Artificial oxygen carriers,from nanometer-to micrometer-sized particles,made of hemoglobin composites substituting for red blood cells

作     者：Takashi Matsuhira Hiromi Sakai Takashi Matsuhira;Hiromi Sakai

作者机构：Department of ChemistryNara Medical University840 Shijo-choKashihara 634-8521Japan 

出 版 物：《Particuology》 (颗粒学报（英文版）)

年 卷 期：2022年第20卷第5期

页      面：43-55页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supporting to our research group with grants from the Japan Society for the Promotion of Science (JSPS) the Japan Agency for Medical Research and Development(AMED) 

主　　题：Blood substitutes Cross-linking Hemoglobin(Hb)-based oxygen carriers(HBOCs) Liposome Supramolecular assembly Transfusion alternatives 

摘      要：Blood transfusions are regarded as the most well-known and frequently performed cell *** current transfusion systems are sophisticated,they cannot be freed from the inherent difficulties that include infection,short shelf life,and blood type *** oxygen carriers produced using hemoglobin(Hb)are designated as Hb-based oxygen carriers(HBOCs),which are anticipated for use as biomaterials that have potential to resolve issues of transfusion by a radical paradigm *** HBOCs,nanometer-sized to micrometer-sized bioparticles having an oxygen-carrying function,are developed for use as substitutes for red blood cells(RBCs).This paper presents an overview of the classification of HBOCs with reference to their histories,preparations,structures,functions,and in vitro and in vivo ***,we give a more detailed introduction of our academic studies of liposome encapsulated Hb,designated as Hb-vesicles(HbV),which mimic the physiologically important corpuscular structure of *** review outlines perennial efforts and approaches to mimic RBC functions through chemical,genetic,and encapsulation *** will provide important insights into the eventual realization of an alternative for RBC transfusion.