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Risk factors for small intestinal adenocarcinomas that are common in the proximal small intestine

World Journal of Gastroenterology 2022年第39期28卷 5658-5665页

作者： Shunji Fujimori Ryohei Hamakubo Aitoshi Hoshimoto takayoshi Nishimoto Jun Omori Naohiko Akimoto Shu Tanaka Atsushi Tatsuguchi Katsuhiko Iwakiri Department of Gastroenterology Chiba Hokusoh HospitalNippon Medical SchoolChiba 270-1694Japan Department of Gastroenterology Nippon Medical SchoolGraduate School of MedicineTokyo 113-8603Japan Department of Gastroenterology Tama-Nagayama HospitalNippon Medical SchoolTokyo 206-0025Japan

The frequency of primary small intestinal adenocarcinoma is increasing but is still *** frequency is approximately 3%of that of colorectal *** that the small intestine occupies 90%of the surface area of the gastrointestinal tract,small intestinal adenocarcinoma is very *** main site of small intestinal adenocarcinoma is the proximal small *** on this characteristic,dietary animal proteins/lipids and bile concentrations are implicated and reported to be involved in *** most nutrients are absorbed in the proximal small intestine,the effect of absorbable intestinal content is a suitable explanation for why small intestinal adenocarcinoma is more common in the proximal small *** proportion of aerobic bacteria is high in the proximal small intestine,but the absolute number of bacteria is *** addition,the length and density of villi are greater in the proximal small ***,the involvement of villi is considered to be low because the number of small intestinal adenocarcinomas is much smaller than that of colorectal *** the other hand,the reason for the low incidence of small intestinal adenocarcinoma in the distal small intestine may be that immune organs reside *** and disease factors increase the likelihood of small intestinal *** carcinogenesis experiments in which the positions of the small and large intestines were exchanged,tumors still occurred in the large intestinal mucosa more *** other words,the influence of the intestinal contents is small,and there is a large difference in epithelial properties between the small intestine and the large *** conclusion,small intestinal adenocarcinoma is rare compared to large intestinal adenocarcinoma due to the nature of the *** is reasonable to assume that diet is a trigger for small intestinal adenocarcinoma.

关键词： Small intestine Large intestine Adenocarcinoma Risk factor Carcinogenesis

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Femtosecond pulses cleaning by transient-grating process in Kerr-optical media

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Chinese Optics Letters 2011年第5期9卷 63-65页

作者： Kotaro Okamura Yuichiro Kida takayoshi Kobayashi Advanced Ultrafast Laser Research Center and Department of Engineering ScienceFaculty of Informatics and EngineeringDepartment of Engineering ScienceThe University of Electro-Communications International Cooperative Research Project (ICORP) Japan Science and Technology Agency Department of Electrophysics National Chiao Tung University Institute of Laser Engineering Osaka University

We use a transient-grating （TG） process in a Kerr bulk medium to clean a femtosecond laser pulse. Using the technique, the temporal contrast of the generated TG signal is improved by more than two orders of magnitude in comparison with the incident pulse in a 0.5-mm-thick fused silica plate. The laser spectrum is smoothed and broadened, and the pulse duration is shortened simultaneously. We expect to extend this technique to a clean pulse with broadband spectral bandwidth at a wide spectral range because it is a phase-matched process.

关键词： Electromagnetic pulse Fused silica Ultrafast lasers

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Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment

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World Journal of Gastroenterology 2023年第40期29卷 5566-5581页

作者： Aitoshi Hoshimoto Atsushi Tatsuguchi Ryohei Hamakubo takayoshi Nishimoto Jun Omori Naohiko Akimoto Shu Tanaka Shunji Fujimori Tsutomu Hatori Akira Shimizu Katsuhiko Iwakiri Department of Gastroenterology Nippon Medical SchoolTokyo 113-8603Japan Department of Analytic Human Pathology Nippon Medical SchoolTokyo 113-8603Japan Department of Pathology Nippon Medical SchoolChiba Hokusoh HospitalChiba 270-1694Japan

