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Effects of inner sleeves on the inner frictional resistance of open-ended piles driven into sand

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Frontiers of Structural and Civil Engineering 2016年第4期10卷 499-505页

作者： Janaka J. KUMARA Yoshiaki kikuchi takashi KURASHINA Takahiro YAJIMA Department of Civil Engineering Tokyo University of Seience Noda 278-8510 Japan Maeda Corporation Tokyo 102-8151 Japan

In open-ended piles, inner friction is developed between inner pile shaf and the inner soil. Inner frictional resistance depends largely on the degree of soil plugging, which is influenced by many factors including pile diameter, relative density and end conditions of piles. In this paper, effects of inner sleeves on inner frictional resistance are discussed. The experiments were conducted on a medium-dense sandy ground using laboratory-scale piles. It was observed that the piles penetrated under partially-plugged or unplugged state. The results suggest that inner fiictional resistance, Qin increases with sleeve height, l linearly and requires 2D （D is pile outer diameter） of l to produce a large as 50% of Qt by Qin （Qt is total resistance）. The results also indicate that bearing capacity increases with wall thickness at the pile tip, which can be attributed to the increase in annular area. The results also indicate that soil plug height is independent of sleeve height. The results also reveal that the penetration of straight piles is closer to unplugged state than the sleeved piles. The results of incremental filling ratio and plug length ratio also indicate that the degree of soil plugging is affected by the sleeve height.

关键词： bearing capacity inner frictional resistance inner sleeve open-ended piles soil plugging

Multiple carcinosarcomas of the esophagus with adenocarcinomatous components: A case report

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World Journal of Gastroenterology 2020年第17期26卷 2111-2118页

作者： Hiroshi Okamoto Hiroshi kikuchi Hiroshi Naganuma takashi Kamei Department of Gastroenterological Surgery Graduate School of MedicineTohoku UniversitySendai 980-8574Japan Department of Surgery South Miyagi Medical CenterMiyagi 989-1253Japan Department of Pathology Sendai City HospitalSendai 982-8502Japan

BACKGROUND Carcinosarcoma(spindle cell carcinoma) of the esophagus is an extremely rare event;the etiology and origins of this neoplasm have not yet been ***-mesenchymal transition(EMT) has been associated with invasion and metastasis, and may be related to the generation of a stem cell population within this *** SUMMARY We present the case of a 61-year-old male with nausea and fever. Upper gastrointestinal endoscopy revealed the presence of type 1 and 0-Ⅱc lesions located 35 cm from the incisors toward the esophago-gastric *** esophagectomy was performed. Macroscopic analysis revealed three polypoid lesions in the abdominal esophagus that accompanied the main lesion in the lower thoracic esophagus and 0-Ⅱc lesions that spread continuously with them. Histologically, the lesions included proliferating spindle cells. Adenocarcinomatous components were detected in a section near the foot, and squamous cell carcinoma was identified in the mucosa at the base of the *** patient was diagnosed with multiple carcinosarcomas, staged at pT1b(SM3),pN1(#110, #7), cM0, Stage Ⅱ(sarcomatous metastasis to the lymph nodes).Spindle cells did not express E-cadherin but were positive for EMT markers,including zinc finger E-box-binding homeobox 1, TWIST, and snail family transcriptional repressor 2. The patient has experienced no recurrence at 5 years and 2 mo after *** This report suggests that multiple sarcomatous tumors may be generated from primary squamous cell carcinoma via mechanisms related to EMT.

关键词： Esophagus Multiple carcinosarcomas Multiple spindle cell carcinomas Epithelial-mesenchymal transition Epithelial-mesenchymal transition markers Case report

Growth of GaN/AlxGa1-xN (x=0.65) Superlattices on Si(111) Substrates Using RF-MBE

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Journal of Rare Earths 2006年第Z1期24卷 1-3页

