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Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke mizutani Tomoyuki Hioki Kumi Kojima takashi Onuma Yukiko Enomoto Tomoaki Doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida Toru Iwama takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

采用双生长室方法汽相生长双异质结结构InGaAsP/InP

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微纳电子技术 1985年第5期 35-37页

作者： takashi mizutani 何梅芬

采用“双生长室”氯化物汽相输运外延技术已研制出异质结InGaAsP/InP。两个独立的生长室,其中一个用来生长InGaAsP,另一个用来生长InP,而它们都连接于一个出口端。衬底是在几秒钟内机械地从一个室传输到另一个室,因而在异质界面不会出... 详细信息

采用“双生长室”氯化物汽相输运外延技术已研制出异质结InGaAsP/InP。两个独立的生长室,其中一个用来生长InGaAsP,另一个用来生长InP,而它们都连接于一个出口端。衬底是在几秒钟内机械地从一个室传输到另一个室,因而在异质界面不会出现互相沾污的生长,获得了陡峭度小于50 的晶格匹配良好的异质结构界面。用这种技术制备的InGaAsP/InP DH激光器,在室温下CW溅射,发现其阈值相当于液相外延制备的激光器。

关键词： InP Ga 异质结半导体结激光器光激射器电子器件晶格匹配衬底基片异质界面光波长汽相外延

利用多个导流装置降低大后壁车辆气动阻力的实验研究

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实验力学 2004年第2期19卷 150-155页

作者：吴志刚魏琪加藤征三竹森洋平柏康弘水谷贵志山本健太江苏大学能源与动力工程学院镇江212013 日本三重大学工学部

安装在车辆尾部1边和2边上的导流装置在降低大后壁车辆气动阻力中的作用和机理已在前面的实验中得出,为了搞清安装在车辆尾部3边和4边上的导流装置在降低大后壁车辆气动阻力中的作用和机理,本文利用1/16缩比的公共汽车模型及两种类型的... 详细信息

安装在车辆尾部1边和2边上的导流装置在降低大后壁车辆气动阻力中的作用和机理已在前面的实验中得出,为了搞清安装在车辆尾部3边和4边上的导流装置在降低大后壁车辆气动阻力中的作用和机理,本文利用1/16缩比的公共汽车模型及两种类型的导流装置,在一带有可移动地面和边界层吸收装置的开放型风洞中,进行了在车辆后端面的上、下、侧边的3边和4边分别安装导流装置时车辆后部尾流区的压强恢复及气动阻力降低的实验。对每一组合的导流装置,其与车辆表面的间隙尺寸是从0mm增加到5mm,间隔为1mm。通过对不同组合、不同间隙的导流装置的压强恢复效果和阻力降低效果的实验对比和分析,最终找出了能使车辆的气动阻力降低16%左右的最佳位置组合,为新型车辆的设计和改造提供了有利依据。

关键词：车辆工程风洞实验气动阻力导流装置

Clipping versus Coiling in Ruptured Aneurysms of the Anterior Cerebral Circulation

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Open Journal of Modern Neurosurgery 2020年第1期10卷 88-104页

作者： Farrag Mohammad takashi Horiguchi Katsuhiro mizutani Kazunari Yoshida Department of Neurosurgery Keio University School of Medicine Tokyo Japan Department of Neurosurgery Faculty of Medicine Assiut University Assiut Egypt

Objective: To evaluate and compare the outcomes of microsurgical clipping and endovascular coiling of ruptured anterior cerebral circulation aneurysms. Methods: The current study retrospectively included 61 patients presented with subarachnoid hemorrhage (SAH), treated by clipping or coiling for ruptured aneurysms located in anterior circulation. Anatomic outcome and post-operative ischemic events were evaluated. The primary clinical outcomes were evaluated as operative complications while the secondary clinical outcome was evaluated by modified Rankin scale (mRS) at discharge. Results: Of 61 ruptured aneurysms, 47 and 14 were treated by surgery and coiling, respectively. The average follow-up duration was 19.1 ± 18.6 months for clipping and 21.7 ± 14.8 months for coiling. Complete occlusion was greater in surgery group (80.8%) than endovascular group (21.4%). Re-growth occurred in 2 cases of the coiling group only. Ischemic events were encountered in both groups;silent ones were higher in coiling group (21.4%) than in clipping group (6.3%), while symptomatic ones were higher in the clipping group (49%). Good outcome (mRS 0 - 2) was 51% and 71.4% after clipping and coiling respectively. Postoperative hospital period was longer after clipping (P = 0.04). Conclusions: For anterior circulation ruptured aneurysms, both treatments are feasible, coiling showed lower rate of morbidity while clipping results were better regarding durability and recurrence. Coil embolization may be preferred, which is the current point proved by the RCT like ISAT, but if you choose the patients carefully and find out the optimal candidate for the clipping, the clipping is still enough feasible as a mainstream.