BACKGROUND Comprehensive genomic analysis has shown that small bowel adenocarcinoma(SBA)has different genomic profiles from gastric and colorectal ***,it is essential to establish chemotherapeutic regimens based on SBA *** expression of programmed cell death-ligand 1(PD-L1)and programmed cell death-ligand 2(PD-L2)in SBA is not fully ***-PD-L1/PD-1 therapy uses tumor-infiltrating lymphocytes(TILs);therefore,the status of TILs in the tumor microenvironment(TME)may influence their *** ratio of FoxP3+to CD8+T cells has been reported to be useful in predicting the prognosis of digestive system *** To investigate the clinicopathological significance of PD-L1/2 expression according to the status of TILs in SBA *** We performed immunohistochemical analysis for PD-L1,PD-L2,CD8,FoxP3,and DNA mismatch repair(MMR)proteins using formalin-fixed,paraffin-embedded tissues from 50 patients diagnosed with primary *** immunoreactivities of PD-L1 and PD-L2 were determined separately in tumor cells and tumor-infiltrating immune cells throughout the tumor center and invasive margins,and finally evaluated using the combined positive score(CPS).We assessed CD8+and FoxP3+T cells in the intratumoral and tumor-surrounding ***,we calculated and summed the ratio of FoxP3 to CD8+T cell ***-related cell densities were graded as low or *** results were compared with clinicopathological factors and patient *** distribution of cancer-specific survival(CSS)was estimated using the Kaplan–Meier method,and the log-rank test was used to test for significant differences in CSS.A Cox proportional hazard model was also used to assess the effect of tumor variables on *** PD-L1 expression was positive in 34%in tumor cells(T-PD-L1)and 54%in tumor-infiltrating immune cells(I-PDL1)of the cases examined.T-PD-L2 was positive in 34%and I-PD-L2 was positive in 42%of the ***-L1

关键词： Small bowel adenocarcinoma Programmed cell death-ligand 1 Programmed cell death-ligand 2 Tumor microenvironment Tumor-infiltrating lymphocytes Regulatory T-cells

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Solvent effect for ruthenium porphyrin

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Science China(Physics,Mechanics & Astronomy) 2010年第6期53卷 1005-1012页

作者： IWAKURA Izumi YABUSHITA Atshi KOBAYASHI takayoshi Innovative Use of Light and Materials/life PRESTJST4-1-8 HonchoKawaguchiSaitama 332-0012Japan Department of Electrophysics National Chiao-Tung University University of Electro-Communications ICORP JST4-1-8 HonchoKawaguchiSaitama 332-0012Japan Institute of Laser Engineering Osaka University

Relaxation of electronic excited-state and vibrational dynamics in the electronic excited state in Ru II(TPP)(CO) [TPP=tetraphenylporphyrin] dissolved in N2 bubbled benzene,O2 bubbled benzene,N2 bubbled chloroform and N2 bubbled acetone were clarified using a sub-5fs laser pulse. The result showed that the transition energy from the 1Q x states,consisting of the 1Q x(1,0)(π,π*) state(existing at 18800 cm-1 ) and 1Q x(0,0)(π,π*) state(existing at 17800 cm-1 ),to the 1M state of six-coordinated ruthenium complex is lower than that of the five-coordinated ruthenium complex. The intersystem crossing 1Q x(0,0)(π,π*)→ 3(d,π*) in the five-coordinate Ru II(TPP)(CO) in the solution was found to take place in about 1 ps.

关键词： femtosecond laser ruthenium porphyrin complex real-time spectroscopy

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利用激光实时频谱直接观测分子结构变化(英文)

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光学精密工程 2011年第2期19卷 200-212页

作者： takayoshi KOBAYASHI University of Electro-Communications 1-5-1 ChofugaokaChofuTokyo 182-8585Japan ICORP JST4-1-8 HonchoKawaguchiSaitama332-0012Japan Depart ment of Electrophysics National Chiao-Tung UniversityHsinchu 30010China Institute of Laser Engineering Osaka University2-6 Yamada-okaSuitaOsaka 565-0971Japan

