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Potential of non-Western medicines in chemoradiotherapy for cervical cancer

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World Journal of Clinical Cases 2025年第2期13卷 21-23页

作者： takashi Ono Masashi Koto Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan

This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical *** radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’***,most treatments are supportive,with no specific treatment options available in Western ***-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical *** these potential benefits,challenges such as limited evidence and restricted application areas *** non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.

关键词： Cervical cancer Radiotherapy Non-Western medicine Kampo Herbal medicine

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胆道肿瘤临床实践指南(英文第三版)

中华消化外科杂志 2021年第4期20卷 359-375页

作者： Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama takashi mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) 爱知癌症中心日本名古屋北海道大学医学院胃肠外二科日本札幌独协医科大学琦玉医学中心普通外科日本越谷独协医科大学普通外二科日本米布静冈癌症中心肝胆胰外科日本长崎东北大学医学院外科系日本仙台名古屋大学医学院外科系日本名古屋国立癌症中心医院东院区肝胆胰外科日本柏市京都大学医学院外科系日本东京国立癌症中心医院日本东京帝京大学千叶医学中心外科系日本市原东京女子医科大学胃肠病研究所普通外科日本东京新泻大学医学与牙科研究生院消化与普通外科日本新泻均天道大学医学研究生院消化内科日本东京国立癌症中心医院肝胆胰肿瘤科日本东京千叶县锯原医院消化内科日本锯原藤田医科大学消化内科及消化肿瘤科日本丰明杏林大学医学院肿瘤内科日本三鹰泰恩金凯医院教育研究中心日本札幌爱知医科大学放射科日本长谷京都府立医科大学医学研究生院放射科日本京都广崎大学医学研究部病理学与生物科学系日本广崎日本红十字会京都第二医院病理科日本京都国际医疗福利大学肝胆胰胃肠外科日本一川横滨市立大学医学研究生院消化外科日本横滨南京大学医学院附属鼓楼医院肝胆胰中心

日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确... 详细信息

日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。

关键词：胆道肿瘤临床实践指南预防性治疗循证医学证据肝胆胰外科胆道引流推荐意见壶腹癌

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

The stay coefficient: a novel quantification of the relationship between stay time and travel time for urban shopping behavior analysis

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Geo-Spatial Information Science 2023年第1期26卷 44-57页

作者： takashi Yamada Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityWakayamaJapan

Shoppers typically want to spend an amount of time at a destination that is proportional to the travel time required to arrive there;thus,the travel time can be considered the cost of their *** is likely to be the case across regions with different urban structures and *** purpose of this study was therefore to analyze the shopping behaviors contained in travel survey data from three metropolitan areas in Japan to identify common patterns and indicators based on travel time and stay time,thereby obtaining an understanding to inform future trade area *** the travel time and stay time associated with shopping behavior were found to be log-normally distributed regardless of metropolitan area,and four shopping behavior patterns common among the metropolitan areas were ***“stay coeffi-cient”was then defined to express the elasticity of stay time according to travel time,and its values were similar according to shopping behavior pattern regardless of metropolitan *** stay coefficient proposed in this study can therefore be applied to identify shopping behavior patterns in any urban area based on the relationship between travel time and stay time,realizing a novel approach to the analysis of and marketing for trade areas when planning the construction or renovation of commercial *** approach can help inform the decisions of urban policy makers,marketing advisors,and commercial facility operators,and should be of interest to researchers and practitioners working with geospatial,shopping,and other human behavioral characteristics.

关键词： Travel survey shopping behavior travel time stay time stay coefficient trade area analysis

The Emergent Constructive Approach to Evolinguistics:Considering Hierarchy and Intention Sharing in Linguistic Communication

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Journal of Systems Science and Systems Engineering 2020年第6期29卷 675-696页

作者： takashi Hashimoto School of Knowledge Science Japan Advanced Institute of Science and Technology(JAIST)Nomi 923-1292Japan

Evolinguistics is an attempt to clarify the origins and evolution of language and communication,thereby deepening our understanding of humans from an evolutionary *** origins of language is characterized by the biological evolution of abilities related to language and communication,and the evolution of language by the structuralization and complexification of language knowledge as well as communication systems through cultural *** Evolinguistics,two idiosyncrasies of human linguistic communication are the primary focus,namely,using hierarchically organized symbol sequences in language and sharing intentions in *** believe that the integration of these two characteristics made humans co-creative and smart,and in particular gave us knowledge co-creation *** emergent constructive approach plays an important role in this research,which is a methodology to analyze complex systems by constructing and operating the evolutionary and emergent process of complex *** studies taking this approach are introduced in this *** is a language evolution experiment in a laboratory to consider the process,mechanisms,and neural basis of symbolic communication *** other is an evolutionary simulation of recursive combination,which is thought of as the essential ability to form hierarchical structures.A hypothesis integrating intention sharing and recursive combination is discussed as an abductive reasoning mechanism for understanding others intentions.