作者： Armando S Somintac Tomo kikuchi Michiya Odawara takashi Udagawa Motoi Wada Tadashi Ohachi Department of Electric Engineering Doshisha University 1-3 Miyakodani Tatara Kyotanabe Kyoto 610-0321 Japan Department of Electric Engineering Doshisha University 1-3 Miyakodani Tatara Kyotanabe Kyoto 610-0321 Japan Electronic Materials Division Electronics Section Showa Denko K.K. 1505 Shimokagemori Chichibu Saitama 369-1871 Japan Electronic Materials Division Electronics Section Showa Denko K.K. 1505 Shimokagemori Chichibu Saitama 369-1871 Japan Department of Electric Engineering Doshisha University 1-3 Miyakodani Tatara Kyotanabe Kyoto 610-0321 Japan Department of Electric Engineering Doshisha University 1-3 Miyakodani Tatara Kyotanabe Kyoto 610-0321 Japan

Superlattices with varying GaN well widths (2, 3, 6, 9 nm) and fixed AlGaN barrier (8 nm) with high Al-content (x=0.65) were grown. Streaky RHEED patterns indicated 2D growth mode for the superlattices. XRD measurements showed multiple satellite peaks corresponding to uniform periodicity of the GaN/AlGaN pairs. The AlGaN barrier XRD peak also shifted with increasing well widths, while the GaN XRD peak was nominally unchanged. Room temperature photoluminescence experiments revealed peak emissions at energies lower than the bulk GaN energy gap. The large red shift with respect to the bulk gap is attributed to significant Stark effect for wide multiple quantum wells.

关键词： molecular beam epitaxy superlattices GaN AlGaN built-in electric field stark effect

gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus

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World Journal of Gastroenterology 2017年第36期23卷 6694-6704页

作者： Midori Fujishiro Akifumi Kushiyama Hiroki Yamazaki Sunao Kaneko Yuko Koketsu Takeshi Yamamotoya Takako kikuchi Hideyuki Sakoda Ryo Suzuki takashi Kadowaki Department of Diabetes and Metabolic Diseases Graduate School of Medicine the University of Tokyo Division of Diabetes and Metabolism Institute for Adult Diseases Asahi Life Foundation Department of Diabetes and Metabolic Diseases Shinko Hospital Department of Medical Science Graduate School of Medicine University of Hiroshima Division of Neurology Respirology Endo-crinology and Metabolism Department of Internal Medicine Faculty of Medicine University of Miyazaki

AIM To unravel relationships between gastrointestinal(GI)symptoms impairing quality of life(QOL)and clinical profiles of diabetes mellitus(DM)patients. METHODS We enrolled 134 outpatients with type 2 *** age was 64.7 years,mean body mass index was 24.7 RESULTS Lower abdominal symptoms were found to be more frequent than those affecting the upper *** duration and medications showed associations with GI *** identified differences in peak prevalences of the five ***(P=0.02vs 10-14 years)and total GI symptoms(P=0.01 and P=0.02 vs 5-9 years and 10-14 years,respectively)peaked at a diabetes duration of 15-19 ***(P=0.004)and postprandial fullness(P=0.03)tended to increase with disease *** and diarrhea showed bimodal peaks,with the first early and the second late(e.g.,P=0.03 at 15-19 years vs 10-14years for diarrhea)in the disease ***,GI symptoms showed clustering that reflected the region of the GI tract affected,i.e.,constipation and diarrhea had similar frequencies(P<0.0001). CONCLUSION Our study highlights the importance of questioning patients about QOL impairment due to abdominal symptoms,especially in the early and the late periods of diabetes.

关键词： Gastrointestinal symptoms Questionnaire survey Disease duration Type 2 diabetes Quality of life Gastrointestinal tract regions

Maternal Anxiety 16 Months after the Great East Japan Earthquake Disaster Area: First Report

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Health 2014年第10期6卷 870-878页

作者： Hatsumi Yoshii Hidemitsu Saito Saya kikuchi takashi Ueno Kineko Sato Department of Psychiatry Tohoku University Hospital Sendai Japan Division of Clinical Psychology Graduate School of Education Tohoku University Sendai Japan Health Sciences Tohoku University Graduate School of Medicine Miyagi Japan

