检索结果-南通市图书馆

Enhancement of Visual Attention by Color Revealed Using Electroencephalography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Therapy and Rehabilitation 2024年第1期12卷 1-9页

作者： Moemi Matsuo takashi Higuchi Takuya Ishibashi Ayano Egashira Toranosuke Abe Hiroya Miyabara Faculty of Rehabilitation Sciences Nishikyushu University Kanzaki Japan Department of Physical Therapy Osaka University of Human Sciences Settsu Japan

Attention constitutes a fundamental psychological feature guiding our mental effort toward specific objects, concurrent with processes such as memory, reasoning, and imagination. Visual attention, crucial for selecting surrounding information, often decreases in older adults and patients with cerebrovascular disorders. Effective methods to enhance attention are scarce. Here, we investigated whether color information influences visual attention and brain activity during task performance, utilizing EEG. We examined 13 healthy young adults (seven women and six men;mean age: 21.2 ± 0.58 years) using 19-electrode electroencephalograms to assess the impact of color information on visual attention. The Clinical Assessment for Attention cancellation test was conducted under the black, red, and blue color conditions. Wilcoxon’s signed-rank test was used to assess differences in task performance (task time and error) between conditions. Spearman’s rank correlation was utilized to examine the correlation in power levels between task performance and color conditions. Significant variations in total task errors were observed among color conditions. The black condition exhibited the highest error frequency (0.7 ± 0.9 times), followed by the red condition (0.5 ± 0.8 times), with the lowest error frequency occurring in the blue (0.2 ± 0.4 times) condition (black vs. red: P = 0.03;black vs. blue: P = 0.00;red vs. blue: P = 0.032). No time difference was observed. The black condition showed negative delta and high-gamma correlations in the central electrodes. The red condition revealed positive alpha and low-gamma correlations in the frontal and occipital areas. Although no correlations were observed in the blue condition, it enhanced attentional performance. Positive alpha and low-gamma waves might be crucial for spotting attentional errors in key areas. Our findings provide insights into the effects of color information on visual attention and potential neural correlates associated

关键词： Attention Higher Brain Function Electroencephalography Neuroimaging Rehabilitation

Giant Brunner's gland hyperplasia of the duodenum successfully resected en bloc by endoscopic mucosal resection: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 368-375页

作者： Makomo Makazu Akiko Sasaki Chikamasa Ichita Chihiro Sumida takashi Nishino Miki Nagayama Shinichi Teshima Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533Japan Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Pathology Shonan Kamakura General HospitalKamakura 247-8533Japan

BACKGROUND Duodenal Brunner's gland hyperplasia(BGH)is a therapeutic target when complications such as bleeding or gastrointestinal obstruction occur or when malignancy cannot be ruled ***,we present a case of large BGH treated with endoscopic mucosal resection(EMR).CASE SUMMARY An 83-year-old woman presented at our hospital with *** tests revealed severe anemia,esophagogastroduodenoscopy showed a 6.5 cm lesion protruding from the anterior wall of the duodenal bulb,and biopsy revealed the presence of glandular *** ultrasonography(EUS)demonstr-ated relatively high echogenicity with a cystic *** muscularis propria was slightly elevated at the base of the *** was performed without *** formalin-fixed lesion size was 6 cm×3.5 cm×3 cm,showing nodular proliferation of non-dysplastic Brunner's glands compartmentalized by fibrous septa,confirming the diagnosis of *** of EMR or hot snare polypectomy are rare for duodenal BGH>6 *** this case,the choice of EMR was made by obtaining information on the base of the lesion as well as on the internal characteristics through *** Large duodenal lesions with good endoscopic maneuverability and no evident muscular layer involvement on EUS may be resectable via EMR.

关键词： Duodenum Brunner’s gland hyperplasia Brunner’s gland hamartoma Brunner’s gland adenoma Endoscopic mucosal resection Case report

Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Radiology 2024年第7期16卷 256-264页

作者： takashi Ono Hiraku Sato Yuya Miyasaka Yasuhito Hagiwara Natsuko Yano Hiroko Akamatsu Mayumi Harada Mayumi Ichikawa Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan Department of Heavy Particle Medical Science Yamagata University Graduate School of Medical ScienceYamagata 990-9585Japan

