Cerebral spinal fluid biomarker profiles in CNS infection associated with HSV and VZV mimic patterns in Alzheimer's disease

作     者：Makiko Shinom oto Takashi Kasai Harutsugu Tatebe Fukiko Kitani-Morii Takuma Ohmichi Yuzo Fujino David Allsop Toshiki Mizuno Takahiko Tokuda Makiko Shinomoto;Takashi Kasai;Harutsugu Tatebe;Fukiko Kitani-Morii;Takuma Ohmichi;Yuzo Fujino;David Allsop;Toshiki Mizuno;Takahiko Tokuda

作者机构：Departm ent of NeurologyKyoto Prefectural University of MedicineKyoto 602-0841Japan Departm ent of Functional Brain Imaging ResearchNational Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Division of Biomedical and Life SciencesFaculty of Health and MedicineLancaster UniversityLancaster LAI 4YQUK 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2021年第10卷第1期

页      面：12-14页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：mainly supported in part by a grant from the Japan Agency for Medical Research and Developm ent(AMED)(to T.T.) partially by Grants-in-Aid(Nos.15 K09319 and 18 K07506 to T.K.,No.20 K16605 to T.O.,No.18K15461 to H.T.)from the Ministry of Education,Culture,Sports,Science and Technology of Japan research grants from Dainippon Sumitomo Pharma in 2018(to T.O.)and 2017(to T.K.) 

主　　题：Alzheimer inflammation infection 

摘      要：Alzheimer’s disease(AD)is the most common cause of *** AD was initially considered to be a cell autonomous neurodegenerative disorder,marked neuroinflammation has been observed in brains of AD *** and molecular biological findings have suggested the central nervous system(CNS)inflammatory processes to be involved in the etiopathogenesis of AD,in which the activated microglia play a key role.