Risk factors for small intestinal adenocarcinomas that are common in the proximal small intestine

作     者：Shunji Fujimori Ryohei Hamakubo Aitoshi Hoshimoto Takayoshi Nishimoto Jun Omori Naohiko Akimoto Shu Tanaka Atsushi Tatsuguchi Katsuhiko Iwakiri 

作者机构：Department of GastroenterologyChiba Hokusoh HospitalNippon Medical SchoolChiba 270-1694Japan Department of GastroenterologyNippon Medical SchoolGraduate School of MedicineTokyo 113-8603Japan Department of GastroenterologyTama-Nagayama HospitalNippon Medical SchoolTokyo 206-0025Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第39期

页      面：5658-5665页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Small intestine Large intestine Adenocarcinoma Risk factor Carcinogenesis 

摘      要：The frequency of primary small intestinal adenocarcinoma is increasing but is still *** frequency is approximately 3%of that of colorectal *** that the small intestine occupies 90%of the surface area of the gastrointestinal tract,small intestinal adenocarcinoma is very *** main site of small intestinal adenocarcinoma is the proximal small *** on this characteristic,dietary animal proteins/lipids and bile concentrations are implicated and reported to be involved in *** most nutrients are absorbed in the proximal small intestine,the effect of absorbable intestinal content is a suitable explanation for why small intestinal adenocarcinoma is more common in the proximal small *** proportion of aerobic bacteria is high in the proximal small intestine,but the absolute number of bacteria is *** addition,the length and density of villi are greater in the proximal small ***,the involvement of villi is considered to be low because the number of small intestinal adenocarcinomas is much smaller than that of colorectal *** the other hand,the reason for the low incidence of small intestinal adenocarcinoma in the distal small intestine may be that immune organs reside *** and disease factors increase the likelihood of small intestinal *** carcinogenesis experiments in which the positions of the small and large intestines were exchanged,tumors still occurred in the large intestinal mucosa more *** other words,the influence of the intestinal contents is small,and there is a large difference in epithelial properties between the small intestine and the large *** conclusion,small intestinal adenocarcinoma is rare compared to large intestinal adenocarcinoma due to the nature of the *** is reasonable to assume that diet is a trigger for small intestinal adenocarcinoma.