosis,anterior segment optical coherence tomography(ASOCT)plays an important role in clinical diagnosis,showing diffuse epithelial thickening with homogeneous high-intensity reflection in case of CIN[2-3].

关键词： diagnosis degeneration neoplasia

Genetic analysis is helpful for the diagnosis of small bowel ulceration

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World Journal of Gastroenterology 2018年第28期24卷 3198-3200页

作者： Junji Umeno takayuki Matsumoto Atsushi Hirano Yuta Fuyuno Motohiro Esaki Department of Medicine and Clinical Science Graduate School of Medical SciencesKyushu UniversityFukuokaFukuoka 812-8582Japan Division of Gastroenterology Department of Internal MedicineFaculty of MedicineIwate Medical UniversityMoriokaIwate 020-8505Japan Department of Endoscopic Diagnostics and Therapeutics Saga University HospitalSaga 849-8501Japan

The widespread use of capsule endoscopy and balloonassisted endoscopy has provided easy access for detailed mucosal assessment of the small intestine. However, the diagnosis of rare small bowel diseases, such as cryptogenic multifocal ulcerous stenosing enteritis(CMUSE), remains difficult because clinical and morphological features of these diseases are obscure even for gastroenterologists. In an issue of this journal in 2017, Hwang et al reviewed and summarized clinical and radiographic features of 20 patients with an established diagnosis of CMUSE. Recently, recessive mutations in the PLA2G4A and SLCO2A1 genes have been shown to cause small intestinal diseases. The small bowel ulcers in each disease mimic those in the other and furthermore those found in nonsteroidal anti-inflammatory drug-induced enteropathy. These recent and novel findings suggest that a clinical diagnosis exclusively based on the characteristics of small bowel lesions is possibly imprecise. Genetic analyses seem to be inevitable for the diagnosis of rare small bowel disorders such as CMUSE.

关键词： cryptogenic multifocal ulcerous stenosing enteritis chronic nonspecific multiple ulcers of the small intestine chronic enteropathy associated with SLCO2A1 gene Crohn’s disease

In situ high-pressure nuclear magnetic resonance crystallography in one and two dimensions

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Matter and Radiation at Extremes 2021年第6期6卷 94-103页

作者： Thomas Meier Alena Aslandukova Florian Trybel Dominique Laniel takayuki Ishii Saiana Khandarkhaeva Natalia Dubrovinskaia Leonid Dubrovinsky Center for High Pressure Science and Technology Advanced Research BeijingChina Bayerisches Geoinstitut University of BayreuthBayreuthGermany Department of Physics Chemistry and Biology(IFM)Linkoping UniversitySE-58183 LinkopingSweden Material Physics and Technology at Extreme Conditions Laboratory of CrystallographyUniversity of BayreuthBayreuthGermany

Recent developments in in situ nuclear magnetic resonance(NMR)spectroscopy under extreme conditions have led to the observation of a wide variety of physical phenomena that are not accessible with standard high-pressure experimental ***,inherent di-or quadrupolar line broadening in diamond anvil cell(DAC)-based NMR experiments often limits detailed investigation of local atomic structures,especially if different phases or local environments ***,we describe our progress in the development of high-resolutionNMRexperiments in DACs using one-and two-dimensional homonuclear decoupling experiments at pressures up to the megabar *** this technique,spectral resolutions of the order of 1 ppm and below have been achieved,enabling high-pressure structural *** examples are presented that demonstrate the wide applicability of this method for extreme conditions research.