关键词： Anterior Circulation SAH Clipping Coiling Ruptured Aneurysms

三相PWM逆变器的功率转换效率优先AC滤波器电感设计

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磁性元件与电源 2023年第1期 148-151页

作者： Hiroaki Matsumori Daisuke mizutani takashi Kosaka Nobuyuki Matsui Tatsuya Miyazaki Yuta Okawauchi 日本名古屋工业大学机电工程系罗姆有限公司

这项研究是为了开发一种包含交流滤波器的三相脉宽调制(PWM)逆变器的功率密度和效率最大化的设计方法。功率密度和效率之间存在折衷关系。通常,已知增加开关频率会增加开关器件损耗并减小无源元件的体积。三相PWM逆变器设计应考虑转换... 详细信息

这项研究是为了开发一种包含交流滤波器的三相脉宽调制(PWM)逆变器的功率密度和效率最大化的设计方法。功率密度和效率之间存在折衷关系。通常,已知增加开关频率会增加开关器件损耗并减小无源元件的体积。三相PWM逆变器设计应考虑转换效率和逆变器体积之间的平衡。但是,据我们所知,尚无实践研究集中在具有交流滤波器的三相PWM逆变器的优化设计上。这是因为交流滤波器电感器的铁损会根据直流偏置励磁、开关纹波电流的幅度等以复杂的方式变化。因此,本文作者阐述了这种铁损机理,并在以前的研究中实现了一种高精度的铁损计算方法。在本文中,当设计交流滤波器电感器以通过调节铁芯直径、高度和绕组匝数,将损耗降至最低时,并分析了效率与开关频率之间的关系。然后通过与基础设计进行比较,验证了通过设计合适的电感器所实现的效率和体积优化。

关键词：交流滤波器功率转换效率电感器电感设计铁芯无源元件效率最大化铁损

Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

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World Journal of Gastroenterology 2020年第42期26卷 6669-6678页

作者： Yoshiki Niwa Masanao Nakamura Hiroki Kawashima Takeshi Yamamura Keiko Maeda Tsunaki Sawada Yasuyuki mizutani Eri Ishikawa Takuya Ishikawa Naomi Kakushima Kazuhiro Furukawa Eizaburo Ohno takashi Honda Masatoshi Ishigami Mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya 466-8560Japan Department of Endoscopy Nagoya University HospitalNagoya 466-8560Japan

BACKGROUND Retrograde cholangiopancreatography using double-balloon endoscopic retrograde cholangiography(DBERC)is a valuable technique to treat biliary stone and jejunobiliary anastomotic stenosis in patients with altered gastrointestinal *** accurate selection of the route at the anastomosis branch is one of the most important factors in reaching the target in a timely *** To determine the accuracy of carbon dioxide insufflation enterography(CDE)at the branch for selecting the correct route during *** We enrolled 52 consecutive patients scheduled for DBERC at our institution from June 2015 to November *** selection via two methods(visual observation and CDE)was performed in each *** determined the correct rate of route selection using *** Thirty-three patients had a jejunojejunal anastomosis and 19 patients had a gastrojejunal *** therapeutic target region was reached in 50 *** mean procedure times from the teeth to the target(total insertion time),from the teeth to the branch,and from the branch to the target,and the mean total examination time were 15.2,5.0,8.2,and 60.3 min,*** rate of correct route selection using visual observation and CDE were 36/52(69.2%)and 48/52(92.3%),respectively(P=0.002).The rate of correct route selection using CDE in patients with a jejunojejunal anastomosis was 29/33(87.8%),and the rate in patients with a gastrojejunal anastomosis was 19/19(100%).CONCLUSION CDE is helpful in selecting the route at the branch in the anastomosis for more timely access to the target in patients with altered gastrointestinal anatomy undergoing DBERC.

关键词： Retrograde cholangiopancreatography Double-balloon endoscopy Carbon dioxide insufflation Anastomosis Accuracy Prospective study

Development of Oral Dissolving Gelatin Beads Containing Allopurinol for the Prevention and Treatment of Mucositis

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Pharmacology & Pharmacy 2012年第3期3卷 295-299页

作者： Yoshifumi Murata takashi Isobe Kyoko Kofuji Masafumi mizutani Ryosei Kamaguchi Faculty of Pharmaceutical Science Hokuriku University Ho-3 Kanagawa-machi Kanazawa Japan Morishita Jintan Co. Osaka Technocenter 2-11-1 Tudayamate Hirakata Japan

Oral dissolving gelatin beads (GBs) containing allopurinol (AP) were prepared by the seamless capsule method and their rheological properties were examined. The release profiles of both gelatin and AP from GBs were also investigated in limited dissolution medium. GBs containing AP provided an easy-to-handle dosage form, but the physical strength of the beads immediately decreased upon contact with physiological saline at 37℃. Gelatin was released from the outer layer of GBs in physiological saline, with almost all the gelatin dissolved after 5 min, together with approximately 30% of the AP contained in the inner layer of the GB. The oral administration of GBs likely results in immediate softening of the GB upon contact with saliva. The released AP acts directly at inflammation sites, in a manner similar following oral rinsing with an AP suspension. Therefore, GBs are a useful dosage form for preventing or treating localized problems in the oral cavity, such as mucositis.