The Great East Japan Earthquake, a magnitude 9.0 quake that occurred on March 11, 2011, left more than 20,000 killed or missing and resulted in more than 400,000 people being displaced. The Fukushima Nuclear Power Plant accident released large amounts of radioactive material into the air. Among the victims of this combined disaster were many pregnant and parturient women, and this study aimed to determine post-disaster anxiety among this specific population and measures for the future. Participants were 259 women (mean age 33.02 ± 4.79 years) who gave birth around the time of the earthquake in Miyagi Prefecture, one of the disaster areas. Sixteen months after the earthquake, we administered survey questionnaires on anxiety. We transcribed questionnaire responses, coded raw data by context, and categorized these codes by commonality. After extracting subcategories of anxiety-related factors, we categorized them into more abstract concepts. Among the participants, 126 (48.6%) reported having no available professionals with whom they could consult about childrearing. Participants reported anxiety in the following 12 categories: “radiation,” “child’s physical and mental growth/development,” “recurrence of earthquake and tsunami,” “financial issues,” “childrearing environment,” “living environment,” “maternal employment,” “stigma,” “familial issues,” “maternal health,” “childrearing,” and “the future”. A beneficial way to reduce maternal anxiety in the 12 areas identified would be to develop support systems that provide continuous support for children’s mental health care needs, psychological guidance, community support for maternal empowerment, outreach for individual support, and professional consultation for mothers who have high anxiety about radioactivity.

关键词： Earthquake Maternal Anxiety Child Care Disaster Area

THE PROPERTIES ON STRUCTURAL LIGHTWEIGHT CONCRETE CONTAINING SINTERED FLY ASH COARSE AGGREGATE.

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THE PROPERTIES ON STRUCTURAL LIGHTWEIGHT CONCRETE CONTAINING...

A Study on Diagnostic Assist Systems of Chronic Obstructive Pulmonary Disease from Medical Images by Deep Learning

1985北京国际水泥及混凝土学术会议

作者： Masafumi kikuchi takashi MUKAI Hideo UMEZU Toshifumi KOREISHI Meiji university KawasakiJapan Kyūshū Electric Power Co.Inc.Fukuoka Japan

The Industries depending on coal for thermal energy resource turn out a large quantity of coal ash as byproduct. The using tiosse coal ash as raw material for lightweight aggregate is one of the effective using resource. The sintered fly ash coarse aggregate used in this investigation was produced from fly ash descharged at thermal power station. This report shows the properties of aggregate, concrete containing this type of aggregate and the behavior of reinforced concrete beam.

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Journal of Computer and Communications 2018年第1期6卷 21-31页

作者： Toru Kimura takashi Kawakami Akihiro kikuchi Ryosuke Ooev Masaki Akiyama Hiroyuki Horikoshi Faculty of Engineering Hokkaido University of Science Sapporo Japan Department of Radiology Gunma Prefecture Cancer Center Gunma Japan

In this paper, we propose new diagnostic assist systems of medical images using deep learning algorithms. Specifically, we aim to develop a diagnostic support system for the very early stage of chronic obstructive pulmonary disease (COPD) based on the CT images. It is said that COPD is a disease that develops due to long-term smoking, and it is said that there are a large number of latent onset reserve forces. By discovering this COPD in the very early period 0 and improving the living conditions, subsequent severity can be avoided in many cases, so a system that will help diagnosis by professional radiologists is needed. We show the some experimental results examined by the constructed system.

关键词： Deep Learning CT Images Diagnostic Assist Systems Chronic Obstructive Pulmonary Disease

New acetogenin katsuurallene from Laurencia saitoi collected from Katsuura, Japan

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Natural Products and Bioprospecting 2022年第1期12卷 121-127页