关键词： NMR extreme dimensions

Nicotine Treatment Induces Expression of Matrix Metalloproteinases in Human Osteoblastic Saos-2 Cells

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Acta Biochimica et Biophysica Sinica 2006年第12期38卷 874-882页

作者： Tomoko KATONO takayuki KAWATO Natsuko TANABE Naoto SUZUKI Kazuhiro YAMANAKA Hitoshi OKA Masafumi MOTOHASHI Masao MAENO Kanda Surugadai Chiyoda-kuTokyo 101-8310Japan Department of Oral Health Sciences Nihon UniversitySchool of DentistryTokyo 101-8310Japan Japan Department of Biochemistry Nihon University School of Dentistry.Tokyo 101-8310Japan

Tobacco smoking is an important risk factor for the development of severe ***,we showed that nicotine affected mineralized nodule formation,and that nicotine andlipopolysaccharide stimulated the formation of osteoclast-like cells by increasing production of macrophagecolony-stimulating factor （M-CSF） and prostaglandin E2（PGE2） by human osteoblastic Saos-2 *** thepresent study,we examined the effects of nicotine on the expression of matrix metalloproteinases （MMPs）,tissue inhibitors of matrix metalloproteinases （TIMPs）,the plasminogen activation system including thecomponent of tissue-type plasminogen activator （tPA）,urokinase-type PA （uPA）,and PA inhibitor type 1（PAI-1）,α7 nicotine receptor,and *** also examined the effect of the nicotine antagonist D-tubocurarineon nicotine-induced expression of *** expression was examined using real-time polymerase chainreaction （PCR） to estimate mRNA *** addition,expression of the MMP,TIMP,uPA,tPA,and PAI-1proteins was determined by Western blotting *** treatment caused expression of MMP-1,2,3,and 13,but not MMP-14,to increase significantly after 5 or 10 d of culture;MMP-14 expression did notchange through day *** of MMP-1 expression by nicotine treatment was eliminated bysimultaneous treatment with *** the presence of nicotine,expression of uPA,PAI-1,orTIMP-1,2,3,or 4 did not change over 14 d of culture,whereas expression of tPA increased significantly byday *** also increased expression of the α7 nicotine receptor and c-fos *** results suggestthat nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1,2,3,and 13,thereby tipping the balance between bone matrix formation and resorption toward the latter process.

关键词： nicotine matrix metalloproteinase tissue inhibitor of matrix metalloproteinase plasminogen activation system

Ultra-large-scale phase-field simulation study of ideal grain growth

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npj Computational Materials 2017年第1期3卷 247-252页

作者： Eisuke Miyoshi Tomohiro Takaki Munekazu Ohno Yasushi Shibuta Shinji Sakane Takashi Shimokawabe takayuki Aoki Graduate School of Science and Technology Kyoto Institute of TechnologyMatsugasakiSakyo-kuKyoto 606-8585Japan Faculty of Mechanical Engineering Kyoto Institute of TechnologyMatsugasakiSakyo-kuKyoto 606-8585Japan Division of Materials Science and Engineering Faculty of EngineeringHokkaido UniversityKita 13 Nishi 8Kita-kuSapporoHokkaido 060-8628Japan Department of Materials Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan The Supercomputing Division Information Technology CenterThe University of Tokyo2-11-16 YayoiBunkyo-kuTokyo 113-8658Japan Global Scientific Information and Computing Center Tokyo Institute of Technology2-12-1 i7-3 O-okayamaMeguro-kuTokyo 152-8550Japan

Grain growth,a competitive growth of crystal grains accompanied by curvature-driven boundary migration,is one of the most fundamental phenomena in the context of metallurgy and other scientific ***,the true picture of grain growth is still controversial,even for the simplest(or‘ideal’)*** problem can be addressed only by large-scale numerical ***,we analyze ideal grain growth via ultra-large-scale phase-field simulations on a supercomputer for elucidating the corresponding authentic statistical *** performed simulations are more than ten times larger in time and space than the ones previously considered as the largest;this computational scale gives a strong indication of the achievement of true steady-state growth with statistically sufficient number of ***,we provide a comprehensive theoretical description of ideal grain growth behaviors correctly quantified by the present *** findings provide conclusive knowledge on ideal grain growth,establishing a platform for studying more realistic growth processes.

关键词： grain field establishing