BACKGROUND Carbon ion radiotherapy(CIRT)is currently used to treat prostate *** bleeding is a major cause of toxicity even with ***,to date,a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been ***,the clinical risk factors for rectal bleeding were absent after 12 fractions of *** To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate *** Among 259 patients who received 51.6 Gy[relative biological effectiveness(RBE)],in 12 fractions of CIRT,15 had grade 1(5.8%)and nine had grade 2 rectal bleeding(3.5%).The dose-volume parameters included the volume(cc)of the rectum irradiated with at least x Gy(RBE)(Vx)and the minimum dose in the most irradiated x cc normal rectal volume(Dx).RESULTS The mean values of D6cc,D2cc,V10 Gy(RBE),V20 Gy(RBE),V30 Gy(RBE),and V40 Gy(RBE)were significantly higher in the patients with rectal bleeding than in those *** cutoff values were D6cc=34.34 Gy(RBE),D2cc=46.46 Gy(RBE),V10 Gy(RBE)=9.85 cc,V20 Gy(RBE)=7.00 cc,V30 Gy(RBE)=6.91 cc,and V40 Gy(RBE)=4.26 *** D2cc,V10 Gy(RBE),and V20 Gy(RBE)cutoff values were significant predictors of grade 2 rectal *** The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.

关键词： Carbon ion radiotherapy Prostate cancer Rectal bleeding Dose volume parameters Prevention

Analysis for Effects of Temperature Rise of PV Modules upon Driving Distance of Vehicle Integrated Photovoltaic Electric Vehicles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy and Power Engineering 2024年第4期16卷 131-150页

作者： Masafumi Yamaguchi Yasuyuki Ota Taizo Masuda Christian Thiel Anastasios Tsakalidis Arnulf Jaeger-Waldau Kenji Araki Kensuke Nishioka Tatsuya Takamoto takashi Nakado Kazumi Yamada Tsutomu Tanimoto Yosuke Tomita Yusuke Zushi Kenichi Okumura takashi Mabuchi Akinori Satou Kyotaro Nakamura Ryo Ozaki Nobuaki Kojima Yoshio Ohshita Toyota Technological Institute Nagoya Japan Faculty of Engineering Miyazaki University Miyazaki Japan Toyota Motor Corporation Susono Japan European Commission— Joint Research Centre Ispra Italy Sharp Corporation Nara Japan Toyota Motor Corporation Toyota Japan Nissan Motor Corporation Yokosuka Japan

The development of vehicle integrated photovoltaics-powered electric vehicles (VIPV-EV) significantly reduces CO2 emissions from the transport sector to realize a decarbonized society. Although long-distance driving of VIPV-EV without electricity charging is expected in sunny regions, driving distance of VIPV-EV is affected by climate conditions such as solar irradiation and temperature rise of PV modules. In this paper, detailed analytical results for effects of climate conditions such as solar irradiation and temperature rise of PV modules upon driving distance of the VIPV-EV were presented by using test data for Toyota Prius and Nissan Van demonstration cars installed with high-efficiency InGaP/GaAs/InGaAs 3-junction solar cell modules with a module efficiency of more than 30%. The temperature rise of some PV modules studied in this study was shown to be expressed by some coefficients related to solar irradiation, wind speed and radiative cooling. The potential of VIPV-EV to be deployed in 10 major cities was also analyzed. Although sunshine cities such as Phoenix show the high reduction ratio of driving range with 17% due to temperature rise of VIPV modules, populous cities such as Tokyo show low reduction ratio of 9%. It was also shown in this paper that the difference between the driving distance of VIPV-EV driving in the morning and the afternoon is due to PV modules’ radiative cooling. In addition, the importance of heat dissipation of PV modules and the development of high-efficiency PV modules with better temperature coefficients was suggested in order to expand driving range of VIPV-EV. The effects of air-conditioner usage and partial shading in addition to the effects of temperature rise of VIPV modules were suggested as the other power losses of VIPV-EV.

关键词： Vehicle Integrated Photovoltaics (VIPV) VIPV-Powered Electric Vehicles Driving Distance PV Modules Solar Irradiation Temperature Rise Radiative Cooling

Pseudolaric acid B induces apoptosis,senescence,and mitotic arrest in human breast cancer MCF-7

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第12期28卷 1975-1983页

作者： Shin-ichi TASHIRO Satoshi onodera takashi IKEJIMA Department of Clinical and Biomedical Sciences Showa Pharmaceutical University Tokyo 194-8543Japan China-Japan Research Institute of Medical Pharmaceutical Sciences Shenyang Pharmaceutical UniversityShenyang 110016China