利用脉宽小于5 fs的激光脉冲超快光谱同时研究了RuⅡ(TPP)(CO)的电子弛豫和振动动力学。研究认为,由1Qx(1,0)(π,π*)and1Qx(0,0)(π,π*)产生的信号按1Qx(1,0)(π,π*)→1Qx(0,0)(π,π*)→3(d,π*)→3(π,π*)和1Qx(0,0)(π,π*)→3(d,π*)→3(π,π*)的顺序从高能态衰减到低能态1。Qx(1,0)(π,π*),1Qx(0,0)(π,π*),3(d,π*),和3(π,π*)的电子寿命依次为(230±70)fs,(1 150±260)fs,(2 150±360)fs和极大于4.8 ps3。(d,π*)和3(π,π*)的寿命估计为(2150±360)fs和极大于4.8 ps。计算动态Stokes-shift过程中的能量衰减率,得到了从1Qx(1,0)(π,π*)到1Qx(0,0)(π,π*)的渡越时间为(190±40)fs,表明1Qx(1,0)(π,π*)的寿命与该渡越时间有相对较好的一致性。对频谱图的分析表明,依赖时间变化的振动光谱与自旋态变化有关,自旋态可以通过曲线交叉点或者单态和三重态之间的势能面的圆锥交面从激发单重态中的Franck-Condon态变化到三重态。研究发现,不能简单地使用单重态信号频谱的指数衰减形式和三重态振动信号频谱的指数增长形式来表示这种动态变化。相反,振动频谱的变化伴随着复杂的动态变化。首先,单重态振动频谱发生衰减,然后产生不同于单重态和三重态的新的振动频谱。新的振动频谱增长和衰减后,三重态的振动频谱开始增长。这种动态变化似乎与电子频谱的动态变化不同,将这种明显差异的原因解释为:振动频谱的变化可以敏感地检测处于平衡点和过渡状态或者接近锥形交集状态中的单重态和三重态的结构差异。

关键词：振动光谱超快光谱学激光光谱法分子结构自旋动力学

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Refractory gastric ulcer with abundant IgG4-positive plasma cell infiltration: A case report

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World Journal of Gastroenterology 2010年第17期16卷 2183-2186页

作者： takayoshi Fujita Takafumi Ando Masatoshi Sakakibara Waki Hosoda Hidemi Goto Department of Gastroenterology Aichi Cancer Center Aichi HospitalOkazaki CityAichi 444-0011Japan Department of Gastroenterology Nagoya University Graduate School of MedicineNagoya CityAichi 466-8550Japan Department of Pathology and Molecular Diagnostics Aichi Cancer CenterNagoya CityAichi 464-8681Japan

We describe a 77-year-old man with refractory gastric ulcer that worsened after Helicobacter pylori eradication *** showed marked infiltration of IgG4-positive plasma cells in the gastric lesions,which led us to suspect IgG4-related sclerosing *** the best of our knowledge,this is the first report of IgG4-related gastric ulcer without the main manifestation of autoimmune pancreatitis.

关键词： Sclerosis Gastric ulcer IgG4 Plasma cells

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2D Layered Double Hydroxide Nanosheets and Their Derivatives Toward E cient Oxygen Evolution Reaction

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Nano-Micro Letters 2020年第7期12卷 89-120页

作者： Xueyi Lu Hairong Xue Hao Gong Mingjun Bai Daiming Tang Renzhi Ma takayoshi Sasaki International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)TsukubaJapan

Layered double hydroxides(LDHs)have attracted tremendous research interest in widely spreading *** notably,transition-metal-bearing LDHs are expected to serve as highly active electrocatalysts for oxygen evolution reaction(OER)due to their layered structure combined with versatile ***,reducing the thickness of platelet LDH crystals to nanometer or even molecular scale via cleavage or delamination provides an important clue to enhance the *** this review,recent progresses on rational design of LDH nanosheets are reviewed,including direct synthesis via traditional coprecipitation,homogeneous precipitation,and newly developed topochemical oxidation as well as chemical exfoliation of parent LDH *** addition,diverse strategies are introduced to modulate their electrochemical activity by tuning the composition of host metal cations and intercalated counter-anions,and incorporating dopants,cavi-ties,and single *** particular,hybridizing LDHs with conductive components or in situ growing them on conductive substrates to produce freestanding electrodes can further enhance their intrinsic catalytic activity.A brief discussion on future research directions and prospects is also summarized.