关键词： Gelatin Bead Seamless Capsule Oral Mucositis Allopurinol

Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival

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World Journal of Gastroenterology 2021年第41期27卷 7190-7206页

作者： Kentaro Yamada Tsunaki Sawada Masanao Nakamura Takeshi Yamamura Keiko Maeda Eri Ishikawa Tadashi Iida Yasuyuki mizutani Naomi Kakushima Takuya Ishikawa Kazuhiro Furukawa Eizaburo Ohno takashi Honda Hiroki Kawashima Masatoshi Ishigami Satoshi Furune Tetsunari Hase Kenji Yokota Osamu Maeda Naozumi Hashimoto Masashi Akiyama Yuichi Ando Mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Endoscopy Nagoya University HospitalNagoya City 4668560AichiJapan Department of Clinical Oncology and Chemotherapy Nagoya University HospitalNagoya City 4668560AichiJapan Department of Respiratory Medicine Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Dermatology Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Gastroenterology and Hepatology Graduate School of MedicineThe University of TokyoTokyo 1138655Japan

BACKGROUND Despite the popularity of immune checkpoint inhibitors(ICIs)in the treatment of advanced cancer,patients often develop gastrointestinal(GI)and non-GI immune-related adverse events(irAEs).The clinical characteristics and survival outcomes of GI-irAEs have not been fully elucidated in previous *** necessitates the evaluation of the impact of GI-irAEs on patients receiving ICI *** To evaluate the clinical characteristics of GI-irAEs and their impact on survival in patients treated with *** In this single-center,retrospective,observational study,we reviewed the records of 661 patients who received ICIs for various cancers at Nagoya University Hospital from September 2014 to August *** analyzed the clinical characteristics of patients who received ICI *** also evaluated the correlation between GI-irAE development and prognosis in non-small cell lung cancer(LC)and malignant melanoma(MM).Kaplan-Meier analysis was used to compare the median overall survival(OS).Multivariate Cox proportional hazards models were used to identify prognostic factors.A P value<0.05 was considered statistically *** GI-irAEs occurred in 34 of 605 patients(5.6%)treated with an anti-programmed cell death-1/programmed death-ligand 1(anti-PD-1/PD-L1)antibody alone and in nine of 56 patients(16.1%)treated with an anti-cytotoxic T-lymphocyte antigen 4(CTLA-4)antibody alone or a combination of anti-PD-1 and anti-CTLA-4 *** cumulative incidence and median daily diarrhea frequency were significantly higher in patients receiving anti-CTLA-4 antibodies(P<0.05).In 130 patients with MM,OS was significantly prolonged in the group that continued ICI treatment despite the development of GI-irAEs compared to the group that did not experience GI-irAEs(P=0.035).In contrast,in 209 patients with non-small cell LC,there was no significant difference in OS between the *** multivariate analyses showed that a performance status of 2-3(ha

关键词： Colitis Cytotoxic T-lymphocyte antigen 4 Diarrhea Drug-related side effects and adverse reactions Immune checkpoint inhibitors Prognosis

Clinical Impact of Endoscopic Submucosal Dissection for Early Gastric Cancer

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Journal of Cancer Therapy 2013年第1期4卷 61-67页

作者： takashi Kosaka Masaki Endo Yousuke Toya Tomomi mizutani Yukito Abiko Norihiko Kudara Masaaki Inomata Toshimi Chiba Yasuhiro Takikawa Kazuyuki Suzuki Tamotsu Sugai Department of Diagnostic Pathology Iwate Medical University School of Medicine Morioka Japan. Department of Gastroenterology and Hepatology Iwate Medical University School of Medicine Morioka Japan

Aim: The aim of this study was to examine the safety and efficacy of endoscopic submucosal dissection (ESD) for early gastric cancer based on approximately 10 years’ experience. Methods: Endoscopic submucosal dissection was performed in 1272 patients with early gastric cancer (1657 lesions). We examined en bloc resection rate, curative resection rate, local recurrence rate, procedure time, and complications. Results: The overall en bloc resection rate was 98.6% for all lesions treated by ESD. The median procedure time of the operation was 54.3 minutes (range 5 - 632 min). The incidence of positive horizontal and vertical margins was 3.8% and 4.0%, respectively. The incidence was 2.5% each for perforation and postoperative bleeding. There were no deaths related to ESD. Local recurrence was observed in 10 lesions (0.06%). Conclusion: Since the procedure time and incidence of complications have been reduced, endoscopic submucosal dissection has been considered a standard treatment for early gastric cancer.

关键词： Endoscopic Submucosal Dissection ESD Gastric Cancer