Aim:The aim of the present study was to investigate the inhibitory effect ofpseudolaric acid B （PAB） on human breast cancer MCF-7 ***:3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide analysis,morphologicalchanges,acridine orange staining,and agarose gel electrophoresis were appliedto detect *** percentage of apoptotic and necrotic cells was calcu-lated by the lactate dehydrogenase activity-based cytotoxicity assay;senescenceassociated （SA）-β-galactosidase activity was detected to evaluate senescence;flow cytometric analysis of propidium iodide staining was carried out to investi-gate the distribution of cell cycle,and the protein expression was examined byWestern blot ***:During apoptosis,the half maximal inhibitoryconcentration IC50was 3.4 and 1.35 μmol/L at 36 and 48 h after PAB treatment,*** MCF-7 cells exposed to PAB showed typical characteristics ofapoptosis,including the morphological changes and DNA ***-7 cells treated with 4 μmol/L PAB for 36 h underwent apoptosis,but *** apoptosis induced by PAB was independent of the death *** senescent cells became larger and flatter,and the SA-β-galactosi-dase staining was *** induced obvious mitotic arrest and it precededapoptosis and *** expressions of p21 and p53 was upregulated withPAB treatment,and cyclin B 1 was upregulated and transported from the cyto-plasm to nuclei,and sustained stable ***:PAB induced mitoticarrest in the MCF-7 cells and inhibited proliferation through apoptosis *** apoptosis was independent of the death receptor pathway.

关键词： apoptosis senescence mitotic arrest human breast cancer MCF-7 pseudolaric acid B

Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin-induced apoptosis in human cervical cancer HeLa cell

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第12期27卷 1622-1629页

作者： takashi IKEJIMA Shin-ichi TASHIRO Satoshi onodera China-Japan Research Institute of Medical Pharmaceutical Sciences Shenyang Pharmaceutical UniversityShenyang 110016China Department of Clinical and Biomedical Sciences Showa Pharmaceutical UniversityTokyo 194-8543Japan

Aim:To study the mechanisms by which N-demethyl-clarithromycin(NDC)induces human cervical cancer HeLa cell apoptosis in ***:The viabilityof N-demethyl-clarithromycin-induced HeLa cells was measured by MTT *** cells with condensed nuclei were visualized by phase *** DNA fragmentation was assayed by agarose *** of mitochondrial transmembrane potential wasanalyzed by a FACScan ***-3,poly-(ADP-ribose)polymerase(PARP),caspase-activated DNase(ICAD),Bcl-2,Bax,p53,and SIRT1 proteinexpression and the release of cytochrome c were detected by Western blot ***:N-demethyl-clarithromycin,an anti-inflammatory substance,inhibitedHeLa cell growth in a dose-and time-dependent manner.N-demethyl-clarithro-mycin induced HeLa cell death through the apoptotic *** pan-caspaseinhibitor(z-VAD-fmk),caspase-3 inhibitor(z-DEVD-fmk)and the caspase-9 inhibi-tor(z-LEHD-fmk)partially enhanced cell viability induced by N-demethyl-clarithromycin,but the caspase-8 inhibitor(z-IETD-fmk)had almost no ***-3 was activated then followed by the degradation of caspase-3 substrates,the inhibitor of ICAD and PARE Simultaneously,mitochondrial transmembranepotential was markedly reduced and the release of cytochrome c in the cytosolwas increased.N-demethyl-clarithromycin upregulated the expression ratio ofmitochondrial Bax/Bcl-2,and significantly increased the expression of the *** also downregulated anti-apoptotic protein SIRT1 ***:N-demethyl-clarithromycin induced apoptosis in HeLa cells via themitochondrial pathway.

关键词： N-demethyl-clarithromycin HeLa cells caspase mitochondria

P53-mediated cell cycle arrest and apoptosis through a caspase-3-independent,but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第7期28卷 1057-1066页

作者： Shin-ichi TASHIRO Satoshi onodera Mutsuhiko MINAMI takashi IKEJIMA Department of Clinical and Biomedical Sciences Showa Pharmaceutical University Tokyo 194-8543Japan Department of ImmunologyYokohama City University School of Medicine Yokohama 235-0004Japan China-Japan Research Institute of Medical Pharmaceutical Sciences Shenyang Pharmaceutical UniversityShenyang 110016China

Aim:To study the caspase-3-independent mechanisms in oridonin-induced MCF-7human breast cancer cell apoptosis in ***:The viability of oridonin-treated MCF-7 cells was measured by MTT （thiazole blue） *** cellswith condensed nuclei were visualized by phase contrast ***-mal DNA fragmentation was assayed by agarose gel *** apoptoticratio was determined by lactate dehydrogenase *** cycle alternation andmitochondrial membrane potential were measured by flow cytometric ***,Bcl-2,caspase-3,caspase-9,heat shock protein （Hsp）90,p53,p-p53,p21,Poly（ADP-ribose） polymerase （PARP）,and the inhibitor of caspase-activated DNase（ICAD） protein expressions were detected by Western blot ***:Oridonin inhibited cell growth in a time-and dose-dependent *** cyclewas altered through the upregulation of p53 and p21 protein ***-caspase inhibitor Z-VAD-fmk and calpain inhibitor Ⅱ both decreased cell *** DNA fragmentation and the downregulation of ΔΨmitweredetected in oridonin-induced MCF-7 cell apoptosis,which was involved in apostmitochondrial caspase-9-dependent *** Bcl-2 and Hsp90expression levels and increased Bax and p21 expression levels were positivelycorrelated with elevated levels of phosphorylated p53 ***,PARP was partially cleaved by calpain rather than by ***:DNAdamage provoked alternations in the mitochondrial and caspase-9 pathways aswell as p53-mediated cell cycle arrest,but was not related to caspase-3 activity inoridonin-induced MCF-7 cells.