关键词： Layered double hydroxides Nanosheets Derivatives Catalysts Oxygen evolution reaction

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Elevated CO2 offsets the alteration of foliar chemicals(n-icosane,geranyl acetate,and elixene)induced by elevated O3 in three taxa of O3-tolerant eucalypts

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Journal of Forestry Research 2021年第2期32卷 789-803页

作者： Eka Novriyanti Qiaozhi Mao Evgenios Agathokleous Makoto Watanabe Yasuyuki Hashidoko takayoshi Koike Research and Development Institute of Forest Fiber Technology FOERDIAMinistry of Environment and ForestryKotak Pos 4/BKN BangkinangKamparRiau 28411Indonesia Division of Environment and Resources Research Research Faculty of AgricultureHokkaido UniversitySapporoHokkaido 060-8589Japan College of Resources and Environment Southwest UniversityChongqing 400700China Institute of Applied Ecology Key Laboratory of Agrometeorology of Jiangsu ProvinceNanjing University of Information Science and TechnologyNanjing 210044JiangsuChina Institute of Agriculture Tokyo University of Agriculture and TechnologyFuchuTokyo 183-8509Japan Division of Applied Biological Sciences Research Faculty of AgricultureHokkaido Univ.SapporoHokkaido 060-8589Japan Shenzhen Graduate School of Environment and Energy Peking UniversityBeijing 518055China Research Center for Eco-Environmental Science Chinese Academy of ScienceBeijing 100085China

Eucalypts are important forest resources in southwestern China,and may be tolerant to elevated ground-level ozone(O3)concentrations that can negatively affect plant *** CO2 may offset O3-induced effects by providing excess carbon to produce secondary metabolites or by inducing stomatal ***,the effects of elevated CO2 and O3 on leaf secondary metabolites and other defense chemicals were studied by exposing seedlings of Eucalyptus globulus,***,and ***×*** to a factorial combination of two levels of O3(<10 nmol mol^(−1)and 60 nmol mol^(−1))and CO2(ambient:370μmol mol^(−1)and 600μmol mol^(−1))in open-top field ***-profiles of leaf extracts illustrated the effect of elevated O3 and the countering effect of high CO2 on compounds in leaf epicuticular wax and essential oils,i.e.,n-icosane,geranyl acetate and elixene,compounds known as a first-line defense against insect herbivores.n-Icosane may be involved in tolerance mechanisms of *** and the hybrid,while geranyl acetate and elixene in the tolerance of *** O3 and CO2,singly or in combination,affected only leaf physiology but not biomass of various *** CO2 impacted several leaf traits,including stomatal conductance,leaf mass per area,carbon,lignin,n-icosane,geranyl acetate and *** effects of elevated O3 on leaf physiology(nitrogen,n-icosane,geranyl acetate,elixene)were commonly offset by elevated *** conclude that ***,*** and the hybrid were tolerant to these O3 and CO2 treatments,and n-icosane,geranyl acetate and elixene may be major players in tolerance mechanisms of the tested species.

关键词： Carbon dioxide Epicuticular wax Eucalypts Secondary metabolism Tropospheric ozone

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Assessment for the minimal invasiveness of laparoscopic liver resection by interleukin-6 and thrombospondin-1

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World Journal of Hepatology 2022年第1期14卷 234-243页

作者： takayoshi Kaida Hiromitsu Hayashi Hiroki Sato Shotaro Kinoshita Takashi Matsumoto Yuta Shiraishi Yuki Kitano Takaaki Higashi Katsunori Imai Yo-ichi Yamashita Hideo Baba Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan

BACKGROUND Laparoscopic surgery has been introduced as a minimally invasive technique for the treatment of various ***,there are few reports that have scientifically investigated the minimally invasive nature of laparoscopic liver resection(LLR).AIM To investigate whether LLR is scientifically less invasive than open liver *** During December 2011 to April 2015,blood samples were obtained from 30 patients who treated with laparoscopic(n=10,33%)or open(n=20,67%)partial liver resection for liver *** levels of serum interleukin-6(IL-6)and plasma thrombospondin-1(TSP-1)were measured using ELISA kit at four time points including preoperative,immediate after operation,postoperative day 1(POD1)and ***,we investigated the impact of the operative approaches during partial hepatectomy on the clinical time course including IL-6 and *** Serum level of IL-6 on POD1 in laparoscopic hepatectomy was significantly lower than those in open hepatectomy(8.7 vs 30.3 pg/mL,respectively)(P=0.003).Plasma level of TSP-1 on POD3 in laparoscopic hepatectomy was significantly higher than those in open hepatectomy(1704.0 vs 548.3 ng/mL,respectively)(P=0.009),and have already recovered to preoperative level in laparoscopic *** patients with higher IL-6 Levels on POD1,plasma level of TSP-1 on POD3 was significantly lower than those in patients with lower IL-6 Levels on *** analysis showed that open approach was the only independent factor related to higher level of IL-6 on POD1[odds ratio(OR),7.48;95%confidence interval(CI):1.28-63.3;P=0.02].Furthermore,the higher level of serum IL-6 on POD1 was significantly associated with lower level of plasm TSP-1 on POD3(OR,5.32;95%CI:1.08-32.2;P=0.04)in multivariate *** In partial hepatectomy,laparoscopic approach might be minimally invasive surgery with less IL-6 production compared to open approach.

关键词： Laparoscopic surgery Liver resection Hepatectomy Minimal invasiveness Interleukin-6 Thrombospondin-1

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高强度和低弹性模量Ti−Nb−Fe−Zr合金的显微组织和力学性能

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Transactions of Nonferrous Metals Society of China 2022年第2期32卷 503-512页

作者：李强黄奇李俊杰何黔峰 Masaaki NAKAI 张柯 Mitsuo NIINOMI Kenta YAMANAKA Akihiko CHIBA takayoshi NAKANO 上海理工大学机械工程学院上海200093 中国科学院新疆理化技术研究所特殊环境功能材料与器件重点实验室乌鲁木齐830011 Division of Mechanical Engineering Faculty of Science and EngineeringKindai University3-4-1 KowakaeHigashiosakaOsaka 577-8502Japan 上海理工大学材料科学与工程学院上海200093 Institute for Materials Research Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1 Yamada-OkaSuitaOsaka 565-0871Japan Department of Materials Science and Engineering Graduate School of Science and TechnologyMeijo University1-501 ShiogamaguchiTempaku-kuNagoya 468-8502Japan

将Zr添加到Ti−Nb−Fe合金中开发生物医用低模量、高强度β钛合金。采用电弧熔炼法制备Ti−12Nb−2Fe−(2,4,6,8,10)Zr(摩尔分数,%)铸锭,随后对其进行均匀化、冷轧和固溶处理。通过光学显微镜、X射线衍射和透射电子显微镜等技术分析合金的物... 详细信息

将Zr添加到Ti−Nb−Fe合金中开发生物医用低模量、高强度β钛合金。采用电弧熔炼法制备Ti−12Nb−2Fe−(2,4,6,8,10)Zr(摩尔分数,%)铸锭,随后对其进行均匀化、冷轧和固溶处理。通过光学显微镜、X射线衍射和透射电子显微镜等技术分析合金的物相和显微组织。采用拉伸试验测定力学性能。结果表明,Zr和Fe在合金中具有显著的固溶强化效果,因此,所有合金的屈服强度和抗拉强度分别高于510 MPa和730 MPa。Zr对变形机制的影响较小,孪晶出现在所有变形合金中,且对强度和塑性有益。具有亚稳β相的Ti−12Nb−2Fe−(8,10)Zr合金表现出低弹性模量、高抗拉强度和良好的塑性,是生物医学植入物的合适候选材料。

关键词：医用钛合金力学性能固溶强化加工硬化孪晶诱导塑性

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