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Development of Performance-Based Tunnel Evaluation Methodology and Performance Evaluation of Existing Railway Tunnels

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Journal of Transportation Technologies 2012年第2期2卷 113-128页

作者： Sadao Kimura takashi kitani Atsushi Koizumi Department of Civil and Environmental Engineering Kanazawa Institute of Technology Ishikawa Japan

The concept of performance-based design, which mainly focuses on mechanical performance, has become the international standard, as in the case for ISO. The standardization of tunnel design has not been achieved because it requires integration of separate specialized fields, such as geotechnical engineering, structural engineering and concrete engineering. It is also required to clarify performance-based criteria for tunnel structures to suit specific use purposes (objectives), establish the concept of survey, planning, design, construction and maintenance based on such criteria, and develop proper management systems for operation and maintenance to suit specific tunnel use purposes. To this end, it is vital to develop a methodology for evaluating and verifying the performance of existing tunnels. This paper presents a new concept of performance requirements for tunnel structures and describes the method of quantitatively evaluating the total performance of existing tunnels in relation to the required performance, assuming the total performance to be based on the Analysis Hierarchy Process.

关键词： Tunnel Performance Criterion Life Cycle Design Performance-Based Design Asset Management Maintenance Analysis Hierarchy Process

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Cerebral spinal fluid biomarker profiles in CNS infection associated with HSV and VZV mimic patterns in Alzheimer's disease

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Translational Neurodegeneration 2021年第1期10卷 12-14页

作者： Makiko Shinom oto takashi Kasai Harutsugu Tatebe Fukiko kitani-Morii Takuma Ohmichi Yuzo Fujino David Allsop Toshiki Mizuno Takahiko Tokuda Departm ent of Neurology Kyoto Prefectural University of MedicineKyoto 602-0841Japan Departm ent of Functional Brain Imaging Research National Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Division of Biomedical and Life Sciences Faculty of Health and MedicineLancaster UniversityLancaster LAI 4YQUK

Alzheimer’s disease(AD)is the most common cause of *** AD was initially considered to be a cell autonomous neurodegenerative disorder,marked neuroinflammation has been observed in brains of AD *** and molecular biological findings have suggested the central nervous system(CNS)inflammatory processes to be involved in the etiopathogenesis of AD,in which the activated microglia play a key role.

关键词： Alzheimer inflammation infection

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