关键词： oridonin MCF-7 cells cell cycle arrest apoptosis p53 caspase-9 caspase-3 calpain mitochondrial pathway

Activation of extracellular signal-regulated kinase during silibinin-protected,isoproterenol-induced apoptosis in rat cardiac myocytes is tyrosine kinase pathway-mediated and protein kinase C-dependent

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第6期28卷 803-810页

作者： Shin-ichi TASHIRO Satoshi onodera Fumiaki UCHIUMI takashi IKEJIMA Department of Clinical and BiomedicalSciences Showa Pharmaceutical UniversityTokyo 194-8543Japan Department of Gene Regulation Faculty of Pharmaceutical SciencesTokyo University of ScienceChiba 278-8510Japan China-Japan Research Institute of Medieal and Pharmaceutical Sciences Shenyang Pharmaceutical UniversityShenyang 110016China

Aim:To investigate the mechanism of silibinin-protected isoproterenol-inducedapoptosis in rat cardiac ***:The viability of rat cardiac myocyteswas measured by MTT *** apoptotic ratio was measured by terminaldeoxynucleotidyl transferase-mediated dUTP nick *** kinase C(PKC) activity assay was carried out according to the instructions of the PepTagnon-radioactive protein kinase C assay *** blot analysis was used toevaluate the level of Ras,Raf-1 and mitogen-activated protein kinase (MAPK)***:The protective effects of silibinin were significantly sup-pressed by inhibitors,including genistein,manumycin A and GW5074 [inhibitorsfor protein tyrosine kinases (PTK),Ras and Raf-1,respectively].The exposure ofrat cardiac myocytes to isoproterenol alone caused decreased PKC activity,whichwas prevented by pretreatment with silibinin ***,the increased expression of Ras and Raf-1 activated by silibinin were blocked bythe PKC inhibitor,*** addition,the extracellularly responsive kinase(ERK) inhibitor,PD98059,suppressed silibinin-protected apoptosis,whereas thep38 MAPK inhibitor,SB203580,protected cardiac myocytes from isoproterenol-induced injury,and the c-Jun N-terminal kinase (JNK) inhibitor,SP600125 had noprotective ***,Western blot analysis showed that the expres-sion of phosphorylated ERK was increased by silibinin,the expression of phos-phorylated p38 MAPK was decreased and total ERK,p38,JNK and phosphory-lated JNK MAPK did not change after treatment with both isoproterenol ***,pretreatment of cardiac myocyte with PKC,Ras and Rafinhibitors significantly blocked ERK ***:Silibinin issuggested to protect isoproterenol-induced rat cardiac myocyte apoptosis byactivating the tyrosine kinase pathway,PKC and MAPK pathways.

关键词： silibinin rat cardiac myocytes tyrosine kinase: protein kinase C mitngen-activated protein kinases

Artificial oxygen carriers,from nanometer-to micrometer-sized particles,made of hemoglobin composites substituting for red blood cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Particuology 2022年第5期20卷 43-55页

作者： takashi Matsuhira Hiromi Sakai Department of Chemistry Nara Medical University840 Shijo-choKashihara 634-8521Japan

Blood transfusions are regarded as the most well-known and frequently performed cell *** current transfusion systems are sophisticated,they cannot be freed from the inherent difficulties that include infection,short shelf life,and blood type *** oxygen carriers produced using hemoglobin(Hb)are designated as Hb-based oxygen carriers(HBOCs),which are anticipated for use as biomaterials that have potential to resolve issues of transfusion by a radical paradigm *** HBOCs,nanometer-sized to micrometer-sized bioparticles having an oxygen-carrying function,are developed for use as substitutes for red blood cells(RBCs).This paper presents an overview of the classification of HBOCs with reference to their histories,preparations,structures,functions,and in vitro and in vivo ***,we give a more detailed introduction of our academic studies of liposome encapsulated Hb,designated as Hb-vesicles(HbV),which mimic the physiologically important corpuscular structure of *** review outlines perennial efforts and approaches to mimic RBC functions through chemical,genetic,and encapsulation *** will provide important insights into the eventual realization of an alternative for RBC transfusion.

关键词： Blood substitutes Cross-linking Hemoglobin(Hb)-based oxygen carriers(HBOCs) Liposome Supramolecular assembly Transfusion alternatives