作者： Yu Minamida Hiroshi Matsuura Takahiro Ishii Miyu Miyagi Yuto Shinjo Kosuke Sato takashi Kamada Yoshihiro Mihara Iwao Togashi Keisuke Sugimoto Tsuyoshi Abe Norio kikuchi Minoru Suzuki Advanced Course of Applied Chemistry National Institute of TechnologyAsahikawa CollegeShunkodai 2-2-1-6AsahikawaHokkaido 071-8142Japan Department of Materials Chemistry National Institute of TechnologyAsahikawa CollageShunkodai 2-2-1-6AsahikawaHokkaido 071-8142Japan Department of Biosciences and Biotechnology Faculty of AgricultureUniversity of the Ryukyus1 SenbaruNishiharaOkinawa 903-0213Japan Department of Materials and Life Science Faculty of Science and TechnologyShizuoka Institute of Science and Technology2200-2 ToyosawaFukuroiShizuoka 437-8555Japan Department of Medicinal Chemistry Faculty of Pharmaceutical SciencesHokkaido University of ScienceMaeda 715-4-1Teine-kuSapporoHokkaido 006-8590Japan The Hokkaido University Museum Hokkaido UniversityN10 W8Kita-kuSapporoHokkaido 060-0810Japan Coastal Branch of Natural History Museum and Institute Chiba123 YoshioKatsuuraChiba 299-5242Japan Department of Life Science Graduate School of Engineering ScienceAkita University1-1 Tegatagakuen-machiAkita 010-8502Japan

We examined the chemical constitution of the red alga Laurencia saitoi Perestenko,collected from Katsuura,Boso Peninsula,Chiba Prefecture,*** specimen produced a new polyhalogenated acetogenin,named katsuural-lene(1),which structure was determined by the spectral methods,along with known diterpene,deoxyparguerol(2)and triterpene,thyrsiferol(3).In this paper we describe the structural elucidation of katsuurallene together with some biological activities.

关键词： Laurencia Rhodomelaceae Acetogenin Triterpene Diterpene Biological activity

Promoter Methylation of the CADM1 and 4.1BGenes Occurs Independently of the EGFRor the KRAS2 Mutation in Non-Small Cell Lung Cancer

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Journal of Cancer Therapy 2015年第3期6卷 273-285页

作者： Hiroyuki Kogai Shinji kikuchi takashi Obana Yumi Tsuboi Tomoko Maruyama Mika Sakurai-Yageta Hisao Asamura Yae Kanai Yoshinori Murakami Division of Molecular Pathology Institute of Medical Science The University of Tokyo Tokyo Japan Division of Thoracic Surgery National Cancer Research Center Hospital Tokyo Japan Division of Pathology National Cancer Research Center Research Institute Tokyo Japan

Objective: Targeting mutated EGFR by EGFR-tyrosine kinase inhibitors (EGFR-TKI) is a potent approach to a subset of non-small cell lung cancer (NSCLC). However, the response to EGFR-TKI varies in individual cases even among tumors carrying the same?EGFR?mutation, suggesting the involvement of modifying factors. To characterize possible modifiers, we examined mutation state of the?EGFR?and the?KRAS?genes in Japanese NSCLC and compared them with the methylation state of lung tumor suppressors, the?CADM1 and?4.1B,?whose products have potentials to modify the functions of EGFR or KRAS. Materials and methods: A total of 103 Japanese NSCLC and 11 NSCLC cell lines were examined. Genomic DNA of exons 18–21 of the?EGFR?and exons 1 and 2 of the?KRAS?were amplified by polymerase chain reaction (PCR), followed by single-strand conformation polymorphism analysis and direct sequencing. Methylation status of gene promoters in NSCLC cells were examined by methylation-specific PCR. Results: Mutations of the?EGFR?and?KRAS?were detected mutually exclusively in 27 and 11 out of 103 NSCLC cases, respectively.?EGFR?mutations were observed exclusively in adenocarcinoma (27 of 69, 41%) and preferentially in tumors from female and non-smokers (p < 0.00001). Eight (30%) and 12 (44%) of 27 tumors carrying mutated?EGFR?and 4 (36%) and 8 (73%) of 11 tumors carrying mutated?KRAS?showed methylation of the?CADM1 and 4.1B, respectively.?EGFR-mutated tumors with methylation of either?CADM1 or 4.1B?showed more malignant features than those with unmethylated?CADM1 and 4.1B?(p < 0.05). Conclusion: Methylation state of the?CADM1 and?4.1B?are independent of the mutation status of the?EGFR?or?KRAS?but play roles in the malignant progression of NSCLC. Integration of epigenetic information would be useful for identifying possible modifiers to predict the response or recurrence of lung adenocarcinoma to the EGFR-TKI therapy.

关键词： Non-Small Cell Lung Cancer EGFR Mutation KRAS Mutation CADM1 Methylation 4.1B Methylation