关键词： Evolinguistics origins and evolution of language hierarchy intention sharing symbolic communication recursive combination abduction

A time-space network based international transportation scheduling problem incorporating CO_2 emission levels

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 927-932页

作者： takashi IROHARA Department of Information and Communication Sciences Faculty of Science and TechnologySophia University

Environmental problems have received a great deal of attention in recent *** particular,CO2 emissions worsen global warming and other environmental *** transport sector accounts for 20% of the total CO2 ***,the CO2 emission reduction of the transport sector is of great *** order to reduce emissions effectively,it is necessary to change the distribution and transportation *** purpose of this study is to minimize both the transportation costs and CO2 emissions during *** model considers a transportation scheduling problem in which loads are transported from an overseas production base to three domestic demand *** need for time-space networks arises naturally to improve the *** is possible to know the distance carriers are moving,and also consider the timetables of carriers during *** choice,less-than carrier load,and domestic transportation among demand centers are considered as the three target areas to reduce CO2 emissions during the distribution *** research model was formulated as a mixed integer programming (MIP) *** achieves cost reduction,and will contribute to improvement of the natural environment.

关键词： Time-space network Timetable Transportation scheduling problem Mixed integer programming (MIP) problem Less-than carrier load

NUMERICAL PREDICTION OF DYNAMIC PERFORMANCE OF PELTON TURBINE

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Journal of Hydrodynamics 2007年第3期19卷 356-364页

作者： KUBOTA takashi College of Electric Power South China University of Technology Guangzhou 510640 China

Different from the reaction turbines, the hydraulic performance of Pelton turbine is dynamic due to the unsteady flow in the rotating buckets in time and space. The dynamic energy efficiency of bucket ηεB and power efficiency of bucket ηPB within a short period can be predicted from the dynamic flow pattern of the free-surface sheet flow in the rotating bucket, whereas the dynamic discharge efficiency of bucket ηQB is defined as the resident discharge in the bucket at the respective moment. Under the operation of higher unit speed non than the optimum one, the power efficiency of bucket is deteriorated by the jet interference with the rear surface of bucket △Prear at the first stage of the dynamic performance, as well as the loss power due to the spilt flow from the cutout of bucket at the later stage of performance. Based on the dynamic performance prediction presented, the future possibility of the quantitative investigation for the negative scale effect of Pelton turbines was discussed.

关键词： dynamic energy efficiency dynamic discharge efficiency dynamic power efficiency rotating bucket Pelton turbine

Cerebral spinal fluid biomarker profiles in CNS infection associated with HSV and VZV mimic patterns in Alzheimer's disease

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Translational Neurodegeneration 2021年第1期10卷 12-14页

作者： Makiko Shinom oto takashi Kasai Harutsugu Tatebe Fukiko Kitani-Morii Takuma Ohmichi Yuzo Fujino David Allsop Toshiki mizuno Takahiko Tokuda Departm ent of Neurology Kyoto Prefectural University of MedicineKyoto 602-0841Japan Departm ent of Functional Brain Imaging Research National Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Division of Biomedical and Life Sciences Faculty of Health and MedicineLancaster UniversityLancaster LAI 4YQUK

Alzheimer’s disease(AD)is the most common cause of *** AD was initially considered to be a cell autonomous neurodegenerative disorder,marked neuroinflammation has been observed in brains of AD *** and molecular biological findings have suggested the central nervous system(CNS)inflammatory processes to be involved in the etiopathogenesis of AD,in which the activated microglia play a key role.

关键词： Alzheimer inflammation infection

Analysis of shopping behavior characteristics in the Keihanshin metropolitan area in Japan based on a person trip survey

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Geo-Spatial Information Science 2020年第4期23卷 305-315页

作者： takashi Yamada Takumi Hayashida Department of Human Factors Engineering and Environmental Design Faculty of Biology-Oriented Science and TechnologyKindai UniversityKinokawaWakayamaJapan

This study analyzed weekday shopping behavior from a home base to a destination using data from the 4th Keihanshin metropolitan area person trip *** first analyzed the relationships between occupation and transportation means,transportation means and travel time,and transportation means and duration of time at the *** of a chi-square test,residual analysis,and correspondence analysis confirmed that employed persons tend to travel by cars while unemployed persons tend to travel by bus or *** relationship between travel time and duration of time at the destination was also revealed according to transportation *** of a cluster analysis then classified shopping behaviors to expose four ***,multiple regression analyzed the degree to which certain variables were related to duration of time at the *** confirmed a strong relationship between duration of time at the destination and travel *** degree of this factor’s influence on other variables was also *** value of these findings is that the relationship between travel time by means of transportation and the duration of time at the destination was clarified using statistical *** then found a highly accurate equation that estimates the duration of time at a destination from the travel *** the duration of time at a destination can be estimated,it may be possible to more accurately develop the structure of rest facilities,the number of parking lots,the degree of congestion,and so on,which can be associated with the customer’s usage behavior in a shopping *** research in this paper contributes to the field of urban analysis and marketing by presenting a new effective method for person trip survey and analysis.

关键词： Person trip survey shopping behavior transportation means travel time duration of time at a destination